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MmpL3 a potential new target for development of novel anti-tuberculosis drugs

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M. S. Raghu, K. Yogesh Kumar, T. Shamala, Fahad A. Alharti, M. K. Prashanth & Byong-Hun Jeon. (2023) Synthesis, antitubercular profile and molecular docking studies of quinazolinone-based pyridine derivatives against drug-resistant tuberculosis. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-11.
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N. Vasudevan, Zenia Motiwala, Remya Ramesh, Sachin B. Wagh, Rahul D. Shingare, Revansiddha Katte, Amitesh Anand, Sushil Choudhary, Ajay Kumar, Rajesh S. Gokhale, Kiran A. Kulkarni & D. Srinivasa Reddy. (2023) Synthesis, biological evaluation and docking studies of silicon incorporated diarylpyrroles as MmpL3 inhibitors: An effective strategy towards development of potent anti-tubercular agents. European Journal of Medicinal Chemistry 259, pages 115633.
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Gautam Kumar & Patil Amruta Adhikrao. (2023) Targeting Mycobacterium tuberculosis iron-scavenging tools: a recent update on siderophores inhibitors . RSC Medicinal Chemistry 14:10, pages 1885-1913.
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R. Chaitra, Rohit Gandhi, N. Jayanna, Sachin Satyanath, Parasuraman Pavadai & Manikanta Murahari. (2022) Computational design of MmpL3 inhibitors for tuberculosis therapy. Molecular Diversity 27:1, pages 357-369.
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Urs A. Ochsner, Mary A. De Groote, Thale C. Jarvis, Hang Liu, Tessa Youmans, Teresa Hoang, Wendy Ribble, Joshua Day, Wei Li, Camron Pearce, Amanda Walz, Chandra M. Panthi, Binayak Rimal, Casey M. Stevens, Helen I. Zgurskaya, Mary Jackson, Diane Ordway, Mercedes Gonzalez-Juarrero, Xicheng Sun, Gyanu Lamichhane & Clifford Mason. (2023) Microbiological profile, preclinical pharmacokinetics and efficacy of CRS0393, a novel antimycobacterial agent targeting MmpL3. Tuberculosis 138, pages 102288.
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Weizhu Yan, Yanhui Zheng, Chao Dou, Guixiang Zhang, Toufic Arnaout & Wei Cheng. (2022) The pathogenic mechanism of Mycobacterium tuberculosis: implication for new drug development. Molecular Biomedicine 3:1.
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Mohd. Imran, Mandeep Kumar Arora, Anurag Chaudhary, Shah Alam Khan, Mehnaz Kamal, Manal Mutlaq Alshammari, Raghad Mohammad Alharbi, Nuha Abdullah Althomali, Ibrahim Mohammed Alzimam, Abdullah Ayed Alshammari, Bashair Hamed Alharbi, Amer Alshengeti, Abdulmonem A. Alsaleh, Shayea A. Alqahtani & Ali A. Rabaan. (2022) MmpL3 Inhibition as a Promising Approach to Develop Novel Therapies against Tuberculosis: A Spotlight on SQ109, Clinical Studies, and Patents Literature. Biomedicines 10:11, pages 2793.
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Hongyi Zhao, Yongxin Gao, Wei Li, Li Sheng, Keli Cui, Bin Wang, Lei Fu, Meng Gao, Ziyun Lin, Xiaowen Zou, Mary Jackson, Haihong Huang, Yu Lu & Dongfeng Zhang. (2022) Design, Synthesis, and Biological Evaluation of Pyrrole-2-carboxamide Derivatives as Mycobacterial Membrane Protein Large 3 Inhibitors for Treating Drug-Resistant Tuberculosis. Journal of Medicinal Chemistry 65:15, pages 10534-10553.
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Jie Mi, Wenping Gong & Xueqiong Wu. (2022) Advances in Key Drug Target Identification and New Drug Development for Tuberculosis. BioMed Research International 2022, pages 1-23.
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Nilesh Gajanan Bajad, Sudhir Kumar Singh, Sushil Kumar Singh, Tryambak Deo Singh & Meenakshi Singh. (2022) Indole: A promising scaffold for the discovery and development of potential anti-tubercular agents. Current Research in Pharmacology and Drug Discovery 3, pages 100119.
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Poojita KFajeelath FathimaRajdeep RayLalit KumarRuchi Verma. (2021) Atom based 3D QSAR and Fingerprint based 2D QSAR of Novel Molecules as MmpL3 receptor inhibitors for Mycobacterium tuberculosis. Research Journal of Pharmacy and Technology, pages 6321-6329.
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Oliver Adams, Justin C. Deme, Joanne L. Parker, Philip W. Fowler, Susan M. Lea & Simon Newstead. (2021) Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target. Structure 29:10, pages 1182-1191.e4.
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Lubhan Singh, Kamal Dua, Sokindra Kumar, Deepak Kumar & Sagarika Majhi. 2021. Targeting Cellular Signalling Pathways in Lung Diseases. Targeting Cellular Signalling Pathways in Lung Diseases 337 353 .
Galyna P Volynets, Michail A Tukalo, Volodymyr G Bdzhola, Nataliia M Derkach, Mykola I Gumeniuk, Sergiy S Tarnavskiy & Sergiy M Yarmoluk. (2020) Novel isoniazid derivative as promising antituberculosis agent. Future Microbiology 15:10, pages 869-879.
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Xiaolin Yang, Tianyu Hu, Xiuna Yang, Wenqing Xu, Haitao Yang, Luke W. Guddat, Bing Zhang & Zihe Rao. (2020) Structural Basis for the Inhibition of Mycobacterial MmpL3 by NITD-349 and SPIRO. Journal of Molecular Biology 432:16, pages 4426-4434.
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Junqi Xu, Yu Chen, Xi Mou, Yu Huang, Shuang Ma, Liyuan Zhang, Yuan Zhang, Quanxin Long, Md Kaisar Ali & Jianping Xie. (2020) Mycobacterium smegmatis msmeg_3314 is involved in pyrazinamide and fluoroquinolones susceptibility via NAD + /NADH dysregulation . Future Microbiology 15:6, pages 413-426.
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Marilena Vlachou, Ioannis P. Papanastasiou, Markos‐Orestis Georgiadis, Argyro Tsakoumagkou, Zacharias Siskos, Angeliki Siamidi, Anna Konstantinou, Anthony Vocat & Stewart T. Cole. (2019) Design, Synthesis and in vitro Controlled Release of New Adamantanodiarylketone Antimycobacterials . ChemistrySelect 4:37, pages 11048-11051.
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Shichun Lun, Rokeya Tasneen, Tridib Chaira, Jozef Stec, Oluseye K. Onajole, Tian J. Yang, Christopher B. Cooper, Khisi Mdluli, Paul J. Converse, Eric L. Nuermberger, V. Samuel Raj, Alan Kozikowski & William R. Bishai. (2019) Advancing the Therapeutic Potential of Indoleamides for Tuberculosis. Antimicrobial Agents and Chemotherapy 63:7.
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Bing Zhang, Jun Li, Xiaolin Yang, Lijie Wu, Jia Zhang, Yang Yang, Yao Zhao, Lu Zhang, Xiuna Yang, Xiaobao Yang, Xi Cheng, Zhijie Liu, Biao Jiang, Hualiang Jiang, Luke W. Guddat, Haitao Yang & Zihe Rao. (2019) Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. Cell 176:3, pages 636-648.e13.
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Mary A. De Groote, Thale C. Jarvis, Christina Wong, James Graham, Teresa Hoang, Casey L. Young, Wendy Ribble, Joshua Day, Wei Li, Mary Jackson, Mercedes Gonzalez-Juarrero, Xicheng Sun & Urs A. Ochsner. (2018) Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent. Frontiers in Microbiology 9.
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Giovanna Poce, Martina Cocozza, Salvatore Alfonso, Sara Consalvi, Giulia Venditti, Raquel Fernandez-Menendez, Robert H. Bates, David Barros Aguirre, Lluis Ballell, Alessandro De Logu, Giulio Vistoli & Mariangela Biava. (2018) In vivo potent BM635 analogue with improved drug-like properties. European Journal of Medicinal Chemistry 145, pages 539-550.
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Padmani Sandhu & Yusuf Akhter. (2017) Evolution of structural fitness and multifunctional aspects of mycobacterial RND family transporters. Archives of Microbiology 200:1, pages 19-31.
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Julien Briffotaux, Wei Huang, Xinwei Wang & Brigitte Gicquel. (2017) MmpS5/MmpL5 as an efflux pump in Mycobacterium species. Tuberculosis 107, pages 13-19.
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E. F. Perkowski, K. E. Zulauf, D. Weerakoon, J. D. Hayden, T. R. Ioerger, D. Oreper, S. M. Gomez, J. C. Sacchettini & M. Braunstein. (2017) The EXIT Strategy: an Approach for Identifying Bacterial Proteins Exported during Host Infection. mBio 8:2.
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Giulia Venditti, Giovanna Poce, Sara Consalvi & Mariangela Biava. (2017) 1,5-Diarylpyrroles as potent antitubercular and anti-inflammatory agents. Chemistry of Heterocyclic Compounds 53:3, pages 281-291.
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Sandeep Thanna & Steven J. Sucheck. (2016) Targeting the trehalose utilization pathways of Mycobacterium tuberculosis . MedChemComm 7:1, pages 69-85.
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Subramanyam J. Tantry, Giulia Degiacomi, Sreevalli Sharma, Lalit kumar Jena, Ashwini Narayan, Supreeth Guptha, Gajanan Shanbhag, Sreenivasaiah Menasinakai, Meenakshi Mallya, Disha Awasthy, Gayathri Balakrishnan, Parvinder Kaur, Deepa Bhattacharjee, Chandan Narayan, Jitendar Reddy, C.N. Naveen Kumar, Radha Shandil, Francesca Boldrin, Marcello Ventura, Riccardo Manganelli, Ruben C. Hartkoorn, Stewart T. Cole, Manoranjan Panda, Shankar D. Markad, Vasanthi Ramachandran, Sandeep R. Ghorpade & Neela Dinesh. (2015) Whole cell screen based identification of spiropiperidines with potent antitubercular properties. Bioorganic & Medicinal Chemistry Letters 25:16, pages 3234-3245.
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Goverdhan Surineni, Perumal Yogeeswari, Dharmarajan Sriram & Srinivas Kantevari. (2015) Design and synthesis of novel carbazole tethered pyrrole derivatives as potent inhibitors of Mycobacterium tuberculosis. Bioorganic & Medicinal Chemistry Letters 25:3, pages 485-491.
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Ana Nobre, Susana Alarico, Ana Maranha, Vitor Mendes & Nuno Empadinhas. (2014) The molecular biology of mycobacterial trehalose in the quest for advanced tuberculosis therapies. Microbiology 160:8, pages 1547-1570.
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