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Expert Opinion on Therapeutic Targets Volume 17, 2013 - Issue 4
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Endoglin for tumor imaging and targeted cancer therapy

Madelon PaauweLeiden University Medical Center, Cancer Genomics Centre Netherlands and Centre for BioMedical Genetics, Department of Molecular Cell Biology, Building-2, S1-P, PO-box 9600, 2300 RC Leiden, The Netherlands+31 71 526 9272; +31 71 526 8270; [email protected]
,
Peter ten DijkeLeiden University Medical Center, Cancer Genomics Centre Netherlands and Centre for BioMedical Genetics, Department of Molecular Cell Biology, Building-2, S1-P, PO-box 9600, 2300 RC Leiden, The Netherlands+31 71 526 9272; +31 71 526 8270; [email protected]
&
Lukas JAC HawinkelsLeiden University Medical Center, Cancer Genomics Centre Netherlands and Centre for BioMedical Genetics, Department of Molecular Cell Biology, Building-2, S1-P, PO-box 9600, 2300 RC Leiden, The Netherlands+31 71 526 9272; +31 71 526 8270; [email protected]
, PhD
Pages 421-435 | Published online: 17 Jan 2013

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Claudia Ollauri-Ibáñez, José M López-Novoa & Miguel Pericacho. (2017) Endoglin-based biological therapy in the treatment of angiogenesis-dependent pathologies. Expert Opinion on Biological Therapy 17:9, pages 1053-1063.
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Lukas JAC Hawinkels, Amaya Garcia de Vinuesa & Peter ten Dijke. (2013) Activin receptor-like kinase 1 as a target for anti-angiogenesis therapy. Expert Opinion on Investigational Drugs 22:11, pages 1371-1383.
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Articles from other publishers (29)

Geyi Zhang, Jinsheng Huang, Shuang Hao, Jingchao Zhang & Nan Zhou. (2022) Radix Astragalus Polysaccharide Accelerates Angiogenesis by Activating AKT/eNOS to Promote Nerve Regeneration and Functional Recovery. Frontiers in Pharmacology 13.
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Yi-Fan Chou, Yu-Hsuan Lan, Jun-Han Hsiao, Chiao-Yun Chen, Pei-Yu Chou & Ming-Jyh Sheu. (2022) Curcuminoids Inhibit Angiogenic Behaviors of Human Umbilical Vein Endothelial Cells via Endoglin/Smad1 Signaling. International Journal of Molecular Sciences 23:7, pages 3889.
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Lan Li, Liping Zhong, Chao Tang, Lu Gan, Tong Mo, Jintong Na, Jian He & Yong Huang. (2022) CD105: tumor diagnosis, prognostic marker and future tumor therapeutic target. Clinical and Translational Oncology 24:8, pages 1447-1458.
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Blanca Ayuso-Íñigo, Lucía Méndez-García, Miguel Pericacho & José M. Muñoz-Félix. (2021) The Dual Effect of the BMP9–ALK1 Pathway in Blood Vessels: An Opportunity for Cancer Therapy Improvement?. Cancers 13:21, pages 5412.
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Piotr K. Zakrzewski. (2021) Canonical TGFβ Signaling and Its Contribution to Endometrial Cancer Development and Progression—Underestimated Target of Anticancer Strategies. Journal of Clinical Medicine 10:17, pages 3900.
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Claudia Ollauri-Ibáñez, Blanca Ayuso-Íñigo & Miguel Pericacho. (2021) Hot and Cold Tumors: Is Endoglin (CD105) a Potential Target for Vessel Normalization?. Cancers 13:7, pages 1552.
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Teresa González Muñoz, Ana Teresa Amaral, Pilar Puerto-Camacho, Héctor Peinado & Enrique de Álava. (2021) Endoglin in the Spotlight to Treat Cancer. International Journal of Molecular Sciences 22:6, pages 3186.
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Yingmiao Liu, Madelon Paauwe, Andrew B. Nixon & Lukas J.A.C. Hawinkels. (2020) Endoglin Targeting: Lessons Learned and Questions That Remain. International Journal of Molecular Sciences 22:1, pages 147.
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Ana Nogués, Eunate Gallardo-Vara, Mª. Paz Zafra, Paloma Mate, Jose Luis Marijuan, Alfredo Alonso, Luisa Mª. Botella & Mª. Isabel Prieto. (2020) Endoglin (CD105) and VEGF as potential angiogenic and dissemination markers for colorectal cancer. World Journal of Surgical Oncology 18:1.
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Zhuoran Ma, Feifei Wang, Yeteng Zhong, Felix Salazar, Jiachen Li, Mingxi Zhang, Fuqiang Ren, Anna M. Wu & Hongjie Dai. (2020) Cross‐Link‐Functionalized Nanoparticles for Rapid Excretion in Nanotheranostic Applications. Angewandte Chemie International Edition 59:46, pages 20552-20560.
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Zhuoran Ma, Feifei Wang, Yeteng Zhong, Felix Salazar, Jiachen Li, Mingxi Zhang, Fuqiang Ren, Anna M. Wu & Hongjie Dai. (2020) Cross‐Link‐Functionalized Nanoparticles for Rapid Excretion in Nanotheranostic Applications. Angewandte Chemie 132:46, pages 20733-20741.
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Gallardo-Vara, Ruiz-Llorente, Casado-Vela, Ruiz-Rodríguez, López-Andrés, Pattnaik, Quintanilla & Bernabeu. (2019) Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners. Cells 8:9, pages 1082.
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M. P. Samoilovich, A. A. Pinevich, N. L. Vartanyan, I. V. Smirnov, I. Yu. Krutetskaya, A. Yu. Stolbovaya, O. A. Shashkova, I. V. Gryazeva, M. A. Berlina, T. D. Smirnova & V. B. Klimovich. (2018) Endoglin Expression in Non-tumor and Tumor Cells of Different Origin. Cell and Tissue Biology 12:6, pages 437-447.
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Cheng Liu, Fei Yan, Yajie Xu, Hairong Zheng & Lei Sun. (2018) I n V ivo Molecular Ultrasound Assessment of Glioblastoma Neovasculature with Endoglin-Targeted Microbubbles . Contrast Media & Molecular Imaging 2018, pages 1-10.
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Sixiang Shi, Feng Chen, Shreya Goel, Stephen A. Graves, Haiming Luo, Charles P. Theuer, Jonathan W. Engle & Weibo Cai. (2018) In Vivo Tumor-Targeted Dual-Modality PET/Optical Imaging with a Yolk/Shell-Structured Silica Nanosystem. Nano-Micro Letters 10:4.
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Chuannan Fan, Jing Zhang, Wan Hua & Peter ten Dijke. 2018. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Selcuk Colak & Peter ten Dijke. (2017) Targeting TGF-β Signaling in Cancer. Trends in Cancer 3:1, pages 56-71.
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M Paauwe, R C Heijkants, C H Oudt, G W van Pelt, C Cui, C P Theuer, J C H Hardwick, C F M Sier & L J A C Hawinkels. (2016) Endoglin targeting inhibits tumor angiogenesis and metastatic spread in breast cancer. Oncogene 35:31, pages 4069-4079.
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Xiangyi Kong, Yu Wang, Shuai Liu, Bing Xing, Yi Yang, Yongning Li, Zuyuan Ren, Changbao Su, Wenbin Ma & Renzhi Wang. (2016) CD105 Over-expression Is Associated with Higher WHO Grades for Gliomas. Molecular Neurobiology 53:5, pages 3503-3512.
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Amaya García de Vinuesa, Salim Abdelilah-Seyfried, Petra Knaus, An Zwijsen & Sabine Bailly. (2016) BMP signaling in vascular biology and dysfunction. Cytokine & Growth Factor Reviews 27, pages 65-79.
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Chang-Han Chen, Hui-Ching Chuang, Yu-Tsai Lin, Fu-Min Fang, Chao-Cheng Huang, Ching-Mei Chen, Hui Lu & Chih-Yen Chien. (2015) Circulating CD105 shows significant impact in patients of oral cancer and promotes malignancy of cancer cells via CCL20. Tumor Biology 37:2, pages 1995-2005.
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Martin C. BoonstraSusanna W.L. De GeusHendrica A.J.M. PrevooLukas J.A.C. HawinkelsCornells J.H. Van De VeldePeter J.K. KuppenAlexander L. VahrmeijerCornelis F.M. Sier. (2016) Selecting Targets for Tumor Imaging: An Overview of Cancer-Associated Membrane Proteins. Biomarkers in Cancer 8, pages BIC.S38542.
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Tanja Dolinsek, Gregor Sersa, Lara Prosen, Masa Bosnjak, Monika Stimac, Urska Razborsek & Maja Cemazar. (2015) Electrotransfer of Plasmid DNA Encoding an Anti-Mouse Endoglin (CD105) shRNA to B16 Melanoma Tumors with Low and High Metastatic Potential Results in Pronounced Anti-Tumor Effects. Cancers 8:1, pages 3.
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Stephanie C. Casey, Amedeo Amedei, Katia Aquilano, Asfar S. Azmi, Fabian Benencia, Dipita Bhakta, Alan E. Bilsland, Chandra S. Boosani, Sophie Chen, Maria Rosa Ciriolo, Sarah Crawford, Hiromasa Fujii, Alexandros G. Georgakilas, Gunjan Guha, Dorota Halicka, William G. Helferich, Petr Heneberg, Kanya Honoki, W. Nicol Keith, Sid P. Kerkar, Sulma I. Mohammed, Elena Niccolai, Somaira Nowsheen, H.P. Vasantha Rupasinghe, Abbas Samadi, Neetu Singh, Wamidh H. Talib, Vasundara Venkateswaran, Richard L. Whelan, Xujuan Yang & Dean W. Felsher. (2015) Cancer prevention and therapy through the modulation of the tumor microenvironment. Seminars in Cancer Biology 35, pages S199-S223.
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J. M. Denbeigh, B. A. Nixon, J. J. Y. Lee, M. Jerkic, P. A. Marsden, M. Letarte, M. C. Puri & F. S. Foster. (2014) Contrast-enhanced molecular ultrasound differentiates endoglin genotypes in mouse embryos. Angiogenesis 18:1, pages 69-81.
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Xiao Huang, Caixia Yi, Yijuan Fan, Yinxing Zhang, Limei Zhao, Zhiqing Liang & Jun Pan. (2014) Magnetic Fe3O4 nanoparticles grafted with single-chain antibody (scFv) and docetaxel loaded β-cyclodextrin potential for ovarian cancer dual-targeting therapy. Materials Science and Engineering: C 42, pages 325-332.
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Valeria Barresi, Giovanni Branca, Maria Caffo, Rosario Caltabiano, Antonio Ieni, Enrica Vitarelli, Salvatore Lanzafame & Giovanni Tuccari. (2014) Immuno-Expression of Endoglin and Smooth Muscle Actin in the Vessels of Brain Metastases. Is There a Rational for Anti-Angiogenic Therapy?. International Journal of Molecular Sciences 15:4, pages 5663-5679.
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Leon Jonker. (2014) TGF- β & BMP Receptors Endoglin and ALK1: Overview of their Functional Role and Status as Antiangiogenic Targets . Microcirculation 21:2, pages 93-103.
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Lee S. Rosen, Michael S. Gordon, Francisco Robert & Daniela E. Matei. (2014) Endoglin for Targeted Cancer Treatment. Current Oncology Reports 16:2.
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