836
Views
97
CrossRef citations to date
0
Altmetric
Reviews

PDE4 as a target for cognition enhancement

, , &
Pages 1011-1027 | Published online: 25 Jul 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Aditya Rathi, Vipul Kumar & Durai Sundar. (2023) Insights into the potential of withanolides as Phosphodiesterase-4 (PDE4D) inhibitors. Journal of Biomolecular Structure and Dynamics 41:6, pages 2108-2117.
Read now
Yong-Woo Jun, Jin-A Lee, Bong-Kiun Kaang & Deok-Jin Jang. (2017) PI4KII activity-dependent Golgi complex targeting of Aplysia phosphodiesterase 4 long-form mutant. Animal Cells and Systems 21:5, pages 316-322.
Read now
Jos Prickaerts, Pim R. A. Heckman & Arjan Blokland. (2017) Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer’s disease. Expert Opinion on Investigational Drugs 26:9, pages 1033-1048.
Read now
David O. Kennedy, Philippa A. Jackson, Joanne Forster, Julie Khan, Torsten Grothe, Tania Perrinjaquet-Moccetti & Crystal F. Haskell-Ramsay. (2017) Acute effects of a wild green-oat (Avena sativa) extract on cognitive function in middle-aged adults: A double-blind, placebo-controlled, within-subjects trial. Nutritional Neuroscience 20:2, pages 135-151.
Read now
Ana Martinez & Carmen Gil. (2014) cAMP-specific phosphodiesterase inhibitors: promising drugs for inflammatory and neurological diseases. Expert Opinion on Therapeutic Patents 24:12, pages 1311-1321.
Read now

Articles from other publishers (92)

Jeferson Machado Batista Sohn, Nathalie Carla Cardoso, Ana Maria Raymundi, Jos Prickaerts & Cristina Aparecida Jark Stern. (2023) Phosphodiesterase 4 inhibition after retrieval switches the memory fate favoring extinction instead of reconsolidation. Scientific Reports 13:1.
Crossref
Bhanu Sharma & Rituraj Purohit. (2023) Structural insights into the lead identification of sub-type selective PDE4B inhibitors from plant bioactive molecule analogues. Journal of Molecular Liquids 390, pages 123039.
Crossref
Yi-Fan Cong, Fu-Wang Liu, Li Xu, Shuang-Shuang Song, Xu-Ri Shen, Dong Liu, Xue-Qin Hou & Han-Ting Zhang. (2023) Rolipram Ameliorates Memory Deficits and Depression-Like Behavior in APP/PS1/tau Triple Transgenic Mice: Involvement of Neuroinflammation and Apoptosis via cAMP Signaling. International Journal of Neuropsychopharmacology.
Crossref
Yuri A. Blednov, Adriana Da Costa, Sonia Mason, Jody Mayfield & Robert O. Messing. (2023) Selective PDE4B and PDE4D inhibitors produce distinct behavioral responses to ethanol and GABAergic drugs in mice. Neuropharmacology 231, pages 109508.
Crossref
Estibaliz Barrio-Alonso, Pablo J. Lituma, Michael J. Notaras, Robert Albero, Youcef Bouchekioua, Natalie Wayland, Isidora N. Stankovic, Tanya Jain, Sijia Gao, Diany Paola Calderon, Pablo E. Castillo & Dilek Colak. (2023) Circadian protein TIMELESS regulates synaptic function and memory by modulating cAMP signaling. Cell Reports 42:4, pages 112375.
Crossref
Melissa Schepers, Dean Paes, Assia Tiane, Ben Rombaut, Elisabeth Piccart, Lieve van Veggel, Pascal Gervois, Esther Wolfs, Ivo Lambrichts, Chiara Brullo, Olga Bruno, Ernesto Fedele, Roberta Ricciarelli, Charles ffrench-Constant, Marie E. Bechler, Pauline van Schaik, Wia Baron, Evy Lefevere, Kobi Wasner, Anne Grünewald, Catherine Verfaillie, Paulien Baeten, Bieke Broux, Paul Wieringa, Niels Hellings, Jos Prickaerts & Tim Vanmierlo. (2023) Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis. Brain, Behavior, and Immunity 109, pages 1-22.
Crossref
Daniel Irelan, Abigail Boyd, Edward Fiedler, Peter Lochmaier, Will McDonough, Ileana V. Aragon, Lyudmila Rachek, Lina Abou Saleh & Wito Richter. (2023) Acute PDE4 Inhibition Induces a Transient Increase in Blood Glucose in Mice. International Journal of Molecular Sciences 24:4, pages 3260.
Crossref
Zizhen Liu, Axiang Li, Tahir Ali, Kaiwu He, Ruyan Gao, Liufang He, Hao Qiang, Tao Li, Ningning Li, Ana M. Garcia, Carmen Gil, Ana Martinez, Tatiana V. Lipina & Shupeng Li. (2023) Neuronal lack of PDE7a disrupted working memory, spatial learning, and memory but facilitated cued fear memory in mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry 120, pages 110655.
Crossref
Xuemei Wei, Guoqi Yu, Hualiang Shen, Yanjuan Luo, Tianbo Shang, Runpu Shen, Meiyang Xi & Haopeng Sun. (2023) Targeting phosphodiesterase 4 as a therapeutic strategy for cognitive improvement. Bioorganic Chemistry 130, pages 106278.
Crossref
Yuichi Wakabayashi, Per Stenkrona, Ryosuke Arakawa, Xuefeng Yan, Maia G. Van Buskirk, Madeline D. Jenkins, Jose A. Montero Santamaria, Kevin P. Maresca, Akihiro Takano, Jeih-San Liow, Thomas A. Chappie, Andrea Varrone, Sangram Nag, Lei Zhang, Zoë A. Hughes, Christopher J. Schmidt, Shawn D. Doran, Andrew Mannes, Paolo Zanotti-Fregonara, Maarten Ooms, Cheryl L. Morse, Sami S. Zoghbi, Christer Halldin, Victor W. Pike & Robert B. Innis. (2022) First-in-Human Evaluation of 18 F-PF-06445974, a PET Radioligand That Preferentially Labels Phosphodiesterase-4B . Journal of Nuclear Medicine 63:12, pages 1919-1924.
Crossref
Yuri A. Blednov, Adriana Da Costa, Sonia Mason, Jody Mayfield, Stephen J. Moss & Robert O. Messing. (2022) Apremilast-induced increases in acute ethanol intoxication and decreases in ethanol drinking in mice involve PKA phosphorylation of GABAA β3 subunits. Neuropharmacology 220, pages 109255.
Crossref
Abigail Boyd, Peter Lochmaier, Daniel Irelan, Edward Fiedler, Ji Lee, Brian Fouty, Lina Abou Saleh & Wito Richter. (2022) Non-Selective PDE4 Inhibition Induces a Rapid and Transient Decrease of Serum Potassium in Mice. Biology 11:11, pages 1582.
Crossref
Letizia Crocetti, Giuseppe Floresta, Agostino Cilibrizzi & Maria Paola Giovannoni. (2022) An Overview of PDE4 Inhibitors in Clinical Trials: 2010 to Early 2022. Molecules 27:15, pages 4964.
Crossref
Amarjot Kaur, Thakur Gurjeet Singh, Heena Khan, Manish Kumar, Nirmal Singh & Mohamed M. Abdel-Daim. (2022) Neuroprotective Effect of Piclamilast-Induced Post-Ischemia Pharmacological Treatment in Mice. Neurochemical Research 47:8, pages 2230-2243.
Crossref
Emmanuel O. Adewuyi, Eleanor K. O’Brien, Dale R. Nyholt, Tenielle Porter & Simon M. Laws. (2022) A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer’s disease and gastrointestinal tract disorders. Communications Biology 5:1.
Crossref
Dongze Chen, Xinpei Wang, Tao Huang & Jinzhu Jia. (2022) Sleep and Late-Onset Alzheimer’s Disease: Shared Genetic Risk Factors, Drug Targets, Molecular Mechanisms, and Causal Effects. Frontiers in Genetics 13.
Crossref
Meiyang Xi, Tianyu Sun, Shejie Chai, Mengjiao Xie, Siqi Chen, Liping Deng, Kui Du, Runpu Shen & Haopeng Sun. (2022) Therapeutic potential of phosphodiesterase inhibitors for cognitive amelioration in Alzheimer's disease. European Journal of Medicinal Chemistry 232, pages 114170.
Crossref
Mitsugi Ookawara & Yasunori Nio. (2022) Phosphodiesterase 4 inhibitors in diabetic nephropathy. Cellular Signalling 90, pages 110185.
Crossref
Martin Alexander Schick & Nicolas Schlegel. (2022) Clinical Implication of Phosphodiesterase-4-Inhibition. International Journal of Molecular Sciences 23:3, pages 1209.
Crossref
Sahithi Attaluri, Meenakshi Arora, Leelavathi N Madhu, Maheedhar Kodali, Bing Shuai, Laila Melissari, Raghavendra Upadhya, Xiaolan Rao, Adrian Bates, Eeshika Mitra, Keyhan R Ghahfarouki, M. N. V Ravikumar & Ashok K Shetty. (2022) Oral Nano-Curcumin in a Model of Chronic Gulf War Illness Alleviates Brain Dysfunction with Modulation of Oxidative Stress, Mitochondrial Function, Neuroinflammation, Neurogenesis, and Gene Expression. Aging and disease 13:2, pages 583.
Crossref
Abigail Boyd, Ileana Aragon, Justin Rich, Will McDonough, Marianna Oditt, Daniel Irelan, Edward Fiedler, Lina Abou Saleh & Wito Richter. (2021) Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice. Biology 10:12, pages 1355.
Crossref
Annette Hus-Citharel, Nadine Bouby, Maithé Corbani, Julie Mion, Christiane Mendre, Judit Darusi, Csaba Tomboly, Miguel Trueba, Claudine Serradeil-Le Gal, Catherine Llorens-Cortes & Gilles Guillon. (2021) Characterization of a functional V 1B vasopressin receptor in the male rat kidney: evidence for cross talk between V 1B and V 2 receptor signaling pathways . American Journal of Physiology-Renal Physiology 321:3, pages F305-F321.
Crossref
Lina Abou Saleh, Abigail Boyd, Ileana V. Aragon, Anna Koloteva, Domenico Spadafora, Wadad Mneimneh, Robert A. Barrington & Wito Richter. (2021) Ablation of PDE4B protects from Pseudomonas aeruginosa ‐induced acute lung injury in mice by ameliorating the cytostorm and associated hypothermia . The FASEB Journal 35:9.
Crossref
Sébastien Delhaye & Barbara Bardoni. (2021) Role of phosphodiesterases in the pathophysiology of neurodevelopmental disorders. Molecular Psychiatry 26:9, pages 4570-4582.
Crossref
Halil Keskin, Filiz Keskin, Taha Tavaci, Hamza Halici, Tugba Nurcan Yuksel, Mustafa Ozkaraca, Arzu Bilen & Zekai Halici. (2021) Neuroprotective effect of roflumilast under cerebral ischaemia/reperfusion injury in juvenile rats through NLRP‐mediated inflammatory response inhibition. Clinical and Experimental Pharmacology and Physiology 48:8, pages 1103-1110.
Crossref
Sung-Jun Park, Faiyaz Ahmad, Robert J. Bahde, Andrew Philp, Jeonghan Kim, Tianjiao Huang, Myung K. Kim, William C. Trenkle & Jay H. Chung. (2021) Potent PDE4 inhibitor activates AMPK and Sirt1 to induce mitochondrial biogenesis. PLOS ONE 16:6, pages e0253269.
Crossref
Do-Yeon Kim, Jin-Sun Park, Yea-Hyun Leem, Jung-Eun Park & Hee-Sun Kim. (2020) The Potent PDE10A Inhibitor MP-10 (PF-2545920) Suppresses Microglial Activation in LPS-Induced Neuroinflammation and MPTP-Induced Parkinson’s Disease Mouse Models. Journal of Neuroimmune Pharmacology 16:2, pages 470-482.
Crossref
Abigail Boyd, Ileana V. Aragon, Lina Abou Saleh, Dylan Southers & Wito Richter. (2021) The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice. Biochemical Journal 478:10, pages 1891-1906.
Crossref
Benjamin Kioussis, Camilla S.L. Tuttle, Daniel S. Heard, Brian K. Kennedy, Nicola T. Lautenschlager & Andrea B. Maier. (2021) Targeting impaired nutrient sensing with repurposed therapeutics to prevent or treat age-related cognitive decline and dementia: A systematic review. Ageing Research Reviews 67, pages 101302.
Crossref
Ileana V. Aragon, Abigail Boyd, Lina Abou Saleh, Justin Rich, Will McDonough, Anna Koloteva & Wito Richter. (2021) Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice. Biochemical Pharmacology 186, pages 114477.
Crossref
Saray Varona, Lídia Puertas, María Galán, Mar Orriols, Laia Cañes, Silvia Aguiló, Mercedes Camacho, Marc Sirvent, Vicente Andrés, José Martínez-González & Cristina Rodríguez. (2021) Rolipram Prevents the Formation of Abdominal Aortic Aneurysm (AAA) in Mice: PDE4B as a Target in AAA. Antioxidants 10:3, pages 460.
Crossref
Chunyuan Zhang, Zeting Xing, Meiyun Tan, Yanwen Wu & Wei Zeng. (2021) Roflumilast Ameliorates Isoflurane-Induced Inflammation in Astrocytes via the CREB/BDNF Signaling Pathway . ACS Omega 6:6, pages 4167-4174.
Crossref
Susan McQuown, Dean Paes, Karsten Baumgärtel, Jos Prickaerts & Marco Peters. (2021) Pharmacological inhibition of phosphodiesterase 7 enhances consolidation processes of spatial memory. Neurobiology of Learning and Memory 177, pages 107357.
Crossref
Mayasah Y. Al-Nema & Anand Gaurav. (2020) Phosphodiesterase as a Target for Cognition Enhancement in Schizophrenia. Current Topics in Medicinal Chemistry 20:26, pages 2404-2421.
Crossref
Lora D. Weidner, Yuichi Wakabayashi, Louise A. Stolz, Michael T. Collins, Lori Guthrie, Milalynn Victorino, Joyce Chung, William Miller, Sami S. Zoghbi, Victor W. Pike, Masahiro Fujita, Robert B. Innis & Alison M. Boyce. (2020) PET Imaging of Phosphodiesterase-4 Identifies Affected Dysplastic Bone in McCune–Albright Syndrome, a Genetic Mosaic Disorder. Journal of Nuclear Medicine 61:11, pages 1672-1677.
Crossref
Shannon N. Leslie, Dibyadeep Datta, Kyle R. Christensen, Christopher H. van Dyck, Amy F. T. Arnsten & Angus C. Nairn. (2020) Phosphodiesterase PDE4D Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau. Frontiers in Aging Neuroscience 12.
Crossref
Will McDonough, Justin Rich, Ileana V. Aragon, Lina Abou Saleh, Abigail Boyd, Aris Richter, Anna Koloteva & Wito Richter. (2020) Inhibition of type 4 cAMP-phosphodiesterases (PDE4s) in mice induces hypothermia via effects on behavioral and central autonomous thermoregulation. Biochemical Pharmacology 180, pages 114158.
Crossref
Will McDonough, Ileana V. Aragon, Justin Rich, James M. Murphy, Lina Abou Saleh, Abigail Boyd, Anna Koloteva & Wito Richter. (2020) PAN‐selective inhibition of cAMP‐phosphodiesterase 4 (PDE4) induces gastroparesis in mice. The FASEB Journal 34:9, pages 12533-12548.
Crossref
Lal Jabaris S Sugin, Arumugam Murugesan, Menon Bindu & K Narayan Sunil. (2020) Roflumilast: A potential drug for the treatment of cognitive impairment?. Neuroscience Letters 736, pages 135281.
Crossref
Jie Xiang, Xin Wang, Yuan Gao, Ting Li, Rui Cao, Ting Yan, Yunxiao Ma, Yan Niu, Jiayue Xue & Bin Wang. (2020) Phosphodiesterase 4D Gene Modifies the Functional Network of Patients With Mild Cognitive Impairment and Alzheimer’s Disease. Frontiers in Genetics 11.
Crossref
Amy J. Tibbo & George S. Baillie. (2020) Phosphodiesterase 4B: Master Regulator of Brain Signaling. Cells 9:5, pages 1254.
Crossref
Jiahong Zhong, Wenli Dong, Yunyun Qin, Jinfeng Xie, Jiao Xiao, Jiangping Xu & Haitao Wang. (2020) Roflupram exerts neuroprotection via activation of CREB/PGC‐1α signalling in experimental models of Parkinson's disease. British Journal of Pharmacology 177:10, pages 2333-2350.
Crossref
Jianle Zhou, Liang Li, Hailu Zhang, Jiangping Xu, Dandan Huang, Ningbo Gong, Weili Han, Xuemei Yang & Zhengzheng Zhou. (2020) Crystal structures, dissolution and pharmacokinetic study on a novel phosphodiesterase-4 inhibitor chlorbipram cocrystals. International Journal of Pharmaceutics 576, pages 118984.
Crossref
Yu-Young Lee, Jin-Sun Park, Yea-Hyun Leem, Jung-Eun Park, Do-Yeon Kim, Youn-Hee Choi, Eun-Mi Park, Jihee Lee Kang & Hee-Sun Kim. (2019) The phosphodiesterase 10 inhibitor papaverine exerts anti-inflammatory and neuroprotective effects via the PKA signaling pathway in neuroinflammation and Parkinson’s disease mouse models. Journal of Neuroinflammation 16:1.
Crossref
Laurie P. Sutton, Brian S. Muntean, Olga Ostrovskaya, Stefano Zucca, Maria Dao, Cesare Orlandi, Chenghui Song, Keqiang Xie & Kirill A. Martemyanov. (2019) NF1-cAMP signaling dissociates cell type–specific contributions of striatal medium spiny neurons to reward valuation and motor control. PLOS Biology 17:10, pages e3000477.
Crossref
Anna Czopek, Adam Bucki, Marcin Kołaczkowski, Agnieszka Zagórska, Marcin Drop, Maciej Pawłowski, Agata Siwek, Monika Głuch-Lutwin, Elżbieta Pękala, Alicja Chrzanowska, Marta Struga, Anna Partyka & Anna Wesołowska. (2019) Novel multitarget 5-arylidenehydantoins with arylpiperazinealkyl fragment: Pharmacological evaluation and investigation of cytotoxicity and metabolic stability. Bioorganic & Medicinal Chemistry 27:18, pages 4163-4173.
Crossref
Brian M. Balog, Abhilasha Tangada, Pooja Sheth, Qi-Xiang Song, Bruna M. Couri, Leah L. Porras, Gary G. Deng & Margot S. Damaser. (2019) Combination phosphodiesterase type 4 inhibitor and phosphodiesterase type 5 inhibitor treatment reduces non-voiding contraction in a rat model of overactive bladder. PLOS ONE 14:8, pages e0220788.
Crossref
Yan-Wei Shi, Bu-Fang Fan, Li Xue, Xiao-Guang Wang & Xue-Ling Ou. (2019) Fear renewal activates cyclic adenosine monophosphate signaling in the dentate gyrus. Brain and Behavior 9:8.
Crossref
Shuichi Yanai & Shogo Endo. (2018) PDE3 Inhibitors Repurposed as Treatments for Age-Related Cognitive Impairment. Molecular Neurobiology 56:6, pages 4306-4316.
Crossref
Arjan Blokland, Marlies A. Van Duinen, Anke Sambeth, Pim R.A. Heckman, Max Tsai, Gezim Lahu, Tolga Uz & Jos Prickaerts. (2019) Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study. Neurobiology of Aging 77, pages 37-43.
Crossref
Bingtian Xu, Tiantian Wang, Jiao Xiao, Wenli Dong, Hui-zhen Wen, Xinyi Wang, Yunyun Qin, Ningbo Cai, Zhongzhen Zhou, Jiangping Xu & Haitao Wang. (2019) FCPR03, a novel phosphodiesterase 4 inhibitor, alleviates cerebral ischemia/reperfusion injury through activation of the AKT/GSK3β/ β-catenin signaling pathway. Biochemical Pharmacology 163, pages 234-249.
Crossref
Ellis Nelissen, Nick P. van Goethem, Vivian T. Bonassoli, Pim R.A. Heckman, Britt T.J. van Hagen, Dila Suay, Caroline Wouters & Jos Prickaerts. (2019) Validation of the xylazine/ketamine anesthesia test as a predictor of the emetic potential of pharmacological compounds in rats. Neuroscience Letters 699, pages 41-46.
Crossref
P.R.A. Heckman, A. Blokland, N.P. Van Goethem, B.T.J. Van Hagen & J. Prickaerts. (2018) The mediating role of phosphodiesterase type 4 in the dopaminergic modulation of motor impulsivity. Behavioural Brain Research 350, pages 16-22.
Crossref
Xiaoqing Feng, Huanchen Wang, Mengchun Ye, Xue-Tao Xu, Ying Xu, Wenzhe Yang, Han-Ting Zhang, Guoqiang Song & Hengming Ke. (2018) Identification of a PDE4-Specific Pocket for the Design of Selective Inhibitors. Biochemistry 57:30, pages 4518-4525.
Crossref
Ying Xu, Naping Zhu, Wen Xu, Han Ye, Kaiping Liu, Feiyan Wu, Meixi Zhang, Yun Ding, Chong Zhang, Hanting Zhang, James O'Donnell & Jiangchun Pan. (2018) Inhibition of Phosphodiesterase-4 Reverses Aβ-Induced Memory Impairment by Regulation of HPA Axis Related cAMP Signaling. Frontiers in Aging Neuroscience 10.
Crossref
P.R.A. Heckman, A. Blokland, E.P.P. Bollen & J. Prickaerts. (2018) Phosphodiesterase inhibition and modulation of corticostriatal and hippocampal circuits: Clinical overview and translational considerations. Neuroscience & Biobehavioral Reviews 87, pages 233-254.
Crossref
M.A. Van Duinen, A. Sambeth, P.R.A. Heckman, S. Smit, M. Tsai, G. Lahu, T. Uz, A. Blokland & J. Prickaerts. (2018) Acute administration of roflumilast enhances immediate recall of verbal word memory in healthy young adults. Neuropharmacology 131, pages 31-38.
Crossref
Ines Barone, Cinzia Giordano, Daniela Bonofiglio, Sebastiano Andò & Stefania Catalano. (2017) Phosphodiesterase type 5 and cancers: progress and challenges. Oncotarget 8:58, pages 99179-99202.
Crossref
Dhrubajyoti Gogoi, Amrita K. Chaliha, Diganta Sarma, Bibhuti B. Kakoti & Alak K. Buragohain. (2017) Identification of potential type 4 cAMP phosphodiesterase inhibitors via 3D pharmacophore modeling, virtual screening, DFT and structural bioisostere design. Medicinal Chemistry Research 26:11, pages 3000-3014.
Crossref
Ken-ichi Kinoshita, Yoshikage Muroi, Toshihiro Unno & Toshiaki Ishii. (2017) Rolipram improves facilitation of contextual fear extinction in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease. Journal of Pharmacological Sciences 134:1, pages 55-58.
Crossref
Roberta Ricciarelli, Chiara Brullo, Jos Prickaerts, Ottavio Arancio, Carla Villa, Claudia Rebosio, Elisa Calcagno, Matilde Balbi, Britt T. J. van Hagen, Elentina K. Argyrousi, Hong Zhang, Maria Adelaide Pronzato, Olga Bruno & Ernesto Fedele. (2017) Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer’s disease. Scientific Reports 7:1.
Crossref
Haibiao Guo, Yufang Cheng, Canmao Wang, Jingang Wu, Zhengqiang Zou, Bo Niu, Hui Yu, Haitao Wang & Jiangping Xu. (2017) FFPM, a PDE4 inhibitor, reverses learning and memory deficits in APP/PS1 transgenic mice via cAMP/PKA/CREB signaling and anti-inflammatory effects. Neuropharmacology 116, pages 260-269.
Crossref
Chong Zhang, Ying Xu, Han-Ting Zhang, Mark E. Gurney & James M. O’Donnell. (2017) Comparison of the Pharmacological Profiles of Selective PDE4B and PDE4D Inhibitors in the Central Nervous System. Scientific Reports 7:1.
Crossref
Mitsugu Yoneda, Naotoshi Sugimoto, Masanori Katakura, Kentaro Matsuzaki, Hayate Tanigami, Akihiro Yachie, Takako Ohno-Shosaku & Osamu Shido. (2017) Theobromine up-regulates cerebral brain-derived neurotrophic factor and facilitates motor learning in mice. The Journal of Nutritional Biochemistry 39, pages 110-116.
Crossref
Rolf T. HansenIIIIII & Han-Ting Zhang. 2017. Phosphodiesterases: CNS Functions and Diseases. Phosphodiesterases: CNS Functions and Diseases 169 199 .
Pim R. A. Heckman, Arjan Blokland & Jos Prickaerts. 2017. Phosphodiesterases: CNS Functions and Diseases. Phosphodiesterases: CNS Functions and Diseases 135 168 .
Steven J. Clapcote. 2017. Phosphodiesterases: CNS Functions and Diseases. Phosphodiesterases: CNS Functions and Diseases 103 131 .
Graeme B. Bolger. 2017. Phosphodiesterases: CNS Functions and Diseases. Phosphodiesterases: CNS Functions and Diseases 63 102 .
Pim R. A. Heckman, Marlies A. van Duinen, Eva P. P. Bollen, Akinori Nishi, Lawrence P. Wennogle, Arjan Blokland & Jos Prickaerts. (2016) Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications. International Journal of Neuropsychopharmacology 19:10, pages pyw030.
Crossref
Christopher M. Olsen & Qing-Song Liu. (2016) Phosphodiesterase 4 inhibitors and drugs of abuse: current knowledge and therapeutic opportunities. Frontiers in Biology 11:5, pages 376-386.
Crossref
Damien D. Pearse & Zoë A. Hughes. (2016) PDE4B as a microglia target to reduce neuroinflammation. Glia 64:10, pages 1698-1709.
Crossref
Yeye Zhuo, Haibiao Guo, Yufang Cheng, Chuang Wang, Canmao Wang, Jingang Wu, Zhengqiang Zou, Danna Gan, Yiwen Li & Jiangping Xu. (2016) Inhibition of phosphodiesterase-4 reverses the cognitive dysfunction and oxidative stress induced by Aβ25–35 in rats. Metabolic Brain Disease 31:4, pages 779-791.
Crossref
Enno Klussmann. (2016) Protein–protein interactions of PDE4 family members — Functions, interactions and therapeutic value. Cellular Signalling 28:7, pages 713-718.
Crossref
Tim Vanmierlo, Pim Creemers, Sven Akkerman, Marlies van Duinen, Anke Sambeth, Jochen De Vry, Tolga Uz, Arjan Blokland & Jos Prickaerts. (2016) The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses. Behavioural Brain Research 303, pages 26-33.
Crossref
Alexander McGirr, Tatiana V Lipina, Ho-Suk Mun, John Georgiou, Ahmed H Al-Amri, Enoch Ng, Dongxu Zhai, Christina Elliott, Ryan T Cameron, Jonathan GL Mullins, Fang Liu, George S Baillie, Steven J Clapcote & John C Roder. (2015) Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition. Neuropsychopharmacology 41:4, pages 1080-1092.
Crossref
Dan Wan, Yehan Zhou, Ke Wang, Yongying Hou, Ruihang Hou & Xiufeng Ye. (2016) Resveratrol provides neuroprotection by inhibiting phosphodiesterases and regulating the cAMP/AMPK/SIRT1 pathway after stroke in rats. Brain Research Bulletin 121, pages 255-262.
Crossref
Su-Min Um, Yong-Woo Jun, Kun-Hyung Kim, Jin-A Lee & Deok-Jin Jang. (2016) Analysis of molecular mechanism of cellular localization of various N-terminal mutants of Aplysia PDE4 in HEK293T cells. Analytical Science and Technology 29:1, pages 10-18.
Crossref
Margaret F. Keil, George Briassoulis & Constantine A. Stratakis. (2016) The Role of Protein Kinase A in Anxiety Behaviors. Neuroendocrinology 103:6, pages 625-639.
Crossref
Marian L. Logrip. (2015) Phosphodiesterase regulation of alcohol drinking in rodents. Alcohol 49:8, pages 795-802.
Crossref
Roberta Ricciarelli & Ernesto Fedele. (2015) Phosphodiesterase 4D: an enzyme to remember. British Journal of Pharmacology 172:20, pages 4785-4789.
Crossref
E. Bollen, S. Akkerman, D. Puzzo, W. Gulisano, A. Palmeri, R. D'Hooge, D. Balschun, H.W.M. Steinbusch, A. Blokland & J. Prickaerts. (2015) Object memory enhancement by combining sub-efficacious doses of specific phosphodiesterase inhibitors. Neuropharmacology 95, pages 361-366.
Crossref
F Ahmad, T Murata, K Shimizu, E Degerman, D Maurice & V Manganiello. (2014) Cyclic Nucleotide Phosphodiesterases: important signaling modulators and therapeutic targets. Oral Diseases 21:1.
Crossref
Shuichi Yanai & Shogo Endo. 2015. Aging Mechanisms. Aging Mechanisms 257 274 .
Carolina Otero, Juan P. Peñaloza, Paula I. Rodas, Ricardo Fernández-Ramires, Luis Velasquez & Juan E. Jung. (2014) Temporal and spatial regulation of cAMP signaling in disease: role of cyclic nucleotide phosphodiesterases. Fundamental & Clinical Pharmacology 28:6, pages 593-607.
Crossref
Kun-Hyung Kim, Yong-Woo Jun, Yongsoo Park, Jin-A Lee, Byung-Chang Suh, Chae-Seok Lim, Yong-Seok Lee, Bong-Kiun Kaang & Deok-Jin Jang. (2014) Intracellular Membrane Association of the Aplysia cAMP Phosphodiesterase Long and Short Forms via Different Targeting Mechanisms. Journal of Biological Chemistry 289:37, pages 25797-25811.
Crossref
Marc A. Wolman, Eric D. de Groh, Sean M. McBride, Thomas A. Jongens, Michael Granato & Jonathan A. Epstein. (2014) Modulation of cAMP and Ras Signaling Pathways Improves Distinct Behavioral Deficits in a Zebrafish Model of Neurofibromatosis Type 1. Cell Reports 8:5, pages 1265-1270.
Crossref
Rolf T. HansenIIIIII, Marco Conti & Han-Ting Zhang. (2014) Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior. Psychopharmacology 231:15, pages 2941-2954.
Crossref
Jane S. Sutcliffe, Vahri Beaumont, James M. Watson, Chang Sing Chew, Maria Beconi, Daniel M. Hutcheson, Celia Dominguez & Ignacio Munoz-Sanjuan. (2014) Efficacy of Selective PDE4D Negative Allosteric Modulators in the Object Retrieval Task in Female Cynomolgus Monkeys (Macaca fascicularis). PLoS ONE 9:7, pages e102449.
Crossref
A. Richard Rutter, Alessandro Poffe, Palmina Cavallini, T. Gregg Davis, Jessica Schneck, Michele Negri, Elena Vicentini, Dino Montanari, Roberto Arban, Frank A. Gray, Ceri H. Davies & Paul B. Wren. (2014) GSK356278, a Potent, Selective, Brain-Penetrant Phosphodiesterase 4 Inhibitor That Demonstrates Anxiolytic and Cognition-Enhancing Effects without Inducing Side Effects in Preclinical Species. Journal of Pharmacology and Experimental Therapeutics 350:1, pages 153-163.
Crossref
Maria Vittoria Podda & Claudio Grassi. (2013) New perspectives in cyclic nucleotide-mediated functions in the CNS: the emerging role of cyclic nucleotide-gated (CNG) channels. Pflügers Archiv - European Journal of Physiology 466:7, pages 1241-1257.
Crossref
J. Guo, P. Lin, X. Zhao, J. Zhang, X. Wei, Q. Wang & C. Wang. (2014) Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP/pCREB/BDNF signaling, neuroinflammatory response and depressive-like behavior in mice. Neuroscience 263, pages 1-14.
Crossref
Elise Blanchard, Lorna Zlock, Anna Lao, Delphine Mika, Wan Namkung, Moses Xie, Colleen Scheitrum, Dieter C. Gruenert, Alan S. Verkman, Walter E. Finkbeiner, Marco Conti & Wito Richter. (2013) Anchored PDE4 regulates chloride conductance in wild‐type and ΔF508‐CFTR human airway epithelia. The FASEB Journal 28:2, pages 791-801.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.