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Utilization of the cellular stress response to sensitize cancer cells to TRAIL-mediated apoptosis

, MD Dr Med
Pages 801-817 | Published online: 05 Jul 2012

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Arin N. Graner, Justin E. Hellwinkel, Alex M. Lencioni, Helen J. Madsen, Tessa A. Harland, Paul Marchando, Ger J. Nguyen, Mary Wang, Laura M. Russell, Lynne T. Bemis, Thomas J. Anchordoquy & Michael W. Graner. (2017) HSP90 inhibitors in the context of heat shock and the unfolded protein response: effects on a primary canine pulmonary adenocarcinoma cell line*. International Journal of Hyperthermia 33:3, pages 303-317.
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Sina Heimer, Gertrud Knoll, Patrick Neubert, Karin P. Hammer, Stefan Wagner, Richard J. Bauer, Jonathan Jantsch & Martin Ehrenschwender. (2020) Hypertonicity counteracts MCL‐1 and renders BCL‐XL a synthetic lethal target in head and neck cancer. The FEBS Journal 288:6, pages 1822-1838.
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Kristie Liu, Kathleen Tsung & Frank J. Attenello. (2020) Characterizing Cell Stress and GRP78 in Glioma to Enhance Tumor Treatment. Frontiers in Oncology 10.
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Zhi-Chuan Zhu, Ji-Wei Liu, Can Yang, Ming-Jie Li, Rong-Jie Wu & Zhi-Qi Xiong. (2019) Targeting KPNB1 overcomes TRAIL resistance by regulating DR5, Mcl-1 and FLIP in glioblastoma cells. Cell Death & Disease 10:2.
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Chiaki T. Ishida, Yiru Zhang, Elena Bianchetti, Chang Shu, Trang T.T. Nguyen, Giulio Kleiner, Maria J. Sanchez-Quintero, Catarina M. Quinzii, Mike-Andrew Westhoff, Georg Karpel-Massler, Varun V. Prabhu, Joshua E. Allen & Markus D. Siegelin. (2018) Metabolic Reprogramming by Dual AKT/ERK Inhibition through Imipridones Elicits Unique Vulnerabilities in Glioblastoma. Clinical Cancer Research 24:21, pages 5392-5406.
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Yiru Zhang, Chiaki Tsuge Ishida, Chang Shu, Giulio Kleiner, Maria J. Sanchez-Quintero, Elena Bianchetti, Catarina M. Quinzii, Mike-Andrew Westhoff, Georg Karpel-Massler & Markus D. Siegelin. (2018) Inhibition of Bcl-2/Bcl-xL and c-MET causes synthetic lethality in model systems of glioblastoma. Scientific Reports 8:1.
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Olivier Micheau. (2018) Regulation of TNF-Related Apoptosis-Inducing Ligand Signaling by Glycosylation. International Journal of Molecular Sciences 19:3, pages 715.
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Adel Naimi, Ali Akbar Movassaghpour, Majid Farshdousti Hagh, Mehdi Talebi, Atefeh Entezari, Farhad Jadidi-Niaragh & Saeed Solali. (2018) TNF-related apoptosis-inducing ligand (TRAIL) as the potential therapeutic target in hematological malignancies. Biomedicine & Pharmacotherapy 98, pages 566-576.
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Li Wang, Yi Zhang, Weiguo Wang, Yunjie Zhu, Yang Chen & Bole Tian. (2017) Gemcitabine treatment induces endoplasmic reticular (ER) stress and subsequently upregulates urokinase plasminogen activator (uPA) to block mitochondrial-dependent apoptosis in Panc-1 cancer stem-like cells (CSCs). PLOS ONE 12:8, pages e0184110.
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Matharage Gayani Dilshara, Jin-Woo Jeong, Rajapaksha Gedara Prasad Tharanga Jayasooriya, Ilandarage Menu Neelaka Molagoda, Seungheon Lee, Sang Rul Park, Yung Hyun Choi & Gi-Young Kim. (2017) Glutamine deprivation sensitizes human breast cancer MDA-MB-231 cells to TRIAL-mediated apoptosis. Biochemical and Biophysical Research Communications 485:2, pages 440-445.
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Diego De Miguel, Ana Gallego-Lleyda, José María Ayuso, Sandra Erviti-Ardanaz, Roberto Pazo-Cid, Celia del Agua, Luis José Fernández, Ignacio Ochoa, Alberto Anel & Luis Martinez-Lostao. (2016) TRAIL-coated lipid-nanoparticles overcome resistance to soluble recombinant TRAIL in non-small cell lung cancer cells. Nanotechnology 27:18, pages 185101.
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Shujie Cheng, Kristen Swanson, Isaac Eliaz, Jeanette N. McClintick, George E. Sandusky & Daniel Sliva. (2015) Pachymic Acid Inhibits Growth and Induces Apoptosis of Pancreatic Cancer In Vitro and In Vivo by Targeting ER Stress. PLOS ONE 10:4, pages e0122270.
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Julianne D. Twomey, Su-Ryun Kim, Liqun Zhao, William P. Bozza & Baolin Zhang. (2015) Spatial dynamics of TRAIL death receptors in cancer cells. Drug Resistance Updates 19, pages 13-21.
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C J Henrich, A D Brooks, K L Erickson, C L Thomas, H R Bokesch, P Tewary, C R Thompson, R J Pompei, K R Gustafson, J B McMahon & T J Sayers. (2015) Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation. Cell Death & Disease 6:2, pages e1666-e1666.
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Georg Karpel-Massler, Fresia Pareja, Pascaline Aimé, Chang Shu, Lily Chau, Mike-Andrew Westhoff, Marc-Eric Halatsch, John F. Crary, Peter Canoll & Markus D. Siegelin. (2014) PARP Inhibition Restores Extrinsic Apoptotic Sensitivity in Glioblastoma. PLoS ONE 9:12, pages e114583.
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Ingrid A M van Roosmalen, Carlos R Reis, Rita Setroikromo, Saravanan Yuvaraj, Justin V Joseph, Pieter G Tepper, Frank A E Kruyt & Wim J Quax. (2014) The ER stress inducer DMC enhances TRAIL-induced apoptosis in glioblastoma. SpringerPlus 3:1.
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Wenwen Chien, Ling-Wen Ding, Qiao-Yang Sun, Lucia A. Torres-Fernandez, Siew Zhuan Tan, Jinfen Xiao, Su Lin Lim, Manoj Garg, Kian Leong Lee, Shojiro Kitajima, Sumiko Takao, Wei Zhong Leong, Haibo Sun, Itay Tokatly, Lorenz Poellinger, Sigal Gery & Phillip H. Koeffler. (2014) Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells. Oncotarget 5:13, pages 4881-4894.
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Fresia Pareja, David Macleod, Chang Shu, John F. Crary, Peter D. Canoll, Alonzo H. Ross & Markus D. Siegelin. (2014) PI3K and Bcl-2 Inhibition Primes Glioblastoma Cells to Apoptosis through Downregulation of Mcl-1 and Phospho-BAD. Molecular Cancer Research 12:7, pages 987-1001.
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Anne-Sophie Gallouet, Marion Travert, Laurence Bresson-Bepoldin, Fabien Guilloton, Céline Pangault, Sylvie Caulet-Maugendre, Thierry Lamy, Karin Tarte & Thierry Guillaudeux. (2014) COX-2–Independent Effects of Celecoxib Sensitize Lymphoma B Cells to TRAIL-Mediated Apoptosis. Clinical Cancer Research 20:10, pages 2663-2673.
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Anfernee Kai-Wing Tse, Hui-Hui Cao, Chi-Yan Cheng, Hiu-Yee Kwan, Hua Yu, Wang-Fun Fong & Zhi-Ling Yu. (2014) Indomethacin Sensitizes TRAIL-Resistant Melanoma Cells to TRAIL-Induced Apoptosis through ROS-Mediated Upregulation of Death Receptor 5 and Downregulation of Survivin. Journal of Investigative Dermatology 134:5, pages 1397-1407.
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Anfernee Kai-Wing Tse, Ka-Yu Chow, Hui-Hui Cao, Chi-Yan Cheng, Hiu-Yee Kwan, Hua Yu, Guo-Yuan Zhu, Yiu-Cheong Wu, Wang-Fun Fong & Zhi-Ling Yu. (2013) The Herbal Compound Cryptotanshinone Restores Sensitivity in Cancer Cells That Are Resistant to the Tumor Necrosis Factor-related Apoptosis-inducing Ligand. Journal of Biological Chemistry 288:41, pages 29923-29933.
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Peng Jiao, Yun-Sheng Zhou, Juan-Xia Yang, Ya-Li Zhao, Qiang-Qiang Liu, Chuang Yuan & Feng-Ze Wang. (2013) MK-2206 induces cell cycle arrest and apoptosis in HepG2 cells and sensitizes TRAIL-mediated cell death. Molecular and Cellular Biochemistry 382:1-2, pages 217-224.
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Markus D. Siegelin. (2013) Inhibition of the mitochondrial Hsp90 chaperone network: A novel, efficient treatment strategy for cancer?. Cancer Letters 333:2, pages 133-146.
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Giovanni Germano, Roberta Frapolli, Cristina Belgiovine, Achille Anselmo, Samantha Pesce, Manuela Liguori, Eugenio Erba, Sarah Uboldi, Massimo Zucchetti, Fabio Pasqualini, Manuela Nebuloni, Nico van Rooijen, Roberta Mortarini, Luca Beltrame, Sergio Marchini, Ilaria Fuso Nerini, Roberta Sanfilippo, Paolo G. Casali, Silvana Pilotti, Carlos M. Galmarini, Andrea Anichini, Alberto Mantovani, Maurizio D’Incalci & Paola Allavena. (2013) Role of Macrophage Targeting in the Antitumor Activity of Trabectedin. Cancer Cell 23:2, pages 249-262.
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