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Targeting STAT3 in gastric cancer

, PhD, , PhD & , PhD
Pages 889-901 | Published online: 26 Jul 2012

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Jinyun Dong, Jing Yang, Wenkai Yu, Haobin Li, Maohua Cai, Jing-Li Xu, Han-Dong Xu, Yun-Fu Shi, Xiaoqing Guan, Xiang‑Dong Cheng & Jiang‑Jiang Qin. (2022) Discovery of benzochalcone derivative as a potential antigastric cancer agent targeting signal transducer and activator of transcription 3 (STAT3). Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2004-2016.
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Fahima Danesh Pouya, Yousef Rasmi & Mohadeseh Nemati. (2022) Signaling Pathways Involved in 5-FU Drug Resistance in Cancer. Cancer Investigation 40:6, pages 516-543.
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Xiaolei Zhang, Tao Lu, Yanhui Ma, Rui Li, Yingxin Pang, Hongluan Mao & Peishu Liu. (2020) Novel Nanocomplexes Targeting STAT3 Demonstrate Promising Anti-Ovarian Cancer Effects in vivo. OncoTargets and Therapy 13, pages 5069-5082.
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Danyan Li, Luqing Zhao, Yuxin Li, Xiuhong Kang & Shengsheng Zhang. (2020) Gastro-Protective Effects of Calycosin Against Precancerous Lesions of Gastric Carcinoma in Rats. Drug Design, Development and Therapy 14, pages 2207-2219.
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Kyoko Inagaki-Ohara, Taisuke Kondo, Minako Ito & Akihiko Yoshimura. (2013) SOCS, inflammation, and cancer. JAK-STAT 2:3.
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Articles from other publishers (61)

Sara Molenda, Agata Sikorska, Anna Florczak, Patryk Lorenc & Hanna Dams-Kozlowska. (2023) Oligonucleotide-Based Therapeutics for STAT3 Targeting in Cancer—Drug Carriers Matter. Cancers 15:23, pages 5647.
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Tala M. Jamal Eddin, Shahd M.O. Nasr, Ishita Gupta, Hatem Zayed & Ala-Eddin Al Moustafa. (2023) Helicobacter pylori and epithelial mesenchymal transition in human gastric cancers: An update of the literature. Heliyon 9:8, pages e18945.
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Yingying Liu, Yu Shi, Ruiqin Han, Chaoge Liu, Xiaogang Qin, Pengfei Li & Renjun Gu. (2023) Signaling pathways of oxidative stress response: the potential therapeutic targets in gastric cancer. Frontiers in Immunology 14.
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Agnieszka Gornowicz, Roman Lesyk, Robert Czarnomysy, Serhii Holota, Yulia Shepeta, Bożena Popławska, Magdalena Podolak, Wojciech Szymanowski, Krzysztof Bielawski & Anna Bielawska. (2023) Multi-Targeting Anticancer Activity of a New 4-Thiazolidinone Derivative with Anti-HER2 Antibodies in Human AGS Gastric Cancer Cells. International Journal of Molecular Sciences 24:7, pages 6791.
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Yanhong Ni, Jun T. Low, John Silke & Lorraine A. O’Reilly. (2022) Digesting the Role of JAK-STAT and Cytokine Signaling in Oral and Gastric Cancers. Frontiers in Immunology 13.
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Yan Zhong, Lin Deng, Shuo Shi, Qiu-yao Huang, Shu-min Ou-Yang, Jian-shan Mo, Kai Zhu, Xin-ming Qu, Pei-qing Liu, Yuan-xiang Wang & Xiao-lei Zhang. (2021) The novel STAT3 inhibitor WZ-2-033 causes regression of human triple-negative breast cancer and gastric cancer xenografts. Acta Pharmacologica Sinica 43:4, pages 1013-1023.
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Bilal Rah, Rafiq A Rather, Gh Rasool Bhat, Abdul Basit Baba, Ifra Mushtaq, Muzamil Farooq, Tahira Yousuf, Sadaf B Dar, Sabra Parveen, Rukhsana Hassan, Fozia Mohammad, Iqbal Qassim, Abida Bhat, Shazia Ali, Mahrukh Hamid Zargar & Dil Afroze. (2022) JAK/STAT Signaling: Molecular Targets, Therapeutic Opportunities, and Limitations of Targeted Inhibitions in Solid Malignancies. Frontiers in Pharmacology 13.
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Ho-Sung Lee, In-Hee Lee, Kyungrae Kang, Sang-In Park, Minho Jung, Seung Gu Yang, Tae-Wook Kwon & Dae-Yeon Lee. (2022) A Network Pharmacology Perspective Investigation of the Pharmacological Mechanisms of the Herbal Drug FDY003 in Gastric Cancer. Natural Product Communications 17:1, pages 1934578X2110730.
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Seok-Jun Kim, Hyeok-Gu Kang, Kyungeun Kim, Hoyoung Kim, Fredrik Zetterberg, Young Soo Park, Hyun-Soo Cho, Stephen M. Hewitt, Joon-Yong Chung, Ulf J. Nilsson, Hakon Leffler & Kyung-Hee Chun. (2021) Crosstalk between WNT and STAT3 is mediated by galectin-3 in tumor progression. Gastric Cancer 24:5, pages 1050-1062.
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Jong Min Park, Jeong Min An, Young Min Han, Young Joon Surh, Sun Jin Hwang, Seong Jin Kim & Ki Baik Hahm. (2021) Walnut polyphenol extracts inhibit <i>Helicobacter pylori</i>-induced STAT3<sup>Tyr705</sup> phosphorylation through activation of PPAR-γ and SOCS1 induction. Journal of Clinical Biochemistry and Nutrition.
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Jong Min Park, Young Min Han, Yong Jin Park & Ki Baik Hahm. (2021) Dietary intake of walnut prevented <i>Helicobacter pylori</i>-associated gastric cancer through rejuvenation of chronic atrophic gastritis. Journal of Clinical Biochemistry and Nutrition 68:1, pages 37-50.
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Yuanyuan Zhang, Shengling Ma, Qian Niu, Yun Han, Xingyu Liu, Jie Jiang, Simiao Chen & Haolong Lin. (2020) Features of alternative splicing in stomach adenocarcinoma and their clinical implication: a research based on massive sequencing data. BMC Genomics 21:1.
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Jiaxin Xu, Yunhe Chen, Rui Yang, Tong Zhou, Wei Ke, Yuan Si, Shusheng Yang, Te Zhang, Xuewen Liu, Liang Zhang, Ke Xiang, Yang Guo & Ying Liu. (2020) Cucurbitacin B inhibits gastric cancer progression by suppressing STAT3 activity. Archives of Biochemistry and Biophysics 684, pages 108314.
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Jie Chen, Haining Liu, Jinggui Chen, Bo Sun, Jianghong Wu & Chunyan Du. (2020) PLXNC1 Enhances Carcinogenesis Through Transcriptional Activation of IL6ST in Gastric Cancer. Frontiers in Oncology 10.
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Jong Min Park, Jeong Min An, Young Min Han, Young Joon Surh, Sun Jin HwangSeong Jin KimKi Baik Hahm. (2020) Walnut polyphenol extracts inhibit <i>Helicobacter pylori</i>-induced STAT3<sup>Tyr705</sup> phosphorylation through activation of PPAR-γ and SOCS1 induction. Journal of Clinical Biochemistry and Nutrition 67:3, pages 248-256.
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Xiaomeng Li, Heya Na, Lijie Xu, Xinsheng Zhang, Zhen Feng, Xu Zhou, Jingyi Cui, Jingbo Zhang, Fang Lin, Shiqing Yang, Fangxia Yue, Haithm Mousa & Yunfei Zuo. (2020) DC-SIGN mediates gastric cancer progression by regulating the JAK2/STAT3 signaling pathway and affecting LncRNA RP11-181G12.2 expression. Biomedicine & Pharmacotherapy 121, pages 109644.
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Kuo-Liang Wei, Jian-Liang Chou, Yin-Chen Chen, Hongchuan Jin, Yu-Min Chuang, Cheng-Shyong Wu & Michael W. Y. Chan. (2019) Methylomics analysis identifies a putative STAT3 target, SPG20, as a noninvasive epigenetic biomarker for early detection of gastric cancer. PLOS ONE 14:6, pages e0218338.
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Sun Tae Hwang, Chulwon Kim, Jong Hyun Lee, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Omar H.M. Shair, Gautam Sethi & Kwang Seok Ahn. (2019) Cycloastragenol can negate constitutive STAT3 activation and promote paclitaxel-induced apoptosis in human gastric cancer cells. Phytomedicine 59, pages 152907.
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Jin Sung Koh, Moon Kyung Joo, Jong-Jae Park, Hyo Soon Yoo, Byung Il Choi, Beom Jae Lee, Hoon Jai Chun & Sang Woo Lee. (2018) Inhibition of STAT3 in gastric cancer: role of pantoprazole as SHP-1 inducer. Cell & Bioscience 8:1.
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Sung Ho Kim, Hyo Soon Yoo, Moon Kyung Joo, Taehyun Kim, Jong-Jae Park, Beom Jae Lee, Hoon Jai Chun, Sang Woo Lee & Young-Tae Bak. (2018) Arsenic trioxide attenuates STAT-3 activity and epithelial-mesenchymal transition through induction of SHP-1 in gastric cancer cells. BMC Cancer 18:1.
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Pei Jou Chua, Jia Pei Lim, Tian Tian Guo, Puja Khanna, Qidong Hu, Boon Huat Bay & Gyeong Hun Baeg. (2018) Y-box binding protein-1 and STAT3 independently regulate ATP-binding cassette transporters in the chemoresistance of gastric cancer cells. International Journal of Oncology.
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Wenjing Xu, Jingwei Fu, Hao Wu & Weijian Sun. (2018) Human epidermal growth factor receptor 2 expressions and Janus-activated kinase/signal transducer and activator of transcription 3-suppressor of cytokine signaling 3 pathway may be associated with clinicopathological features and prognosis of gastric cancer. Journal of Cancer Research and Therapeutics 14:Suppl 2, pages S311-S318.
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Arvind Pandey, Satyendra Chandra Tripathi, Shirish Shukla, Sutapa Mahata, Kanchan Vishnoi, Sri Prakash Misra, Vatsala Misra, Sankar Mitra, Manisha Dwivedi & Alok C. Bharti. (2018) Differentially localized survivin and STAT3 as markers of gastric cancer progression: Association with Helicobacter pylori . Cancer Reports 1:1, pages e1004.
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Puja Khanna, Pei Jou Chua, Belinda Shu Ee Wong, Changhong Yin, Aye Aye Thike, Wei Keat Wan, Puay Hoon Tan & Gyeong Hun Baeg. (2017) GRAM domain-containing protein 1B (GRAMD1B), a novel component of the JAK/STAT signaling pathway, functions in gastric carcinogenesis. Oncotarget 8:70, pages 115370-115383.
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Min Rao, Yonggang Zhu, Xiaoxia Cong & Qianxun Li. (2017) Knockdown of CREB1 inhibits tumor growth of human gastric cancer in vitro and in vivo. Oncology Reports.
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