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The therapeutic potential of targeting the epithelial–mesenchymal transition in cancer

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Wenli Mao, Heng Yin, Wenya Chen, Tingxiu Zhao, Shaofeng Wu, He Jin, Biaoyan Du, Yuhui Tan, Ren Zhang & Yanli He. (2020) Network Pharmacology and Experimental Evidence Reveal Dioscin Suppresses Proliferation, Invasion, and EMT via AKT/GSK3b/mTOR Signaling in Lung Adenocarcinoma. Drug Design, Development and Therapy 14, pages 2135-2147.
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Wenting Xu, Zhen Yang & Nonghua Lu. (2015) A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition. Cell Adhesion & Migration 9:4, pages 317-324.
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Sarah Eltahir & Aamir Ahmad. (2023) Flavonoids on the Frontline against Cancer Metastasis. Cancers 15:16, pages 4139.
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Monaza Adeeb, Lubna Therachiyil, Safwan Moton, Joerg Buddenkotte, Majid Ali Alam, Shahab Uddin, Martin Steinhoff & Aamir Ahmad. 2023. Epigenetic Regulation of Cancer - Part A. Epigenetic Regulation of Cancer - Part A 149 171 .
Sheng-Nan Jia, Ying-Bo Han, Rui Yang & Ze-Cheng Yang. (2022) Chemokines in colon cancer progression. Seminars in Cancer Biology 86, pages 400-407.
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Qing-Chao Zhu, Jian-Hua Sun, Ming-Jun Liang, Zheng-Yun Zhang & Yang Xia. (2022) PHF20L1 mediates PAX2 expression to promote angiogenesis and liver metastasis in colorectal cancer through regulating HIC1. Biological Chemistry 403:10, pages 917-928.
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Ying Sun, Yining Jiang, Ying Wang, Pengyue Yu, Xing Su, Yanke Song, Min Wang, Yao Li & Liyan Zhao. (2022) The epithelial-mesenchymal transition of glioma cells promotes tissue factor expression via the miR200a/ZEB1 axis. Brain Research 1778, pages 147782.
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Fang Liu, Zhen-Mei Song, Xiao-Di Wang, Shi-Yu Du, Na Peng, Jing-Rui Zhou & Ming-Gang Zhang. (2021) Long Non-coding RNA Signature for Liver Metastasis of Colorectal Cancers. Frontiers in Cell and Developmental Biology 9.
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Abdul Q. Khan, Sabah Akhtar, Kirti S. Prabhu, Lubna Zarif, Rehan Khan, Majid Alam, Joerg Buddenkotte, Aamir Ahmad, Martin Steinhoff & Shahab Uddin. (2020) Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases. International Journal of Molecular Sciences 21:23, pages 9264.
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Marilisa Cortesi, Chiara Liverani, Laura Mercatali, Toni Ibrahim & Emanuele Giordano. (2020) Computational models to explore the complexity of the epithelial to mesenchymal transition in cancer. WIREs Systems Biology and Medicine 12:6.
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Gye Lim Kim, Eun Hyang Jang, Da-Eun Lee, Chaeeun Bang, Haewon Kang, SooHyeon Kim, So Young Yoon, Do Hyun Lee, Jin Hee Na, Sangmin Lee & Jong-Ho Kim. (2020) Amentoflavone, active compound of Selaginella tamariscina, inhibits in vitro and in vivo TGF-β-induced metastasis of human cancer cells. Archives of Biochemistry and Biophysics 687, pages 108384.
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Zhengguang Zhang, Jingjing Xu, Bing Liu, Feiyan Chen, Jiao Li, Yuchen Liu, Jiapeng Zhu & Cunsi Shen. (2018) Ponicidin inhibits pro-inflammatory cytokine TNF-α-induced epithelial–mesenchymal transition and metastasis of colorectal cancer cells via suppressing the AKT/GSK-3β/Snail pathway. Inflammopharmacology 27:3, pages 627-638.
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Daniel Girardi, Adriana Barrichello, Gustavo Fernandes & Allan Pereira. (2019) Targeting the Hedgehog Pathway in Cancer: Current Evidence and Future Perspectives. Cells 8:2, pages 153.
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Ying-Xue Huang, Hao Song, Yue Tao, Xue-Bao Shao, Xue-Si Zeng, Xiu-Lian Xu, Jin-Liang Qi & Jian-Fang Sun. (2018) Ovostatin 2 knockdown significantly inhibits the growth, migration, and tumorigenicity of cutaneous malignant melanoma cells. PLOS ONE 13:4, pages e0195610.
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Manuel Viotti, Catherine Wilson, Mark McCleland, Hartmut Koeppen, Benjamin Haley, Suchit Jhunjhunwala, Christiaan Klijn, Zora Modrusan, David Arnott, Marie Classon, Jean-Philippe Stephan & Ira Mellman. (2018) SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer. Journal of Cell Biology 217:2, pages 763-777.
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Darong Hong, Min-Ju Park, Eun Hyang Jang, Bom Jung, Nam-Jung Kim & Jong-Ho Kim. (2017) Hispolon as an inhibitor of TGF-β-induced epithelial-mesenchymal transition in human epithelial cancer cells by co-regulation of TGF-β-Snail/Twist axis. Oncology Letters 14:4, pages 4866-4872.
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Min-Ju Park, Da-Eun Lee, Man Kyu Shim, Eun Hyang Jang, Jong Kil Lee, Seo Young Jeong & Jong-Ho Kim. (2017) Piperlongumine inhibits TGF-β-induced epithelial-to-mesenchymal transition by modulating the expression of E-cadherin, Snail1, and Twist1. European Journal of Pharmacology 812, pages 243-249.
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Tanaya WalimbeAlyssa PanitchM. Preeti Sivasankar. (2017) An in vitro scaffold-free epithelial-fibroblast coculture model for the larynx. The Laryngoscope 127:6, pages E185-E192.
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H. Zubair & A. Ahmad. 2017. Introduction to Cancer Metastasis. Introduction to Cancer Metastasis 3 12 .
Christine-Maria Horejs. (2016) Basement membrane fragments in the context of the epithelial-to-mesenchymal transition. European Journal of Cell Biology 95:11, pages 427-440.
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Simona Dinicola, Gianmarco Fabrizi, Maria Grazia Masiello, Sara Proietti, Alessandro Palombo, Mirko Minini, Abdel Halim Harrath, Saleh H. Alwasel, Giulia Ricci, Angela Catizone, Alessandra Cucina & Mariano Bizzarri. (2016) Inositol induces mesenchymal-epithelial reversion in breast cancer cells through cytoskeleton rearrangement. Experimental Cell Research 345:1, pages 37-50.
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Vivek Mittal. 2016. Lung Cancer and Personalized Medicine: Novel Therapies and Clinical Management. Lung Cancer and Personalized Medicine: Novel Therapies and Clinical Management 37 56 .
Monica Faronato, Van T.M. Nguyen, Darren K. Patten, Ylenia Lombardo, Jennifer H. Steel, Naina Patel, Laura Woodley, Sami Shousha, Giancarlo Pruneri, R. Charles Coombes & Luca Magnani. (2015) DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through notch hyper-activation. Oncotarget 6:26, pages 22467-22479.
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Kaja Lund, Jennifer L. Dembinski, Nina Solberg, Alfonso Urbanucci, Ian G. Mills & Stefan Krauss. (2015) Slug-Dependent Upregulation of L1CAM Is Responsible for the Increased Invasion Potential of Pancreatic Cancer Cells following Long-Term 5-FU Treatment. PLOS ONE 10:4, pages e0123684.
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Teneale A. Stewart, Iman Azimi, Erik W. Thompson, Sarah J. Roberts-Thomson & Gregory R. Monteith. (2015) A role for calcium in the regulation of ATP-binding cassette, sub-family C, member 3 (ABCC3) gene expression in a model of epidermal growth factor-mediated breast cancer epithelial–mesenchymal transition. Biochemical and Biophysical Research Communications 458:3, pages 509-514.
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Rui Du, Shanshan Wu, Xiaoning Lv, Henghu Fang, Sudong Wu & Jingbo Kang. (2014) Overexpression of brachyury contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma. Journal of Experimental & Clinical Cancer Research 33:1.
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