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Expert Opinion on Therapeutic Targets Volume 16, 2012 - Issue 12
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Therapeutic targeting of the p53 pathway in cancer stem cells

Varun V PrabhuPenn State Hershey Cancer Institute, Penn State College of Medicine, Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Medicine (Hematology/Oncology), 500 University Drive, Room T4423, Hershey, PA 17033, USA
,
Joshua E AllenPenn State Hershey Cancer Institute, Penn State College of Medicine, Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Medicine (Hematology/Oncology), 500 University Drive, Room T4423, Hershey, PA 17033, USA;University of Pennsylvania School of Medicine, Biochemistry and Molecular Biophysics Graduate Group, Philadelphia, PA, USA
,
Bo HongPenn State Hershey Cancer Institute, Penn State College of Medicine, Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Medicine (Hematology/Oncology), 500 University Drive, Room T4423, Hershey, PA 17033, USA
,
Shengliang ZhangPenn State Hershey Cancer Institute, Penn State College of Medicine, Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Medicine (Hematology/Oncology), 500 University Drive, Room T4423, Hershey, PA 17033, USA
,
Hairong ChengPenn State Hershey Cancer Institute, Penn State College of Medicine, Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Medicine (Hematology/Oncology), 500 University Drive, Room T4423, Hershey, PA 17033, USA
&
Wafik S El-DeiryPenn State Hershey Cancer Institute, Penn State College of Medicine, Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Medicine (Hematology/Oncology), 500 University Drive, Room T4423, Hershey, PA 17033, USA;Penn State Hershey Cancer Institute, Department of Medicine (Hematology/Oncology), Penn State College of Medicine, Laboratory of Translational Oncology and Experimental Cancer Therapeutics, 500 University Drive, Room T4423, Hershey, PA 17033, USA+1 717 531 5059; +1 717 531 5076; [email protected]
, MD PhD
Pages 1161-1174 | Published online: 24 Sep 2012

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Natalia Frączek, Iwona Bronisz, Magdalena Pietryka, Dorota Kępińska, Patrycja Strzała, Kamila Mielnicka, Agnieszka Korga & Jaroslaw Dudka. (2016) An outline of main factors of drug resistance influencing cancer therapy. Journal of Chemotherapy 28:6, pages 457-464.
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Varun V Prabhu & Wafik S El-Deiry. (2015) 4th international conference on tumor progression and therapeutic resistance: meeting report. Cancer Biology & Therapy 16:3, pages 363-376.
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Garrett M Brodeur, Radhika Iyer, Jamie L Croucher, Tiangang Zhuang, Mayumi Higashi & Venkatadri Kolla. (2014) Therapeutic targets for neuroblastomas. Expert Opinion on Therapeutic Targets 18:3, pages 277-292.
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Articles from other publishers (25)

Mohammed Moustapha Anwar, Chris Albanese, Nadia M. Hamdy & Ahmed S. Sultan. (2022) Rise of the natural red pigment ‘prodigiosin’ as an immunomodulator in cancer. Cancer Cell International 22:1.
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Chuan-Wen Fan, Ran Lu, Chao Fang, Xue-Li Zhang, Zhao-Ying Lv, Yuan Li, Hong Zhang, Zong-Guang Zhou, Xian-Ming Mo & Xiao-Feng Sun. (2021) Expression profile, molecular functions, and prognostic significance of miRNAs in primary colorectal cancer stem cells. Aging 13:8, pages 12067-12085.
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Dishari Ghatak, Damayanti Das Ghosh & Susanta Roychoudhury. (2021) Cancer Stemness: p53 at the Wheel. Frontiers in Oncology 10.
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Yong Tae Ahn, Min Sung Kim, Youn Sook Kim & Won Gun An. (2020) Astaxanthin Reduces Stemness Markers in BT20 and T47D Breast Cancer Stem Cells by Inhibiting Expression of Pontin and Mutant p53. Marine Drugs 18:11, pages 577.
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Marta Celegato, Lorenzo Messa, Laura Goracci, Beatrice Mercorelli, Chiara Bertagnin, Francesca Spyrakis, Irina Suarez, Alexandra Cousido-Siah, Gilles Travé, Lawrence Banks, Gabriele Cruciani, Giorgio Palù & Arianna Loregian. (2020) A novel small-molecule inhibitor of the human papillomavirus E6-p53 interaction that reactivates p53 function and blocks cancer cells growth. Cancer Letters 470, pages 115-125.
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Xueping Zhu, Wei Zhang, Jie Guo, Xuejie Zhang, Liping Li, Ting Wang, Jinghua Yan, Fuping Zhang, Baidong Hou, Ning Gao, George F. Gao & Xuyu Zhou. (2019) Noc4L-Mediated Ribosome Biogenesis Controls Activation of Regulatory and Conventional T Cells. Cell Reports 27:4, pages 1205-1220.e4.
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Jianjun Chen, Hui Ouyang, Xuemei An & Shixi Liu. (2018) miR‑125a is upregulated in cancer stem‑like cells derived from TW01 and is responsible for maintaining stemness by inhibiting p53. Oncology Letters.
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Rui‐Fang Sun, Qian‐Qian Yu & Ken H. Young. (2018) Critically dysregulated signaling pathways and clinical utility of the pathway biomarkers in lymphoid malignancies. Chronic Diseases and Translational Medicine 4:1, pages 29-44.
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Natasha Hodgkinson, Cherie A Kruger & Heidi Abrahamse. (2017) Targeted photodynamic therapy as potential treatment modality for the eradication of colon cancer and colon cancer stem cells. Tumor Biology 39:10, pages 101042831773469.
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Weiying Li, Baitang Lai, Xuehui Yang, Chunyan Zhang & Hui Wang. (2017) A truncated p53 in human lung cancer cells as a critical determinant of proliferation and invasiveness. Tumor Biology 39:6, pages 101042831770382.
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Leanne K. Archer, Fiona M. Frame & Norman J. Maitland. (2017) Stem cells and the role of ETS transcription factors in the differentiation hierarchy of normal and malignant prostate epithelium. The Journal of Steroid Biochemistry and Molecular Biology 166, pages 68-83.
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Warapen Treekitkarnmongkol, Hiroshi Katayama, Kazuharu Kai, Kaori Sasai, Jennifer Carter Jones, Jing Wang, Li Shen, Aysegul A. Sahin, Mihai Gagea, Naoto T. Ueno, Chad J. Creighton & Subrata Sen. (2016) Aurora kinase-A overexpression in mouse mammary epithelium induces mammary adenocarcinomas harboring genetic alterations shared with human breast cancer. Carcinogenesis, pages bgw097.
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Elke Firat & Gabriele Niedermann. (2016) FoxO proteins or loss of functional p53 maintain stemness of glioblastoma stem cells and survival after ionizing radiation plus PI3K/mTOR inhibition. Oncotarget 7:34, pages 54883-54896.
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Varun V. Prabhu, Bo Hong, Joshua E. Allen, Shengliang Zhang, Amriti R. Lulla, David T. Dicker & Wafik S. El-Deiry. (2016) Small-Molecule Prodigiosin Restores p53 Tumor Suppressor Activity in Chemoresistant Colorectal Cancer Stem Cells via c-Jun-Mediated ΔNp73 Inhibition and p73 Activation. Cancer Research 76:7, pages 1989-1999.
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Sheng-Ta Tsai, Po-Jen Wang, Nia-Jhen Liou, Pei-Shan Lin, Chung-Hsuan Chen & Wei-Chao Chang. (2015) ICAM1 Is a Potential Cancer Stem Cell Marker of Esophageal Squamous Cell Carcinoma. PLOS ONE 10:11, pages e0142834.
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. (2015) Retraction: ‘p53-induced Rap2B positively regulates migration in cells exposed to glucose deprivation’ by D.-S. Pei, J.-H. Di, W.-Q. Du and J.-N. Zheng. Molecular Carcinogenesis 54:11, pages 1528-1528.
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Varun V. Prabhu, Wafik S. El-Deiry & Niklas Finnberg. 2015. Principles of Stem Cell Biology and Cancer. Principles of Stem Cell Biology and Cancer 169 192 .
Claudia CattoglioElisa T. ZhangIvan Grubisic, Kunitoshi ChibaYick W. Fong & Robert Tjian. (2015) Functional and mechanistic studies of XPC DNA-repair complex as transcriptional coactivator in embryonic stem cells. Proceedings of the National Academy of Sciences 112:18.
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Varun V. Prabhu, Joshua E. Allen, David T. Dicker & Wafik S. El-Deiry. (2015) Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem–like Cells in an Akt/Foxo3a/TRAIL–Dependent Manner. Cancer Research 75:7, pages 1423-1432.
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Qi Zhang, Shelya X. Zeng & Hua Lu. (2015) Determination of maximum tolerated dose and toxicity of Inauhzin in mice. Toxicology Reports 2, pages 546-554.
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Minoo Battiwalla. (2014) Abnl(17p) in AML: who will guard the guardian?. Blood 123:19, pages 2906-2907.
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Bo Hong, Varun V. Prabhu, Shengliang Zhang, A. Pieter J. van den Heuvel, David T. Dicker, Levy Kopelovich & Wafik S. El-Deiry. (2014) Prodigiosin Rescues Deficient p53 Signaling and Antitumor Effects via Upregulating p73 and Disrupting Its Interaction with Mutant p53. Cancer Research 74:4, pages 1153-1165.
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Yao-An Shen, Chien-Hung Lin, Wei-Hsin Chi, Chia-Yu Wang, Yi-Tao Hsieh, Yau-Huei Wei & Yann-Jang Chen. (2013) Resveratrol Impedes the Stemness, Epithelial-Mesenchymal Transition, and Metabolic Reprogramming of Cancer Stem Cells in Nasopharyngeal Carcinoma through p53 Activation. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-13.
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Wen-Ying Liao, Chih-Chuang Liaw, Yuan-Chao Huang, Hsin-Ying Han, Hung-Wei Hsu, Shiaw-Min Hwang, Sheng-Chu Kuo & Chia-Ning Shen. (2013) Cyclohexylmethyl Flavonoids Suppress Propagation of Breast Cancer Stem Cells via Downregulation of NANOG. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-14.
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Xueping Zhu, Wei Zhang, Jie Guo, Xuejie Zhang, Jinghua Yan, George F. Gao & Xuyu Zhou. (2018) Noc4L Dependent Ribosome Biogenesis Controls Treg Activation. SSRN Electronic Journal.
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