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Expert Opinion on Therapeutic Targets Volume 19, 2015 - Issue 2
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Original Research

Fenofibrate enhances barrier function of endothelial continuum within the metastatic niche of prostate cancer cells

Katarzyna PiwowarczykJagiellonian University, Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Krakow, [email protected]
,
Ewa WybieralskaJagiellonian University, Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Krakow, [email protected]
,
Jarosław BaranPolish-American Institute of Pediatrics, Jagiellonian University Medical College, Department of Clinical Immunology, Krakow, Poland
,
Julia BorowczykJagiellonian University, Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Laboratory of Tissue Engineering, Krakow, Poland
,
Paulina RybakJagiellonian University, Division of Cell Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Krakow, Poland
,
Milena KosińskaJagiellonian University, Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Krakow, [email protected]
,
Anna Julia WłodarczykCardiff University, School of Biosciences, Cardiff, UK
,
Marta MichalikJagiellonian University, Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Krakow, [email protected]
,
Maciej SiedlarPolish-American Institute of Pediatrics, Jagiellonian University Medical College, Department of Clinical Immunology, Krakow, Poland
,
Zbigniew MadejaJagiellonian University, Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Krakow, [email protected]
,
Jerzy DobruckiJagiellonian University, Division of Cell Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Krakow, Poland
,
Krzysztof ReissSchool of Medicine, Stanley S. Scott Cancer Center, LSU Health Sciences Center, Neurological Cancer Research, New Orleans, USA
&
Jarosław CzyżJagiellonian University, Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Krakow, [email protected]
 show all
Pages 163-176 | Published online: 12 Nov 2014

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Jianguo Sun, Zhibao Zheng, Qi Chen, Yin Pan, Mingming Quan & Yuechu Dai. (2019) Fenofibrate potentiates chemosensitivity to human breast cancer cells by modulating apoptosis via AKT/NF-κB pathway. OncoTargets and Therapy 12, pages 773-783.
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Articles from other publishers (25)

Jin Jin, Xujun Liang, Wu Bi, Ruijie Liu, Sai Zhang, Yi He, Qingming Xie, Shilei Liu, Ji-Chang Xiao & Pengfei Zhang. (2023) Identification of a Difluorinated Alkoxy Sulfonyl Chloride as a Novel Antitumor Agent for Hepatocellular Carcinoma through Activating Fumarate Hydratase Activity. Pharmaceuticals 16:12, pages 1705.
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Jonaid Ahmad Malik, Sakeel Ahmed, Sadiya Sikandar Momin, Sijal Shaikh, Ahmed Alafnan, Jowaher Alanazi, Mohammad Hajaj Said Almermesh & Sirajudheen Anwar. (2022) Drug Repurposing: A New Hope in Drug Discovery for Prostate Cancer. ACS Omega 8:1, pages 56-73.
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Jessica Catapano, Marcin Luty, Tomasz Wróbel, Maciej Pudełek, Katarzyna Piwowarczyk, Sylwia Kędracka-Krok, Maciej Siedlar, Zbigniew Madeja & Jarosław Czyż. (2022) Acquired drug resistance interferes with the susceptibility of prostate cancer cells to metabolic stress. Cellular & Molecular Biology Letters 27:1.
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Versha Tripathi, Pooja Jaiswal, Khageswar Sahu, Shovan Kumar Majumder, Dharmendra Kashyap, Hem Chandra Jha, Amit Kumar Dixit & Hamendra Singh Parmar. (2022) Repurposing of metabolic drugs and mitochondrial modulators as an emerging class of cancer therapeutics with a special focus on breast cancer. Advances in Cancer Biology - Metastasis 6, pages 100065.
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Karolina W. Warzecha, Maciej Pudełek, Jessica Catapano, Zbigniew Madeja & Jarosław Czyż. (2022) Long-Term Fenofibrate Treatment Stimulates the Phenotypic Microevolution of Prostate Cancer Cells In Vitro. Pharmaceuticals 15:11, pages 1320.
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Wei Zhu, Hongyang Zhao, Fenfen Xu, Bin Huang, Xiaojing Dai, Jikui Sun, Alphonce M. K. Nyalali, Kailiang Zhang & Shilei Ni. (2021) The lipid-lowering drug fenofibrate combined with si-HOTAIR can effectively inhibit the proliferation of gliomas. BMC Cancer 21:1.
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Ryota Kikuchi, Yuki Maeda, Takao Tsuji, Kazuhiro Yamaguchi, Shinji Abe, Hiroyuki Nakamura & Kazutetsu Aoshiba. (2021) Fenofibrate inhibits TGF‐β‐induced myofibroblast differentiation and activation in human lung fibroblasts in vitro . FEBS Open Bio 11:8, pages 2340-2349.
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Tomasz Wróbel, Marcin Luty, Jessica Catapano, Elżbieta Karnas, Małgorzata Szczygieł, Katarzyna Piwowarczyk, Damian Ryszawy, Grażyna Drabik, Ewa Zuba-Surma, Maciej Siedlar, Zbigniew Madeja, Martyna Elas & Jarosław Czyż. (2020) CD44+ cells determine fenofibrate-induced microevolution of drug-resistance in prostate cancer cell populations. Stem Cells 38:12, pages 1544-1556.
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Sandra Senkała, Jan Grzegorz Małecki, Marharyta Vasylieva, Aleksandra Łabuz, Katarzyna Nosek, Katarzyna Piwowarczyk, Jarosław Czyż, Ewa Schab-Balcerzak, Henryk Janeczek & Mateusz Korzec. (2020) Hydrolysis of Schiff bases with phenyl-ethynyl-phenyl system: The importance for biological and physicochemical studies. Journal of Photochemistry and Photobiology B: Biology 212, pages 112020.
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Damian Ryszawy, Maciej Pudełek, Paweł Kochanowski, Natalia Janik-Olchawa, Joanna Bogusz, Michał Rąpała, Paulina Koczurkiewicz, Justyna Mikołajczyk, Izabela Borek, Sylwia Kędracka-Krok, Elżbieta Karnas, Ewa Zuba-Surma, Zbigniew Madeja & Jarosław Czyż. (2020) High bisphenol A concentrations augment the invasiveness of tumor cells through Snail-1/Cx43/ERRγ-dependent epithelial-mesenchymal transition. Toxicology in Vitro 62, pages 104676.
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Urszula Gawlik-Dziki, Marcin Luty, Dariusz Dziki, Michał Świeca, Katarzyna Piwowarczyk, Urszula Złotek & Jarosław Czyż. (2019) Cytoprotective Compounds Interfere with the Nutraceutical Potential of Bread Supplemented with Green Coffee Beans. Antioxidants 8:7, pages 228.
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Marcin Luty, Katarzyna Piwowarczyk, Anna Łabędź-Masłowska, Tomasz Wróbel, Małgorzata Szczygieł, Jessica Catapano, Grażyna Drabik, Damian Ryszawy, Sylwia Kędracka-Krok, Zbigniew Madeja, Maciej Siedlar, Martyna Elas & Jarosław Czyż. (2019) Fenofibrate Augments the Sensitivity of Drug-Resistant Prostate Cancer Cells to Docetaxel. Cancers 11:1, pages 77.
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Katarzyna Piwowarczyk, Edyta Kwiecień, Justyna Sośniak, Eliza Zimoląg, Emiliana Guzik, Jolanta Sroka, Zbigniew Madeja & Jarosław Czyż. (2018) Fenofibrate Interferes with the Diapedesis of Lung Adenocarcinoma Cells through the Interference with Cx43/EGF-Dependent Intercellular Signaling. Cancers 10:10, pages 363.
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Milena Paw, Dawid Wnuk, Dominika Kądziołka, Aleksandra Sęk, Sławomir Lasota, Jarosław Czyż, Zbigniew Madeja & Marta Michalik. (2018) Fenofibrate Reduces the Asthma-Related Fibroblast-To-Myofibroblast Transition by TGF-Β/Smad2/3 Signaling Attenuation and Connexin 43-Dependent Phenotype Destabilization. International Journal of Molecular Sciences 19:9, pages 2571.
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Xin Lian, Junlian Gu, Baoshan Gao, Yan Li, Chendil Damodaran, Wei Wei, Yaowen Fu & Lu Cai. (2018) Fenofibrate inhibits mTOR-p70S6K signaling and simultaneously induces cell death in human prostate cancer cells. Biochemical and Biophysical Research Communications 496:1, pages 70-75.
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Jonathan Boucher, Arnaud Monvoisin, Justine Vix, Marc Mesnil, Dominique Thuringer, Françoise Debiais & Laurent Cronier. (2018) Connexins, important players in the dissemination of prostate cancer cells. Biochimica et Biophysica Acta (BBA) - Biomembranes 1860:1, pages 202-215.
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Milena Paw, Izabela Borek, Dawid Wnuk, Damian Ryszawy, Katarzyna Piwowarczyk, Katarzyna Kmiotek, Katarzyna A. Wójcik-Pszczoła, Małgorzata Pierzchalska, Zbigniew Madeja, Marek Sanak, Przemysław Błyszczuk, Marta Michalik & Jarosław Czyż. (2017) Connexin43 Controls the Myofibroblastic Differentiation of Bronchial Fibroblasts from Patients with Asthma. American Journal of Respiratory Cell and Molecular Biology 57:1, pages 100-110.
Crossref
Katarzyna Piwowarczyk, Milena Paw, Damian Ryszawy, Magdalena Rutkowska-Zapała, Zbigniew Madeja, Maciej Siedlar & Jarosław Czyż. (2017) Connexin43high prostate cancer cells induce endothelial connexin43 up-regulation through the activation of intercellular ERK1/2-dependent signaling axis. European Journal of Cell Biology 96:4, pages 337-346.
Crossref
Chi Huu Nguyen, Nicole Huttary, Atanas G. Atanasov, Waranya Chatuphonprasert, Stefan Brenner, Adryan Fristiohady, Junli Hong, Serena Stadler, Silvio Holzner, Daniela Milovanovic, Verena M. Dirsch, Brigitte Kopp, Philipp Saiko, Liselotte Krenn, Walter Jäger & Georg Krupitza. (2017) Fenofibrate inhibits tumour intravasation by several independent mechanisms in a 3-dimensional co-culture model. International Journal of Oncology 50:5, pages 1879-1888.
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Ákos GasparicsLászló RosivallIstván A. Krizbai & Attila Sebe. (2016) When the endothelium scores an own goal: endothelial cells actively augment metastatic extravasation through endothelial-mesenchymal transition. American Journal of Physiology-Heart and Circulatory Physiology 310:9, pages H1055-H1063.
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Duanmin Hu, Cunjin Su, Min Jiang, Yating Shen, Aiming Shi, Fenglun Zhao, Ruidong Chen, Zhu Shen, Junjie Bao & Wen Tang. (2016) Fenofibrate inhibited pancreatic cancer cells proliferation via activation of p53 mediated by upregulation of LncRNA MEG3. Biochemical and Biophysical Research Communications 471:2, pages 290-295.
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Joan McIntyre Caron & Jane McIntyre Caron. (2015) Methyl Sulfone Blocked Multiple Hypoxia- and Non-Hypoxia-Induced Metastatic Targets in Breast Cancer Cells and Melanoma Cells. PLOS ONE 10:11, pages e0141565.
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JK Ecke, LD Valle, AP Struckhoff, P Waligorski & K Reiss. (2015) Increased Survival after Treatment of Canine Hemangiosarcoma with Fenofibrate. International Journal of Veterinary Science and Research 1:1, pages 008-010.
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Tomas Koltai. (2015) Fenofibrate in cancer: mechanisms involved in anticancer activity. F1000Research 4, pages 55.
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Hamendra Singh Singh Parmar, Versha Tripathi, Pooja Jaiswal, Khageshwar Sahu, Shovan Kumar Majumder, Dharmendra Kashyap, Amit Kumar Dixit & Hem Chandra Jha. (2022) Repurposing of Metabolic Drugs and Mitochondrial Modulators as an Emerging Class of Cancer Therapeutics with a Special Focus on Breast Cancer. SSRN Electronic Journal.
Crossref

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