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Targeting the type III secretion system to treat bacterial infections

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R. M. Huebinger, D. H. Do, D. L. Carlson, X. Yao, D. H. Stones, M. De Souza Santos, D. P. Vaz, E. Keen, S. E. Wolf, JP Minei, K. P. Francis, K. Orth & A. M. Krachler. (2020) Bacterial adhesion inhibitor prevents infection in a rodent surgical incision model. Virulence 11:1, pages 695-706.
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Xin Wang, Lulu He, Yu-Qing Zhang, Hao Tian, Min He, Alastair N. Herron & Zi-Ning Cui. (2023) Innovative Strategy for the Control of Citrus Canker: Inhibitors Targeting the Type III Secretion System of Xanthomonas citri Subsp. citri . Journal of Agricultural and Food Chemistry 71:43, pages 15971-15980.
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Chao Lv, Ying Li, Yuxia Wei, Jiayu Wang, Hui Yu, Feng Gao, Chao Zhu, Xiangdi Jia, Mingqiong Tong, Pingxuan Dong, Qianqian Gao & Longlong Geng. (2022) Research Progress on Small Molecular Inhibitors of the Type 3 Secretion System. Molecules 27:23, pages 8348.
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Anqun Hu, Ming Hu, Shanshan Chen, Yang Xue, Xu Tan & Jianuan Zhou. (2022) Five Plant Natural Products Are Potential Type III Secretion System Inhibitors to Effectively Control Soft-Rot Disease Caused by Dickeya. Frontiers in Microbiology 13.
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Israel Castillo-Juárez, Blanca Esther Blancas-Luciano, Rodolfo García-Contreras & Ana María Fernández-Presas. (2022) Antimicrobial peptides properties beyond growth inhibition and bacterial killing. PeerJ 10, pages e12667.
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Dipak Kathayat, Dhanashree Lokesh, Sochina Ranjit & Gireesh Rajashekara. (2021) Avian Pathogenic Escherichia coli (APEC): An Overview of Virulence and Pathogenesis Factors, Zoonotic Potential, and Control Strategies. Pathogens 10:4, pages 467.
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Lucía Fernández, María Dolores Cima-Cabal, Ana Catarina Duarte, Ana Rodriguez, Pilar García & María del Mar García-Suárez. (2020) Developing Diagnostic and Therapeutic Approaches to Bacterial Infections for a New Era: Implications of Globalization. Antibiotics 9:12, pages 916.
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Heather A. Pendergrass, Adam L. Johnson, Julia A. Hotinger & Aaron E. May. (2020) Fluorescence Detection of Type III Secretion Using a Glu-CyFur Reporter System in Citrobacter rodentium. Microorganisms 8:12, pages 1953.
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Julia A. Hotinger & Aaron E. May. (2020) Antibodies Inhibiting the Type III Secretion System of Gram-Negative Pathogenic Bacteria. Antibodies 9:3, pages 35.
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Heather A. Pendergrass & Aaron E. May. (2020) Delivery of Heterologous Proteins, Enzymes, and Antigens via the Bacterial Type III Secretion System. Microorganisms 8:5, pages 777.
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Charlotta Sundin, Caroline E. Zetterström, Duc Duy Vo, Robert Brkljača, Sylvia Urban & Mikael Elofsson. (2020) Exploring resveratrol dimers as virulence blocking agents – Attenuation of type III secretion in Yersinia pseudotuberculosis and Pseudomonas aeruginosa. Scientific Reports 10:1.
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Dimitrios Lampaki, Andreas Diepold & Timo Glatter. (2019) A Serial Sample Processing Strategy with Improved Performance for in-Depth Quantitative Analysis of Type III Secretion Events in Pseudomonas aeruginosa . Journal of Proteome Research 19:1, pages 543-553.
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Susu Fan, Fang Tian, Liwei Fang, Ching-Hong Yang & Chenyang He. (2019) Transcriptional responses of Xanthomonas oryzae pv. oryzae to type III secretion system inhibitor ortho-coumaric acid. BMC Microbiology 19:1.
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Heather A. Pendergrass & Aaron E. May. (2019) Natural Product Type III Secretion System Inhibitors. Antibiotics 8:4, pages 162.
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Shan Jiang, Hui Li, Wasim Ahmed, Xuwen Xiang, Gaopeng Song & Zi-Ning Cui. (2019) Discovery of Ethyl 2-Nitro-3-Arylacrylates Molecules as T3SS Inhibitor Reducing the Virulence of Plant Pathogenic Bacteria Xanthomonas. Frontiers in Microbiology 10.
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Bronwyn J. E. Lyons & Natalie C. J. Strynadka. (2019) On the road to structure-based development of anti-virulence therapeutics targeting the type III secretion system injectisome. MedChemComm 10:8, pages 1273-1289.
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Hui Tao, Hao Tian, Shan Jiang, Xuwen Xiang, Wasim Ahmed, Riyuan Tang & Zi-Ning Cui. (2019) Synthesis and bioactivity of 1,3-thiazolidine-2-thione derivatives against type III secretion system of Xanthomonas oryzae. Bioorganic & Medicinal Chemistry 27:15, pages 3364-3371.
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Ali A. Rabaan, Shamsah H. Al-Ahmed, Shahab A. Alsuliman, Fatimah A. Aldrazi, Wadha A. Alfouzan & Shafiul Haque. (2019) The rise of pneumonic plague in Madagascar: current plague outbreak breaks usual seasonal mould. Journal of Medical Microbiology 68:3, pages 292-302.
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Hui Tao, Su-Su Fan, Shan Jiang, Xuwen Xiang, Xiaojing Yan, Lian-Hui Zhang & Zi-Ning Cui. (2019) Small Molecule Inhibitors Specifically Targeting the Type III Secretion System of Xanthomonas oryzae on Rice. International Journal of Molecular Sciences 20:4, pages 971.
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Parasuraman Paramanantham, V. T. Anju, Madhu Dyavaiah & Busi Siddhardha. 2019. Microbial Nanobionics. Microbial Nanobionics 237 259 .
Andreas Diepold. 2020. Bacterial Type III Protein Secretion Systems. Bacterial Type III Protein Secretion Systems 35 66 .
Theresa Nauth, Franziska Huschka, Michaela Schweizer, Jens B. Bosse, Andreas Diepold, Antonio Virgilio Failla, Anika Steffen, Theresia E. B. Stradal, Manuel Wolters & Martin Aepfelbacher. (2018) Visualization of translocons in Yersinia type III protein secretion machines during host cell infection. PLOS Pathogens 14:12, pages e1007527.
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Jessica M. Morgan, Hanh N. Lam, Jocelyn Delgado, Justin Luu, Sina Mohammadi, Ralph R. Isberg, Helen Wang & Victoria Auerbuch. (2018) An Experimental Pipeline for Initial Characterization of Bacterial Type III Secretion System Inhibitor Mode of Action Using Enteropathogenic Yersinia. Frontiers in Cellular and Infection Microbiology 8.
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Jia-Qi Fang, Muhammad Imran, Wei-Lin Hu, David M. Ojcius, Yang Li, Yu-Mei Ge, Kai-Xuan Li, Xu'ai Lin & Jie Yan. (2018) vWA proteins of Leptospira interrogans induce hemorrhage in leptospirosis by competitive inhibition of vWF/GPIb-mediated platelet aggregation. EBioMedicine 37, pages 428-441.
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Markus Lakemeyer, Weining Zhao, Franziska A. Mandl, Peter Hammann & Stephan A. Sieber. (2018) Thinking Outside the Box-Novel Antibacterials To Tackle the Resistance Crisis. Angewandte Chemie International Edition 57:44, pages 14440-14475.
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Markus Lakemeyer, Weining Zhao, Franziska A. Mandl, Peter Hammann & Stephan A. Sieber. (2018) Über bisherige Denkweisen hinaus - neue Wirkstoffe zur Überwindung der Antibiotika-Krise. Angewandte Chemie 130:44, pages 14642-14682.
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Christian Rüter, Marie-Luise Lubos, Stefanie Norkowski & M. Alexander Schmidt. (2018) All in—Multiple parallel strategies for intracellular delivery by bacterial pathogens. International Journal of Medical Microbiology 308:7, pages 872-881.
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Xiaopan Gao, Zhixia Mu, Xia Yu, Bo Qin, Justyna Wojdyla, Meitian Wang & Sheng Cui. (2018) Structural Insight Into Conformational Changes Induced by ATP Binding in a Type III Secretion-Associated ATPase From Shigella flexneri. Frontiers in Microbiology 9.
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Xuwen Xiang, Hui Tao, Shan Jiang, Lian-Hui Zhang & Zi-Ning Cui. (2018) Synthesis and bioactivity of thiazolidin-2-cyanamide derivatives against type III secretion system of Xanthomonas oryzae on rice. Pesticide Biochemistry and Physiology 149, pages 89-97.
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Alexander V. Grishin, Sergey I. Luyksaar, Lidiya N. Kapotina, Dmitry D. Kirsanov, Egor S. Zayakin, Anna S. Karyagina & Naylia A. Zigangirova. (2018) Identification of chlamydial T3SS inhibitors through virtual screening against T3SS ATPase. Chemical Biology & Drug Design 91:3, pages 717-727.
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Irit Tseytin, Avner Dagan, Sonia Oren & Neta Sal-Man. (2018) The role of EscD in supporting EscC polymerization in the type III secretion system of enteropathogenic Escherichia coli. Biochimica et Biophysica Acta (BBA) - Biomembranes 1860:2, pages 384-395.
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Nathaniel J. Rhodes, Caroline E. Cruce, J. Nicholas O’Donnell, Richard G. Wunderink & Alan R. Hauser. (2018) Resistance Trends and Treatment Options in Gram-Negative Ventilator-Associated Pneumonia. Current Infectious Disease Reports 20:2.
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Douglas I. JohnsonDouglas I. Johnson. 2018. Bacterial Pathogens and Their Virulence Factors. Bacterial Pathogens and Their Virulence Factors 439 461 .
Nichollas E. Scott & Elizabeth L. Hartland. (2017) Post-translational Mechanisms of Host Subversion by Bacterial Effectors. Trends in Molecular Medicine 23:12, pages 1088-1102.
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Sweta S. Talreja & Anuradha S. Nerurkar. (2017) Small molecules cause virulence attenuation of Xanthomonas oryzae pv. oryzae, the pathogen causing bacterial blight of rice. European Journal of Plant Pathology.
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Shaohui Wang, Xuan Xu, Xin Liu, Dong Wang, Hua Liang, Xiaojun Wu, Mingxing Tian, Chan Ding, Guijun Wang & Shengqing Yu. (2017) Escherichia coli type III secretion system 2 regulator EtrA promotes virulence of avian pathogenic Escherichia coli. Microbiology 163:10, pages 1515-1524.
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Andreas Diepold, Erdinc Sezgin, Miles Huseyin, Thomas Mortimer, Christian Eggeling & Judith P. Armitage. (2017) A dynamic and adaptive network of cytosolic interactions governs protein export by the T3SS injectisome. Nature Communications 8:1.
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Ahalieyah Anantharajah, Julien M. Buyck, Charlotta Sundin, Paul M. Tulkens, Marie-Paule Mingeot-Leclercq & Françoise Van Bambeke. (2017) Salicylidene Acylhydrazides and Hydroxyquinolines Act as Inhibitors of Type Three Secretion Systems in Pseudomonas aeruginosa by Distinct Mechanisms. Antimicrobial Agents and Chemotherapy 61:6.
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Wanyin Deng, Natalie C. Marshall, Jennifer L. Rowland, James M. McCoy, Liam J. Worrall, Andrew S. Santos, Natalie C. J. Strynadka & B. Brett Finlay. (2017) Assembly, structure, function and regulation of type III secretion systems. Nature Reviews Microbiology 15:6, pages 323-337.
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Susu Fan, Fang Tian, Jianyu Li, William Hutchins, Huamin Chen, Fenghuan Yang, Xiaochen Yuan, Zining Cui, Ching-Hong Yang & Chenyang He. (2017) Identification of phenolic compounds that suppress the virulence of Xanthomonas oryzae on rice via the type III secretion system . Molecular Plant Pathology 18:4, pages 555-568.
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Natalie C. Marshall, B. Brett Finlay & Christopher M. Overall. (2017) Sharpening Host Defenses during Infection: Proteases Cut to the Chase. Molecular & Cellular Proteomics 16:4, pages S161-S171.
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Shaohui Wang, Xin Liu, Xuan Xu, Denghui Yang, Dong Wang, Xiangan Han, Yonghong Shi, Mingxing Tian, Chan Ding, Daxin Peng & Shengqing Yu. (2016) Escherichia coli Type III Secretion System 2 ATPase EivC Is Involved in the Motility and Virulence of Avian Pathogenic Escherichia coli. Frontiers in Microbiology 7.
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Alan R. Hauser, Joan Mecsas & Donald T. Moir. (2016) Beyond Antibiotics: New Therapeutic Approaches for Bacterial Infections. Clinical Infectious Diseases 63:1, pages 89-95.
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Ludmila N Nesterenko, Nailya A Zigangirova, Egor S Zayakin, Sergey I Luyksaar, Natalie V Kobets, Denis V Balunets, Ludmila A Shabalina, Tatiana N Bolshakova, Olga Y Dobrynina & Alexander L Gintsburg. (2016) A small-molecule compound belonging to a class of 2,4-disubstituted 1,3,4-thiadiazine-5-ones suppresses Salmonella infection in vivo. The Journal of Antibiotics 69:6, pages 422-427.
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Julie Guignot & Guy Tran Van Nhieu. (2016) Bacterial Control of Pores Induced by the Type III Secretion System: Mind the Gap. Frontiers in Immunology 7.
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Chun Chen, Jihye Park, Eric T. Harvill, Edward G. Dudley & Ying Zhang. (2015) Diversity of secretion systems associated with virulence characteristics of the classical bordetellae. Microbiology 161:12, pages 2328-2340.
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Roger D. Pechous & William E. Goldman. (2015) Illuminating Targets of Bacterial Secretion. PLOS Pathogens 11:8, pages e1004981.
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Andrey M. Grishin, Ksenia A. Beyrakhova & Miroslaw Cygler. (2015) Structural insight into effector proteins of Gram‐negative bacterial pathogens that modulate the phosphoproteome of their host. Protein Science 24:5, pages 604-620.
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Lan Gong, Shu-Chin Lai, Puthayalai Treerat, Mark Prescott, Ben Adler, John D. Boyce & Rodney J. Devenish. (2015) Burkholderia pseudomallei Type III Secretion System Cluster 3 ATPase BsaS, a Chemotherapeutic Target for Small-Molecule ATPase Inhibitors. Infection and Immunity 83:4, pages 1276-1285.
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Julien R.C. Bergeron, Liam J. Worrall, Soumya De, Nikolaos G. Sgourakis, Adrienne H. Cheung, Emilie Lameignere, Mark Okon, Gregory A. Wasney, David Baker, Lawrence P. McIntosh & Natalie C.J. Strynadka. (2015) The Modular Structure of the Inner-Membrane Ring Component PrgK Facilitates Assembly of the Type III Secretion System Basal Body. Structure 23:1, pages 161-172.
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Sabrina Mühlen & Petra Dersch. 2016. How to Overcome the Antibiotic Crisis. How to Overcome the Antibiotic Crisis 147 183 .
Wilbert Bitter & Coen Kuijl. (2014) Targeting Bacterial Virulence: The Coming Out of Type VII Secretion Inhibitors. Cell Host & Microbe 16:4, pages 430-432.
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David Steadman, Alvin Lo, Gabriel Waksman & Han Remaut. (2014) Bacterial surface appendages as targets for novel antibacterial therapeutics. Future Microbiology 9:7, pages 887-900.
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