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Targeting Hsp90 and its co-chaperones to treat Alzheimer’s disease

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Heike Fuhrmann-Stroissnigg, Laura J. Niedernhofer & Paul D. Robbins. (2018) Hsp90 inhibitors as senolytic drugs to extend healthy aging. Cell Cycle 17:9, pages 1048-1055.
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Allison A. Dilliott, Catherine M. Andary, Meaghan Stoltz, Andrey A. Petropavlovskiy, Sali M. K. Farhan & Martin L. Duennwald. (2022) DnaJC7 in Amyotrophic Lateral Sclerosis. International Journal of Molecular Sciences 23:8, pages 4076.
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Lei Wang, Qiuyue Zhang & Qidong You. (2021) Targeting the HSP90–CDC37–kinase chaperone cycle: A promising therapeutic strategy for cancer. Medicinal Research Reviews 42:1, pages 156-182.
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Marangelie Criado-Marrero, Niat T. Gebru, Danielle M. Blazier, Lauren A. Gould, Jeremy D. Baker, David Beaulieu-Abdelahad & Laura J. Blair. (2021) Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice. Acta Neuropathologica Communications 9:1.
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Zhiqiang Hou, Pawel M. Wydorski, Valerie A. Perez, Aydé Mendoza-Oliva, Bryan D. Ryder, Hilda Mirbaha, Omar Kashmer & Lukasz A. Joachimiak. (2021) DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation. Nature Communications 12:1.
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Beena Hasan, Ayesha Khan, Christof Lenz, Abdul R. Asif & Nikhat Ahmed. (2021) Characterization of functional protein complexes from Alzheimer’s disease and healthy brain by mass spectrometry-based proteome analysis. Scientific Reports 11:1.
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Françoise A. Dekker & Stefan G. D. Rüdiger. (2021) The Mitochondrial Hsp90 TRAP1 and Alzheimer’s Disease. Frontiers in Molecular Biosciences 8.
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Rajib Das, Abdur Rauf, Saima Akhter, Mohammad Nazmul Islam, Talha Bin Emran, Saikat Mitra, Ishaq N. Khan & Mohammad S. Mubarak. (2021) Role of Withaferin A and Its Derivatives in the Management of Alzheimer’s Disease: Recent Trends and Future Perspectives. Molecules 26:12, pages 3696.
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Yusuf Oloruntoyin Ayipo, Mohd Nizam Mordi, Muzaimi Mustapha & Thenmoly Damodaran. (2021) Neuropharmacological potentials of β-carboline alkaloids for neuropsychiatric disorders. European Journal of Pharmacology 893, pages 173837.
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Antonio Dominguez-Meijide, Eftychia Vasili & Tiago Fleming Outeiro. (2020) Pharmacological Modulators of Tau Aggregation and Spreading. Brain Sciences 10:11, pages 858.
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Vanessa J. Ibarra-Bracamontes, Jaime Escobar-Herrera, Zdena Kristofikova, Daniela Rípova, Benjamín Florán-Garduño & Francisco Garcia-Sierra. (2020) Early but not late conformational changes of tau in association with ubiquitination of neurofibrillary pathology in Alzheimer’s disease brains. Brain Research 1744, pages 146953.
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Marta Lualdi, Tiziana Alberio & Mauro Fasano. (2020) Proteostasis and Proteotoxicity in the Network Medicine Era. International Journal of Molecular Sciences 21:17, pages 6405.
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Li Li, Lei Wang, Qi-Dong You & Xiao-Li Xu. (2019) Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions. Journal of Medicinal Chemistry 63:5, pages 1798-1822.
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Alexandra Rehn, Jannis Lawatscheck, Marie-Lena Jokisch, Sophie L. Mader, Qi Luo, Franziska Tippel, Birgit Blank, Klaus Richter, Kathrin Lang, Ville R. I. Kaila & Johannes Buchner. (2020) A methylated lysine is a switch point for conformational communication in the chaperone Hsp90. Nature Communications 11:1.
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Xia Sun, YueHao Yin, Lingchao Kong, Wei Chen, Changhong Miao & Jiawei Chen. (2019) The effect of propofol on hypoxia-modulated expression of heat shock proteins: potential mechanism in modulating blood–brain barrier permeability. Molecular and Cellular Biochemistry 462:1-2, pages 85-96.
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Dominique Thuringer & Carmen Garrido. (2019) Molecular chaperones in the brain endothelial barrier: neurotoxicity or neuroprotection?. The FASEB Journal 33:11, pages 11629-11639.
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Meenakshisundaram Balasubramaniam, Srinivas Ayyadevara, Akshatha Ganne, Samuel Kakraba, Narsimha Reddy Penthala, Xiuxia Du, Peter A. Crooks, Sue T. Griffin & Robert J. Shmookler Reis. (2019) Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases. iScience 20, pages 248-264.
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