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G-protein-coupled receptor type A heteromers as an emerging therapeutic target

, PhD (Assistant Professor) , , MD (Emeritus Professor) , , MD (Assistant Professor) , , PhD (Research Scientist) & , MD (Emeritus Professor)

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Rafael Franco, Alejandro Lillo, Gemma Navarro & Irene Reyes-Resina. (2022) The adenosine A2A receptor is a therapeutic target in neurological, heart and oncogenic diseases. Expert Opinion on Therapeutic Targets 26:9, pages 791-800.
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David R. Janero & Ganesh A. Thakur. (2016) Leveraging allostery to improve G protein-coupled receptor (GPCR)-directed therapeutics: cannabinoid receptor 1 as discovery target. Expert Opinion on Drug Discovery 11:12, pages 1223-1237.
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Kjell Fuxe & Dasiel O Borroto-Escuela. (2015) Basimglurant for treatment of major depressive disorder: a novel negative allosteric modulator of metabotropic glutamate receptor 5. Expert Opinion on Investigational Drugs 24:9, pages 1247-1260.
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Articles from other publishers (32)

Chiara Cervetto, Guido Maura, Diego Guidolin, Sarah Amato, Cristina Ceccoli, Luigi F. Agnati & Manuela Marcoli. (2023) Striatal astrocytic A2A-D2 receptor-receptor interactions and their role in neuropsychiatric disorders. Neuropharmacology 237, pages 109636.
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Alice Taddeucci, Guendalina Olivero, Alessandra Roggeri, Claudio Milanese, Francesco Paolo Di Giorgio, Massimo Grilli, Mario Marchi, Beatrice Garrone & Anna Pittaluga. (2022) Presynaptic 5-HT2A-mGlu2/3 Receptor–Receptor Crosstalk in the Prefrontal Cortex: Metamodulation of Glutamate Exocytosis. Cells 11:19, pages 3035.
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Diego Guidolin, Cinzia Tortorella, Manuela Marcoli, Guido Maura & Luigi F. Agnati. (2022) Intercellular Communication in the Central Nervous System as Deduced by Chemical Neuroanatomy and Quantitative Analysis of Images: Impact on Neuropharmacology. International Journal of Molecular Sciences 23:10, pages 5805.
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Elena Stocco, Maria Martina Sfriso, Giulia Borile, Martina Contran, Silvia Barbon, Filippo Romanato, Veronica Macchi, Diego Guidolin, Raffaele De Caro & Andrea Porzionato. (2021) Experimental Evidence of A2A–D2 Receptor–Receptor Interactions in the Rat and Human Carotid Body. Frontiers in Physiology 12.
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Nicholas A. KalogriopoulosInmaculada Lopez-SanchezChangsheng LinTony Ngo, Krishna K. MiddeSuchismita Roy, Nicolas Aznar, Fiona Murray, Mikel Garcia-Marcos, Irina Kufareva, Majid Ghassemian & Pradipta Ghosh. (2020) Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of Gαi. Proceedings of the National Academy of Sciences 117:46, pages 28763-28774.
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Mark Soave, Stephen J. Briddon, Stephen J. Hill & Leigh A. Stoddart. (2020) Fluorescent ligands: Bringing light to emerging GPCR paradigms. British Journal of Pharmacology 177:5, pages 978-991.
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Diego Guidolin, Manuela Marcoli, Cinzia Tortorella, Guido Maura & Luigi F. Agnati. 2020. Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors. Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors 247 277 .
Ana Cristina de Bem AlvesViviane José de Oliveira BristotMirieli Denardi LimanaAna Elisa SpeckLeonardo Soares de BarrosAlexandre Francisco SolanoAderbal S. Aguiar, Jr., Jr.. (2019) Role of Adenosine A 2A Receptors in the Central Fatigue of Neurodegenerative Diseases . Journal of Caffeine and Adenosine Research 9:4, pages 145-156.
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Valentina Di Liberto, Giuseppa Mudò & Natale Belluardo. (2019) Crosstalk between receptor tyrosine kinases (RTKs) and G protein-coupled receptors (GPCR) in the brain: Focus on heteroreceptor complexes and related functional neurotrophic effects. Neuropharmacology 152, pages 67-77.
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Simone Pelassa, Diego Guidolin, Arianna Venturini, Monica Averna, Giulia Frumento, Letizia Campanini, Rosa Bernardi, Pietro Cortelli, Giovanna Calandra Buonaura, Guido Maura, Luigi F. Agnati, Chiara Cervetto & Manuela Marcoli. (2019) A2A-D2 Heteromers on Striatal Astrocytes: Biochemical and Biophysical Evidence. International Journal of Molecular Sciences 20:10, pages 2457.
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Sandra Blasco-BenitoEstefanía MorenoMarta Seijo-VilaIsabel TundidorClara AndradasMaría M. Caffarel, Miriam Caro-VillalobosLeyre UrigüenRebeca Diez-AlarciaGema Moreno-BuenoLucía HernándezLuis MansoPatricia Homar-RuanoPeter J. McCormickLucka BibicCristina Bernadó-MoralesJoaquín ArribasMeritxell CanalsVicent CasadóEnric I. CanelaManuel Guzmán, Eduardo Pérez-GómezCristina Sánchez. (2019) Therapeutic targeting of HER2–CB 2 R heteromers in HER2-positive breast cancer . Proceedings of the National Academy of Sciences 116:9, pages 3863-3872.
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Diego Guidolin, Manuela Marcoli, Cinzia Tortorella, Guido Maura & Luigi F. Agnati. (2019) Receptor-Receptor Interactions as a Widespread Phenomenon: Novel Targets for Drug Development?. Frontiers in Endocrinology 10.
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Diego Guidolin, Manuela Marcoli, Cinzia Tortorella, Guido Maura & Luigi F. Agnati. (2018) G protein-coupled receptor-receptor interactions give integrative dynamics to intercellular communication. Reviews in the Neurosciences 29:7, pages 703-726.
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Piotr Stępnicki, Magda Kondej & Agnieszka A. Kaczor. (2018) Current Concepts and Treatments of Schizophrenia. Molecules 23:8, pages 2087.
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Chiara Cervetto, Arianna Venturini, Diego Guidolin, Guido Maura, Mario Passalacqua, Carlo Tacchetti, Pietro Cortelli, Susanna Genedani, Simona Candiani, Paola Ramoino, Simone Pelassa, Manuela Marcoli & Luigi F. Agnati. (2018) Homocysteine and A2A-D2 Receptor-Receptor Interaction at Striatal Astrocyte Processes. Journal of Molecular Neuroscience 65:4, pages 456-466.
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Andrea Porzionato, Elena Stocco, Diego Guidolin, Luigi Agnati, Veronica Macchi & Raffaele De Caro. (2018) Receptor–Receptor Interactions of G Protein-Coupled Receptors in the Carotid Body: A Working Hypothesis. Frontiers in Physiology 9.
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Christa E. Müller, Younis Baqi, Sonja Hinz & Vigneshwaran Namasivayam. 2018. The Adenosine Receptors. The Adenosine Receptors 137 168 .
Sergio Tanganelli, Tiziana Antonelli, Sarah Beggiato, Maria Cristina Tomasini, Kjell Fuxe, Dasiel O. Borroto-Escuela & Luca Ferraro. 2018. Receptor-Receptor Interactions in the Central Nervous System. Receptor-Receptor Interactions in the Central Nervous System 91 107 .
Sarah Beggiato, Sergio Tanganelli, Tiziana Antonelli, Maria Cristina Tomasini, Kjell Fuxe, Dasiel O. Borroto-Escuela & Luca Ferraro. 2018. Receptor-Receptor Interactions in the Central Nervous System. Receptor-Receptor Interactions in the Central Nervous System 41 55 .
Alicia Rivera, Alejandra Valderrama-Carvajal, Diana Suárez-Boomgaard, Kirill Shumilov, M. Ángeles Real, Kjell Fuxe & Belén Gago. 2018. Receptor-Receptor Interactions in the Central Nervous System. Receptor-Receptor Interactions in the Central Nervous System 25 39 .
Agnieszka A. Kaczor, Damian Bartuzi, Tomasz Maciej Stępniewski, Dariusz Matosiuk & Jana Selent. 2018. Computational Drug Discovery and Design. Computational Drug Discovery and Design 285 305 .
K.C. Jonas & A.C. Hanyaloglu. (2017) Impact of G protein-coupled receptor heteromers in endocrine systems. Molecular and Cellular Endocrinology 449, pages 21-27.
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Dasiel O. Borroto-Escuela, Jens Carlsson, Patricia Ambrogini, Manuel Narváez, Karolina Wydra, Alexander O. Tarakanov, Xiang Li, Carmelo Millón, Luca Ferraro, Riccardo Cuppini, Sergio Tanganelli, Fang Liu, Malgorzata Filip, Zaida Diaz-Cabiale & Kjell Fuxe. (2017) Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease. Frontiers in Cellular Neuroscience 11.
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Diego Guidolin, Manuela Marcoli, Guido Maura & Luigi F. Agnati. (2017) New dimensions of connectomics and network plasticity in the central nervous system. Reviews in the Neurosciences 28:2, pages 113-132.
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Chiara Cervetto, Arianna Venturini, Mario Passalacqua, Diego Guidolin, Susanna Genedani, Kjell Fuxe, Dasiel O. Borroto-Esquela, Pietro Cortelli, Amina Woods, Guido Maura, Manuela Marcoli & Luigi F. Agnati. (2017) A2A-D2 receptor-receptor interaction modulates gliotransmitter release from striatal astrocyte processes. Journal of Neurochemistry 140:2, pages 268-279.
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S. Al-Sweidi, M. Morissette & T. Di Paolo. (2016) Estrogen receptors modulate striatal metabotropic receptor type 5 in intact and MPTP male mice model of Parkinson’s disease. The Journal of Steroid Biochemistry and Molecular Biology 161, pages 84-91.
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Luigi F. Agnati, Manuela Marcoli, Guido Maura, Kjell Fuxe & Diego Guidolin. (2016) The multi-facet aspects of cell sentience and their relevance for the integrative brain actions: role of membrane protein energy landscape. Reviews in the Neurosciences 27:4, pages 347-363.
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Ramon Guixà-González, Matti Javanainen, Maricel Gómez-Soler, Begoña Cordobilla, Joan Carles Domingo, Ferran Sanz, Manuel Pastor, Francisco Ciruela, Hector Martinez-Seara & Jana Selent. (2016) Membrane omega-3 fatty acids modulate the oligomerisation kinetics of adenosine A2A and dopamine D2 receptors. Scientific Reports 6:1.
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Luigi F. Agnati, Diego Guidolin, Chiara Cervetto, Dasiel O. Borroto-Escuela & Kjell Fuxe. (2016) Role of iso-receptors in receptor-receptor interactions with a focus on dopamine iso-receptor complexes. Reviews in the Neurosciences 27:1, pages 1-25.
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Diego Guidolin, Cinzia Tortorella, Raffaele De Caro & Luigi F. Agnati. 2016. The Fractal Geometry of the Brain. The Fractal Geometry of the Brain 137 156 .
Kenneth A. Jacobson. (2015) New paradigms in GPCR drug discovery. Biochemical Pharmacology 98:4, pages 541-555.
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Yuji Odagaki, Masakazu Kinoshita, Toshio Ota, J. Javier Meana, Luis F. Callado & Jesús A. García-Sevilla. (2015) Adenosine A1 receptors are selectively coupled to Gαi-3 in postmortem human brain cortex: Guanosine-5′-O-(3-[35S]thio)triphosphate ([35S]GTPγS) binding/immunoprecipitation study. European Journal of Pharmacology 764, pages 592-598.
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