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Expert Opinion on Therapeutic Targets Volume 17, 2013 - Issue 9
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Reviews

Oxysterol receptors and their therapeutic applications in cancer conditions

Hugues De BoussacClermont Université, Université Blaise Pascal, Génétique Reproduction et Développement, BP 10448, F-63000 Clermont-Ferrand, France;CNRS, UMR 6293, GReD, Clermont Université-INSERM U1103, 24, Avenue des Landais BP80026, 63171 Aubière Cedex, France;INSERM, UMR 1103, GReD, BP 80026, F-63171 Aubière, [email protected];Centre de Recherche en Nutrition Humaine d'Auvergne, F-63000 Clermont-Ferrand, France.
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Anthony AliouiClermont Université, Université Blaise Pascal, Génétique Reproduction et Développement, BP 10448, F-63000 Clermont-Ferrand, France;CNRS, UMR 6293, GReD, Clermont Université-INSERM U1103, 24, Avenue des Landais BP80026, 63171 Aubière Cedex, France;INSERM, UMR 1103, GReD, BP 80026, F-63171 Aubière, [email protected];Centre de Recherche en Nutrition Humaine d'Auvergne, F-63000 Clermont-Ferrand, France.
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Emilie ViennoisClermont Université, Université Blaise Pascal, Génétique Reproduction et Développement, BP 10448, F-63000 Clermont-Ferrand, France;CNRS, UMR 6293, GReD, Clermont Université-INSERM U1103, 24, Avenue des Landais BP80026, 63171 Aubière Cedex, France;INSERM, UMR 1103, GReD, BP 80026, F-63171 Aubière, [email protected];Centre de Recherche en Nutrition Humaine d'Auvergne, F-63000 Clermont-Ferrand, France.;Georgia State University, Department of Biology, Center for Diagnostics and Therapeutics, Atlanta, GA, USA
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Julie DufourClermont Université, Université Blaise Pascal, Génétique Reproduction et Développement, BP 10448, F-63000 Clermont-Ferrand, France;CNRS, UMR 6293, GReD, Clermont Université-INSERM U1103, 24, Avenue des Landais BP80026, 63171 Aubière Cedex, France;INSERM, UMR 1103, GReD, BP 80026, F-63171 Aubière, [email protected];Centre de Recherche en Nutrition Humaine d'Auvergne, F-63000 Clermont-Ferrand, France.
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Amalia TroussonClermont Université, Université Blaise Pascal, Génétique Reproduction et Développement, BP 10448, F-63000 Clermont-Ferrand, France;CNRS, UMR 6293, GReD, Clermont Université-INSERM U1103, 24, Avenue des Landais BP80026, 63171 Aubière Cedex, France;INSERM, UMR 1103, GReD, BP 80026, F-63171 Aubière, [email protected];Centre de Recherche en Nutrition Humaine d'Auvergne, F-63000 Clermont-Ferrand, France.
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Aurélie VegaClermont Université, Université Blaise Pascal, Génétique Reproduction et Développement, BP 10448, F-63000 Clermont-Ferrand, France;CNRS, UMR 6293, GReD, Clermont Université-INSERM U1103, 24, Avenue des Landais BP80026, 63171 Aubière Cedex, France;INSERM, UMR 1103, GReD, BP 80026, F-63171 Aubière, [email protected];Centre de Recherche en Nutrition Humaine d'Auvergne, F-63000 Clermont-Ferrand, France.
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Laurent GuyService d'Urologie, Hôpital Gabriel Montpied, F-63003 Clermont-Ferrand, France
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David H VolleClermont Université, Université Blaise Pascal, Génétique Reproduction et Développement, BP 10448, F-63000 Clermont-Ferrand, France;CNRS, UMR 6293, GReD, Clermont Université-INSERM U1103, 24, Avenue des Landais BP80026, 63171 Aubière Cedex, France;INSERM, UMR 1103, GReD, BP 80026, F-63171 Aubière, [email protected];Centre de Recherche en Nutrition Humaine d'Auvergne, F-63000 Clermont-Ferrand, France.
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Jean-Marc A. LobaccaroClermont Université, Université Blaise Pascal, Génétique Reproduction et Développement, BP 10448, F-63000 Clermont-Ferrand, France;CNRS, UMR 6293, GReD, Clermont Université-INSERM U1103, 24, Avenue des Landais BP80026, 63171 Aubière Cedex, France;INSERM, UMR 1103, GReD, BP 80026, F-63171 Aubière, [email protected];Centre de Recherche en Nutrition Humaine d'Auvergne, F-63000 Clermont-Ferrand, France.
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Silvère BaronClermont Université, Université Blaise Pascal, Génétique Reproduction et Développement, BP 10448, F-63000 Clermont-Ferrand, France;CNRS, UMR 6293, GReD, Clermont Université-INSERM U1103, 24, Avenue des Landais BP80026, 63171 Aubière Cedex, France;INSERM, UMR 1103, GReD, BP 80026, F-63171 Aubière, [email protected];Centre de Recherche en Nutrition Humaine d'Auvergne, F-63000 Clermont-Ferrand, France.
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Pages 1029-1038 | Published online: 22 Jul 2013

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Cédric Rébé, Valentin Derangère & François Ghiringhelli. (2015) Induction of pyroptosis in colon cancer cells by LXRβ. Molecular & Cellular Oncology 2:1.
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Mohamed Ksila, Imen Ghzaiel, Khouloud Sassi, Amira Zarrouk, Valerio Leoni, Giuseppe Poli, Leila Rezig, Vivien Pires, Smail Meziane, Atanas G. Atanasov, Sonia Hammami, Mohamed Hammami, Olfa Masmoudi-Kouki, Oumaima Hamdi, Pierre Jouanny, Mohammad Samadi, Anne Vejux, Taoufik Ghrairi & Gérard Lizard. 2024. Implication of Oxysterols and Phytosterols in Aging and Human Diseases. Implication of Oxysterols and Phytosterols in Aging and Human Diseases 379 400 .
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Rexiati Ruze, Jianlu Song, Xinpeng Yin, Yuan Chen, Ruiyuan Xu, Chengcheng Wang & Yupei Zhao. (2023) Mechanisms of obesity- and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review. Signal Transduction and Targeted Therapy 8:1.
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Sura Salman Ejam, Raed Obaid Saleh, Maria Jade Catalan Opulencia, Mazin AA Najm, Aziza Makhmudova, Abduladheem Turki Jalil, Walid Kamal Abdelbasset, Moaed E Al-Gazally, Ali Thaeer Hammid, Yasser Fakri Mustafa, Sergushina Elena Sergeevna, Sajad Karampoor & Rasoul Mirzaei. (2022) Pathogenic role of 25-hydroxycholesterol in cancer development and progression. Future Oncology 18:39, pages 4415-4442.
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Jianglian She, Tanwei Gu, Xiaoyan Pang, Yonghong Liu, Lan Tang & Xuefeng Zhou. (2022) Natural Products Targeting Liver X Receptors or Farnesoid X Receptor. Frontiers in Pharmacology 12.
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Andrew J. Brown, Laura J. Sharpe & Michael J. Rogers. (2020) Oxysterols: From physiological tuners to pharmacological opportunities. British Journal of Pharmacology 178:16, pages 3089-3103.
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Yuki Matsushita, Hayato Nakagawa & Kazuhiko Koike. (2021) Lipid Metabolism in Oncology: Why It Matters, How to Research, and How to Treat. Cancers 13:3, pages 474.
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Afshin Samadi, Suna Sabuncuoglu, Mahshid Samadi, Selen Yilmaz Isikhan, Salvatore Chirumbolo, Massimiliano Peana, Incilay Lay, Ahmet Yalcinkaya & Geir Bjørklund. (2020) A Comprehensive Review on Oxysterols and Related Diseases. Current Medicinal Chemistry 28:1, pages 110-136.
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Binlu Huang, Bao-liang Song & Chenqi Xu. (2020) Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities. Nature Metabolism 2:2, pages 132-141.
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Kevin Mouzat, Aleksandra Chudinova, Anne Polge, Jovana Kantar, William Camu, Cédric Raoul & Serge Lumbroso. (2019) Regulation of Brain Cholesterol: What Role Do Liver X Receptors Play in Neurodegenerative Diseases?. International Journal of Molecular Sciences 20:16, pages 3858.
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Urša Kovač, Cene Skubic, Laura Bohinc, Damjana Rozman & Tadeja Režen. (2019) Oxysterols and Gastrointestinal Cancers Around the Clock. Frontiers in Endocrinology 10.
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Weijun Wan, Yongying Hou, Ke Wang, Yue Cheng, Xia Pu & Xiufeng Ye. (2019) The LXR-623-induced long non-coding RNA LINC01125 suppresses the proliferation of breast cancer cells via PTEN/AKT/p53 signaling pathway. Cell Death & Disease 10:3.
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Olivier Celhay, Laura Bousset, Laurent Guy, Jean-Louis Kemeny, Valerio Leoni, Claudio Caccia, Amalia Trousson, Christelle Damon-Soubeyrant, Angélique De Haze, Laura Sabourin, Catherine Godfraind, Cyrille de Joussineau, Bruno Pereira, Laurent Morel, Jean Marc Lobaccaro & Silvère Baron. (2019) Individual Comparison of Cholesterol Metabolism in Normal and Tumour Areas in Radical Prostatectomy Specimens from Patients with Prostate Cancer: Results of the CHOMECAP Study. European Urology Oncology 2:2, pages 198-206.
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Tian Du, Matthew J. Sikora, Kevin M. Levine, Nilgun Tasdemir, Rebecca B. Riggins, Stacy G. Wendell, Bennett Van Houten & Steffi Oesterreich. (2018) Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer. Breast Cancer Research 20:1.
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Liqiang Zhong, Sihao Yang, Yuming Jia & Kaijian Lei. (2018) Inhibition of cyclin‐dependent kinase 7 suppresses human hepatocellular carcinoma by inducing apoptosis. Journal of Cellular Biochemistry 119:12, pages 9742-9751.
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P. Holy, A. Kloudova & P. Soucek. (2018) Importance of genetic background of oxysterol signaling in cancer. Biochimie 153, pages 109-138.
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Anthony Alioui, Julie Dufour, Valerio Leoni, Anke Loregger, Martina Moeton, Luigi Iuliano, Chiara Zerbinati, Amandine Septier, Pierre Val, Allan Fouache, Vincenzo Russo, David H. Volle, Jean-Marc A. Lobaccaro, Noam Zelcer & Silvère Baron. (2017) RETRACTED ARTICLE: Liver X receptors constrain tumor development and metastasis dissemination in PTEN-deficient prostate cancer. Nature Communications 8:1.
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Maura Marinozzi, Francisco Fermin Castro Navas, Daniela Maggioni, Emanuele Carosati, Giovanni Bocci, Maria Carloncelli, Gianluca Giorgi, Gabriele Cruciani, Raffaella Fontana & Vincenzo Russo. (2017) Side-Chain Modified Ergosterol and Stigmasterol Derivatives as Liver X Receptor Agonists. Journal of Medicinal Chemistry 60:15, pages 6548-6562.
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Simon Ducheix, Alexandra Montagner, Arnaud Polizzi, Frédéric Lasserre, Marion Régnier, Alice Marmugi, Fadila Benhamed, Justine Bertrand-Michel, Laila Mselli-Lakhal, Nicolas Loiseau, Pascal G. Martin, Jean-Marc Lobaccaro, Laurent Ferrier, Catherine Postic & Hervé Guillou. (2017) Dietary oleic acid regulates hepatic lipogenesis through a liver X receptor-dependent signaling. PLOS ONE 12:7, pages e0181393.
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Alzbeta Kloudova, F. Peter Guengerich & Pavel Soucek. (2017) The Role of Oxysterols in Human Cancer. Trends in Endocrinology & Metabolism 28:7, pages 485-496.
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Kuang Youlin, Zhang Li, He Weiyang, Kang Jian, Liang Siming & Gou Xin. (2017) Liver X receptor activation inhibits PC-3 prostate cancer cells via the beta-catenin pathway. Pathology - Research and Practice 213:3, pages 267-270.
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Ying Wu, Dan-dan Yu, Da-li Yan, Yong Hu, Dan Chen, Yun Liu, He-da Zhang, Shao-rong Yu, Hai-xia Cao & Ji-feng Feng. (2016) Liver X receptor as a drug target for the treatment of breast cancer. Anti-Cancer Drugs 27:5, pages 373-382.
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Irundika H.K. DiasMaria C. Polidori & Helen R. Griffiths. (2014) Hypercholesterolaemia-induced oxidative stress at the blood–brain barrier. Biochemical Society Transactions 42:4, pages 1001-1005.
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