Citations (46)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (1)
Simon Malenfant, Guillaume Margaillan, Jérémy Edwin Loehr, Sébastien Bonnet & Steeve Provencher. (2013) The emergence of new therapeutic targets in pulmonary arterial hypertension: from now to the near future. Expert Review of Respiratory Medicine 7:1, pages 43-55.
Read now
Read now
Articles from other publishers (45)
Xinghe Chen, Xiaozhen Wei, Saijie Ma, Huating Xie, Sirui Huang, Mengge Yao & Li Zhang. (2022) Cysteine and glycine rich protein 2 exacerbates vascular fibrosis in pulmonary hypertension through the nuclear translocation of yes-associated protein and transcriptional coactivator with PDZ-binding motif. Toxicology and Applied Pharmacology 457, pages 116319.
Crossref
Crossref
Xiaoyi Hu, Qian Wang, Hui Zhao, Wenhui Wu, Qinhua Zhao, Rong Jiang, Jinming Liu, Lan Wang & Ping Yuan. (2022)
Role of
miR
‐21‐5p/
FilGAP
axis in estradiol alleviating the progression of monocrotaline‐induced pulmonary hypertension
. Animal Models and Experimental Medicine 5:3, pages 217-226.
Crossref
Crossref
Bibi Marjan Razavi & Hossein Hosseinzadeh. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology
812
828
.
Pei Long, Yong Li, Qing Wen, Maohua Huang, Songtao Li, Yuning Lin, Xiaojun Huang, Minfeng Chen, Jie Ouyang, Yunlin Ao, Qi Qi, Haipeng Zhang, Wencai Ye, Guohua Cheng, Xiaoqi Zhang & Dongmei Zhang. (2021) 3′-Oxo-tabernaelegantine A (OTNA) selectively relaxes pulmonary arteries by inhibiting AhR. Phytomedicine 92, pages 153751.
Crossref
Crossref
Hui Huang, Kuizhong Shan, Min Cai, Hong Chen, Fengmei Wu, Xiaoyan Zhao, Huawei Zhuang, Hong Li & Suofang Shi. (2021) “Yiqi Huayu, Wenyang Lishui” Prescription (YHWLP) Improves the Symptoms of Chronic Obstructive Pulmonary Disease-Induced Chronic Pulmonary Heart Disease by Inhibiting the RhoA/ROCK Signaling Pathway. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-8.
Crossref
Crossref
Rong Song, Si Lei, Song Yang & Shang‐Jie Wu. (2021) LncRNA PAXIP1‐AS1 fosters the pathogenesis of pulmonary arterial hypertension via ETS1/WIPF1/RhoA axis. Journal of Cellular and Molecular Medicine 25:15, pages 7321-7334.
Crossref
Crossref
Qunhui Yang & Masatoshi Hori. (2021) Characterization of Contractile Machinery of Vascular Smooth Muscles in Hypertension. Life 11:7, pages 702.
Crossref
Crossref
Ravikumar Sitapara, TuKiet T. Lam, Aneta Gandjeva, Rubin M. Tuder & Lawrence S. Zisman. (2021) Phosphoproteomic analysis of lung tissue from patients with pulmonary arterial hypertension. Pulmonary Circulation 11:3, pages 1-15.
Crossref
Crossref
Taslim A. Al-Hilal, Mohammad Anwar Hossain, Ahmed Alobaida, Farzana Alam, Ali Keshavarz, Eva Nozik-Grayck, Kurt R. Stenmark, Nadezhda A. German & Fakhrul Ahsan. (2021) Design, synthesis and biological evaluations of a long-acting, hypoxia-activated prodrug of fasudil, a ROCK inhibitor, to reduce its systemic side-effects. Journal of Controlled Release 334, pages 237-247.
Crossref
Crossref
Liping ZhuFangbo LiuQiang HaoTian FengZeshuai ChenShengquan LuoRui XiaoMengxiang SunTing ZhangXiaohang FanXianqin ZengJianguo HePing YuanJinming LiuMatthieu RuizJocelyn Dupuis & Qinghua Hu. (2021) Dietary Geranylgeranyl Pyrophosphate Counteracts the Benefits of Statin Therapy in Experimental Pulmonary Hypertension. Circulation 143:18, pages 1775-1792.
Crossref
Crossref
Huifeng Xu, Yi Shen, Chenyu Liang, Haifeng Wang, Junling Huang, Pengcheng Xue & Ming Luo. (2021) Inhibition of the mevalonate pathway improves myocardial fibrosis. Experimental and Therapeutic Medicine 21:3.
Crossref
Crossref
Natascha Sommer, Hossein A. Ghofrani, Oleg Pak, Sebastien Bonnet, Steve Provencher, Olivier Sitbon, Stephan Rosenkranz, Marius M. Hoeper & David G. Kiely. (2020) Current and future treatments of pulmonary arterial hypertension. British Journal of Pharmacology 178:1, pages 6-30.
Crossref
Crossref
Meemansha Sharma, Thakur Uttam Singh, Madhu Cholanhalli Lingaraju & Subhashree Parida. 2021. Targeting Cellular Signalling Pathways in Lung Diseases. Targeting Cellular Signalling Pathways in Lung Diseases
435
445
.
Ronald Zolty. (2020) Pulmonary arterial hypertension specific therapy: The old and the new. Pharmacology & Therapeutics 214, pages 107576.
Crossref
Crossref
Yafeng Wang, Delong Duo, Yingjun Yan, Rongyue He & Xinan Wu. (2020) Magnesium lithospermate B ameliorates hypobaric hypoxia-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition and its potential targets. Biomedicine & Pharmacotherapy 130, pages 110560.
Crossref
Crossref
Zongye Cai, Ly Tu, Christophe Guignabert, Daphne Merkus & Zhichao Zhou. (2020) Purinergic Dysfunction in Pulmonary Arterial Hypertension. Journal of the American Heart Association 9:18.
Crossref
Crossref
Si Lei, Fei Peng, Mei-Lei Li, Wen-Bing Duan, Cai-Qin Peng & Shang-Jie Wu. (2020) LncRNA-SMILR modulates RhoA/ROCK signaling by targeting miR-141 to regulate vascular remodeling in pulmonary arterial hypertension. American Journal of Physiology-Heart and Circulatory Physiology 319:2, pages H377-H391.
Crossref
Crossref
Tadanori Hamano, Norimichi Shirafuji, Shu-Hui Yen, Hirotaka Yoshida, Nicholas M. Kanaan, Kouji Hayashi, Masamichi Ikawa, Osamu Yamamura, Youshi Fujita, Masaru Kuriyama & Yasunari Nakamoto. (2020) Rho-kinase ROCK inhibitors reduce oligomeric tau protein. Neurobiology of Aging 89, pages 41-54.
Crossref
Crossref
Seyed Vahid Jasemi, Hosna Khazaei, Ina Yosifova Aneva, Mohammad Hosein Farzaei & Javier Echeverría. (2020) Medicinal Plants and Phytochemicals for the Treatment of Pulmonary Hypertension. Frontiers in Pharmacology 11.
Crossref
Crossref
Yanqiu Zhang, Wei Li, Zuhong He, Yunfeng Wang, Buwei Shao, Cheng Cheng, Shasha Zhang, Mingliang Tang, Xiaoyun Qian, Weijia Kong, Hui Wang, Renjie Chai & Xia Gao. (2019) Pre-treatment With Fasudil Prevents Neomycin-Induced Hair Cell Damage by Reducing the Accumulation of Reactive Oxygen Species. Frontiers in Molecular Neuroscience 12.
Crossref
Crossref
Min Zhang, Zhi Chang, Peng Zhang, Zhicheng Jing, Lin Yan, Jun Feng, Zhiqiang Hu, Qingbin Xu, Wei Zhou, Ping Ma, Yinju Hao & Ru Zhou. (2019) Protective effects of 18β-glycyrrhetinic acid on pulmonary arterial hypertension via regulation of Rho A/Rho kinsase pathway. Chemico-Biological Interactions 311, pages 108749.
Crossref
Crossref
Cheng Li, Ping-ping Liu, Dou-dou Tang, Rong Song, Yi-qing Zhang, Si Lei & Shang-jie Wu. (2018) Targeting the RhoA-ROCK pathway to regulate T-cell homeostasis in hypoxia-induced pulmonary arterial hypertension. Pulmonary Pharmacology & Therapeutics 50, pages 111-122.
Crossref
Crossref
Allan K. N. Alencar, Guilherme C. Montes, Eliezer J. Barreiro, Roberto T. Sudo & Gisele Zapata-Sudo. (2017) Adenosine Receptors As Drug Targets for Treatment of Pulmonary Arterial Hypertension. Frontiers in Pharmacology 8.
Crossref
Crossref
Ying Gu, Yaling Feng, Jinjin Yu, Hua Yuan, Yongxiang Yin, Jian Ding, Jun Zhao, Yaohui Xu, Jianjuan Xu & Haisha Che. (2017) Fasudil attenuates soluble fms-like tyrosine kinase-1 (sFlt-1)-induced hypertension in pregnant mice through RhoA/ROCK pathway. Oncotarget 8:61, pages 104104-104112.
Crossref
Crossref
Fan Wu, Wanxia Yao, Jiamei Yang, Min Zhang, Yanping Xu, Yinju Hao, Lin Yan, Yang Niu, Tao Sun, Jianqiang Yu & Ru Zhou. (2017) Protective effects of aloperin on monocroline-induced pulmonary hypertension via regulation of Rho A/Rho kinsase pathway in rats. Biomedicine & Pharmacotherapy 95, pages 1161-1168.
Crossref
Crossref
Scott D Collum, Ning-Yuan Chen, Adriana M Hernandez, Ankit Hanmandlu, Heather Sweeney, Tinne C J Mertens, Tingting Weng, Fayong Luo, Jose G Molina, Jonathan Davies, Ian P Horan, Nick W Morrell, Javier Amione-Guerra, Odeaa Al-Jabbari, Keith Youker, Wenchao Sun, Jayakumar Rajadas, Paul L Bollyky, Bindu H Akkanti, Soma Jyothula, Neeraj Sinha, Ashrith Guha & Harry Karmouty-Quintana. (2017) Inhibition of hyaluronan synthesis attenuates pulmonary hypertension associated with lung fibrosis. British Journal of Pharmacology 174:19, pages 3284-3301.
Crossref
Crossref
Yiqing Zhang & Shangjie Wu. (2017) Effects of fasudil on pulmonary hypertension in clinical practice. Pulmonary Pharmacology & Therapeutics 46, pages 54-63.
Crossref
Crossref
Lin Wang, Moying Qu, Yao Chen, Yaxiong Zhou & Zhi Wan. (2016) Statins Have No Additional Benefit for Pulmonary Hypertension: A Meta-Analysis of Randomized Controlled Trials. PLOS ONE 11:12, pages e0168101.
Crossref
Crossref
Nandy C. LopezGerman EbenspergerEmilio A. HerreraRoberto V. ReyesGloria CalafGertrudis CabelloFernando A. MoragaFelipe A. BeñaldoMarcela Diaz, Julian T. Parer & Anibal J. Llanos. (2016) Role of the RhoA/ROCK pathway in high-altitude associated neonatal pulmonary hypertension in lambs. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 310:11, pages R1053-R1063.
Crossref
Crossref
Yangbo Feng, Philip V. LoGrasso, Olivier Defert & Rongshi Li. (2015) Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential. Journal of Medicinal Chemistry 59:6, pages 2269-2300.
Crossref
Crossref
Ming-xing Li, De-qi Jiang, Yan Wang, Qing-zhuang Chen, Yan-jiao Ma, Shan-shan Yu & Yong Wang. (2016) Signal Mechanisms of Vascular Remodeling in the Development of Pulmonary Arterial Hypertension. Journal of Cardiovascular Pharmacology 67:2, pages 182-190.
Crossref
Crossref
Alessandra B. Pernis, Edd RickerChien-Huan WengCristina RozoWoelsung Yi. (2016) Rho Kinases in Autoimmune Diseases. Annual Review of Medicine 67:1, pages 355-374.
Crossref
Crossref
Ping Shang, Zhi-Yong He, Jiang-Fan Chen, Shi-Yuan Huang, Bao-Hua Liu, Hai-Xiao Liu & Xiao-Tong Wang. (2015) Absence of the Adenosine A2A Receptor Confers Pulmonary Arterial Hypertension Through RhoA/ROCK Signaling Pathway in Mice. Journal of Cardiovascular Pharmacology 66:6, pages 569-575.
Crossref
Crossref
Yulia Shifrin, Sina Sadeghi, Jingyi Pan, Amish Jain, Andres F. Fajardo, Patrick J. McNamara & Jaques Belik. (2015) Maternal-pup interaction disturbances induce long-lasting changes in the newborn rat pulmonary vasculature. American Journal of Physiology-Lung Cellular and Molecular Physiology 309:10, pages L1186-L1198.
Crossref
Crossref
Jeremy Green, Jingrong Cao, Upul K. Bandarage, Huai Gao, John Court, Craig Marhefka, Marc Jacobs, Paul Taslimi, David Newsome, Tomoko Nakayama, Sundeep Shah & Steve Rodems. (2015) Design, Synthesis, and Structure–Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors. Journal of Medicinal Chemistry 58:12, pages 5028-5037.
Crossref
Crossref
Kiranjot Gosal, Kristyn Dunlop, Rupinder Dhaliwal, Julijana Ivanovska, Crystal Kantores, Jean-François Desjardins, Kim A. Connelly, Patrick J. McNamara, Amish Jain & Robert P. Jankov. (2015) Rho Kinase Mediates Right Ventricular Systolic Dysfunction in Rats with Chronic Neonatal Pulmonary Hypertension. American Journal of Respiratory Cell and Molecular Biology 52:6, pages 717-727.
Crossref
Crossref
Sandro Boland, Arnaud Bourin, Jo Alen, Jacques Geraets, Pieter Schroeders, Karolien Castermans, Nele Kindt, Nicki Boumans, Laura Panitti, Silke Fransen, Jessica Vanormelingen, Jean Marie Stassen, Dirk Leysen & Olivier Defert. (2015) Design, Synthesis, and Biological Evaluation of Novel, Highly Active Soft ROCK Inhibitors. Journal of Medicinal Chemistry 58:10, pages 4309-4324.
Crossref
Crossref
Ya-yun Yan, Xiao-ming Wang, Yan Jiang, Han Chen, Jin-ting He, Jing Mang, Yan-kun Shao & Zhong-xin Xu. (2015) The role of Rho/Rho-kinase pathway and the neuroprotective effects of fasudil in chronic cerebral ischemia. Neural Regeneration Research 10:9, pages 1441.
Crossref
Crossref
Duncan Shaw, Greg Hollingworth, Nicolas Soldermann, Elizabeth Sprague, Walter Schuler, Eric Vangrevelinghe, Nicholas Duggan, Matthew Thomas, Takatoshi Kosaka, Nigel Waters & Maurice J. van Eis. (2014) Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension. Bioorganic & Medicinal Chemistry Letters 24:20, pages 4812-4817.
Crossref
Crossref
Steven Pennock, Luis J. Haddock, Dean Eliott, Shizuo Mukai & Andrius Kazlauskas. (2014) Is neutralizing vitreal growth factors a viable strategy to prevent proliferative vitreoretinopathy?. Progress in Retinal and Eye Research 40, pages 16-34.
Crossref
Crossref
Nikki L. Jernigan & Thomas C. Resta. (2014) Calcium Homeostasis and Sensitization in Pulmonary Arterial Smooth Muscle. Microcirculation 21:3, pages 259-271.
Crossref
Crossref
Huanlong Liu, Xueyan Chen, Yu Han, Chaoyi Li, Pingping Chen, Suwen Su, Yongjian Zhang & Zhenhua Pan. (2014) Rho kinase inhibition by fasudil suppresses lipopolysaccharide-induced apoptosis of rat pulmonary microvascular endothelial cells via JNK and p38 MAPK pathway. Biomedicine & Pharmacotherapy 68:3, pages 267-275.
Crossref
Crossref
Salvatore Rosanio, Francesco Pelliccia, Carlo Gaudio, Cesare Greco, Abdul M. Keylani & Darrin C. D’Agostino. (2014) Pulmonary Arterial Hypertension in Adults: Novel Drugs and Catheter Ablation Techniques Show Promise? Systematic Review on Pharmacotherapy and Interventional Strategies. BioMed Research International 2014, pages 1-17.
Crossref
Crossref
Urs ScherrerYves AllemannEmrush RexhajStefano F. RimoldiClaudio Sartori. (2013) Mechanisms and Drug Therapy of Pulmonary Hypertension at High Altitude. High Altitude Medicine & Biology 14:2, pages 126-133.
Crossref
Crossref
Mirjana Jerkić. (2012) Transforming growth factor-beta superfamily members in the pathogenesis of pulmonary arterial hypertension. Scripta Medica 43:2, pages 106-110.
Crossref
Crossref