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Targeting homologous recombination-mediated DNA repair in cancer

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Xiaoyu Sun, Suying Xu, Yiming Li, Xuemei Lv, Minjie Wei & Miao He. (2023) Efficacy and safety of PARP inhibitors in the treatment of BRCA-mutated breast cancer: an updated systematic review and meta-analysis of randomized controlled trials. Expert Review of Clinical Pharmacology 16:3, pages 245-256.
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Juan Jin, Wenwen Zhang, Wenfei Ji, Fang Yang & Xiaoxiang Guan. (2017) Predictive biomarkers for triple negative breast cancer treated with platinum-based chemotherapy. Cancer Biology & Therapy 18:6, pages 369-378.
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Bianca K. Verlinden, Abraham Louw & Lyn-Marié Birkholtz. (2016) Resisting resistance: is there a solution for malaria?. Expert Opinion on Drug Discovery 11:4, pages 395-406.
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David Abasiwani Alagpulinsa, Shmuel Yaccoby, Srinivas Ayyadevara & Robert Joseph Shmookler Reis. (2015) A peptide nucleic acid targeting nuclear RAD51 sensitizes multiple myeloma cells to melphalan treatment. Cancer Biology & Therapy 16:6, pages 976-986.
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Luigi Fiume. (2014) Comment on: Targeting homologous recombination-mediated DNA repair in cancer. Expert Opinion on Therapeutic Targets 18:7, pages 833-833.
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Articles from other publishers (31)

Indu Kohaar, Xijun Zhang, Shyh-Han Tan, Darryl Nousome, Kevin Babcock, Lakshmi Ravindranath, Gauthaman Sukumar, Elisa Mcgrath-Martinez, John Rosenberger, Camille Alba, Amina Ali, Denise Young, Yongmei Chen, Jennifer Cullen, Inger L. Rosner, Isabell A. Sesterhenn, Albert Dobi, Gregory Chesnut, Clesson Turner, Clifton Dalgard, Matthew D. Wilkerson, Harvey B. Pollard, Shiv Srivastava & Gyorgy Petrovics. (2022) Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes. Nature Communications 13:1.
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Muhammad Ayaz Farid Shah, Sami Ud Din & Asghar Ali Shah. (2021) Analysis of Machine Learning Techniques for Detection Framework for DNA Repair Genes to help Diagnose Cancer: A Systematic Literature Review. Analysis of Machine Learning Techniques for Detection Framework for DNA Repair Genes to help Diagnose Cancer: A Systematic Literature Review.
Matthews M. Malka, Julia Eberle, Kathrin Niedermayer, Darius P. Zlotos & Lisa Wiesmüller. (2021) Dual PARP and RAD51 Inhibitory Drug Conjugates Show Synergistic and Selective Effects on Breast Cancer Cells. Biomolecules 11:7, pages 981.
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Marjolijn M. Ladan, Dik C. van Gent & Agnes Jager. (2021) Homologous Recombination Deficiency Testing for BRCA-Like Tumors: The Road to Clinical Validation. Cancers 13:5, pages 1004.
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Xiaolan Zhu, Xiangyu Wang, Wei Yan, Haibo Yang, Yufei Xiang, Fengping Lv, Yi Shi, Hong-yu Li & Li Lan. (2021) Ubiquitination-mediated degradation of TRDMT1 regulates homologous recombination and therapeutic response. NAR Cancer 3:1.
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Andrea Balboni, Marzia Govoni, Valentina Rossi, Marinella Roberti, Andrea Cavalli, Giuseppina Di Stefano & Marcella Manerba. (2021) Lactate dehydrogenase inhibition affects homologous recombination repair independently of cell metabolic asset; implications for anticancer treatment. Biochimica et Biophysica Acta (BBA) - General Subjects 1865:1, pages 129760.
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Sergio O. Angel, Laura Vanagas, Diego M. Ruiz, Constanza Cristaldi, Ana M. Saldarriaga Cartagena & William J. SullivanJr.Jr.. (2020) Emerging Therapeutic Targets Against Toxoplasma gondii: Update on DNA Repair Response Inhibitors and Genotoxic Drugs. Frontiers in Cellular and Infection Microbiology 10.
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Erik Laurini, Domenico Marson, Alice Fermeglia, Suzana Aulic, Maurizio Fermeglia & Sabrina Pricl. (2020) Role of Rad51 and DNA repair in cancer: A molecular perspective. Pharmacology & Therapeutics 208, pages 107492.
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Dalton R. Gibbs & Soma Dhakal. (2019) Homologous Recombination under the Single-Molecule Fluorescence Microscope. International Journal of Molecular Sciences 20:23, pages 6102.
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Nathalie van den Tempel, Alex Zelensky, Hanny Odijk, Charlie Laffeber, Christine Schmidt, Inger Brandsma, Jeroen Demmers, Przemek Krawczyk & Roland Kanaar. (2019) On the Mechanism of Hyperthermia-Induced BRCA2 Protein Degradation. Cancers 11:1, pages 97.
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Pavel Vodicka, Ludovit Musak, Ludmila Vodickova, Sona Vodenkova, Calogerina Catalano, Michal Kroupa, Alessio Naccarati, Zdena Polivkova, Veronika Vymetalkova, Asta Försti & Kari Hemminki. (2018) Genetic variation of acquired structural chromosomal aberrations. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 836, pages 13-21.
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Anika Trenner, Julia Godau & Alessandro A. Sartori. (2018) A Short BRCA2-Derived Cell-Penetrating Peptide Targets RAD51 Function and Confers Hypersensitivity toward PARP Inhibition. Molecular Cancer Therapeutics 17:7, pages 1392-1404.
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Hiroshi Kobayashi, Naoki Kawahara, Kenji Ogawa, Yuki Yamada, Kana Iwai, Emiko Niiro & Sachiko Morioka. (2018) Conceptual frameworks of synthetic lethality in clear cell carcinoma of the ovary (Review). Biomedical Reports.
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Min Zhao, Dan-dan Wang, Yuan Che, Meng-qiu Wu, Qing-ran Li, Chang Shao, Yun Wang, Li-juan Cao, Guang-ji Wang & Hai-ping Hao. (2017) Ginsenosides synergize with mitomycin C in combating human non-small cell lung cancer by repressing Rad51-mediated DNA repair. Acta Pharmacologica Sinica 39:3, pages 449-458.
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S. Mazzucchelli, M. Truffi, F. Baccarini, M. Beretta, L. Sorrentino, M. Bellini, M. A. Rizzuto, R. Ottria, A. Ravelli, P. Ciuffreda, D. Prosperi & F. Corsi. (2017) H-Ferritin-nanocaged olaparib: a promising choice for both BRCA-mutated and sporadic triple negative breast cancer. Scientific Reports 7:1.
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Zhibing Wu, Saisai Jing, Yanhong Li, Yabo Gao, Shuhuan Yu, Zhitian Li, Yanyan Zhao, Jigang Piao, Shenglin Ma & Xufeng Chen. (2017) The effects of SAHA on radiosensitivity in pancreatic cancer cells by inducing apoptosis and targeting RAD51. Biomedicine & Pharmacotherapy 89, pages 705-710.
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S Kumar, X Peng, J Daley, L Yang, J Shen, N Nguyen, G Bae, H Niu, Y Peng, H-J Hsieh, L Wang, C Rao, C C Stephan, P Sung, G Ira & G Peng. (2017) Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells. Oncogenesis 6:4, pages e319-e319.
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Xiuli Chen, Dong Qian, Jingjing Cheng, Yong Guan, Bin Zhang, Xiaofeng Ding, Jing Zeng, Xi Chen, Puchun Er, Furong Zhang, Na Zhao, Xiaocen Chen, Lujun Zhao, Zhiyong Yuan, Qingsong Pang & Ping Wang. (2016) High expression of Rad51c predicts poor prognostic outcome and induces cell resistance to cisplatin and radiation in non-small cell lung cancer. Tumor Biology 37:10, pages 13489-13498.
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Ping Wang, Dan Ma, Jishi Wang, Qin Fang, Rui Gao, Weibing Wu, Lu Cao, Xiuying Hu, Jiangyuan Zhao & Yan Li. (2016) INPP4B-mediated DNA repair pathway confers resistance to chemotherapy in acute myeloid leukemia. Tumor Biology 37:9, pages 12513-12523.
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Sarah-Felicitas Himmels & Alessandro A. Sartori. (2016) Controlling DNA-End Resection: An Emerging Task for Ubiquitin and SUMO. Frontiers in Genetics 7.
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Wei Lv, Brian Budke, Michal Pawlowski, Philip P. Connell & Alan P. Kozikowski. (2016) Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51. Journal of Medicinal Chemistry 59:10, pages 4511-4525.
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S.S. Jenkins, S. Mukherjee & W.-D. Heyer. 2016. Encyclopedia of Cell Biology. Encyclopedia of Cell Biology 567 579 .
S.S. Jenkins, S. Mukherjee & W.-D. Heyer. 2016. Encyclopedia of Cell Biology. Encyclopedia of Cell Biology 456 467 .
Jingjing Cheng, Weiran Liu, Xianliang Zeng, Bin Zhang, Yihang Guo, Minghan Qiu, Chao Jiang, Huanhuan Wang, Zhiqiang Wu, Maobin Meng, Hongqing Zhuang, Lujun Zhao, Jihui Hao, Qingqing Cai, Dan Xie, Qingsong Pang, Ping Wang, Zhiyong Yuan & Dong Qian. (2015) XRCC 3 is a promising target to improve the radiotherapy effect of esophageal squamous cell carcinoma . Cancer Science 106:12, pages 1678-1686.
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Michael Tsabar, Jennifer M. Mason, Yuen-Ling Chan, Douglas K. Bishop & James E. Haber. (2015) Caffeine inhibits gene conversion by displacing Rad51 from ssDNA. Nucleic Acids Research 43:14, pages 6902-6918.
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Michael A. McIlhatton, Kevin Murnan, Daniel Carson, Gregory P. Boivin, Carlo M. Croce & Joanna Groden. (2015) Genetic Manipulation of Homologous Recombination In Vivo Attenuates Intestinal Tumorigenesis . Cancer Prevention Research 8:7, pages 650-656.
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Jiewen Zhu, Hongyuan Chen, Xuning Emily Guo, Xiao-Long Qiu, Chun-Mei Hu, A. Richard Chamberlin & Wen-Hwa Lee. (2015) Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors. European Journal of Medicinal Chemistry 96, pages 196-208.
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Chris Fisher. (2015) Recent Insights into the Control of Human Papillomavirus (HPV) Genome Stability, Loss, and Degradation. Journal of Clinical Medicine 4:2, pages 204-230.
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Mrinal Srivastava & Sathees C. Raghavan. (2015) DNA Double-Strand Break Repair Inhibitors as Cancer Therapeutics. Chemistry & Biology 22:1, pages 17-29.
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Ron R Allison. (2014) Radiobiological modifiers in clinical radiation oncology: current reality and future potential. Future Oncology 10:15, pages 2359-2379.
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David A. Alagpulinsa, Srinivas Ayyadevara & Robert Joseph Shmookler Reis. (2014) A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin. Frontiers in Oncology 4.
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