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Microtubule-associated protein tau as a therapeutic target in Alzheimer's disease

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Ayomide Victor Atoki, Patrick Maduabuchi Aja, Erick Nyakundi Ondari & Tijjani Salihu Shinkafi. (2023) Advances in Alzheimer’s disease therapeutics: biochemistry, exploring bioactive compounds and novel approaches. International Journal of Food Properties 26:1, pages 2091-2127.
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Guang Fang, Baoyan Shi, Kefeng Wu, Siyu Chen, Xiang Gao, Sa Xiao, Jing X. Kang, Wende Li & Ren Huang. (2019) The protective role of endogenous n-3 polyunsaturated fatty acids in Tau Alzheimer’s disease mouse model. International Journal of Neuroscience 129:4, pages 325-336.
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Davide Seripa, Vincenzo Solfrizzi, Bruno P. Imbimbo, Antonio Daniele, Andrea Santamato, Madia Lozupone, Giovanni Zuliani, Antonio Greco, Giancarlo Logroscino & Francesco Panza. (2016) Tau-directed approaches for the treatment of Alzheimer’s disease: focus on leuco-methylthioninium. Expert Review of Neurotherapeutics 16:3, pages 259-277.
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Christian BehlChristian Behl. 2023. Alzheimer’s Disease Research. Alzheimer’s Disease Research 227 260 .
Afreen Hashmi, Vivek Srivastava, Syed Abul Kalam & Devesh Kumar Mishra. 2022. Alzheimer's Disease. Alzheimer's Disease.
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Livia La Barbera, Emanuele Mauri, Marcello D’Amelio & Manuele Gori. (2022) Functionalization strategies of polymeric nanoparticles for drug delivery in Alzheimer’s disease: Current trends and future perspectives. Frontiers in Neuroscience 16.
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Hadeel Y. Tarawneh, Wilhelmina H.A.M. Mulders, Hamid R. Sohrabi, Ralph N. Martins & Dona M.P. Jayakody. (2021) Investigating Auditory Electrophysiological Measures of Participants with Mild Cognitive Impairment and Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Event-Related Potential Studies. Journal of Alzheimer's Disease 84:1, pages 419-448.
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Julie Gregory, Yasaswi V. Vengalasetti, Dale E. Bredesen & Rammohan V. Rao. (2021) Neuroprotective Herbs for the Management of Alzheimer’s Disease. Biomolecules 11:4, pages 543.
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Maryam Ghaffari, Nima Sanadgol & Mohammad Abdollahi. (2020) A Systematic Review of Current Progresses in the Nucleic Acid-Based Therapies for Neurodegeneration with Implications for Alzheimer’s Disease. Mini-Reviews in Medicinal Chemistry 20:15, pages 1499-1517.
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Howard Friel. (2019) Biopharmaceutical Monotargeting versus ‘Universal Targeting’ of Late-Onset Alzheimer’s Disease Using Mixtures of Pleiotropic Natural Compounds. Journal of Alzheimer's Disease Reports 3:1, pages 219-232.
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Miren Ettcheto, Amanda Cano, Oriol Busquets, Patricia Regina Manzine, Elena Sánchez-López, Rubén D. Castro-Torres, Carlos Beas-Zarate, Ester Verdaguer, María Luisa García, Jordi Olloquequi, Carme Auladell, Jaume Folch & Antoni Camins. (2019) A metabolic perspective of late onset Alzheimer’s disease. Pharmacological Research 145, pages 104255.
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Kamlesh Sharma. (2019) Cholinesterase inhibitors as Alzheimer's therapeutics (Review). Molecular Medicine Reports.
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Hao Wang, Haijuan Sui, Yan Zheng, Yibing Jiang, Yijie Shi, Jia Liang & Liang Zhao. (2019) Curcumin-primed exosomes potently ameliorate cognitive function in AD mice by inhibiting hyperphosphorylation of the Tau protein through the AKT/GSK-3β pathway. Nanoscale 11:15, pages 7481-7496.
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Geir Bjørklund, Alexey A. Tinkov, Maryam Dadar, Md. Mostafizur Rahman, Salvatore Chirumbolo, Anatoly V. Skalny, Margarita G. Skalnaya, Boyd E. Haley, Olga P. Ajsuvakova & Jan Aaseth. (2019) Insights into the Potential Role of Mercury in Alzheimer’s Disease. Journal of Molecular Neuroscience.
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Pegah Javadpour, Leila Dargahi, Abolhassan Ahmadiani & Rasoul Ghasemi. (2019) To be or not to be: PP2A as a dual player in CNS functions, its role in neurodegeneration, and its interaction with brain insulin signaling. Cellular and Molecular Life Sciences.
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Haibo Zhang, Ding Wang, Ping Gong, Aihua Lin, Yan Zhang, Richard D. Ye & Yang Yu. (2019) Formyl Peptide Receptor 2 Deficiency Improves Cognition and Attenuates Tau Hyperphosphorylation and Astrogliosis in a Mouse Model of Alzheimer’s Disease. Journal of Alzheimer's Disease 67:1, pages 169-179.
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Jyoti Gupta & Mehboob Hoque. 2019. Biological, Diagnostic and Therapeutic Advances in Alzheimer's Disease. Biological, Diagnostic and Therapeutic Advances in Alzheimer's Disease 271 293 .
Chao Wu, Wei-Gang Gong, Yan-Juan Wang, Jun-Jun Sun, Hong Zhou, Zhi-Jun Zhang & Qing-Guo Ren. (2018) Escitalopram alleviates stress-induced Alzheimer's disease-like tau pathologies and cognitive deficits by reducing hypothalamic-pituitary-adrenal axis reactivity and insulin/GSK-3β signal pathway activity. Neurobiology of Aging 67, pages 137-147.
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Gustavo Basurto-Islas, Jin-hua Gu, Yunn Chyn Tung, Fei Liu & Khalid Iqbal. (2018) Mechanism of Tau Hyperphosphorylation Involving Lysosomal Enzyme Asparagine Endopeptidase in a Mouse Model of Brain Ischemia. Journal of Alzheimer's Disease 63:2, pages 821-833.
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Ai-Hua Xu, Yang Yang, Yong-Xin Sun & Chao-Dong Zhang. (2018) Exogenous brain-derived neurotrophic factor attenuates cognitive impairment induced by okadaic acid in a rat model of Alzheimer's disease. Neural Regeneration Research 13:12, pages 2173.
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Mange Ram Yadav, Mahesh A. Barmade, Rupesh V. Chikhale & Prashant R. Murumkar. 2018. Computational Modeling of Drugs Against Alzheimer’s Disease. Computational Modeling of Drugs Against Alzheimer’s Disease 347 417 .
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Daisuke Tanokashira, Naomi Mamada, Fumiko Yamamoto, Kaori Taniguchi, Akira Tamaoka, Madepalli K. Lakshmana & Wataru Araki. (2017) The neurotoxicity of amyloid ?-protein oligomers is reversible in a primary neuron model. Molecular Brain 10:1.
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Agnieszka Wnuk & Małgorzata Kajta. (2017) Steroid and Xenobiotic Receptor Signalling in Apoptosis and Autophagy of the Nervous System. International Journal of Molecular Sciences 18:11, pages 2394.
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Veena Theendakara, Dale E. Bredesen & Rammohan V. Rao. (2017) Downregulation of protein phosphatase 2A by apolipoprotein E: Implications for Alzheimer's disease. Molecular and Cellular Neuroscience 83, pages 83-91.
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J. Alex Grizzell, Sagar Patel, George E. Barreto & Valentina Echeverria. (2017) Cotinine improves visual recognition memory and decreases cortical Tau phosphorylation in the Tg6799 mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry 78, pages 75-81.
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Cristina Di Primio, Valentina Quercioli, Giacomo Siano, Matteo Rovere, Branislav Kovacech, Michal Novak & Antonino Cattaneo. (2017) The Distance between N and C Termini of Tau and of FTDP-17 Mutants Is Modulated by Microtubule Interactions in Living Cells. Frontiers in Molecular Neuroscience 10.
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Bei Zhang, Qiongqiong Li, Xingkun Chu, Suya Sun & Shengdi Chen. (2016) Salidroside reduces tau hyperphosphorylation via up-regulating GSK-3β phosphorylation in a tau transgenic Drosophila model of Alzheimer’s disease. Translational Neurodegeneration 5:1.
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Francesco Panza, Vincenzo Solfrizzi, Davide Seripa, Bruno P Imbimbo, Madia Lozupone, Andrea Santamato, Rosanna Tortelli, Ilaria Galizia, Camilla Prete, Antonio Daniele, Alberto Pilotto, Antonio Greco & Giancarlo Logroscino. (2016) Tau-based therapeutics for Alzheimer’s disease: active and passive immunotherapy. Immunotherapy 8:9, pages 1119-1134.
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David L. Sloman, Njamkou Noucti, Michael D. Altman, Dapeng Chen, Andrea C. Mislak, Alexander Szewczak, Mansuo Hayashi, Lee Warren, Tammy Dellovade, Zhenhua Wu, Jacob Marcus, Deborah Walker, Hua-Poo Su, Suzanne C. Edavettal, Sanjeev Munshi, Michael Hutton, Hugh Nuthall & Matthew G. Stanton. (2016) Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties. Bioorganic & Medicinal Chemistry Letters 26:17, pages 4362-4366.
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