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Editorial

Could the Ebola virus matrix protein VP40 be a drug target?

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Pedro Buzon, Javier Ruiz-Sanz, Jose C. Martinez & Irene Luque. (2020) Stability, conformational plasticity, oligomerization behaviour and equilibrium unfolding intermediates of the Ebola virus matrix protein VP40. Journal of Biomolecular Structure and Dynamics 38:14, pages 4289-4303.
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Sinosh Skariyachan, Archana B. Acharya, Saumya Subramaniyan, Sumangala Babu, Shruthi Kulkarni & Rajeswari Narayanappa. (2016) Secondary metabolites extracted from marine sponge associated Comamonas testosteroni and Citrobacter freundii as potential antimicrobials against MDR pathogens and hypothetical leads for VP40 matrix protein of Ebola virus: an in vitro and in silico investigation. Journal of Biomolecular Structure and Dynamics 34:9, pages 1865-1883.
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Articles from other publishers (35)

Sahil Jain, Svetlana Khaiboullina, Ekaterina Martynova, Sergey Morzunov & Manoj Baranwal. (2023) Epidemiology of Ebolaviruses from an Etiological Perspective. Pathogens 12:2, pages 248.
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Igor José dos Santos Nascimento, Paulo Fernando da Silva Santos-Júnior, João Xavier de Araújo-Júnior & Edeildo Ferreira da Silva-Júnior. (2022) Strategies in Medicinal Chemistry to Discover New Hit Compounds against Ebola Virus: Challenges and Perspectives in Drug Discovery. Mini-Reviews in Medicinal Chemistry 22:22, pages 2896-2924.
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Pradakshina Sharma, Shariq Suleman, Asim Farooqui, Wajid Ali, Jagriti Narang, Shweta J. Malode & Nagaraj P. Shetti. (2022) Analytical methods for Ebola virus detection. Microchemical Journal 178, pages 107333.
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Xiao Liu, Ethan J. Pappas, Monica L. Husby, Balindile B. Motsa, Robert V. Stahelin & Elsje Pienaar. (2022) Mechanisms of phosphatidylserine influence on viral production: A computational model of Ebola virus matrix protein assembly. Journal of Biological Chemistry 298:7, pages 102025.
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Fernando Bergasa-Caceres & Herschel A. Rabitz. (2022) Protein Folding Interdiction Strategy for Therapeutic Drug Development in Viral Diseases: Ebola VP40 and Influenza A M1. International Journal of Molecular Sciences 23:7, pages 3906.
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Nisha Bhattarai, Elumalai Pavadai, Rudramani Pokhrel, Prabin Baral, Md Lokman Hossen, Robert V. Stahelin, Prem P. Chapagain & Bernard S. Gerstman. (2021) Ebola virus protein VP40 binding to Sec24c for transport to the plasma membrane . Proteins: Structure, Function, and Bioinformatics 90:2, pages 340-350.
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Ashish Ranjan Sharma, Yeon-Hee Lee, Sudarshini Nath & Sang-Soo Lee. (2021) Recent developments and strategies of Ebola virus vaccines. Current Opinion in Pharmacology 60, pages 46-53.
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Alexander Hargreaves, Caolann Brady, Jack Mellors, Tom Tipton, Miles W. Carroll & Stephanie Longet. (2021) Filovirus Neutralising Antibodies: Mechanisms of Action and Therapeutic Application. Pathogens 10:9, pages 1201.
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Kristen A. Johnson, Nisha Bhattarai, Melissa R. Budicini, Carolyn M. LaBonia, Sarah Catherine B. Baker, Bernard S. Gerstman, Prem P. Chapagain & Robert V. Stahelin. (2021) Cysteine Mutations in the Ebolavirus Matrix Protein VP40 Promote Phosphatidylserine Binding by Increasing the Flexibility of a Lipid-Binding Loop. Viruses 13:7, pages 1375.
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Elumalai Pavadai, Nisha Bhattarai, Prabin Baral, Robert V. Stahelin, Prem P. Chapagain & Bernard S. Gerstman. (2019) Conformational Flexibility of the Protein–Protein Interfaces of the Ebola Virus VP40 Structural Matrix Filament. The Journal of Physical Chemistry B 123:43, pages 9045-9053.
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Ding-Yi Fu, Ya-Rong Xue, Xianghui Yu & Yuqing Wu. (2019) Anti-virus reagents targeting the capsid protein assembly. Journal of Materials Chemistry B 7:21, pages 3331-3340.
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Elumalai Pavadai, Bernard S. Gerstman & Prem P. Chapagain. (2018) A cylindrical assembly model and dynamics of the Ebola virus VP40 structural matrix. Scientific Reports 8:1.
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Mohamad Ariff Mohamad Yusoff, Azzmer Azzar Abdul Hamid, Noraslinda Mohammad Bunori & Khairul Bariyyah Abd Halim. (2018) Interaction of monomeric Ebola VP40 protein with a plasma membrane: A coarse-grained molecular dynamics (CGMD) simulation study. Journal of Molecular Graphics and Modelling 82, pages 137-144.
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Diego Cantoni & Jeremy S. Rossman. (2018) Ebolaviruses: New roles for old proteins. PLOS Neglected Tropical Diseases 12:5, pages e0006349.
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Baptiste Martin, Olivier Reynard, Viktor Volchkov & Etienne Decroly. (2018) Filovirus proteins for antiviral drug discovery: Structure/function of proteins involved in assembly and budding. Antiviral Research 150, pages 183-192.
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Jeevan B. GC, Rudramani Pokhrel, Nisha Bhattarai, Kristen A. Johnson, Bernard S. Gerstman, Robert V. Stahelin & Prem P. Chapagain. (2017) Graphene-VP40 interactions and potential disruption of the Ebola virus matrix filaments. Biochemical and Biophysical Research Communications 493:1, pages 176-181.
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Marissa Balmith, Mbuso Faya & Mahmoud E. S. Soliman. (2017) Ebola virus: A gap in drug design and discovery - experimental and computational perspective. Chemical Biology & Drug Design 89:3, pages 297-308.
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Marissa Balmith & Mahmoud E. S. Soliman. (2017) Potential Ebola drug targets — filling the gap: a critical step forward towards the design and discovery of potential drugs. Biologia 72:1, pages 1-13.
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Nisha Bhattarai, Jeevan B. GC, Bernard S. Gerstman, Robert V. Stahelin & Prem P. Chapagain. (2017) Plasma membrane association facilitates conformational changes in the Marburg virus protein VP40 dimer. RSC Advances 7:37, pages 22741-22748.
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V. Karthick, N. Nagasundaram, C. George Priya Doss, Chiranjib Chakraborty, R. Siva, Aiping Lu, Ge Zhang & Hailong Zhu. (2016) Virtual screening of the inhibitors targeting at the viral protein 40 of Ebola virus. Infectious Diseases of Poverty 5:1.
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Salma Teimoori, Watee Seesuay, Surasak Jittavisutthikul, Urai Chaisri, Nitat Sookrung, Jaslan Densumite, Nawannaporn Saelim, Monrat Chulanetra, Santi Maneewatch & Wanpen Chaicumpa. (2016) Human transbodies to VP40 inhibit cellular egress of Ebola virus-like particles. Biochemical and Biophysical Research Communications 479:2, pages 245-252.
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Ming Ni, Chen Chen, Jun Qian, Hai-Xia Xiao, Wei-Feng Shi, Yang Luo, Hai-Yin Wang, Zhen Li, Jun Wu, Pei-Song Xu, Su-Hong Chen, Gary Wong, Yuhai Bi, Zhi-Ping Xia, Wei Li, Hui-jun Lu, Juncai Ma, Yi-Gang Tong, Hui Zeng, Sheng-Qi Wang, George F. Gao, Xiao-Chen Bo & Di Liu. (2016) Intra-host dynamics of Ebola virus during 2014. Nature Microbiology 1:11.
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Beuy Joob & Viroj Wiwanitkit. (2016) Determination of ligand cluster and binding site within VP40 of Ebola virus: Clue for drug development. Asian Pacific Journal of Tropical Medicine 9:4, pages 410-411.
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Kaveesha J. Wijesinghe & Robert V. Stahelin. (2016) Investigation of the Lipid Binding Properties of the Marburg Virus Matrix Protein VP40. Journal of Virology 90:6, pages 3074-3085.
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Kristen A. Johnson, Geoffrey J. F. Taghon, Jordan L. Scott & Robert V. Stahelin. (2016) The Ebola Virus matrix protein, VP40, requires phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) for extensive oligomerization at the plasma membrane and viral egress. Scientific Reports 6:1.
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Jeevan B. GC, Bernard S. Gerstman, Robert V. Stahelin & Prem P. Chapagain. (2016) The Ebola virus protein VP40 hexamer enhances the clustering of PI(4,5)P 2 lipids in the plasma membrane . Physical Chemistry Chemical Physics 18:41, pages 28409-28417.
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Matthew C. Clifton, Jessica F. Bruhn, Kateri Atkins, Terry L. Webb, Ruth O. Baydo, Amy Raymond, Donald D. Lorimer, Thomas E. Edwards, Peter J. Myler & Erica Ollmann Saphire. (2015) High-resolution Crystal Structure of Dimeric VP40 From Sudan ebolavirus . Journal of Infectious Diseases 212:suppl 2, pages S167-S171.
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Cary T. Frick & Robert V. Stahelin. (2015) The Ebola Virus Matrix Protein VP40 Interacts With Several Host Protein Networks to Facilitate Viral Replication. Current Clinical Microbiology Reports 2:3, pages 137-141.
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Jonathan J Madara, Ziying Han, Gordon Ruthel, Bruce D Freedman & Ronald N Harty. (2015) The multifunctional Ebola virus VP40 matrix protein is a promising therapeutic target. Future Virology 10:5, pages 537-546.
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Marina Jerebtsova & Sergei Nekhai. (2015) Therapeutics for postexposure treatment of Ebola virus infection. Future Virology 10:3, pages 221-232.
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Nikki M. Curthoys, Matthew Parent, Michael Mlodzianoski, Andrew J. Nelson, Jennifer Lilieholm, Michael B. Butler, Matthew Valles & Samuel T. Hess. 2015. Lipid Domains. Lipid Domains 59 123 .
Kang Yiu Lai, Wing Yiu George Ng & Fan Fanny Cheng. (2014) Human Ebola virus infection in West Africa: a review of available therapeutic agents that target different steps of the life cycle of Ebola virus. Infectious Diseases of Poverty 3:1.
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Viroj Wiwanitkit. (2014) Binding site prediction within Ebola virus VP40 protein: clue for further drug development. Asian Pacific Journal of Tropical Biomedicine 4:11, pages 846.
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Smita P. Soni & Robert V. Stahelin. (2014) The Ebola Virus Matrix Protein VP40 Selectively Induces Vesiculation from Phosphatidylserine-enriched Membranes. Journal of Biological Chemistry 289:48, pages 33590-33597.
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Emmanuel Adu-Gyamfi, Smita Soni, Clara Jee, Michelle Digman, Enrico Gratton & Robert Stahelin. (2014) A Loop Region in the N-Terminal Domain of Ebola Virus VP40 Is Important in Viral Assembly, Budding, and Egress. Viruses 6:10, pages 3837-3854.
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