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Targeting tumor invasion: the roles of MDA-9/Syntenin

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Yizhi Peng, Sheng Yin & Min Wang. (2021) Extracellular vesicles of bacteria as potential targets for immune interventions. Human Vaccines & Immunotherapeutics 17:3, pages 897-903.
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Joanna Fares, Rudra Kashyap & Pascale Zimmermann. (2017) Syntenin: Key player in cancer exosome biogenesis and uptake?. Cell Adhesion & Migration 11:2, pages 124-126.
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Roger Carles-Fontana, Nigel Heaton, Elena Palma & Shirin Khorsandi. (2022) Extracellular Vesicle-Mediated Mitochondrial Reprogramming in Cancer. Cancers 14:8, pages 1865.
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Ding Ma, Shuwen Liu, Lili Hu, Qinyu He, Weiwei Shi, Dongliang Yan, Yin Cao, Guang Zhang, Zhongxia Wang, Junhua Wu & Chunping Jiang. (2021) Single‐cell RNA sequencing identify SDCBP in ACE2‐positive bronchial epithelial cells negatively correlates with COVID‐19 severity. Journal of Cellular and Molecular Medicine 25:14, pages 7001-7012.
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Anjan K. PradhanSantanu Maji, Praveen BhoopathiSarmistha TalukdarPadmanabhan MannangattiChunqing GuoXiang-Yang Wang, Lorraine Colon Cartagena, Michael IdowuJoseph W. Landry, Devanand Sarkar, Luni EmdadWebster K. Cavenee, Swadesh K. Das & Paul B. Fisher. (2021) Pharmacological inhibition of MDA-9/Syntenin blocks breast cancer metastasis through suppression of IL-1β. Proceedings of the National Academy of Sciences 118:21.
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Linda M. Haugaard-Kedström, Louise S. Clemmensen, Vita Sereikaite, Zeyu Jin, Eduardo F. A. Fernandes, Bianca Wind, Flor Abalde-Gil, Jan Daberger, Maria Vistrup-Parry, Diana Aguilar-Morante, Raphael Leblanc, Antonio L. Egea-Jimenez, Marte Albrigtsen, Kamilla. E. Jensen, Thomas M. T. Jensen, Ylva Ivarsson, Renaud Vincentelli, Petra Hamerlik, Jeanette Hammer Andersen, Pascale Zimmermann, Weontae Lee & Kristian Strømgaard. (2021) A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma. Journal of Medicinal Chemistry 64:3, pages 1423-1434.
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Pengyong Luo, Xuli Yang, Shiren Huang, Shu Feng & Zongxing Ou. (2020) Syntenin overexpression in human lung cancer tissue and serum is associated with poor prognosis. BMC Cancer 20:1.
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R. Leblanc, R. Kashyap, K. Barral, A.L. Egea‐Jimenez, D. Kovalskyy, M. Feracci, M. Garcia, C. Derviaux, S. Betzi, R. Ghossoub, M. Platonov, P. Roche, X. Morelli, L. Hoffer & Pascale Zimmermann. (2020) Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loading with syndecan and EpCAM cargo. Journal of Extracellular Vesicles 10:2.
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Anjan K. Pradhan, Santanu Maji, Swadesh K. Das, Luni Emdad, Devanand Sarkar & Paul B. Fisher. (2020) MDA-9/Syntenin/SDCBP: new insights into a unique multifunctional scaffold protein. Cancer and Metastasis Reviews 39:3, pages 769-781.
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Swadesh K. Das, Timothy P. Kegelman, Anjan K. Pradhan, Xue-Ning Shen, Praveen Bhoopathi, Sarmistha Talukdar, Santanu Maji, Devanand Sarkar, Luni Emdad & Paul B. Fisher. (2019) Suppression of Prostate Cancer Pathogenesis Using an MDA-9/Syntenin (SDCBP) PDZ1 Small-Molecule Inhibitor. Molecular Cancer Therapeutics 18:11, pages 1997-2007.
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Marie Lafitte, Céline Lecointre & Serge Roche. (2019) Roles of exosomes in metastatic colorectal cancer. American Journal of Physiology-Cell Physiology 317:5, pages C869-C880.
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Olivia Majer, Bo Liu, Lieselotte S. M. Kreuk, Nevan Krogan & Gregory M. Barton. (2019) UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity. Nature 575:7782, pages 366-370.
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Praveen Bhoopathi, Anjan K. Pradhan, Manny D. Bacolod, Luni Emdad, Devanand Sarkar, Swadesh K. Das & Paul B. Fisher. (2019) Regulation of neuroblastoma migration, invasion, and in vivo metastasis by genetic and pharmacological manipulation of MDA-9/Syntenin. Oncogene 38:41, pages 6781-6793.
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Tadayuki Shimada, Shin Yasuda, Hiroko Sugiura & Kanato Yamagata. (2019) Syntenin: PDZ Protein Regulating Signaling Pathways and Cellular Functions. International Journal of Molecular Sciences 20:17, pages 4171.
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Jianbo Yang, Matthew A. Price, Leah E.C. Wanshura, Jinsong He, Mei Yi, Danny R. Welch, Guiyuan Li, Sean Conner, Jonathan Sachs, Eva A. Turley & James B. McCarthy. (2019) Chondroitin sulfate proteoglycan 4 enhanced melanoma motility and growth requires a cysteine in the core protein transmembrane domain. Melanoma Research 29:4, pages 365-375.
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Croce, Ferrini, Pfeffer & Gangemi. (2019) Targeted Therapy of Uveal Melanoma: Recent Failures and New Perspectives. Cancers 11:6, pages 846.
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Shelian Lu & Qunyuan Xu. (2018) MicroRNA‐23a inhibits melanoma cell proliferation, migration, and invasion in mice through a negative feedback regulation of sdcbp and the MAPK/ERK signaling pathway. IUBMB Life 71:5, pages 587-600.
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Nikolaj R. Christensen, Jelena Čalyševa, Eduardo F. A. Fernandes, Susanne Lüchow, Louise S. Clemmensen, Linda M. Haugaard‐Kedström & Kristian Strømgaard. (2019) PDZ Domains as Drug Targets. Advanced Therapeutics, pages 1800143.
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Xu Liu & Ernesto J. Fuentes. 2019. 129 218 .
Swadesh K. Das, Devanand Sarkar, Luni Emdad & Paul B. Fisher. 2019. 137 191 .
Uljana A. Boyarskikh, Alexandra S. Shadrina, Mariya A. Smetanina, Yakov A. Tsepilov, Igor P. Oscorbin, Vadim V. Kozlov, Alexander E. Kel & Maxim L. Filipenko. (2018) Mycoplasma hyorhinis reduces sensitivity of human lung carcinoma cells to Nutlin-3 and promotes their malignant phenotype. Journal of Cancer Research and Clinical Oncology 144:7, pages 1289-1300.
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Swadesh K. Das, Anjan K. Pradhan, Praveen Bhoopathi, Sarmistha Talukdar, Xue-Ning Shen, Devanand Sarkar, Luni Emdad & Paul B. Fisher. (2018) The MDA-9/Syntenin/IGF1R/STAT3 Axis Directs Prostate Cancer Invasion. Cancer Research 78:11, pages 2852-2863.
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Sarmistha TalukdarAnjan K. PradhanPraveen BhoopathiXue-Ning ShenLaura A. AugustJolene J. WindleDevanand SarkarFrank B. Furnari, Webster K. Cavenee, Swadesh K. DasLuni EmdadPaul B. Fisher. (2018) MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells. Proceedings of the National Academy of Sciences 115:22, pages 5768-5773.
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Malika Foy, Océane Anézo, Simon Saule & Nathalie Planque. (2017) PRL-3/PTP4A3 phosphatase regulates integrin β1 in adhesion structures during migration of human ocular melanoma cells. Experimental Cell Research 353:2, pages 88-99.
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Timothy P. KegelmanBainan WuSwadesh K. DasSarmistha TalukdarJason M. BecktaBin HuLuni EmdadKristoffer ValerieDevanand SarkarFrank B. FurnariWebster K. CaveneeJun WeiAngela PurvesSurya K. De, Maurizio Pellecchia & Paul B. Fisher. (2016) Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/Syntenin. Proceedings of the National Academy of Sciences 114:2, pages 370-375.
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Linda Gräßel, Laura Aline Fast, Konstanze D. Scheffer, Fatima Boukhallouk, Gilles A. Spoden, Stefan Tenzer, Klaus Boller, Ruzica Bago, Sundaresan Rajesh, Michael Overduin, Fedor Berditchevski & Luise Florin. (2016) The CD63-Syntenin-1 Complex Controls Post-Endocytic Trafficking of Oncogenic Human Papillomaviruses. Scientific Reports 6:1.
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Sarmistha Talukdar, Swadesh K. Das, Anjan K. Pradhan, Luni Emdad, Xue-Ning Shen, Jolene J. Windle, Devanand Sarkar & Paul B. Fisher. (2016) Novel function of MDA-9/Syntenin (SDCBP) as a regulator of survival and stemness in glioma stem cells. Oncotarget 7:34, pages 54102-54119.
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Swadesh K. Das, Chunqing Guo, Anjan K. Pradhan, Praveen Bhoopathi, Sarmistha Talukdar, Xue-Ning Shen, Luni Emdad, Mark A. Subler, Jolene J. Windle, Devanand Sarkar, Xiang-Yang Wang & Paul B. Fisher. (2016) Knockout of MDA-9/Syntenin (SDCBP) expression in the microenvironment dampens tumor-supporting inflammation and inhibits melanoma metastasis. Oncotarget 7:30, pages 46848-46861.
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Lu Lu, Ashutosh K. Pandey, M. Trevor Houseal & Megan K. Mulligan. (2016) The Genetic Architecture of Murine Glutathione Transferases. PLOS ONE 11:2, pages e0148230.
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John R Couchman, Hinke Multhaupt & Ralph D. Sanderson. (2016) Recent Insights into Cell Surface Heparan Sulphate Proteoglycans and Cancer. F1000Research 5, pages 1541.
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Sarah Garrido‐Urbani, Pankaj Garg, Rania Ghossoub, Roland Arnold, Frédérique Lembo, Gustav N. Sundell, Philip M. Kim, Marc Lopez, Pascale Zimmermann, Sachdev S. Sidhu & Ylva Ivarsson. (2016) Proteomic peptide phage display uncovers novel interactions of the PDZ1‐2 supramodule of syntenin. FEBS Letters 590:1, pages 3-12.
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Véronique Friand, Guido David & Pascale Zimmermann. (2015) Syntenin and syndecan in the biogenesis of exosomes. Biology of the Cell 107:10, pages 331-341.
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Manny D. Bacolod, Swadesh K. Das, Upneet K. Sokhi, Steven Bradley, David A. Fenstermacher, Maurizio Pellecchia, Luni Emdad, Devanand Sarkar & Paul B. Fisher. 2015. 49 121 .

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