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Expert Opinion on Therapeutic Targets Volume 17, 2013 - Issue 8
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The promise of CaMKII inhibition for heart disease: preventing heart failure and arrhythmias

B Daan WestenbrinkUniversity of California, Department of Pharmacology, San Diego, La Jolla, CA, USA;The University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
,
Andrew G EdwardsUniversity of California, The Department of Bioengineering, San Diego, CA, USA
,
Andrew D McCullochUniversity of California, The Department of Bioengineering, San Diego, CA, USA
&
Joan Heller BrownDistinguished Professor and Chair, University of California, Department of Pharmacology, 9500 Gilman Drive, MC 0636, San Diego, La Jolla, CA, USA+1 92093 0636; [email protected]
, PhD
Pages 889-903 | Published online: 24 Jun 2013

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Alexander J. Winkle, Drew M. Nassal, Rebecca Shaheen, Evelyn Thomas, Shivangi Mohta, Daniel Gratz, Seth H. Weinberg & Thomas J. Hund. (2022) Emerging therapeutic targets for cardiac hypertrophy. Expert Opinion on Therapeutic Targets 26:1, pages 29-40.
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Harmen G. Booij, Anne M. Koning, Harry van Goor, Rudolf A. de Boer & B. Daan Westenbrink. (2017) Selecting heart failure patients for metabolic interventions. Expert Review of Molecular Diagnostics 17:2, pages 141-152.
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Articles from other publishers (22)

Niyati Parekh, Sarthak Lakhani, Ayushi Patel, Dhyanesh Oza, Bhumika Patel, Ruchi Yadav & Udit Chaube. (2023) Discovery of novel CaMK-II inhibitor for the possible mitigation of arrhythmia through pharmacophore modelling, virtual screening, molecular docking, and toxicity prediction. Artificial Intelligence Chemistry 1:2, pages 100009.
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Erin Sanders & Pilar Alcaide. (2023) Red light-green light: T-cell trafficking in cardiac and vascular inflammation. American Journal of Physiology-Cell Physiology 324:1, pages C58-C66.
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Ali Khalilimeybodi, Muhammad Riaz, Stuart G. Campbell, Jeffrey H. Omens, Andrew D. McCulloch, Yibing Qyang & Jeffrey J. Saucerman. (2023) Signaling network model of cardiomyocyte morphological changes in familial cardiomyopathy. Journal of Molecular and Cellular Cardiology 174, pages 1-14.
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Dongdong Qian, Jing Tian, Sining Wang, Xiaoli Shan, Pei Zhao, Huihua Chen, Ming Xu, Wei Guo, Chen Zhang & Rong Lu. (2022) Trans-cinnamaldehyde protects against phenylephrine-induced cardiomyocyte hypertrophy through the CaMKII/ERK pathway. BMC Complementary Medicine and Therapies 22:1.
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Daan Nie, Chaorui Xia, Zhiyu Wang, Peiwu Ding, Yidi Meng, Jie Liu, Ting Li, Ting Gan, Baijun Xuan, Yun Huang, Jiaming Zhang, Guanhua Su & Jingdong Li. (2022) CaMKII inhibition protects against hyperthyroid arrhythmias and adverse myocardial remodeling. Biochemical and Biophysical Research Communications 615, pages 136-142.
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Mitchell Simon, Christopher Y. Ko, Robyn T. Rebbeck, Sonya Baidar, Razvan L. Cornea & Donald M. Bers. (2021) CaMKIIδ post-translational modifications increase affinity for calmodulin inside cardiac ventricular myocytes. Journal of Molecular and Cellular Cardiology 161, pages 53-61.
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Drew M. Nassal, Nehal J. Patel, Sathya D. Unudurthi, Rebecca Shaheen, Jane Yu, Peter J. Mohler & Thomas J. Hund. (2021) Ca2+/calmodulin kinase II–dependent regulation of βIV-spectrin modulates cardiac fibroblast gene expression, proliferation, and contractility. Journal of Biological Chemistry 297:1, pages 100893.
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Mario G. Pavez-Giani, Pablo I. Sánchez-Aguilera, Nils Bomer, Shigeki Miyamoto, Harmen G. Booij, Paula Giraldo, Silke U. Oberdorf-Maass, Kirsten T. Nijholt, Salva R. Yurista, Hendrik Milting, Peter van der Meer, Rudolf A. de Boer, Joan Heller Brown, Herman W. H. Sillje & B. Daan Westenbrink. (2021) ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ. International Journal of Molecular Sciences 22:9, pages 4427.
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Salva R. Yurista, Herman H. W. Silljé, Michiel Rienstra, Rudolf A. de Boer & B. Daan Westenbrink. (2020) Sodium-glucose co-transporter 2 inhibition as a mitochondrial therapy for atrial fibrillation in patients with diabetes?. Cardiovascular Diabetology 19:1.
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Drew Nassal, Daniel Gratz & Thomas J. Hund. (2020) Challenges and Opportunities for Therapeutic Targeting of Calmodulin Kinase II in Heart. Frontiers in Pharmacology 11.
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Jung-Hoon Pyun, Hyun-Ji Kim, Myong-Ho Jeong, Byeong-Yun Ahn, Tuan Anh Vuong, Dong I. Lee, Seri Choi, Seung-Hoi Koo, Hana Cho & Jong-Sun Kang. (2018) Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation. Nature Communications 9:1.
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Daniel M. Johnson & Gudrun Antoons. (2018) Arrhythmogenic Mechanisms in Heart Failure: Linking β-Adrenergic Stimulation, Stretch, and Calcium. Frontiers in Physiology 9.
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Friederike Cuello & Kristina Lorenz. (2016) Inhibition of cardiac CaMKII to cure heart failure: step by step towards translation?. Basic Research in Cardiology 111:6.
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Károly Acsai, Balázs Ördög, András Varró & Péter P. Nánási. (2016) Role of the dysfunctional ryanodine receptor - Na+-Ca2+exchanger axis in progression of cardiovascular diseases: What we can learn from pharmacological studies?. European Journal of Pharmacology 779, pages 91-101.
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Mariya Kronlage, Hugo A. Katus & Johannes Backs. 2016. Epigenetics in Cardiac Disease. Epigenetics in Cardiac Disease 191 208 .
Lorna Daniels, James R. Bell, Lea M. D. Delbridge, Fiona J. McDonald, Regis R. Lamberts & Jeffrey R. Erickson. (2015) The role of CaMKII in diabetic heart dysfunction. Heart Failure Reviews 20:5, pages 589-600.
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Hui Wang, Yimu Lai, Bryan J. Mathis, Wenjuan Wang, Siying Li, Chen Qu, Bin Li, Lei Shao, Haibo Song, Joseph S. Janicki, Sao-Cong Sun, Xing Li Wang, Dongqi Tang & Taixing Cui. (2015) Deubiquitinating enzyme CYLD mediates pressure overload-induced cardiac maladaptive remodeling and dysfunction via downregulating Nrf2. Journal of Molecular and Cellular Cardiology 84, pages 143-153.
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Ralph J. van Oort, Joan Heller Brown & B. Daan Westenbrink. (2014) CaMKII confirms its promise in ischaemic heart disease. European Journal of Heart Failure 16:12, pages 1268-1269.
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M. M. Maleckar, G. T. Lines, J. T. Koivumaki, J. M. Cordeiro & K. Calloe. (2014) NS5806 partially restores action potential duration but fails to ameliorate calcium transient dysfunction in a computational model of canine heart failure. Europace 16:suppl 4, pages iv46-iv55.
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Eunhyun Choi, Min-Ji Cha & Ki-Chul Hwang. (2014) Roles of Calcium Regulating MicroRNAs in Cardiac Ischemia-Reperfusion Injury. Cells 3:3, pages 899-913.
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Eleonora Grandi, Andrew G. Edwards, Anthony W. Herren & Donald M. Bers. (2014) CaMKII comes of age in cardiac health and disease. Frontiers in Pharmacology 5.
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Licette C. Y. Liu, Kevin Damman, Eric Lipsic, Alexander H. Maass, Michiel Rienstra & B. Daan Westenbrink. (2014) Heart failure highlights in 2012-2013. European Journal of Heart Failure 16:2, pages 122-132.
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