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Original Research

Nobiletin inhibits invasion and migration of human nasopharyngeal carcinoma cell lines by involving ERK1/2 and transcriptional inhibition of MMP-2

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Yun-Yi Chen, Jiao-Jiao Liang, Deng-Liang Wang, Jie-Biao Chen, Jin-Ping Cao, Yue Wang & Chong-De Sun. (2023) Nobiletin as a chemopreventive natural product against cancer, a comprehensive review. Critical Reviews in Food Science and Nutrition 63:23, pages 6309-6329.
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Chengying Zhao, Feng Wang, Yunhe Lian, Hang Xiao & Jinkai Zheng. (2020) Biosynthesis of citrus flavonoids and their health effects. Critical Reviews in Food Science and Nutrition 60:4, pages 566-583.
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Franck Gallardo, Bernard Mariamé, Remi Gence & Anne-Francoise Tilkin-Mariamé. (2018) Macrocyclic lactones inhibit nasopharyngeal carcinoma cells proliferation through PAK1 inhibition and reduce in vivo tumor growth. Drug Design, Development and Therapy 12, pages 2805-2814.
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Articles from other publishers (32)

Dorcas A. Gado, Muna Ali Abdalla, Marthie M. Ehlers & Lyndy J. McGaw. (2023) Pharmacological properties and radical scavenging potential of 5-demethyl sinensetin obtained from Loxostylis alata. South African Journal of Botany 156, pages 385-391.
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Qiyang Chen, Yue Gu, Chun Tan, Balasubramani Sundararajan, Zhenqing Li, Dan Wang & Zhiqin Zhou. (2022) Comparative effects of five polymethoxyflavones purified from Citrus tangerina on inflammation and cancer. Frontiers in Nutrition 9.
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Nipin Sp, Dong Young Kang, Jin-Moo Lee & Kyoung-Jin Jang. (2021) Mechanistic Insights of Anti-Immune Evasion by Nobiletin through Regulating miR-197/STAT3/PD-L1 Signaling in Non-Small Cell Lung Cancer (NSCLC) Cells. International Journal of Molecular Sciences 22:18, pages 9843.
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Nikita Aggarwal, Joni Yadav, Suhail Chhakara, Divya Janjua, Tanya Tripathi, Apoorva Chaudhary, Arun Chhokar, Kulbhushan Thakur, Tejveer Singh & Alok Chandra Bharti. (2021) Phytochemicals as Potential Chemopreventive and Chemotherapeutic Agents for Emerging Human Papillomavirus–Driven Head and Neck Cancer: Current Evidence and Future Prospects. Frontiers in Pharmacology 12.
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Yuan Wu, Chien-shan Cheng, Qiong Li, Jing-xian Chen, Ling-ling Lv, Jia-yue Xu, Kai-yuan Zhang & Lan Zheng. (2021) The Application of Citrus folium in Breast Cancer and the Mechanism of Its Main Component Nobiletin: A Systematic Review. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-15.
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Xiang Ren, Yuran Ma, Xiao Wang, Xuetao Xu, Panpan Wu, Wenfeng Liu, Kun Zhang, Susan Goodin, Dongli Li & Xi Zheng. (2021) Nobiletin Inhibits Cell Growth, Migration and Invasion, and Enhances the Anti-Cancer Effect of Gemcitabine on Pancreatic Cancer Cells. Natural Product Communications 16:4, pages 1934578X2110040.
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Cheng-Chen Huang, Po-Hui Wang, Yen-Ting Lu, Jia-Sin Yang, Shun-Fa Yang, Yu-Ting Ho, Chiao-Wen Lin & Chung-Han Hsin. (2020) Morusin Suppresses Cancer Cell Invasion and MMP-2 Expression through ERK Signaling in Human Nasopharyngeal Carcinoma. Molecules 25:20, pages 4851.
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Xiang-Yun Lan, Tzu-Ting Chung, Chien-Ling Huang, Yi-Jang Lee & Wan-Chun Li. (2020) Traditional Herbal Medicine Mediated Regulations during Head and Neck Carcinogenesis. Biomolecules 10:9, pages 1321.
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Jian-Ming Chen, Pei-Yin Chen, Chia-Chieh Lin, Ming-Chang Hsieh & Jen-Tsun Lin. (2020) Antimetastatic Effects of Sesamin on Human Head and Neck Squamous Cell Carcinoma through Regulation of Matrix Metalloproteinase-2. Molecules 25:9, pages 2248.
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Milad Ashrafizadeh, Ali Zarrabi, Sedigheh Saberifar, Farid Hashemi, Kiavash Hushmandi, Fardin Hashemi, Ebrahim Rahmani Moghadam, Reza Mohammadinejad, Masoud Najafi & Manoj Garg. (2020) Nobiletin in Cancer Therapy: How This Plant Derived-Natural Compound Targets Various Oncogene and Onco-Suppressor Pathways. Biomedicines 8:5, pages 110.
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Mengling Zhang, Rui Zhang, Jian Liu, Hongliang Wang, Zhen Wang, Juan Liu, Yang Shan & Huanling Yu. (2020) The Effects of 5,6,7,8,3′,4′-Hexamethoxyflavone on Apoptosis of Cultured Human Choriocarcinoma Trophoblast Cells. Molecules 25:4, pages 946.
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Hsu‐Chueh Ho, Cheng‐Chen Huang, Yen‐Ting Lu, Chia‐Ming Yeh, Yu‐Ting Ho, Shun‐Fa Yang, Chung‐Han Hsin & Chiao‐Wen Lin. (2019) Epigallocatechin‐3‐gallate inhibits migration of human nasopharyngeal carcinoma cells by repressing MMP‐2 expression. Journal of Cellular Physiology 234:11, pages 20915-20924.
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Janani Rajasekar, Madan Kumar Perumal & Baskaran Vallikannan. (2019) A critical review on anti-angiogenic property of phytochemicals. The Journal of Nutritional Biochemistry 71, pages 1-15.
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Mu-Kuan Chen, Yen-Tze Liu, Jen-Tsun Lin, Chia-Chieh Lin, Yi-Ching Chuang, Yu-Sheng Lo, Yi-Ting Hsi & Ming-Ju Hsieh. (2019) Pinosylvin reduced migration and invasion of oral cancer carcinoma by regulating matrix metalloproteinase-2 expression and extracellular signal-regulated kinase pathway. Biomedicine & Pharmacotherapy 117, pages 109160.
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Yen-Chen Tung, Ya-Chun Chou, Wei-Lun Hung, An-Chin Cheng, Roch-Chui Yu, Chi-Tang Ho & Min-Hsiung Pan. (2019) Polymethoxyflavones: Chemistry and Molecular Mechanisms for Cancer Prevention and Treatment. Current Pharmacology Reports 5:2, pages 98-113.
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Guo Dong Zheng, Ping Jun Hu, Ying Xin Chao, Ying Zhou, Xiu Juan Yang, Bai Zhong Chen, Xi Yong Yu & Yi Cai. (2019) Nobiletin induces growth inhibition and apoptosis in human nasopharyngeal carcinoma C666‐1 cells through regulating PARP ‐2/ SIRT 1/ AMPK signaling pathway . Food Science & Nutrition 7:3, pages 1104-1112.
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Jingyi MaXuelin Zhou. 2019. Nutraceuticals and Natural Product Derivatives. Nutraceuticals and Natural Product Derivatives 81 109 .
Nipin Sp, Dong Kang, Doh Kim, Jong Park, Hyo Lee, Hye Kim, Pramod Darvin, Yeong-Min Park & Young Yang. (2018) Nobiletin Inhibits CD36-Dependent Tumor Angiogenesis, Migration, Invasion, and Sphere Formation Through the Cd36/Stat3/Nf-Κb Signaling Axis. Nutrients 10:6, pages 772.
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Qinghai LinHuige WangXinqiang LinWenrui ZhangShuhua HuangYandan Zheng. (2018) PTPN12 Affects Nasopharyngeal Carcinoma Cell Proliferation and Migration Through Regulating EGFR. Cancer Biotherapy and Radiopharmaceuticals 33:2, pages 60-64.
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Zhao Gao, Wen Gao, Su-Ling Zeng, Ping Li & E-Hu Liu. (2018) Chemical structures, bioactivities and molecular mechanisms of citrus polymethoxyflavones. Journal of Functional Foods 40, pages 498-509.
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Natasha Borah, Shimara Gunawardana, Haydee Torres, Susan McDonnell & Severine Van Slambrouck. (2017) 5,6,7,3′,4′,5′-Hexamethoxyflavone inhibits growth of triple-negative breast cancer cells via suppression of MAPK and Akt signaling pathways and arresting cell cycle. International Journal of Oncology 51:6, pages 1685-1693.
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Qing Shi, Zhou Jiang, Jingyi Yang, Yunlong Cheng, Yaqiong Pang, Ning Zheng, Jiahang Chen, Wenge Chen & Lee Jia. (2017) A Flavonoid Glycoside Compound from Murraya paniculata (L.) Interrupts Metastatic Characteristics of A549 Cells by Regulating STAT3/NF-κB/COX-2 and EGFR Signaling Pathways. The AAPS Journal 19:6, pages 1779-1790.
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Nipin Sp, Dong Kang, Youn Joung, Jong Park, Wan Kim, Hak Lee, Ki-Duk Song, Yeong-Min Park & Young Yang. (2017) Nobiletin Inhibits Angiogenesis by Regulating Src/FAK/STAT3-Mediated Signaling through PXN in ER+ Breast Cancer Cells. International Journal of Molecular Sciences 18:5, pages 935.
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Ming-Ju Hsieh, Jui-Chieh Chen, Wei-En Yang, Su-Yu Chien, Mu-Kuan Chen, Yu-Sheng Lo, Yi-Ting Hsi, Yi-Ching Chuang, Chia-Chieh Lin & Shun-Fa Yang. (2017) Dehydroandrographolide inhibits oral cancer cell migration and invasion through NF-κB-, AP-1-, and SP-1-modulated matrix metalloproteinase-2 inhibition. Biochemical Pharmacology 130, pages 10-20.
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Chung-Han Hsin, Cheng-Chen Huang, Pei-Ni Chen, Yih-Shou Hsieh, Shun-Fa Yang, Yu-Ting Ho & Chiao-Wen Lin. (2017) Rubus idaeus Inhibits Migration and Invasion of Human Nasopharyngeal Carcinoma Cells by Suppression of MMP-2 through Modulation of the ERK1/2 Pathway . The American Journal of Chinese Medicine 45:07, pages 1557-1572.
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Santa Cirmi, Nadia Ferlazzo, Giovanni Lombardo, Alessandro Maugeri, Gioacchino Calapai, Sebastiano Gangemi & Michele Navarra. (2016) Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?. Nutrients 8:11, pages 698.
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Hsin-Lin Cheng, Ming-Ju Hsieh, Jia-Sin Yang, Chiao-Wen Lin, Ko-Haung Lue, Ko-Hsiu Lu & Shun-Fa Yang. (2016) Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression. Oncotarget 7:23, pages 35208-35223.
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CHUNLI DA, YUTING LIU, YIYI ZHAN, KAI LIU & RUOZHENG WANG. (2016) Nobiletin inhibits epithelial-mesenchymal transition of human non-small cell lung cancer cells by antagonizing the TGF-β1/Smad3 signaling pathway. Oncology Reports 35:5, pages 2767-2774.
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Chia-Ming Yeh, Chiao-Wen Lin, Jia-Sin Yang, Wei-En Yang, Shih-Chi Su & Shun-Fa Yang. (2016) Melatonin inhibits TPA-induced oral cancer cell migration by suppressing matrix metalloproteinase-9 activation through the histone acetylation. Oncotarget 7:16, pages 21952-21967.
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Li-Ming Lien, Meng-Jiy Wang, Ray-Jade Chen, Hou-Chang Chiu, Jia-Lun Wu, Ming-Yi Shen, Duen-Suey Chou, Joen-Rong Sheu, Kuan-Hung Lin & Wan-Jung Lu. (2016) Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways. Phytotherapy Research 30:2, pages 214-221.
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Hao Huang, Linfu Li, Weimei Shi, Hai Liu, Jianqiong Yang, Xiaoliang Yuan & Longhuo Wu. (2016) The Multifunctional Effects of Nobiletin and Its Metabolites In Vivo and In Vitro . Evidence-Based Complementary and Alternative Medicine 2016, pages 1-14.
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