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Expert Opinion on Therapeutic Targets Volume 17, 2013 - Issue 3
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Anti-inflammatory role and immunomodulation of mesenchymal stem cells in systemic joint diseases: potential for treatment

Robert J MacFarlaneThe Royal Liverpool University Hospital, Department of Trauma and Orthopaedics, Prescot Street, Liverpool, Merseyside L7 8XP, UK
, MBChB MRCS,
Simon Matthew GrahamThe Royal Liverpool University Hospital, Department of Trauma and Orthopaedics, Prescot Street, Liverpool, Merseyside L7 8XP, UK
, MBChB MRCS,
Peter SE DaviesThe Royal Liverpool University Hospital, Department of Trauma and Orthopaedics, Prescot Street, Liverpool, Merseyside L7 8XP, UK
,
Nectarios KorresAristotle University Medical School, Academic Department of Orthopaedics and Trauma, University Campus GR 54124, Thessaloniki, Greece;Aristotle University Medical School, Academic Department of Orthopaedics and Trauma, University Campus GR 54124, Thessaloniki, Greece
, MD MSc,
Helen TsouchnicaAristotle University Medical School, Academic Department of Orthopaedics and Trauma, University Campus GR 54124, Thessaloniki, Greece;Aristotle University Medical School, Academic Department of Orthopaedics and Trauma, University Campus GR 54124, Thessaloniki, Greece
, MD,
Manolis HeliotisAristotle University Medical School, Academic Department of Orthopaedics and Trauma, University Campus GR 54124, Thessaloniki, Greece;Aristotle University Medical School, Academic Department of Orthopaedics and Trauma, University Campus GR 54124, Thessaloniki, Greece
, MBBS MSc FDS FRCS,
Athanasios MantalarisImperial College London, Division of Surgery, Department of Surgery and Cancer, B-block Hammersmith, Du-Cane Road, London W12 0HS, UK;Division of Surgery, Department of Surgery and Cancer, B-block Hammersmith, Du-Cane Road, London W12 0HS, UK
, PhD &
Eleftherios TsiridisAristotle University Medical School, Academic Department of Orthopaedics and Trauma, University Campus GR 54124, Thessaloniki, Greece;Imperial College London, Division of Surgery, Department of Surgery and Cancer, B-block Hammersmith, Du-Cane Road, London W12 0HS, UK;Aristotle University Medical School, Academic Department of Orthopaedics and Trauma, University Campus GR 54124, Thessaloniki, [email protected]
, MD MSc PhD FRCS show all
Pages 243-254 | Published online: 08 Jan 2013

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Phimon Atsawasuwan. (2021) Stem Cells and Dentofacial Orthodontic Treatment Potential. Journal of the California Dental Association 49:11, pages 677-684.
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Ji Eun Kim, Sang Mok Lee, Soo Hyun Kim, Phil Tatman, Albert O Gee, Deok-Ho Kim, Kyung Eun Lee, Youngmee Jung & Sang Jun Kim. (2014) Effect of self-assembled peptide–mesenchymal stem cell complex on the progression of osteoarthritis in a rat model. International Journal of Nanomedicine 9:sup1, pages 141-157.
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Articles from other publishers (45)

Mina Entessari & Leonardo P Oliveira. (2023) Current evidence on mesenchymal stem cells for hip osteoarthritis: a narrative review. Regenerative Medicine.
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Joeri van Boxtel, Lucienne A. Vonk, Hieronymus P. Stevens & Joris A. van Dongen. (2022) Mechanically Derived Tissue Stromal Vascular Fraction Acts Anti-inflammatory on TNF Alpha-Stimulated Chondrocytes In Vitro. Bioengineering 9:8, pages 345.
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Xiaobo Feng, Qian Xiang, Jie Jia, Tingting Guo, Zhiwei Liao, Shuhua Yang, Xianyi Cai & Xianzhe Liu. (2022) CircHGF suppressed cell proliferation and osteogenic differentiation of BMSCs in ONFH via inhibiting miR-25-3p binding to SMAD7. Molecular Therapy - Nucleic Acids 28, pages 99-113.
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Vilim Molnar, Eduard Pavelić, Kristijan Vrdoljak, Martin Čemerin, Emil Klarić, Vid Matišić, Roko Bjelica, Petar Brlek, Ivana Kovačić, Carlo Tremolada & Dragan Primorac. (2022) Mesenchymal Stem Cell Mechanisms of Action and Clinical Effects in Osteoarthritis: A Narrative Review. Genes 13:6, pages 949.
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Konstantinos TheodoridisMaria Eleni ManthouEleni AggelidouAristeidis Kritis. (2022) In Vivo Cartilage Regeneration with Cell-Seeded Natural Biomaterial Scaffold Implants: 15-Year Study . Tissue Engineering Part B: Reviews 28:1, pages 206-245.
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Xiufen Zhuang, Xiao Hu, Shuren Zhang, Xingmin Li, Xiaoying Yuan & Yanhong Wu. (2022) Mesenchymal Stem Cell–Based Therapy as a New Approach for the Treatment of Systemic Sclerosis. Clinical Reviews in Allergy & Immunology 64:3, pages 284-320.
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Lang Guo, Xu Wei & Ping Jiang. (2021) The use of gene-modified bone marrow mesenchymal stem cells for cochlear cell therapy. Transplant Immunology 68, pages 101433.
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Alberto González-González, Daniel García-Sánchez, Monica Dotta, José C Rodríguez-Rey & Flor M Pérez-Campo. (2020) Mesenchymal stem cells secretome: The cornerstone of cell-free regenerative medicine. World Journal of Stem Cells 12:12, pages 1529-1552.
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Lizhi Han, Song Gong, Ruoyu Wang, Shaokai Liu, Bo Wang, Guo Chen, Tianlun Gong & Weihua Xu. (2020) Knockdown of POSTN Inhibits Osteogenic Differentiation of Mesenchymal Stem Cells From Patients With Steroid-Induced Osteonecrosis. Frontiers in Cell and Developmental Biology 8.
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Hiroki Ohta, Xiaolan Liu & Miho Maeda. (2020) Autologous adipose mesenchymal stem cell administration in arteriosclerosis and potential for anti-aging application: a retrospective cohort study. Stem Cell Research & Therapy 11:1.
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Alexia Karamini, Athina Bakopoulou, Dimitrios Andreadis, Konstantinos Gkiouras & Aristeidis Kritis. (2020) Therapeutic Potential of Mesenchymal Stromal Stem Cells in Rheumatoid Arthritis: a Systematic Review of In Vivo Studies. Stem Cell Reviews and Reports 16:2, pages 276-287.
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Lizhi Han, Bo Wang, Ruoyu Wang, Song Gong, Guo Chen & Weihua Xu. (2019) The shift in the balance between osteoblastogenesis and adipogenesis of mesenchymal stem cells mediated by glucocorticoid receptor. Stem Cell Research & Therapy 10:1.
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Donghak Kim, Justin J. Chung, Youngmee Jung & Soo Hyun Kim. (2019) The effect of Substance P/Heparin conjugated PLCL polymer coating of bioinert ePTFE vascular grafts on the recruitment of both ECs and SMCs for accelerated regeneration. Scientific Reports 9:1.
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Kamal Abdolmohammadi, Fatemeh Dadgar Pakdel, Hamideh Aghaei, Sara Assadiasl, Yousef Fatahi, Negin Hosseini Rouzbahani, Alireza Rezaiemanesh, Masoud Soleimani, Lobat Tayebi & Mohammad Hossein Nicknam. (2019) Ankylosing spondylitis and mesenchymal stromal/stem cell therapy: a new therapeutic approach. Biomedicine & Pharmacotherapy 109, pages 1196-1205.
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Rong Huang, Yinghong Zhou & Yin Xiao. 2019. Encyclopedia of Biomedical Engineering. Encyclopedia of Biomedical Engineering 249 256 .
Krzysztof Orczyk & Elzbieta Smolewska. (2017) Are We Right to Consider Mesenchymal Stem Cells to Be a New Perspective for Patients with Juvenile Idiopathic Arthritis?. Archivum Immunologiae et Therapiae Experimentalis 66:4, pages 267-271.
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Fei Hua, Yueqiu Chen, Ziying Yang, Xiaomei Teng, Haoyue Huang & Zhenya Shen. (2018) Protective action of bone marrow mesenchymal stem cells in immune tolerance of allogeneic heart transplantation by regulating CD45RB + dendritic cells . Clinical Transplantation 32:4, pages e13231.
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Masato Kantake, Atsuyuki Hirano, Masayuki Sano, Naoki Urushihata, Hideki Tanemura, Katsuyuki Oki & Emi Suzaki. (2017) Transplantation of allogeneic adipose-derived mesenchymal stem cells in a cerebral palsy patient (Retracted). Regenerative Medicine 12:5, pages 575-575.
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Madison C. B. Paton, Courtney A. McDonald, Beth J. Allison, Michael C. Fahey, Graham Jenkin & Suzanne L. Miller. (2017) Perinatal Brain Injury As a Consequence of Preterm Birth and Intrauterine Inflammation: Designing Targeted Stem Cell Therapies. Frontiers in Neuroscience 11.
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Leilei Chen, Yuan Zhang, Liangliang Tao, Zhijian Yang & Liansheng Wang. (2016) Mesenchymal Stem Cells with eNOS Over-Expression Enhance Cardiac Repair in Rats with Myocardial Infarction. Cardiovascular Drugs and Therapy 31:1, pages 9-18.
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Dixin Cui, Hongyu Li, Xin Xu, Ling Ye, Xuedong Zhou, Liwei Zheng & Yachuan Zhou. (2017) Mesenchymal Stem Cells for Cartilage Regeneration of TMJ Osteoarthritis. Stem Cells International 2017, pages 1-11.
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Yusuf H. Mirza & Sam Oussedik. 2017. Joint Preservation in the Adult Knee. Joint Preservation in the Adult Knee 29 41 .
Ann Ouyang, Alec E. Cerchiari, Xinyan Tang, Ellen Liebenberg, Tamara Alliston, Zev J. Gartner & Jeffrey C. Lotz. (2017) Effects of cell type and configuration on anabolic and catabolic activity in 3D co-culture of mesenchymal stem cells and nucleus pulposus cells. Journal of Orthopaedic Research 35:1, pages 61-73.
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Kenan Özler, Erdem Aktaş, Çiğdem Atay, Barış Yılmaz, Murat Arıkan & Şafak Güngör. (2016) Serum and knee synovial fluid matrixmetalloproteinase-13 and tumor necrosis factor-alpha levels in patients with late stage osteoarthritis. Acta Orthopaedica et Traumatologica Turcica 50:6, pages 670-673.
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Min Li, Jingxing Xu, Tongxin Shi, Haiyang Yu, Jianping Bi & Guanzhi Chen. (2016) Epigallocatechin‐3‐gallate augments therapeutic effects of mesenchymal stem cells in skin wound healing. Clinical and Experimental Pharmacology and Physiology 43:11, pages 1115-1124.
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Jia Sun, Jintao Chen, Juan Cao, Tianxiang Li, Shaoxia Zhuang & Xiufeng Jiang. (2016) IL-1β-stimulated β-catenin up-regulation promotes angiogenesis in human lung-derived mesenchymal stromal cells through a NF-κB-dependent microRNA-433 induction. Oncotarget 7:37, pages 59429-59440.
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He Liu, Jianxun Ding, Chen Li, Chenyu Wang, Yinan Wang, Jincheng Wang & Fei Chang. (2016) Hydrogel is Superior to Fibrin Gel as Matrix of Stem Cells in Alleviating Antigen-Induced Arthritis. Polymers 8:5, pages 182.
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Rebecca S.Y. Wong. (2015) Role of stem cells in spondyloarthritis: Pathogenesis, treatment and complications. Human Immunology 76:10, pages 781-788.
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Fang-Pey Chen, Ching-Mao Chang, Shinn-Jang Hwang, Yu-Chun Chen & Fun-Jou Chen. (2014) Chinese herbal prescriptions for osteoarthritis in Taiwan: analysis of national health insurance dataset. BMC Complementary and Alternative Medicine 14:1.
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Zhu Xishan, Yu Haojun, He Baoxin, Zhou Xinna, Jiang Ni, Zhang Hongmei, Wang Xiaoli & Ren Jun. (2014) Mouse Flk-1+Sca-1- Mesenchymal Stem Cells. Transplantation 97:5, pages 509-517.
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Girolamo A. OrtolanoBarry Wenz. (2014) A Review of the Pathogenesis of Osteoarthritis and the Use of Intra-articular Platelet Therapy for Joint Disease in Animals and Humans. Bone and Tissue Regeneration Insights 5, pages BTRI.S14578.
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Chang-qiang Tan, Xia Gao, Lang Guo & He Huang. (2014) Exogenous IL-4-Expressing Bone Marrow Mesenchymal Stem Cells for the Treatment of Autoimmune Sensorineural Hearing Loss in a Guinea Pig Model. BioMed Research International 2014, pages 1-10.
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