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William H. Chappell, Stephen L. Abrams, Richard A. Franklin, Michelle M. LaHair, Giuseppe Montalto, Melchiorre Cervello, Alberto M. Martelli, Ferdinando Nicoletti, Saverio Candido, Massimo Libra, Jerry Polesel, Renato Talamini, Michele Milella, Agostino Tafuri, Linda S. Steelman & James A. McCubrey. (2012) Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine. Cell Cycle 11:23, pages 4447-4461.
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Meng Zhang, Heli Yang, Tao Fu, Meizhu Meng, Yi Feng, Changda Qu, Zhongwu Li, Xiaofang Xing, Wenmei Li, Meiying Ye, Sisi Li, Zhaode Bu & Shuqin Jia. (2023)
Liquid biopsy: circulating tumor
DNA
monitors neoadjuvant chemotherapy response and prognosis in stage
II
/
III
gastric cancer
. Molecular Oncology.
Crossref
Crossref
Cen Liu, Danyang Ye, Hongliu Yang, Xu Chen, Zhijun Su, Xia Li, Mei Ding & Yonggang Liu. (2023) RAS‐targeted cancer therapy: Advances in drugging specific mutations. MedComm 4:3.
Crossref
Crossref
Yi Zhang, Fang Zhou, Jiaheng Guan, Lukun Zhou & Baoan Chen. (2023) Action Mechanism of Metformin and Its Application in Hematological Malignancy Treatments: A Review. Biomolecules 13:2, pages 250.
Crossref
Crossref
Przemysław Duda, Shaw M. Akula, Stephen L. Abrams, Linda S. Steelman, Agnieszka Gizak, Dariusz Rakus & James A. McCubrey. (2020) GSK-3 and miRs: Master regulators of therapeutic sensitivity of cancer cells. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1867:10, pages 118770.
Crossref
Crossref
Christopher J. Matheson, Kimberly A. Casalvieri, Donald S. Backos, Mohammed Minhajuddin, Craig T. Jordan & Philip Reigan. (2020) Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors. European Journal of Medicinal Chemistry 197, pages 112316.
Crossref
Crossref
Ying Xu, Yongxing Gao, Zufang Huang, Yan Zheng, Wenjuan Teng, Deyan Zheng & Xiaohua Zheng. (2019)
LKB
1 suppresses androgen synthesis in a mouse model of hyperandrogenism via
IGF
‐1 signaling
. FEBS Open Bio 9:10, pages 1817-1825.
Crossref
Crossref
Isabel Castro, Belém Sampaio-Marques & Paula Ludovico. (2019) Targeting Metabolic Reprogramming in Acute Myeloid Leukemia. Cells 8:9, pages 967.
Crossref
Crossref
Ruth L. Madera-Sandoval, József Tóvári, József Lövey, Ivan Ranđelović, Alejandro Jiménez-Orozco, Victor G. Hernández-Chávez, Elba Reyes-Maldonado & Armando Vega-López. (2019) Combination of pentoxifylline and α-galactosylceramide with radiotherapy promotes necro-apoptosis and leukocyte infiltration and reduces the mitosis rate in murine melanoma. Acta Histochemica 121:6, pages 680-689.
Crossref
Crossref
Saverio Candido, Stephen L. Abrams, Linda Steelman, Kvin Lertpiriyapong, Alberto M. Martelli, Lucio Cocco, Stefano Ratti, Matilde Y. Follo, Ramiro M. Murata, Pedro L. Rosalen, Paolo Lombardi, Giuseppe Montalto, Melchiorre Cervello, Agnieszka Gizak, Dariusz Rakus, Pann-Gill Suh, Massimo Libra & James A. McCubrey. (2018) Metformin influences drug sensitivity in pancreatic cancer cells. Advances in Biological Regulation 68, pages 13-30.
Crossref
Crossref
James A. McCubrey, Dariusz Rakus, Agnieszka Gizak, Linda S. Steelman, Steve L. Abrams, Kvin Lertpiriyapong, Timothy L. Fitzgerald, Li V. Yang, Giuseppe Montalto, Melchiorre Cervello, Massimo Libra, Ferdinando Nicoletti, Aurora Scalisi, Francesco Torino, Concettina Fenga, Luca M. Neri, Sandra Marmiroli, Lucio Cocco & Alberto M. Martelli. (2016) Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity—Diverse effects on cell growth, metabolism and cancer. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863:12, pages 2942-2976.
Crossref
Crossref
Ilaria Laurenzana, Antonella Caivano, Francesco La Rocca, Stefania Trino, Luciana De Luca, Francesca D’Alessio, Silvia Schenone, Geppino Falco, Maurizio Botta, Luigi Del Vecchio & Pellegrino Musto. (2016) A Pyrazolo[3,4-d]pyrimidine Compound Reduces Cell Viability and Induces Apoptosis in Different Hematological Malignancies. Frontiers in Pharmacology 7.
Crossref
Crossref
Camilla Evangelisti, Vittoria Cenni & Giovanna Lattanzi. (2016) Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria‐related disorders. British Journal of Clinical Pharmacology 82:5, pages 1229-1244.
Crossref
Crossref
Juliana Velez, Rongqing Pan, Jason T.C. Lee, Leonardo Enciso, Marta Suarez, Jorge Eduardo Duque, Daniel Jaramillo, Catalina Lopez, Ludis Morales, William Bornmann, Marina Konopleva, Gerald Krystal, Michael Andreeff & Ismael Samudio. (2016) Biguanides sensitize leukemia cells to ABT-737-induced apoptosis by inhibiting mitochondrial electron transport. Oncotarget 7:32, pages 51435-51449.
Crossref
Crossref
CHEOL PARK, JI-SUK JEONG, JIN-WOO JEONG, YONG-JOO KIM, YEON-KWON JUNG, GEUN-BAE GO, SUNG OK KIM, GI-YOUNG KIM, SU-HYUN HONG, YOUNG HYUN YOO & YUNG HYUN CHOI. (2016) Ethanol extract of Kalopanax septemlobus leaf induces caspase-dependent apoptosis associated with activation of AMPK in human hepatocellular carcinoma cells. International Journal of Oncology 48:1, pages 261-270.
Crossref
Crossref
Jesus Garcia-Donas, Juan Francisco Rodriguez-Moreno, Nuria Romero-Laorden & Manuel Hidalgo. 2016. mTOR Inhibition for Cancer Therapy: Past, Present and Future. mTOR Inhibition for Cancer Therapy: Past, Present and Future
191
215
.
Ângela Fernandes, Maria M. Azevedo, Olga Pereira, Belém Sampaio-Marques, Artur Paiva, Margarida Correia-Neves, Isabel Castro & Paula Ludovico. (2014) Proteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemia therapeutic approaches. Oncotarget 6:31, pages 31428-31440.
Crossref
Crossref
Cecilia Evangelisti, Camilla Evangelisti, Francesca Chiarini, Annalisa Lonetti, Francesca Buontempo, Luca M. Neri, James A. McCubrey & Alberto M. Martelli. (2015) Autophagy in acute leukemias: A double-edged sword with important therapeutic implications. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1853:1, pages 14-26.
Crossref
Crossref
James A. McCubrey, Nicole M. Davis, Stephen L. Abrams, Giuseppe Montalto, Melchiorre Cervello, Massimo Libra, Ferdinando Nicoletti, Antonino B. D'Assoro, Lucio Cocco, Alberto M. Martelli & Linda S. Steelman. (2014) Targeting breast cancer initiating cells: Advances in breast cancer research and therapy. Advances in Biological Regulation 56, pages 81-107.
Crossref
Crossref
Nicole M. Davis, Melissa Sokolosky, Kristin Stadelman, Stephen L. Abrams, Massimo Libra, Saverio Candido, Ferdinando Nicoletti, Jerry Polesel, Roberta Maestro, Antonino D’Assoro, Lyudmyla Drobot, Dariusz Rakus, Agnieszka Gizak, Piotr Laidler, Joanna Dulińska-Litewka, Joerg Basecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Giuseppe Montalto, Melchiorre Cervello, Timothy L. Fitzgerald, Zoya N. Demidenko, Alberto M. Martelli, Lucio Cocco, Linda S. Steelman & James A. McCubrey. (2014) Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention. Oncotarget 5:13, pages 4603-4650.
Crossref
Crossref
James A. McCubrey, Linda S. Steelman, Fred E. Bertrand, Nicole M. Davis, Melissa Sokolosky, Steve L. Abrams, Giuseppe Montalto, Antonino B. D’Assoro, Massimo Libra, Ferdinando Nicoletti, Roberta Maestro, Jorg Basecke, Dariusz Rakus, Agnieszka Gizak, Zoya Demidenko, Lucio Cocco, Alberto M. Martelli & Melchiorre Cervello. (2014) GSK-3 as potential target for therapeutic intervention in cancer. Oncotarget 5:10, pages 2881-2911.
Crossref
Crossref
Xinbing Sui, Yinghua Xu, Jie Yang, Yong Fang, Haizhou Lou, Weidong Han, Maolin Zhang, Wei Chen, Kaifeng Wang, Da Li, Wei Jin, Fang Lou, Yu Zheng, Hong Hu, Liu Gong, Xiaoyun Zhou, Qin Pan, Hongming Pan, Xian Wang & Chao He. (2014) Use of Metformin Alone Is Not Associated with Survival Outcomes of Colorectal Cancer Cell but AMPK Activator AICAR Sensitizes Anticancer Effect of 5-Fluorouracil through AMPK Activation. PLoS ONE 9:5, pages e97781.
Crossref
Crossref
Célia Rosilio, Issam Ben-Sahra, Frédéric Bost & Jean-François Peyron. (2014) Metformin: A metabolic disruptor and anti-diabetic drug to target human leukemia. Cancer Letters 346:2, pages 188-196.
Crossref
Crossref
Otto Quintus Russe, Christine V. Möser, Katharina L. Kynast, Tanya S. King, Katrin Olbrich, Sabine Grösch, Gerd Geisslinger & Ellen Niederberger. (2014) LPS inhibits caspase 3-dependent apoptosis in RAW264.7 macrophages induced by the AMPK activator AICAR. Biochemical and Biophysical Research Communications 447:3, pages 520-525.
Crossref
Crossref
Mihajlo Bosnjak, Biljana Ristic, Katarina Arsikin, Aleksandar Mircic, Violeta Suzin-Zivkovic, Vladimir Perovic, Andrija Bogdanovic, Verica Paunovic, Ivanka Markovic, Vladimir Bumbasirevic, Vladimir Trajkovic & Ljubica Harhaji-Trajkovic. (2014) Inhibition of mTOR-Dependent Autophagy Sensitizes Leukemic Cells to Cytarabine-Induced Apoptotic Death. PLoS ONE 9:4, pages e94374.
Crossref
Crossref
James A. McCubrey, Nicole M. Davis, Stephen L. Abrams, Giuseppe Montalto, Melchiorre Cervello, Jorg Basecke, Massimo Libra, Ferdinando Nicoletti, Lucio Cocco, Alberto M. Martelli & Linda S. Steelman. (2014) Diverse roles of GSK-3: Tumor promoter–tumor suppressor, target in cancer therapy. Advances in Biological Regulation 54, pages 176-196.
Crossref
Crossref
Alejandro Bravo-Cuellar, Georgina Hernández-Flores, José Manuel Lerma-Díaz, Jorge Ramiro Domínguez-Rodríguez, Luis F Jave-Suárez, Ruth De Célis-Carrillo, Adriana Aguilar-Lemarroy, Paulina Gómez-Lomeli & Pablo Cesar Ortiz-Lazareno. (2013) Pentoxifylline and the proteasome inhibitor MG132 induce apoptosis in human leukemia U937 cells through a decrease in the expression of Bcl-2 and Bcl-XL and phosphorylation of p65. Journal of Biomedical Science 20:1.
Crossref
Crossref
Jing Xue, Hui Zhang, Wei Liu, Ming Liu, Min Shi, Zeqing Wen & Changzhong Li. (2013) Metformin inhibits growth of eutopic stromal cells from adenomyotic endometrium via AMPK activation and subsequent inhibition of AKT phosphorylation: a possible role in the treatment of adenomyosis. REPRODUCTION 146:4, pages 397-406.
Crossref
Crossref
Diana M. González-Gironès, Cristina Moncunill-Massaguer, Daniel Iglesias-Serret, Ana M. Cosialls, Alba Pérez-Perarnau, Claudia M. Palmeri, Camila Rubio-Patiño, Andreas Villunger, Gabriel Pons & Joan Gil. (2013) AICAR induces Bax/Bak-dependent apoptosis through upregulation of the BH3-only proteins Bim and Noxa in mouse embryonic fibroblasts. Apoptosis 18:8, pages 1008-1016.
Crossref
Crossref
Benjamin Wiench, Yet-Ran Chen, Malte Paulsen, Rebecca Hamm, Sven Schröder, Ning-Sun Yang & Thomas Efferth. (2013) Integration of Different “-omics” Technologies Identifies Inhibition of the IGF1R-Akt-mTOR Signaling Cascade Involved in the Cytotoxic Effect of Shikonin against Leukemia Cells. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-11.
Crossref
Crossref
James A. McCubrey, Linda S. Steelman, William H. Chappell, Stephen L. Abrams, Richard A. Franklin, Giuseppe Montalto, Melchiorre Cervello, Ferdinando Nicoletti, Graziella Malaponte, Clorinda Massarino, Massimo Libra, Jörg Bäsecke, Agostino Tafuri, Michele Milella, Francesca Chiarini, Camilla Evangelisti, Lucio Cocco & Alberto M. Martelli. 2013. Cell Death Signaling in Cancer Biology and Treatment. Cell Death Signaling in Cancer Biology and Treatment
331
372
.
James A. McCubrey, Linda S. Steelman, William H. Chappell, Lin Sun, Nicole M. Davis, Stephen L. Abrams, Richard A. Franklin, Lucio Cocco, Camilla Evangelisti, Francesca Chiarini, Alberto M. Martelli, Massimo Libra, Saverio Candido, Giovanni Ligresti, Grazia Malaponte, Maria C. Mazzarino, Paolo Fagone, Marco Donia, Ferdinando Nicoletti, Jerry Polesel, Renato Talamini, Jörg Bäsecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Joanna Dulińska-Litewka, Piotr Laidler, Antonio B. D’Assoro, Lyudmyla Drobot, Kazuo Umezawa, Giuseppe Montalto, Melchiorre Cervello & Zoya N. Demidenko. (2012) Advances in Targeting Signal Transduction Pathways. Oncotarget 3:12, pages 1505-1521.
Crossref
Crossref
James A. McCubrey, Linda S. Steelman, William H. Chappell, Stephen L. Abrams, Richard A. Franklin, Giuseppe Montalto, Melchiorre Cervello, Massimo Libra, Saverio Candido, Grazia Malaponte, Maria C. Mazzarino, Paolo Fagone, Ferdinando Nicoletti, Jörg Bäsecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Francesca Chiarini, Camilla Evangelisti, Lucio Cocco & Alberto M. Martelli. (2012) Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance. Oncotarget 3:10, pages 1068-1111.
Crossref
Crossref
James A. McCubrey, Linda S. Steelman, William H. Chappell, Stephen L. Abrams, Giuseppe Montalto, Melchiorre Cervello, Ferdinando Nicoletti, Paolo Fagone, Grazia Malaponte, Maria C. Mazzarino, Saverio Candido, Massimo Libra, Jörg Bäsecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Lucio Cocco, Camilla Evangelisti, Francesca Chiarini & Alberto M. Martelli. (2012) Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response.. Oncotarget 3:9, pages 954-987.
Crossref
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