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The roles of hepatitis B virus-encoded X protein in virus replication and the pathogenesis of chronic liver disease

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Linsen Xie & Yongjie Huang. (2019) Antagonism of RIP1 using necrostatin-1 (Nec-1) ameliorated damage and inflammation of HBV X protein (HBx) in human normal hepatocytes. Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 1194-1199.
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Gu-Choul Shin, Hong Seok Kang, Ah Ram Lee & Kyun-Hwan Kim. (2016) Hepatitis B virus–triggered autophagy targets TNFRSF10B/death receptor 5 for degradation to limit TNFSF10/TRAIL response. Autophagy 12:12, pages 2451-2466.
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Michael C Kew. (2014) Hepatocellular carcinoma: epidemiology and risk factors. Journal of Hepatocellular Carcinoma 1, pages 115-125.
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Enakshi Sivasudhan, Neil Blake, Zhiliang Lu, Jia Meng & Rong Rong. (2022) Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review. Cells 11:4, pages 741.
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Hongjuan You, Suping Qin, Fulong Zhang, Wei Hu, Xiaocui Li, Dongsheng Liu, Fanyun Kong, Xiucheng Pan, Kuiyang Zheng & Renxian Tang. (2022) Regulation of Pattern-Recognition Receptor Signaling by HBX During Hepatitis B Virus Infection. Frontiers in Immunology 13.
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Ah Ram Lee, Yong Kwang Park, Mehrangiz Dezhbord & Kyun-Hwan Kim. (2022) Interaction between the Hepatitis B Virus and Cellular FLIP Variants in Viral Replication and the Innate Immune System. Viruses 14:2, pages 373.
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Chang Liu, Qinghai Dai, Qian Ding, Min Wei & Xiaohong Kong. (2021) Identification of key genes in hepatitis B associated hepatocellular carcinoma based on WGCNA. Infectious Agents and Cancer 16:1.
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Arvin Medhat, Alla Arzumanyan & Mark A. Feitelson. (2021) Hepatitis B x antigen (HBx) is an important therapeutic target in the pathogenesis of hepatocellular carcinoma. Oncotarget 12:24, pages 2421-2433.
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Yayun Lin, Yan Liu, Dongping Xu, Fanfan Guo, Wentao Zhang, Yidan Zhang & Guiqin Bai. (2021) HBxAg promotes HBV replication and EGFR activation in human placental trophoblasts. Experimental and Therapeutic Medicine 22:5.
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Kevin Dzobo. (2021) The Role of Viruses in Carcinogenesis and Molecular Targeting: From Infection to Being a Component of the Tumor Microenvironment. OMICS: A Journal of Integrative Biology 25:6, pages 358-371.
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Georgia-Myrto Prifti, Dimitrios Moianos, Erofili Giannakopoulou, Vasiliki Pardali, John Tavis & Grigoris Zoidis. (2021) Recent Advances in Hepatitis B Treatment. Pharmaceuticals 14:5, pages 417.
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Ning Han, Libo Yan, Xueer Wang, Xuehong Sun, Feijun Huang & Hong Tang. (2020) An updated literature review: how HBV X protein regulates the propagation of the HBV. Future Virology 15:9, pages 649-658.
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Yanjie Li, Chenguang Shen, Liuqing Yang, Yang Yang, Miao Wang, Shanqin Li, Feng Chen, Min Yang, Ling Peng, Jinmin Ma, Zhongping Duan, Liqiang Li & Yingxia Liu. (2020) Intra-host diversity of hepatitis B virus during mother-to-child transmission: the X gene may play a key role in virus survival in children after transmission. Archives of Virology 165:6, pages 1279-1288.
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Sooyeon Oh, YoungJoon Park, Hyun-Jung Lee, Jooho Lee, Soo-Hyeon Lee, Young-Seok Baek, Su-Kyung Chun, Seung-Min Lee, Mina Kim, Young-Eun Chon, Yeonjung Ha, Yuri Cho, Gi Jin Kim, Seong-Gyu Hwang & KyuBum Kwack. (2020) A Disintegrin and Metalloproteinase 9 (ADAM9) in Advanced Hepatocellular Carcinoma and Their Role as a Biomarker During Hepatocellular Carcinoma Immunotherapy. Cancers 12:3, pages 745.
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Fan Wang, Fang Shen, Yang Wang, Ze Li, Jieliang Chen & Zhenghong Yuan. (2020) Residues Asn118 and Glu119 of hepatitis B virus X protein are critical for HBx-mediated inhibition of RIG-I-MAVS signaling. Virology 539, pages 92-103.
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Yuan‐Yuan Chen, Yi Lin, Pei‐Yu Han, Shan Jiang, Lin Che, Cheng‐Yong He, Yu‐Chun Lin & Zhong‐Ning Lin. (2019) HBx combined with AFB1 triggers hepatic steatosis via COX‐2‐mediated necrosome formation and mitochondrial dynamics disorder. Journal of Cellular and Molecular Medicine 23:9, pages 5920-5933.
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Chiao-Fang Teng, Chun-Hui Yu, Hong-Yi Chang, Wen-Chuan Hsieh, Tzu-Hua Wu, Jia-Hui Lin, Han-Chieh Wu, Long-Bin Jeng & Ih-Jen Su. (2019) Chemopreventive Effect of Phytosomal Curcumin on Hepatitis B Virus-Related Hepatocellular Carcinoma in A Transgenic Mouse Model. Scientific Reports 9:1.
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Xiaoqiong Tang, Libo Yan, Hong Li, Lingyao Du, Ying Shi, Feijun Huang & Hong Tang. (2018) Increased expression of phosphoenolpyruvate carboxykinase cytoplasmic isoform by hepatitis B virus X protein affects hepatitis B virus replication. Journal of Medical Virology 91:2, pages 258-264.
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Andrea Caballero, David Tabernero, Maria Buti & Francisco Rodriguez-Frias. (2018) Hepatitis B virus: The challenge of an ancient virus with multiple faces and a remarkable replication strategy. Antiviral Research 158, pages 34-44.
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Fabien Abdul, Fabien Filleton, Laetitia Gerossier, Alexia Paturel, Janet Hall, Michel Strubin & Lucie Etienne. (2018) Smc5/6 Antagonism by HBx Is an Evolutionarily Conserved Function of Hepatitis B Virus Infection in Mammals. Journal of Virology 92:16.
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Maria Francesca Armentano, Marianna Caterino, Rocchina Miglionico, Angela Ostuni, Maria Carmela Pace, Flora Cozzolino, Maria Monti, Luigi Milella, Monica Carmosino, Piero Pucci & Faustino Bisaccia. (2018) New insights on the functional role of URG7 in the cellular response to ER stress. Biology of the Cell 110:7, pages 147-158.
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Mingjie Xie, Zhenggang Yang, Yanning Liu & Min Zheng. (2018) The role of HBV-induced autophagy in HBV replication and HBV related-HCC. Life Sciences 205, pages 107-112.
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Li-Bo Yan, You-Jia Yu, Qing-Bo Zhang, Xiao-Qiong Tang, Lang Bai, FeiJun Huang & Hong Tang. (2018) Identification of p90 Ribosomal S6 Kinase 2 as a Novel Host Protein in HBx Augmenting HBV Replication by iTRAQ-Based Quantitative Comparative Proteomics. PROTEOMICS - Clinical Applications 12:3, pages 1700090.
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Arnolfo Petruzziello. (2018) Epidemiology of Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) Related Hepatocellular Carcinoma. The Open Virology Journal 12:1, pages 26-32.
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Pierre Van Damme, John W. Ward, Daniel Shouval & Alessandro Zanetti. 2018. Plotkin's Vaccines. Plotkin's Vaccines 342 374.e17 .
Xiao Xiang, Hong-Gui Qin, Xue-Mei You, Yan-Yan Wang, Lu-Nan Qi, Liang Ma, Bang-De Xiang, Jian-Hong Zhong & Le-Qun Li. (2017) Expression of P62 in hepatocellular carcinoma involving hepatitis B virus infection and aflatoxin B1 exposure. Cancer Medicine 6:10, pages 2357-2369.
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Linmao Zhong, Wangqin Shu, Wangbin Dai, Bo Gao & Sidong Xiong. (2017) Reactive Oxygen Species-Mediated c-Jun NH 2 -Terminal Kinase Activation Contributes to Hepatitis B Virus X Protein-Induced Autophagy via Regulation of the Beclin-1/Bcl-2 Interaction . Journal of Virology 91:15.
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Fanyun Kong, Hongjuan You, Renxian Tang & Kuiyang Zheng. (2017) The regulation of proteins associated with the cytoskeleton by hepatitis B virus X protein during hepatocarcinogenesis. Oncology Letters 13:4, pages 2514-2520.
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Fanyun Kong, Wei Hu, Kai Zhou, Xiao Wei, Yanbo Kou, Hongjuan You, Kuiyang Zheng & Renxian Tang. (2016) Hepatitis B virus X protein promotes interleukin-7 receptor expression via NF-?B and Notch1 pathway to facilitate proliferation and migration of hepatitis B virus-related hepatoma cells. Journal of Experimental & Clinical Cancer Research 35:1.
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Yu Zhang, Hongli Liu, Ruitian Yi, Taotao Yan, Yingli He, Yingren Zhao & Jinfeng Liu. (2016) Hepatitis B virus whole-X and X protein play distinct roles in HBV-related hepatocellular carcinoma progression. Journal of Experimental & Clinical Cancer Research 35:1.
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Song Cao, Michael C. Wendl, Matthew A. Wyczalkowski, Kristine Wylie, Kai Ye, Reyka Jayasinghe, Mingchao Xie, Song Wu, Beifang Niu, Robert GrubbIIIIII, Kimberly J. Johnson, Hiram Gay, Ken Chen, Janet S. Rader, John F. Dipersio, Feng Chen & Li Ding. (2016) Divergent viral presentation among human tumors and adjacent normal tissues. Scientific Reports 6:1.
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Weiya Bai, Xiaoxian Cui, Youhua Xie & Jing Liu. (2016) Engineering Hepadnaviruses as Reporter-Expressing Vectors: Recent Progress and Future Perspectives. Viruses 8:5, pages 125.
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Adrien Decorsière, Henrik Mueller, Pieter C. van Breugel, Fabien Abdul, Laetitia Gerossier, Rudolf K. Beran, Christine M. Livingston, Congrong Niu, Simon P. Fletcher, Olivier Hantz & Michel Strubin. (2016) Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor. Nature 531:7594, pages 386-389.
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Hong Kim, Seoung-Ae Lee & Bum-Joon Kim. (2016) X region mutations of hepatitis B virus related to clinical severity. World Journal of Gastroenterology 22:24, pages 5467.
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Nicholas A. Wallace & Denise A. Galloway. 2016. Viral Pathogenesis. Viral Pathogenesis 95 105 .
Man Kuen Yung, Kwok Wai Lo, Chi Wai Yip, Grace TY Chung, Carol YK Tong, Phyllis FY Cheung, Tan To Cheung, Ronnie TP Poon, Samuel So, Sheung Tat Fan & Siu Tim Cheung. (2015) Copy number gain of granulin-epithelin precursor (GEP) at chromosome 17q21 associates with overexpression in human liver cancer. BMC Cancer 15:1.
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Ranxu Zhu, Myth TS Mok, Wei Kang, Suki SK Lau, Wing-Kit Yip, Yangchao Chen, Paul BS Lai, Vincent WS Wong, Ka-Fai To, Joseph JY Sung, Alfred SL Cheng & Henry LY Chan. (2015) Truncated HBx-dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53-mediated apoptosis. The Journal of Pathology 237:1, pages 38-49.
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Kaku Goto & Naoya Kato. (2014) MICA SNPs and the NKG2D system in virus-induced HCC. Journal of Gastroenterology 50:3, pages 261-272.
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