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Therapeutic targets for neuroblastomas

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Lei Gan, Yang Ren, Jicheng Lu, Junzhe Ma, Xudong Shen & Zhixiang Zhuang. (2020) Synergistic Effect of 3-Bromopyruvate in Combination with Rapamycin Impacted Neuroblastoma Metabolism by Inhibiting Autophagy. OncoTargets and Therapy 13, pages 11125-11137.
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Natarajan Aravindan, Terence Herman & Sheeja Aravindan. (2020) Emerging therapeutic targets for neuroblastoma. Expert Opinion on Therapeutic Targets 24:9, pages 899-914.
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Holly L Pacenta & Margaret E Macy. (2018) Entrectinib and other ALK/TRK inhibitors for the treatment of neuroblastoma. Drug Design, Development and Therapy 12, pages 3549-3561.
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Articles from other publishers (39)

Arif Mermer, Burak Tüzün, Sevgi Durna Daştan & Özge Çevik. (2023) Synthesis of novel Cu(II) complexes with N2O2 ligands: Characterization, theoretical calculations, antimicrobial, antioxidant, DNA binding, and in vitro anticancer activity studies. Polyhedron 242, pages 116487.
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Ayca Tas, Burak Tüzün, Ali N. Khalilov, Parham Taslimi, Tugba Ağbektas & Nese Keklikcioglu Cakmak. (2023) In vitro cytotoxic effects, in silico studies, some metabolic enzymes inhibition, and vibrational spectral analysis of novel β-amino alcohol compounds. Journal of Molecular Structure 1273, pages 134282.
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Yue Jiang, Chengda Zhang, Yang Chen, Shiyu Zhao, Yipeng He & Jun He. (2022) Prognostic risk assessment model for alternative splicing events and splicing factors in malignant pleural mesothelioma. Cancer Medicine 12:4, pages 4895-4906.
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Souhaila H. El Moukhtari, Elisa Garbayo, Ana Fernández-Teijeiro, Carlos Rodríguez-Nogales, Patrick Couvreur & María J. Blanco-Prieto. (2022) Nanomedicines and cell-based therapies for embryonal tumors of the nervous system. Journal of Controlled Release 348, pages 553-571.
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Tianyou Yang, Jiahao Li, Zhenjian Zhuo, Huijuan Zeng, Tianbao Tan, Lei Miao, Manna Zheng, Jiliang Yang, Jing Pan, Chao Hu, Yan Zou, Jing He & Huimin Xia. (2022) TTF1 suppresses neuroblastoma growth and induces neuroblastoma differentiation by targeting TrkA and the miR-204/TrkB axis. iScience 25:7, pages 104655.
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Enrico Rango, Fabio Pastorino, Chiara Brignole, Arianna Mancini, Federica Poggialini, Salvatore Di Maria, Claudio Zamperini, Giulia Iovenitti, Anna Lucia Fallacara, Samantha Sabetta, Letizia Clementi, Massimo Valoti, Silvia Schenone, Adriano Angelucci, Mirco Ponzoni, Elena Dreassi & Maurizio Botta. (2022) The Pyrazolo[3,4-d]Pyrimidine Derivative Si306 Encapsulated into Anti-GD2-Immunoliposomes as Therapeutic Treatment of Neuroblastoma. Biomedicines 10:3, pages 659.
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Yaoyao Gu, Xiaoxiao Hu, Xiaowei Liu, Cheng Cheng, Kai Chen, Yeming Wu & Zhixiang Wu. (2021) MCM6 indicates adverse tumor features and poor outcomes and promotes G1/S cell cycle progression in neuroblastoma. BMC Cancer 21:1.
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Jennifer C. Kasemeier-Kulesa, Jennifer A. Spengler, Connor E. Muolo, Jason A. Morrison, Thomas E. Woolley, Santiago Schnell & Paul M. Kulesa. (2021) The embryonic trunk neural crest microenvironment regulates the plasticity and invasion of human neuroblastoma via TrkB signaling. Developmental Biology 480, pages 78-90.
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Ozlem Ozen Karakus, Kavitha Godugu, Taher Salaheldin, Kazutoshi Fujioka & Shaker A Mousa. (2021) Norepinephrine transporter analog benzylguanidine-conjugated nanoparticles for the delivery of paclitaxel in neuroblastoma. Nanomedicine 16:26, pages 2331-2342.
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Ozlem Ozen Karakus, Kavitha Godugu, Kazutoshi Fujioka & Shaker A. Mousa. (2021) Design, synthesis, and biological evaluation of novel bifunctional thyrointegrin antagonists for neuroblastoma. Bioorganic & Medicinal Chemistry 42, pages 116250.
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Mohamed Jemaà, Wondossen Sime, Yasmin Abassi, Vito Lasorsa, Julie Bonne Køhler, Martin Michaelis, Jindrich Cinatl, Mario Capasso & Ramin Massoumi. (2020) Gene Expression Signature of Acquired Chemoresistance in Neuroblastoma Cells. International Journal of Molecular Sciences 21:18, pages 6811.
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Silvana Alfei, Barbara Marengo, Guendalina Zuccari, Federica Turrini & Cinzia Domenicotti. (2020) Dendrimer Nanodevices and Gallic Acid as Novel Strategies to Fight Chemoresistance in Neuroblastoma Cells. Nanomaterials 10:6, pages 1243.
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Yuchen Zhang & Joanne Wang. (2020) Targeting uptake transporters for cancer imaging and treatment. Acta Pharmaceutica Sinica B 10:1, pages 79-90.
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Elizabeth R. Pastor & Shaker A. Mousa. (2019) Current management of neuroblastoma and future direction. Critical Reviews in Oncology/Hematology 138, pages 38-43.
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Fabio Pastorino, Chiara Brignole, Daniela Di Paolo, Patrizia Perri, Flavio Curnis, Angelo Corti & Mirco Ponzoni. (2019) Overcoming Biological Barriers in Neuroblastoma Therapy: The Vascular Targeting Approach with Liposomal Drug Nanocarriers. Small 15:10.
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Xiaokun Lin, Lei Han, Jialei Weng, Kelai Wang & Tongke Chen. (2018) Rapamycin inhibits proliferation and induces autophagy in human neuroblastoma cells. Bioscience Reports 38:6.
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Jing Shen, Sara Najafi, Sina Stäble, Johannes Fabian, Emily Koeneke, Fiona R. Kolbinger, Jagoda K. Wrobel, Benjamin Meder, Martin Distel, Tino Heimburg, Wolfgang Sippl, Manfred Jung, Heike Peterziel, Dominique Kranz, Michael Boutros, Frank Westermann, Olaf Witt & Ina Oehme. (2018) A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment. Cell Death & Differentiation 25:12, pages 2053-2070.
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Mirco Ponzoni, Flavio Curnis, Chiara Brignole, Silvia Bruno, Daniela Guarnieri, Leopoldo Sitia, Roberto Marotta, Angelina Sacchi, Matteo Bauckneht, Ambra Buschiazzo, Andrea Rossi, Daniela Di Paolo, Patrizia Perri, Alessandro Gori, Angela R. Sementa, Laura Emionite, Michele Cilli, Roberto Tamma, Domenico Ribatti, Pier Paolo Pompa, Cecilia Marini, Gianmario Sambuceti, Angelo Corti & Fabio Pastorino. (2018) Enhancement of Tumor Homing by Chemotherapy-Loaded Nanoparticles. Small 14:45, pages 1802886.
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Zhongyan Hua, Yue Zhan, Simeng Zhang, Yudi Dong, Min Jiang, Fei Tan, Zhihui Liu, Carol J. Thiele & Zhijie Li. (2018) P53/PUMA are potential targets that mediate the protection of brain-derived neurotrophic factor (BDNF)/TrkB from etoposide-induced cell death in neuroblastoma (NB). Apoptosis 23:7-8, pages 408-419.
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Régis Afonso Costa & Héctor N. Seuánez. (2018) Investigation of major genetic alterations in neuroblastoma. Molecular Biology Reports 45:3, pages 287-295.
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Tino Heimburg, Fiona R. Kolbinger, Patrik Zeyen, Ehab Ghazy, Daniel Herp, Karin Schmidtkunz, Jelena Melesina, Tajith Baba Shaik, Frank Erdmann, Matthias Schmidt, Christophe Romier, Dina Robaa, Olaf Witt, Ina Oehme, Manfred Jung & Wolfgang Sippl. (2017) Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity. Journal of Medicinal Chemistry 60:24, pages 10188-10204.
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Conny Tümmler, Igor Snapkov, Malin Wickström, Ugo Moens, Linda Ljungblad, Lotta Helena Maria Elfman, Jan-Olof Winberg, Per Kogner, John Inge Johnsen & Baldur Sveinbjørnsson. (2017) Inhibition of chemerin/CMKLR1 axis in neuroblastoma cells reduces clonogenicity and cell viability in vitro and impairs tumor growth in vivo . Oncotarget 8:56, pages 95135-95151.
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Wenjing Sun, Yesenia Rojas, Hao Wang, Yang Yu, Yongfeng Wang, Zhenghu Chen, Kimal Rajapakshe, Xin Xu, Wei Huang, Saurabh Agarwal, Roma H. Patel, Sarah Woodfield, Yanling Zhao, Jingling Jin, Hong Zhang, Angela Major, M. John Hicks, Jason M. Shohet, Sanjeev A. Vasudevan, Cristian Coarfa, Jianhua Yang & Jed G. Nuchtern. (2017) EWS-FLI1 and RNA helicase A interaction inhibitor YK-4-279 inhibits growth of neuroblastoma. Oncotarget 8:55, pages 94780-94792.
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Céline Delloye-Bourgeois, Lorette Bertin, Karine Thoinet, Loraine Jarrosson, Karine Kindbeiter, Thomas Buffet, Servane Tauszig-Delamasure, Muriel Bozon, Aurélien Marabelle, Valérie Combaret, Christophe Bergeron, Edmund Derrington & Valérie Castellani. (2017) Microenvironment-Driven Shift of Cohesion/Detachment Balance within Tumors Induces a Switch toward Metastasis in Neuroblastoma. Cancer Cell 32:4, pages 427-443.e8.
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Laurent Sakka, Nathalie Delétage, Maryse Chalus, Youssef Aissouni, Valérie Sylvain-Vidal, Stéphane Gobron & Guillaume Coll. (2017) Assessment of citalopram and escitalopram on neuroblastoma cell lines: Cell toxicity and gene modulation. Oncotarget 8:26, pages 42789-42807.
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Yanna Cao, Yan Jin, Jinpu Yu, Jingfu Wang, Jie Yan & Qiang Zhao. (2016) Research progress of neuroblastoma related gene variations. Oncotarget 8:11, pages 18444-18455.
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Kristian W Pajtler, Natalie Sadowski, Sandra Ackermann, Kristina Althoff, Kerstin Schönbeck, Katharina Batzke, Simonäfers Sch, Andrea Odersky, Lukas Heukamp, Kathy Astrahantseff, Annette Künkele, Hedwig E Deubzer, Alexander Schramm, Annikaüssel Spr, Theresa Thor, Sven Lindner, Angelika Eggert, Matthias Fischer & Johannes H Schulte. (2016) The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models. Oncotarget 8:4, pages 6730-6741.
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Emanuela Mari, Stefania Mardente, Emanuela Morgante, Marco Tafani, Emanuela Lococo, Flavia Fico, Federica Valentini & Alessandra Zicari. (2016) Graphene Oxide Nanoribbons Induce Autophagic Vacuoles in Neuroblastoma Cell Lines. International Journal of Molecular Sciences 17:12, pages 1995.
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Renata Colla, Alberto Izzotti, Chiara De Ciucis, Daniela Fenoglio, Silvia Ravera, Andrea Speciale, Roberta Ricciarelli, Anna Lisa Furfaro, Alessandra Pulliero, Mario Passalacqua, Nicola Traverso, Maria Adelaide Pronzato, Cinzia Domenicotti & Barbara Marengo. (2016) Glutathione-mediated antioxidant response and aerobic metabolism: two crucial factors involved in determining the multi-drug resistance of high-risk neuroblastoma. Oncotarget 7:43, pages 70715-70737.
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Elisa Matas-Rico, Michiel van?Veen, Daniela Leyton-Puig, Jeroen van?den?Berg, Jan Koster, Katarzyna?M. Kedziora, Bas Molenaar, Marjolein?J.A. Weerts, Iris de?Rink, Ren??H. Medema, Ben?N.G. Giepmans, Anastassis Perrakis, Kees Jalink, Rogier Versteeg & Wouter?H. Moolenaar. (2016) Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome. Cancer Cell 30:4, pages 548-562.
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Nagendra K. Chaturvedi, Timothy R. McGuire, Don W. Coulter, Ashima Shukla, Erin M. McIntyre, John Graham Sharp & Shantaram S. Joshi. (2016) Improved therapy for neuroblastoma using a combination approach: superior efficacy with vismodegib and topotecan. Oncotarget 7:12, pages 15215-15229.
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Radhika Iyer, Lea Wehrmann, Rebecca L. Golden, Koumudi Naraparaju, Jamie L. Croucher, Suzanne P. MacFarland, Peng Guan, Venkatadri Kolla, Ge Wei, Nicholas Cam, Gang Li, Zachary Hornby & Garrett M. Brodeur. (2016) Entrectinib is a potent inhibitor of Trk-driven neuroblastomas in a xenograft mouse model. Cancer Letters 372:2, pages 179-186.
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Irene Cossu, Gianluca Bottoni, Monica Loi, Laura Emionite, Alice Bartolini, Daniela Di Paolo, Chiara Brignole, Francesca Piaggio, Patrizia Perri, Angelina Sacchi, Flavio Curnis, Maria Cristina Gagliani, Silvia Bruno, Cecilia Marini, Alessandro Gori, Renato Longhi, Daniele Murgia, Angela Rita Sementa, Michele Cilli, Carlo Tacchetti, Angelo Corti, Gianmario Sambuceti, Serena Marchiò, Mirco Ponzoni & Fabio Pastorino. (2015) Neuroblastoma-targeted nanocarriers improve drug delivery and penetration, delay tumor growth and abrogate metastatic diffusion. Biomaterials 68, pages 89-99.
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Radhika Iyer, Jamie L. Croucher, Michael Chorny, Jennifer L. Mangino, Ivan S. Alferiev, Robert J. Levy, Venkatadri Kolla & Garrett M. Brodeur. (2015) Nanoparticle delivery of an SN38 conjugate is more effective than irinotecan in a mouse model of neuroblastoma. Cancer Letters 360:2, pages 205-212.
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Jessica L. BellRaseswari TurlapatiTao LiuJohannes H. SchulteStefan Hüttelmaier. (2015) IGF2BP1 Harbors Prognostic Significance by Gene Gain and Diverse Expression in Neuroblastoma . Journal of Clinical Oncology 33:11, pages 1285-1293.
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Alessandra di Masi, Loris Leboffe, Elisabetta De Marinis, Francesca Pagano, Laura Cicconi, Cécile Rochette-Egly, Francesco Lo-Coco, Paolo Ascenzi & Clara Nervi. (2015) Retinoic acid receptors: From molecular mechanisms to cancer therapy. Molecular Aspects of Medicine 41, pages 1-115.
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Jamie L. Croucher, Radhika Iyer, Nanxin Li, Valentina Molteni, Jon Loren, W. Perry Gordon, Tove Tuntland, Bo Liu & Garrett M. Brodeur. (2014) TrkB inhibition by GNF-4256 slows growth and enhances chemotherapeutic efficacy in neuroblastoma xenografts. Cancer Chemotherapy and Pharmacology 75:1, pages 131-141.
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Jing Wang, Song Gu, Jun Huang, Sheng Chen, Zhen Zhang & Min Xu. (2014) Inhibition of autophagy potentiates the efficacy of Gli inhibitor GANT-61 in MYCN-amplified neuroblastoma cells. BMC Cancer 14:1.
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Venkatadri Kolla, Tiangang Zhuang, Mayumi Higashi, Koumudi Naraparaju & Garrett M. Brodeur. (2014) Role of CHD5 in Human Cancers: 10 Years Later . Cancer Research 74:3, pages 652-658.
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