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Review

Targeting microRNAs in epithelial-to-mesenchymal transition-induced cancer stem cells: therapeutic approaches in cancer

(Assistant Professor)

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Claudia Burz, Andreea Rosca, Vlad-Vasile Pop, Rares Buiga, Cornel Aldea, Gabriel Samasca, Ciprian Silaghi, Daniel Sur, Iulia Lupan & Andreea Pricopie. (2019) Liquid biopsy challenge and hope in colorectal cancer. Expert Review of Molecular Diagnostics 19:4, pages 341-348.
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Minal Garg. (2018) Epithelial plasticity and metastatic cascade. Expert Opinion on Therapeutic Targets 22:1, pages 5-7.
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Zhen-Jun Zhao & Jun Shen. (2017) Circular RNA participates in the carcinogenesis and the malignant behavior of cancer . RNA Biology 14:5, pages 514-521.
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Roberta Rosa, Valentina D’Amato, Sabino De Placido & Roberto Bianco. (2016) Approaches for targeting cancer stem cells drug resistance. Expert Opinion on Drug Discovery 11:12, pages 1201-1212.
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Ulrike Erb & Margot Zöller. (2016) Progress and potential of exosome analysis for early pancreatic cancer detection. Expert Review of Molecular Diagnostics 16:7, pages 757-767.
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Articles from other publishers (47)

Shimen Gevargiz Sangar, Negar Agahi, Alireza Azizi, Nikoo Sadat Hasheminezhad, Emad Ghannad, Parmida Nafei & Mohammad Moeen Babayi. (2023) In Vivo Stem Cell Discoveries: Promising Implications in Cancer Therapy. Journal of Lab Animal Research 2:5, pages 23-32.
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Khalid Rashid, Aqeel Ahmad, Semmal Syed Meerasa, Abdul Q. Khan, Xiaobo Wu, Li Liang, Yuehong Cui & Tianshu Liu. (2023) Cancer stem cell-derived exosome-induced metastatic cancer: An orchestra within the tumor microenvironment. Biochimie 212, pages 1-11.
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Kiran Tripathi, Niharika Maurya, Apul Goel, Atin Singhai & Minal Garg. (2022) Immunohistochemical expressions of EMT markers in pan-RAS–pERK1/2-positive tumors improve diagnosis and prognosis assessment of non-muscle invasive bladder cancer and muscle invasive bladder cancer patients. Molecular and Cellular Biochemistry 478:6, pages 1169-1190.
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AV Timofeeva, IS Fedorov, AM Tarasova, KA Gorina, YuV Suhova, VA Gusar & TYu Ivanets. (2022) Role of clusterin in predicting development of early- and late-onset preeclampsia in the first trimester of pregnancy. Bulletin of Russian State Medical University:2022(6).
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Narges Hosseini Nasab, Yohan Han, Fahad Hassan Shah, Balasaheb D. Vanjare & Song Ja Kim. (2022) Synthesis, Biological Evaluation, Migratory Inhibition and Docking Study of Indenopyrazolones as Potential Anticancer Agents. Chemistry & Biodiversity 19:9.
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Ankit Banik, Rishika Sharma, Akansha Chauhan & Sandhya Singh. (2022) Cutting the umbilical cord: Cancer stem cell-targeted therapeutics. Life Sciences 299, pages 120502.
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Vladimir I. Vashchenko, Juliya E. Romashova & Petr D. Shabanov. (2021) Pathophysiology of miR-146a in lung cancer. Prospects of rising of efficiency of targeted therapy. Reviews on Clinical Pharmacology and Drug Therapy 19:4, pages 359-381.
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Bing Dong, Shiyu Li, Shuangli Zhu, Ming Yi, Suxia Luo & Kongming Wu. (2021) MiRNA-mediated EMT and CSCs in cancer chemoresistance. Experimental Hematology & Oncology 10:1.
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Yong ZhangLi JiangNianqun QinMi CaoXiujuan LiangRensheng Wang. (2021) hCINAP is potentially a direct target gene of HIF-1 and is required for hypoxia-induced EMT and apoptosis in cervical cancer cells. Biochemistry and Cell Biology 99:2, pages 203-213.
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Angelika V. Timofeeva, Ivan S. Fedorov, Mariya M. Pirogova, Oksana N. Vasilchenko, Vitaliy V. Chagovets, Larisa S. Ezhova, Tatiana M. Zabelina, Roman G. Shmakov & Gennadiy T. Sukhikh. (2021) Clusterin and Its Potential Regulatory microRNAs as a Part of Secretome for the Diagnosis of Abnormally Invasive Placenta: Accreta, Increta, and Percreta Cases. Life 11:4, pages 270.
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Sijia Duan, Xuliang Luo, Huihui Zeng, Xiang Zhan & Chunlei Yuan. (2020) SNORA71B promotes breast cancer cells across blood–brain barrier by inducing epithelial-mesenchymal transition. Breast Cancer 27:6, pages 1072-1081.
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Minghua Bai, Yiping Dong, Congya Zhou, Xiao Sun, Jinlu Ma & Suxia Han. (2020) Effect of miR-196a inhibition on esophageal cancer growth in vitro. Anti-Cancer Drugs 31:2, pages 169-176.
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Amira Abugomaa, Mohamed Elbadawy, Hideyuki Yamawaki, Tatsuya Usui & Kazuaki Sasaki. (2020) Emerging Roles of Cancer Stem Cells in Bladder Cancer Progression, Tumorigenesis, and Resistance to Chemotherapy: A Potential Therapeutic Target for Bladder Cancer. Cells 9:1, pages 235.
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Hao-Ran Sun, Shun Wang, Shi-Can Yan, Yu Zhang, Peter J. Nelson, Hu-Liang Jia, Lun-Xiu Qin & Qiong-Zhu Dong. (2019) Therapeutic Strategies Targeting Cancer Stem Cells and Their Microenvironment. Frontiers in Oncology 9.
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Xuan Zhu, Lijie Chen, Ling Liu & Xing Niu. (2019) EMT-Mediated Acquired EGFR-TKI Resistance in NSCLC: Mechanisms and Strategies. Frontiers in Oncology 9.
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Aynaz Mihanfar, Javad Aghazadeh Attari, Iraj Mohebbi, Maryam Majidinia, Mojtaba Kaviani, Mehdi Yousefi & Bahman Yousefi. (2018) Ovarian cancer stem cell: A potential therapeutic target for overcoming multidrug resistance. Journal of Cellular Physiology 234:4, pages 3238-3253.
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Gang Zhou, Olivier Latchoumanin, Lionel Hebbard, Wei Duan, Christopher Liddle, Jacob George & Liang Qiao. (2018) Aptamers as targeting ligands and therapeutic molecules for overcoming drug resistance in cancers. Advanced Drug Delivery Reviews 134, pages 107-121.
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Zhe Wang, Kun Zhao, Thilo Hackert & Margot Zöller. (2018) CD44/CD44v6 a Reliable Companion in Cancer-Initiating Cell Maintenance and Tumor Progression. Frontiers in Cell and Developmental Biology 6.
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Zhihong Cai, Yijing Cao, Yichen Luo, Haobin Hu & Hui Ling. (2018) Signalling mechanism(s) of epithelial–mesenchymal transition and cancer stem cells in tumour therapeutic resistance. Clinica Chimica Acta 483, pages 156-163.
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Xinwei Yun, Keqiang Zhang, Jinhui Wang, Rajendra P. Pangeni, Lu Yang, Melissa Bonner, Jun Wu, Jami Wang, Isaac K. Nardi, Ming Gao & Dan J. Raz. (2018) Targeting USP22 Suppresses Tumorigenicity and Enhances Cisplatin Sensitivity Through ALDH1A3 Downregulation in Cancer-Initiating Cells from Lung Adenocarcinoma. Molecular Cancer Research 16:7, pages 1161-1171.
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Zhiqiang Ma, Zhenlong Xin, Wei Hu, Shuai Jiang, Zhi Yang, Xiaolong Yan, Xiaofei Li, Yang Yang & Fulin Chen. (2018) Forkhead box O proteins: Crucial regulators of cancer EMT. Seminars in Cancer Biology 50, pages 21-31.
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Kinan Drak Alsibai & Didier Meseure. (2018) Tumor microenvironment and noncoding RNAs as co-drivers of epithelial-mesenchymal transition and cancer metastasis. Developmental Dynamics 247:3, pages 405-431.
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Margot Zöller. (2018) Janus-Faced Myeloid-Derived Suppressor Cell Exosomes for the Good and the Bad in Cancer and Autoimmune Disease. Frontiers in Immunology 9.
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Zhiping Liu, Weijiao Zhan, Minzhi Zeng, Jinghong Chen, Huyong Zou & Zhiqun Min. (2017) Enhanced functional properties of human limbal stem cells by inhibition of the miR-31/FIH-1/P21 axis. Acta Ophthalmologica 95:6, pages e495-e502.
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Antoine Legras, Nicolas Pécuchet, Sandrine Imbeaud, Karine Pallier, Audrey Didelot, Hélène Roussel, Laure Gibault, Elizabeth Fabre, Françoise Le Pimpec-Barthes, Pierre Laurent-Puig & Hélène Blons. (2017) Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer. Cancers 9:12, pages 101.
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Xiaodong Wang, Ran Wang, Fenghuan Li, Yuan Wu, Yu Liu & Wenfang Zhang. (2017) Relationship between miR-21 and miR-182 levels in peripheral blood and gastric cancer tissue. Oncology Letters 14:2, pages 1427-1432.
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Chang Dong Yeo, Nahyeon Kang, Su Yeon Choi, Bit Na Kim, Chan Kwon Park, Jin Woo Kim, Young Kyoon Kim & Seung Joon Kim. (2017) The role of hypoxia on the acquisition of epithelial-mesenchymal transition and cancer stemness: a possible link to epigenetic regulation. The Korean Journal of Internal Medicine 32:4, pages 589-599.
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Hui Pang & Xiuying Yue. (2017) MiR-205 serves as a prognostic factor and suppresses proliferation and invasion by targeting insulin-like growth factor receptor 1 in human cervical cancer. Tumor Biology 39:6, pages 101042831770130.
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Carlos Palma Flores, Ra�l Garc�a-V�zquez, Dolores Gallardo Rinc�n, Erika Ruiz-Garc�a, Horacio Astudillo de la Vega, Laurence Marchat, Yarely Salinas Vera & C�sar L�pez-Camarillo. (2017) MicroRNAs driving invasion and metastasis in ovarian cancer: Opportunities for translational medicine (Review). International Journal of Oncology.
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Chi-Cheng Huang, Chien-Min Lin, Yan-Jiun Huang, Li Wei, Lei-Li Ting, Chia-Chun Kuo, Cheyu Hsu, Jeng-Fong Chiou, Alexander T. H. Wu & Wei-Hwa Lee. (2017) Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells. Biotechnology and Applied Biochemistry 64:2, pages 165-173.
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Minal Garg. (2017) Epithelial, mesenchymal and hybrid epithelial/mesenchymal phenotypes and their clinical relevance in cancer metastasis. Expert Reviews in Molecular Medicine 19.
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Yinan Ma, Baofeng Wang, Ya Guo, Yang Zhang, Shan Huang, Xing Bao & Minghua Bai. (2016) Inhibition of miR-196a affects esophageal cancer cell growth in vitro. Biomedicine & Pharmacotherapy 84, pages 22-27.
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Jeong-Yeon Lee & Gu Kong. (2016) Roles and epigenetic regulation of epithelial–mesenchymal transition and its transcription factors in cancer initiation and progression. Cellular and Molecular Life Sciences 73:24, pages 4643-4660.
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Reiner Hoppe, Ping Fan, Florian Büttner, Stefan Winter, Amit K. Tyagi, Heather Cunliffe, V. Craig Jordan & Hiltrud Brauch. (2016) Profiles of miRNAs matched to biology in aromatase inhibitor resistant breast cancer. Oncotarget 7:44, pages 71235-71254.
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Zhen-Hua Wu, Zhong-Hua Tao, Jian Zhang, Ting Li, Chen Ni, Jie Xie, Jin-Feng Zhang & Xi-Chun Hu. (2015) MiRNA-21 induces epithelial to mesenchymal transition and gemcitabine resistance via the PTEN/AKT pathway in breast cancer. Tumor Biology 37:6, pages 7245-7254.
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Yasufumi Matsuda, Koh Miura, Junko Yamane, Hiroshi Shima, Wataru Fujibuchi, Kazuyuki Ishida, Fumiyoshi Fujishima, Shinobu Ohnuma, Hiroyuki Sasaki, Munenori Nagao, Naoki Tanaka, Kennichi Satoh, Takeshi Naitoh & Michiaki Unno. (2016) SERPINI1 regulates epithelial–mesenchymal transition in an orthotopic implantation model of colorectal cancer. Cancer Science 107:5, pages 619-628.
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Chang Xu, Ming'e Li, Lin Zhang, Yueyang Bi, Peiyuan Wang, Jun Li & Xingyue Jiang. (2016) MicroRNA-205 suppresses the invasion and epithelial-mesenchymal transition of human gastric cancer cells. Molecular Medicine Reports.
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Isabel Fabregat, Andrea Malfettone & Jitka Soukupova. (2016) New Insights into the Crossroads between EMT and Stemness in the Context of Cancer. Journal of Clinical Medicine 5:3, pages 37.
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Minal Garg. (2016) Epithelial plasticity in urothelial carcinoma: Current advancements and future challenges. World Journal of Stem Cells 8:8, pages 260.
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Sarah Heiler, Zhe Wang & Margot Zöller. (2016) Pancreatic cancer stem cell markers and exosomes - the incentive push. World Journal of Gastroenterology 22:26, pages 5971.
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Yong Han, Yueyang Bi, Haiyang Bi, Caimei Diao, Guoqiang Zhang, Kai Cheng & Zhenlin Yang. (2015) miR-137 suppresses the invasion and procedure of EMT of human breast cancer cell line MCF-7 through targeting CtBP1. Human Cell 29:1, pages 30-36.
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