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Expert Opinion on Therapeutic Targets Volume 19, 2015 - Issue 7
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Review

Homocysteine as a potential biomarker in bipolar disorders: a critical review and suggestions for improved studies

Ahmad GhanizadehShiraz University of Medical Sciences, School of Medicine, Research Center for Psychiatry and Behavioral Sciences, Department of Psychiatry, Shiraz, Iran+00987116273070; [email protected];Shiraz University of Medical Sciences, School of Advanced Medical Sciences and Technologies, Department of Neuroscience, Shiraz, Iran
, MD (Psychiatrist) ,
Ajeet B SinghDeakin University, School of Medicine, IMPACT Strategic Research Centre, Barwon Health, Geelong, Victoria, Australia
, MBBS MPsych MD FRANZCP,
Michael BerkDeakin University, School of Medicine, IMPACT Strategic Research Centre, Barwon Health, Geelong, Victoria, Australia;The University of Melbourne, The Florey Institute of Neuroscience and Mental Health, The National Centre of Excellence in Youth Mental Health, Department of Psychiatry, Orygen, Parkville, Australia
, MBBCh MMed (Psych) FF(Psych)SA PhD FRANZCP (Psychiatrist) &
Mohammad Torabi-NamiShiraz University of Medical Sciences, School of Advanced Medical Sciences and Technologies, Department of Neuroscience, Shiraz, Iran;Shiraz University of Medical Sciences, Shiraz Neuroscience Research Center, Brain and Cognition Study Group (BCSG)-Shiraz, Shiraz, Iran
, MD PhD
Pages 927-939 | Published online: 16 Apr 2015

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Paola Mangiapane, Manuel Glauco Carbone, Alessandro Arone, Lucia Massa, Stefania Palermo, Walter Flamini, Elisabetta Parra, Benedetto Morana, Florinda Morana, Giovanni Bertini & Donatella Marazziti. (2023) Vitamin B12, homocysteine, and folic acid in patients suffering from bipolar disorders: Relationship with suicide. The World Journal of Biological Psychiatry 24:6, pages 476-484.
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Meral Gunes Ozdogan, Esat Fahri Aydin, Mehmet Fatih Ustundag, Hacer Akgul Ceyhun, Elif Oral & Ebubekir Bakan. (2020) Homocysteine, chronotype and clinical course in bipolar disorder patients. Nordic Journal of Psychiatry 74:5, pages 340-345.
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Articles from other publishers (16)

Marcin Gołyński, Michał Metyk, Jagoda Ciszewska, Marcin Paweł Szczepanik, Gareth Fitch & Paweł Marek Bęczkowski. (2023) Homocysteine—Potential Novel Diagnostic Indicator of Health and Disease in Horses. Animals 13:8, pages 1311.
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Kamil Karolczak & Cezary Watala. (2021) Melatonin as a Reducer of Neuro- and Vasculotoxic Oxidative Stress Induced by Homocysteine. Antioxidants 10:8, pages 1178.
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Katarzyna Nowak, Sylvia Chiriboga, Izabela Halczuk & Hanna Karakuła-Juchnowicz. (2021) When should a psychiatrist remember to test homocysteine levels? - a literature review. Current Problems of Psychiatry 22:2, pages 69-82.
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Marika Cordaro, Rosalba Siracusa, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola & Daniela Impellizzeri. (2021) Involvements of Hyperhomocysteinemia in Neurological Disorders. Metabolites 11:1, pages 37.
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Li Mu, Yezhe Lin, Xingbing Huang, Yuping Ning, Fengchun Wu & Xiang Yang Zhang. (2020) Sex differences in the prevalence and clinical correlates of hyperhomocysteinemia in patients with bipolar disorder. Human Psychopharmacology: Clinical and Experimental 35:2.
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Samira Menegas, Gustavo C. Dal-Pont, José H. Cararo, Roger B. Varela, Jorge M. Aguiar-Geraldo, Taise Possamai-Della, Monica L. Andersen, João Quevedo & Samira S. Valvassori. (2019) Efficacy of folic acid as an adjunct to lithium therapy on manic-like behaviors, oxidative stress and inflammatory parameters in an animal model of mania. Metabolic Brain Disease 35:2, pages 413-425.
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E. N. Andreeva, E. V. Sheremetyeva, O. R. Grigoryan & Yu. S. Absatarova. (2020) Acne is a disease of civilization. Problemy reproduktsii 26:1, pages 6.
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茜 农. (2020) Advances in Homocysteine, Methyl Metabolism and Cystathionidase Gene. Advances in Clinical Medicine 10:07, pages 1277-1284.
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Marc Østergaard Nielsen, Nanna Aagaard Petersen, Klara Coello, Sharleny Stanislaus, Sigurd A. Melbye, Hanne Lie Kjærstad, Kimie Stefanie Ormstrup Sletved, Ruth Frikke-Schmidt, Roger S. McIntyre, Maj Vinberg & Lars Vedel Kessing. (2020) High-sensitive C-reactive protein and homocysteine levels in patients with newly diagnosed bipolar disorder, their first-degree relatives, and healthy control persons—Results from a clinical study. European Psychiatry 63:1.
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Belén Arranz, Mónica Sanchez-Autet, Luis San, Gemma Safont, Lorena De La Fuente-Tomás, Carla Hernandez, José Luis Bogas & María Paz García-Portilla. (2019) Are plasma 25-hydroxyvitamin D and retinol levels and one-carbon metabolism related to metabolic syndrome in patients with a severe mental disorder?. Psychiatry Research 273, pages 22-29.
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M. Sanchez-Autet, B. Arranz, G. Safont, P. Sierra, A. Garcia-Blanco, L. de la Fuente, M. Garriga & M.P. García-Portilla. (2018) Gender differences in C-reactive protein and homocysteine modulation of cognitive performance and real-world functioning in bipolar disorder. Journal of Affective Disorders 229, pages 95-104.
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Shuang-Jiang Zhou, Li-Gang Zhang, Hong-Mei Chen, Ju-Yan Li, Ran Li, Xi-Mei Zhang, Ning Wang, Jair C. Soares, Ryan M. Cassidy, Yingjun Zheng, Yuping Ning, Shao-Li Wang, Jing-Xu Chen & Xiang-Yang Zhang. (2018) Prevalence and clinical-demographic correlates of hyperhomocysteinemia in inpatients with bipolar disorder in a Han Chinese population. Psychiatry Research 259, pages 364-369.
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Helen Barnett, Nathan M. D’Cunha, Ekavi N. Georgousopoulou, Jane Kellett, Duane D. Mellor, Andrew J. McKune & Nenad Naumovski. (2017) Effect of Folate Supplementation on Inflammatory Markers in Individuals Susceptible to Depression: A Systematic Review. Exploratory Research and Hypothesis in Medicine 2:4, pages 1-15.
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E. Salagre, A.F. Vizuete, M. Leite, D.J. Brownstein, A. McGuinness, F. Jacka, S. Dodd, B. Stubbs, C.A. Köhler, E. Vieta, A.F. Carvalho, M. Berk & B.S. Fernandes. (2020) Homocysteine as a peripheral biomarker in bipolar disorder: A meta-analysis. European Psychiatry 43, pages 81-91.
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Vanessa Cavalcante da Silva, Allan Chiaratti de Oliveira & Vânia D’Almeida. (2017) Homocysteine and Psychiatric Disorders. Journal of Inborn Errors of Metabolism and Screening 5, pages 232640981770147.
Crossref
Zahra Sepehrmanesh, Abdollah Omidi & Narges Gholampoor. (2016) Acid Folic Supplementation in Major Depressive Disorder Treatment: A Double-Blind Randomized Clinical Trial. Iranian Red Crescent Medical Journal 19:2.
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