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Review

The SIX1-EYA transcriptional complex as a therapeutic target in cancer

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Roméo Sébastien Blanc, Gillian Vogel, Xing Li, Zhenbao Yu, Shawn Li & Stéphane Richard. (2017) Arginine Methylation by PRMT1 Regulates Muscle Stem Cell Fate. Molecular and Cellular Biology 37:3.
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Christina G. Towers & Heide L. Ford. (2016) A tale of two ends. Cell Cycle 15:12, pages 1523-1524.
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Ilaria Rebay. (2016) Multiple Functions of the Eya Phosphotyrosine Phosphatase. Molecular and Cellular Biology 36:5, pages 668-677.
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Articles from other publishers (56)

Arthur R Wolin, Melanie Y Vincent, Taylor Hotz, Stephen C Purdy, Sheera R Rosenbaum, Connor J Hughes, Jessica Y Hsu, Michael U J Oliphant, Brock Armstrong, Veronica Wessells, Marileila Varella-Garcia, Matthew D Galbraith, Angela Pierce, Dong Wang, Sujatha Venkataraman, Etienne Danis, Bethany Veo, Natalie Serkova, Joaquin M Espinosa, Daniel L Gustafson, Rajeev Vibhakar & Heide L Ford. (2023) EYA2 tyrosine phosphatase inhibition reduces MYC and prevents medulloblastoma progression. Neuro-Oncology 25:12, pages 2287-2301.
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Liantao Guo, Faminzi Li, Hanqing Liu, Deguang Kong, Chuang Chen & Shengrong Sun. (2023) SIX1 amplification modulates stemness and tumorigenesis in breast cancer. Journal of Translational Medicine 21:1.
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Priyanka Dey Talukdar & Urmi Chatterji. (2023) Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases. Signal Transduction and Targeted Therapy 8:1.
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Connor J. Hughes, Kaiah M. Fields, Etienne P. Danis, Jessica Y. Hsu, Deepika Neelakantan, Melanie Y. Vincent, Annika L. Gustafson, Michael J. Oliphant, Varsha Sreekanth, Vadym Zaberezhnyy, James C. Costello, Paul Jedlicka & Heide L. Ford. (2023) SIX1 and EWS/FLI1 co-regulate an anti-metastatic gene network in Ewing Sarcoma. Nature Communications 14:1.
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Shuangli Zhu, Wanling Li, Hao Zhang, Yuheng Yan, Qi Mei & Kongming Wu. (2023) Retinal determination gene networks: from biological functions to therapeutic strategies. Biomarker Research 11:1.
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Shuyan Cai, Jianwei Zheng, Huimin Song, Haoliang Wu & Wang Cai. (2023) Relationship between serum TGF- β 1, MMP-9 and IL-1β and pathological features and prognosis in breast cancer. Frontiers in Genetics 13.
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Cory Wilson, Tinne C.J. Mertens, Pooja Shivshankar, Weizen Bi, Scott D. Collum, Nancy Wareing, Junsuk Ko, Tingting Weng, Ram P. Naikawadi, Paul J. Wolters, Pascal Maire, Soma S.K. Jyothula, Rajarajan A. Thandavarayan, Dewei Ren, Nathan D. Elrod, Eric J. Wagner, Howard J. Huang, Burton F. Dickey, Heide L. Ford & Harry Karmouty-Quintana. (2022) Sine oculis homeobox homolog 1 plays a critical role in pulmonary fibrosis. JCI Insight 7:10.
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Reham M. Elhassan, Xuben Hou & Hao Fang. (2021) Recent advances in the development of allosteric protein tyrosine phosphatase inhibitors for drug discovery. Medicinal Research Reviews 42:3, pages 1064-1110.
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Yan Li, Elizabeth YiHui Ng, Ying Ru Loh, Chong Yu Gea, Qiwei Huang, Qingxin Li & CongBao Kang. (2021) Secondary structures, dynamics, and DNA binding of the homeodomain of human SIX1. Journal of Peptide Science 28:4.
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Jia Z. Shen, Zhixin Qiu, Qiulian Wu, Guoxin Zhang, Rebecca Harris, Dahui Sun, Juha Rantala, William D. Barshop, Linjie Zhao, Deguan Lv, Kwang-Ai Won, James Wohlschlegel, Olle Sangfelt, Heike Laman, Jeremy N. Rich & Charles Spruck. (2022) A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells. Molecular Cell 82:6, pages 1123-1139.e8.
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Jothi Anantharajan, Nithya Baburajendran, Grace Lin, Yong Yao Loh, Weijun Xu, Nur Huda Binte Ahmad, Shuang Liu, Anna E. Jansson, John Wee Liang Kuan, Elizabeth Yihui Ng, Yee Khoon Yeo, Alvin W. Hung, Joma Joy, Jeffrey Hill, Heide L. Ford, Rui Zhao, Thomas H. Keller & CongBao Kang. (2021) Structure–activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase . Protein Science 31:2, pages 422-431.
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Pan Tang, Yanyan Shen, Jihui Yang, Nan Wen, Ying Liu, Qiqing Zeng & Tingting Yin. (2022) miR-622 Induces Breast Cancer Cell MCF-7 Proliferation, Migration, and Invasion by Directly Negatively Targeting EYA1. Journal of Nanomaterials 2022, pages 1-10.
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Asma Rafiq, Sabreena Aashaq, Iqra Jan & Mushtaq A. Beigh. (2021) SIX1 transcription factor: A review of cellular functions and regulatory dynamics. International Journal of Biological Macromolecules 193, pages 1151-1164.
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Marwa Mohammed Dawoud, Hayam Abd El Samie Aiad, Eman Abd Elrazeq Tawfiq, Fatma Samir Ali Al-qalashy, Nehad Eissa & Hala Said El-Rebey. (2021) Role of SIX1, EYA2, and E-cadherin in ovarian carcinoma. Evidence on epithelial-mesenchymal transition from an immunohistochemical study. Annals of Diagnostic Pathology 55, pages 151815.
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Ajaz Ahmad Waza, Najeebul Tarfeen, Sabhiya Majid, Yasmeena Hassan, Rashid Mir, Mohd Younis Rather & Naseer Ue Din Shah. (2021) Metastatic Breast Cancer, Organotropism and Therapeutics: A Review. Current Cancer Drug Targets 21:10, pages 813-828.
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Pelin Balcik-Ercin, Laure Cayrefourcq, Rama Soundararajan, Sendurai A. Mani & Catherine Alix-Panabières. (2021) Epithelial-to-Mesenchymal Plasticity in Circulating Tumor Cell Lines Sequentially Derived from a Patient with Colorectal Cancer. Cancers 13:21, pages 5408.
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Jing Wu, Bin HuangHong-Bo He, Wen-Zhu Lu, Wei-Guo Wang & Hong Liu. (2021) Two naturally derived small molecules disrupt the sineoculis homeobox homolog 1–eyes absent homolog 1 (SIX1–EYA1) interaction to inhibit colorectal cancer cell growth. Chinese Medical Journal 134:19, pages 2340-2352.
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Xinguo Lu, Fang Liu, Qiumai Miao, Ping Liu, Yan Gao & Keren He. (2021) A novel method to identify gene interaction patterns. BMC Genomics 22:S1.
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Soledad A Camolotto, Veronika K Belova, Luke Torre-Healy, Jeffery M Vahrenkamp, Kristofer C Berrett, Hannah Conway, Jill Shea, Chris Stubben, Richard Moffitt, Jason Gertz & Eric L Snyder. (2021) Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4α and SIX1/4. Gut 70:5, pages 900-914.
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Fadi Abboodi, Nella C. Delva, Jennifer Emmel, Ariana Renrick, Phillip Buckhaults, Carolyn E. Banister, Kim E. Creek & Lucia Pirisi. (2021) Human papillomavirus-mediated carcinogenesis and tumor progression. Genome Instability & Disease 2:2, pages 71-91.
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Deyu Zhang, Xiaojie Xu & Qinong Ye. (2020) Metabolism and immunity in breast cancer. Frontiers of Medicine 15:2, pages 178-207.
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Deguang Kong, Hengbo Zhou, Deepika Neelakantan, Connor J. Hughes, Jessica Y. Hsu, Ramakrishnan Rajaram Srinivasan, Michael T. Lewis & Heide L. Ford. (2020) VEGF-C mediates tumor growth and metastasis through promoting EMT-epithelial breast cancer cell crosstalk. Oncogene 40:5, pages 964-979.
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Ziliang Wang, Yufei Yang, Shuang Hu, Jian He, Zheng Wu, Zihao Qi, Mingzhu Huang, Rujiao Liu, Ying Lin, Cong Tan, Midie Xu & Zhe Zhang. (2020) Short-form RON (sf-RON) enhances glucose metabolism to promote cell proliferation via activating β-catenin/SIX1 signaling pathway in gastric cancer. Cell Biology and Toxicology 37:1, pages 35-49.
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Qingxin Li & CongBao Kang. (2020) Mechanisms of Action for Small Molecules Revealed by Structural Biology in Drug Discovery. International Journal of Molecular Sciences 21:15, pages 5262.
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Hengbo Zhou, Melanie A. Blevins, Jessica Y. Hsu, Deguang Kong, Matthew D. Galbraith, Andrew Goodspeed, Rachel Culp-Hill, Michael U.J. Oliphant, Dominique Ramirez, Lingdi Zhang, Jennyvette Trinidad-Pineiro, Lesley Mathews Griner, Rebecca King, Elena Barnaeva, Xin Hu, Noel T. Southall, Marc Ferrer, Daniel L. Gustafson, Daniel P. Regan, Angelo D'Alessandro, James C. Costello, Samarjit Patnaik, Juan Marugan, Rui Zhao & Heide L. Ford. (2020) Identification of a Small-Molecule Inhibitor That Disrupts the SIX1/EYA2 Complex, EMT, and Metastasis. Cancer Research 80:12, pages 2689-2702.
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Guangyong Chen, Zhuo Chen & Hang Zhao. (2020) MicroRNA‐155‐3p promotes glioma progression and temozolomide resistance by targeting Six1. Journal of Cellular and Molecular Medicine 24:9, pages 5363-5374.
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Congbao Kang & Thomas H. Keller. (2020) Probing biological mechanisms with chemical tools. Pharmacological Research 153, pages 104656.
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Deguang Kong, Anping Li, Yu Liu, Qiuxia Cui, Kun Wang, Dan Zhang, Jianing Tang, Yaying Du, Zhisu Liu, Gaosong Wu & Kongming Wu. (2019) SIX1 Activates STAT3 Signaling to Promote the Proliferation of Thyroid Carcinoma via EYA1. Frontiers in Oncology 9.
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Alisa A. Suen, Wendy N. Jefferson, Charles E. Wood & Carmen J. Williams. (2019) SIX1 Regulates Aberrant Endometrial Epithelial Cell Differentiation and Cancer Latency Following Developmental Estrogenic Chemical Exposure. Molecular Cancer Research 17:12, pages 2369-2382.
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CongBao Kang. (2019) 19 F-NMR in Target-based Drug Discovery . Current Medicinal Chemistry 26:26, pages 4964-4983.
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Jothi Anantharajan, Hengbo Zhou, Lingdi Zhang, Taylor Hotz, Melanie Y. Vincent, Melanie A. Blevins, Anna E. Jansson, John Wee Liang Kuan, Elizabeth Yihui Ng, Yee Khoon Yeo, Nithya Baburajendran, Grace Lin, Alvin W. Hung, Joma Joy, Samarjit Patnaik, Juan Marugan, Pratyaydipta Rudra, Debashis Ghosh, Jeffrey Hill, Thomas H. Keller, Rui Zhao, Heide L. Ford & CongBao Kang. (2019) Structural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On-Target Effects in Human Lung Cancer Cells. Molecular Cancer Therapeutics 18:9, pages 1484-1496.
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Dan Tang, Lijin Zhao, Cijun Peng, Kaiqiong Ran, Rui Mu & Yu Ao. (2019) LncRNA CRNDE promotes hepatocellular carcinoma progression by upregulating SIX1 through modulating miR‐337‐3p. Journal of Cellular Biochemistry 120:9, pages 16128-16142.
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Yajing Chu, Yangpeng Chen, Mengke Li, Deyang Shi, Bichen Wang, Yu Lian, Xuelian Cheng, Xiaomin Wang, Mingjiang Xu, Tao Cheng, Jun Shi & Weiping Yuan. (2019) Six1 regulates leukemia stem cell maintenance in acute myeloid leukemia . Cancer Science 110:7, pages 2200-2210.
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Xuhui Yang, Hui Zhao, Jing Yang, Yongfu Ma, Zihao Liu, Chenxi Li, Tao Wang, Zhifeng Yan & Nan Du. (2019) MiR-150-5p regulates melanoma proliferation, invasion and metastasis via SIX1-mediated Warburg Effect. Biochemical and Biophysical Research Communications 515:1, pages 85-91.
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Cristina De Lope, Samara Martín-Alonso, Jaione Auzmendi-Iriarte, Carmen Escudero, Isabel Mulet, Javier Larrasa-Alonso, Irene López-Antona, Ander Matheu & Ignacio Palmero. (2019) SIX1 represses senescence and promotes SOX2-mediated cellular plasticity during tumorigenesis. Scientific Reports 9:1.
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Wenxin Song, Jian Ma, Bingbing Lei, Xin Yuan, Binfeng Cheng, Haijie Yang, Mian Wang, Zhiwei Feng & Lei Wang. (2019) Sine oculis homeobox 1 promotes proliferation and migration of human colorectal cancer cells through activation of Wnt/β‐catenin signaling. Cancer Science 110:2, pages 608-616.
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Michael Creed, Rajkumar Baldeosingh, Christian L. Eberly, Caroline S. Schlee, MinJung Kim, Jevon A. Cutler, Akhilesh Pandey, Curt I. Civin, Nancy G. Fossett & Tami J. Kingsbury. (2019) PAX-SIX-EYA-DACH Network modulates GATA-FOG function in fly hematopoiesis and human erythropoiesis. Development.
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Tami J. Kingsbury, MinJung Kim & Curt I. Civin. 2019. Cancer Stem Cells. Cancer Stem Cells 1 42 .
Yuhua Wang, Ram Naresh Pandey, Stephen Riffle, Hemabindu Chintala, Kathryn A. Wikenheiser-Brokamp & Rashmi S. Hegde. (2018) The Protein Tyrosine Phosphatase Activity of Eyes Absent Contributes to Tumor Angiogenesis and Tumor Growth. Molecular Cancer Therapeutics 17:8, pages 1659-1669.
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Rebecca L. Vartuli, Hengbo Zhou, Lingdi Zhang, Rani K. Powers, Jared Klarquist, Pratyaydipta Rudra, Melanie Y. Vincent, Debashis Ghosh, James C. Costello, Ross M. Kedl, Jill E. Slansky, Rui Zhao & Heide L. Ford. (2018) Eya3 promotes breast tumor–associated immune suppression via threonine phosphatase–mediated PD-L1 upregulation. Journal of Clinical Investigation 128:6, pages 2535-2550.
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Lingdi Zhang, Hengbo Zhou, Xueni Li, Rebecca L Vartuli, Michael Rowse, Yongna Xing, Pratyaydipta Rudra, Debashis Ghosh, Rui Zhao & Heide L Ford. (2018) Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression. Nature Communications 9:1.
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John S. Lazo, Kelley E. McQueeney, James C. Burnett, Peter Wipf & Elizabeth R. Sharlow. (2018) Small molecule targeting of PTPs in cancer. The International Journal of Biochemistry & Cell Biology 96, pages 171-181.
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Hengbo Zhou, Lingdi Zhang, Rebecca L. Vartuli, Heide L. Ford & Rui Zhao. (2018) The Eya phosphatase: Its unique role in cancer. The International Journal of Biochemistry & Cell Biology 96, pages 165-170.
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Ali Razaghi, Kirsten Heimann, Patrick M. Schaeffer & Spencer B. Gibson. (2018) Negative regulators of cell death pathways in cancer: perspective on biomarkers and targeted therapies. Apoptosis 23:2, pages 93-112.
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Zhaoming Li, Ran Qiu, Xia Qiu & Tian Tian. (2017) EYA2 promotes lung cancer cell proliferation by downregulating the expression of PTEN. Oncotarget 8:67, pages 110837-110848.
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Zhifeng Wen, Chuansheng Liang, Qichen Pan & Yunjie Wang. (2017) Eya2 overexpression promotes the invasion of human astrocytoma through the regulation of ERK/MMP9 signaling. International Journal of Molecular Medicine 40:5, pages 1315-1322.
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Yingchun Liang, Xiaojie Xu, Tao Wang, Ying Li, Wenye You, Jing Fu, Yang Liu, Shuai Jin, Quanbo Ji, Wei Zhao, Qi Song, Ling Li, Tian Hong, Junjian Huang, Zhaohui Lyu & Qinong Ye. (2017) The EGFR/miR-338-3p/EYA2 axis controls breast tumor growth and lung metastasis. Cell Death & Disease 8:7, pages e2928-e2928.
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Deepika Neelakantan, Hengbo Zhou, Michael U. J. Oliphant, Xiaomei Zhang, Lukas M. Simon, David M. Henke, Chad A. Shaw, Meng-Fen Wu, Susan G. Hilsenbeck, Lisa D. White, Michael T. Lewis & Heide L. Ford. (2017) EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells. Nature Communications 8:1.
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Alisa A. Suen, Wendy N. Jefferson, Charles E. Wood, Elizabeth Padilla-Banks, Victoria L. Bae-Jump & Carmen J. Williams. (2016) SIX1 Oncoprotein as a Biomarker in a Model of Hormonal Carcinogenesis and in Human Endometrial Cancer. Molecular Cancer Research 14:9, pages 849-858.
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Nick Riddiford & Gerhard Schlosser. (2016) Dissecting the pre-placodal transcriptome to reveal presumptive direct targets of Six1 and Eya1 in cranial placodes. eLife 5.
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Deguang Kong, Yu Liu, Qian Liu, Na Han, Cuntai Zhang, Richard G. Pestell, Kongming Wu & Gaosong Wu. (2016) The retinal determination gene network: from developmental regulator to cancer therapeutic target. Oncotarget 7:31, pages 50755-50765.
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Yu Liu, Na Han, Si Zhou, Rong Zhou, Xun Yuan, Hanxiao Xu, Cuntai Zhang, Tiejun Yin & Kongming Wu. (2016) The DACH/EYA/SIX gene network and its role in tumor initiation and progression. International Journal of Cancer 138:5, pages 1067-1075.
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