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Can targeting SIRT-1 to treat type 2 diabetes be a good strategy? A review

, MSc, , MS Pharm, , MPharm, , PhD & , PhD
Pages 819-832 | Published online: 05 Jul 2012

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Geetika Garg, Abhishek Kumar Singh, Sandeep Singh & Syed Ibrahim Rizvi. (2021) Promising drug discovery strategies for sirtuin modulators: what lessons have we learnt?. Expert Opinion on Drug Discovery 16:8, pages 915-927.
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Kuan-Chung Chen, Yi-Ru Jian, Mao-Feng Sun, Tung-Ti Chang, Cheng-Chun Lee & Calvin Yu-Chian Chen. (2013) Investigation of silent information regulator 1 (Sirt1) agonists from Traditional Chinese Medicine. Journal of Biomolecular Structure and Dynamics 31:11, pages 1207-1218.
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Articles from other publishers (22)

Ojaskumar D. Agrawal & Yogesh A. Kulkarni. (2023) Treatment with Terminalia chebula Extract Reduces Insulin Resistance, Hyperglycemia and Improves SIRT1 Expression in Type 2 Diabetic Rats. Life 13:5, pages 1168.
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Peng Wang, Ruikai Li, Yuqi Li, Siwei Tan, Jie Jiang, Huiling Liu & Xiuqing Wei. (2023) Berberine alleviates non-alcoholic hepatic steatosis partially by promoting SIRT1 deacetylation of CPT1A in mice. Gastroenterology Report 11.
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Yikai Liu, Zian Zhang, Tao Li, Hao Xu & Haining Zhang. (2022) Senescence in osteoarthritis: from mechanism to potential treatment. Arthritis Research & Therapy 24:1.
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Shreya C. Pal, Mohammed Eslam & Nahum Mendez-Sanchez. (2022) Detangling the interrelations between MAFLD, insulin resistance, and key hormones. Hormones 21:4, pages 573-589.
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Alireza Shirpoor & Roya Naderi. (2022) Maternal Ethanol Exposure-Induced Cardiac Fibrosis is Associated with Changes in TGF-β and SIRT1/FOXO3a Signaling in Male Rat Offspring: A Three-Month Follow-up Study. Cardiovascular Toxicology 22:9, pages 858-865.
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Yulong Xu, Zude Chen, Hsiao‐Ying Wey, Yingxia Liang, Rudolph E. Tanzi, Can Zhang & Changning Wang. (2021) Molecular imaging of NAD + ‐dependent deacetylase SIRT1 in the brain . Alzheimer's & Dementia 17:12, pages 1988-1997.
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Charng-Cherng Chyau, Hsueh-Fang Wang, Wen-Juan Zhang, Chin-Chu Chen, Shiau-Huei Huang, Chun-Chao Chang & Robert Y. Peng. (2020) Antrodan Alleviates High-Fat and High-Fructose Diet-Induced Fatty Liver Disease in C57BL/6 Mice Model via AMPK/Sirt1/SREBP-1c/PPARγ Pathway. International Journal of Molecular Sciences 21:1, pages 360.
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Azminah Azminah, Linda Erlina, Maksum Radji, Abdul Mun’im, Rezi Riadhi Syahdi & Arry Yanuar. (2019) In silico and in vitro identification of candidate SIRT1 activators from Indonesian medicinal plants compounds database. Computational Biology and Chemistry 83, pages 107096.
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Ole L Dollerup, Samuel A J Trammell, Bolette Hartmann, Jens J Holst, Britt Christensen, Niels Møller, Matthew P Gillum, Jonas T Treebak & Niels Jessen. (2019) Effects of Nicotinamide Riboside on Endocrine Pancreatic Function and Incretin Hormones in Nondiabetic Men With Obesity. The Journal of Clinical Endocrinology & Metabolism 104:11, pages 5703-5714.
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Ling-Hong Miao, Yan Lin, Wen-Jing Pan, Xin Huang, Xian-Ping Ge, Bo Liu, Ming-Chun Ren, Qun-Lan Zhou & Liang-Kun Pan. (2019) MiR-34a regulates the glucose metabolism of Blunt snout bream (Megalobrama amblycephala) fed high-carbohydrate diets through the mediation of the Sirt1/FoxO1 axis. Aquaculture 500, pages 206-214.
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Robin Bonomi, Vadim Popov, Maxwell T. Laws, David Gelovani, Anjoy Majhi, Aleksandr Shavrin, Xin Lu, Otto Muzik, Nashaat Turkman, Renshyan Liu, Thomas Mangner & Juri G. Gelovani. (2018) Molecular Imaging of Sirtuin1 Expression–Activity in Rat Brain Using Positron-Emission Tomography–Magnetic-Resonance Imaging with [ 18 F]-2-Fluorobenzoylaminohexanoicanilide . Journal of Medicinal Chemistry 61:16, pages 7116-7130.
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Nathalie KhouryKevin B. KoronowskiJuan I. YoungMiguel A. Perez-Pinzon. (2018) The NAD + -Dependent Family of Sirtuins in Cerebral Ischemia and Preconditioning . Antioxidants & Redox Signaling 28:8, pages 691-710.
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Bryan Tungland. 2018. Human Microbiota in Health and Disease. Human Microbiota in Health and Disease 37 106 .
Ebubekir Başpınar, Seyid Ahmet Ay, Ferhat Deniz, Şeref Başal, Levent Özsarı, Osman Metin Ipcioglu, Eylem Cagiltay, Kamil Baskoy, Yalçın Onem & Arif Yonem. (2017) Serum SIRT1 level is higher in male patient with isolated hypogonadotropic hypogonadism: The first study in human. Revista Internacional de Andrología 15:1, pages 2-7.
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Dorota Rogacka, Agnieszka Piwkowska, Irena Audzeyenka, Stefan Angielski & Maciej Jankowski. (2016) SIRT1-AMPK crosstalk is involved in high glucose-dependent impairment of insulin responsiveness in primary rat podocytes. Experimental Cell Research 349:2, pages 328-338.
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Yue Cao, Xinli Jiang, Huijie Ma, Yuling Wang, Peng Xue & Yan Liu. (2016) SIRT1 and insulin resistance. Journal of Diabetes and its Complications 30:1, pages 178-183.
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Sherine M. Rizk, Shohda A. El-Maraghy & Noha N. Nassar. (2014) A Novel Role for SIRT-1 in L-Arginine Protection against STZ Induced Myocardial Fibrosis in Rats. PLoS ONE 9:12, pages e114560.
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Mustafa Tunalı, Tamer Ataoğlu & Ilhami Çelik. (2013) Apoptosis: an underlying factor for accelerated periodontal disease associated with diabetes in rats. Clinical Oral Investigations 18:7, pages 1825-1833.
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Venkat Koushik Pulla, Mallika Alvala, Dinavahi Saketh Sriram, Srikant Viswanadha, Dharmarajan Sriram & Perumal Yogeeswari. (2014) Structure-based drug design of small molecule SIRT1 modulators to treat cancer and metabolic disorders. Journal of Molecular Graphics and Modelling 52, pages 46-56.
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Anne Williams Augustine, Akilavalli Narasimhan, Mangalapriya Vishwanathan & Balasubramanian Karundevi. (2014) Evaluation of antidiabetic property of Andrographis paniculata powder in high fat and sucrose-induced type-2 diabetic adult male rat. Asian Pacific Journal of Tropical Disease 4, pages S140-S147.
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Ravi Alvala, Mallika Alvala, Venkatesh Sama, Sriram Dharmarajan, Jeankumar Variam Ullas & Madhava Reddy B. (2013) Scientific evidence for traditional claim of anti-obesity activity of Tecomella undulata bark. Journal of Ethnopharmacology 148:2, pages 441-448.
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M. L. Balestrieri, L. Servillo, A. Esposito, N. D’Onofrio, A. Giovane, R. Casale, M. Barbieri, P. Paolisso, M. R. Rizzo, G. Paolisso & R. Marfella. (2012) Poor glycaemic control in type 2 diabetes patients reduces endothelial progenitor cell number by influencing SIRT1 signalling via platelet-activating factor receptor activation. Diabetologia 56:1, pages 162-172.
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