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Expert Opinion on Therapeutic Targets Volume 19, 2015 - Issue 7
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Review

Are big potassium-type Ca2+-activated potassium channels a viable target for the treatment of epilepsy?

Antonio LeoUniversity “Magna Graecia” of Catanzaro, School of Medicine, Science of Health Department, Catanzaro, Italy
,
Rita CitraroUniversity “Magna Graecia” of Catanzaro, School of Medicine, Science of Health Department, Catanzaro, Italy
,
Andrew ConstantiUCL School of Pharmacy, Department of Pharmacology, 29/39 Brunswick Square, London, UK
,
Giovambattista De SarroUniversity “Magna Graecia” of Catanzaro, School of Medicine, Science of Health Department, Via T. Campanella, 115, Catanzaro 88100, Italy+39 0961 3694191; +39 0961 3694192; [email protected]
, MD (Professor, Chair of Pharmacology) &
Emilio RussoUniversity “Magna Graecia” of Catanzaro, School of Medicine, Science of Health Department, Catanzaro, Italy
Pages 911-926 | Published online: 03 Apr 2015

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ES Nikitin & LV Vinogradova. (2021) Potassium channels as prominent targets and tools for the treatment of epilepsy. Expert Opinion on Therapeutic Targets 25:3, pages 223-235.
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Carmen De Caro, Antonio Leo, Rita Citraro, Caterina De Sarro, Roberto Russo, Antonio Calignano & Emilio Russo. (2017) The potential role of cannabinoids in epilepsy treatment. Expert Review of Neurotherapeutics 17:11, pages 1069-1079.
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Articles from other publishers (11)

Evgeny S. Nikitin, Tatiana Y. Postnikova, Elena Y. Proskurina, Anastasia A. Borodinova, Violetta Ivanova, Matvey V. Roshchin, Maria P. Smirnova, Ilya Kelmanson, Vsevolod V. Belousov, Pavel M. Balaban & Aleksey V. Zaitsev. (2023) Overexpression of KCNN4 channels in principal neurons produces an anti-seizure effect without reducing their coding ability. Gene Therapy.
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Luke R. Odell, Nigel C. Jones, Ngoc Chau, Mark J. Robertson, Joseph I. Ambrus, Fiona M. Deane, Kelly A. Young, Ainslie Whiting, Jing Xue, Kate Prichard, James A. Daniel, Nick N. Gorgani, Terence J. O'Brien, Phillip J. Robinson & Adam McCluskey. (2023) The sulfonadyns: a class of aryl sulfonamides inhibiting dynamin I GTPase and clathrin mediated endocytosis are anti-seizure in animal models. RSC Medicinal Chemistry 14:8, pages 1492-1511.
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Anatoly Buchin, Rebecca de Frates, Anirban Nandi, Rusty Mann, Peter Chong, Lindsay Ng, Jeremy Miller, Rebecca Hodge, Brian Kalmbach, Soumita Bose, Ueli Rutishauser, Stephen McConoughey, Ed Lein, Jim Berg, Staci Sorensen, Ryder Gwinn, Christof Koch, Jonathan Ting & Costas A. Anastassiou. (2022) Multi-modal characterization and simulation of human epileptic circuitry. Cell Reports 41:13, pages 111873.
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Ming-Chi Lai, Sheng-Nan Wu & Chin-Wei Huang. (2022) Rufinamide, a Triazole-Derived Antiepileptic Drug, Stimulates Ca2+-Activated K+ Currents While Inhibiting Voltage-Gated Na+ Currents. International Journal of Molecular Sciences 23:22, pages 13677.
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E. S. Nikitin, P. M. Balaban & A. V. Zaitsev. (2022) Prospects for Gene Therapy of Epilepsy Using Calcium-Acivated Potassium Channel Vectors. Journal of Evolutionary Biochemistry and Physiology 58:4, pages 1065-1074.
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Mengmeng Du, Jiajia Li, Wu Ying & Yuguo Yu. (2021) A dynamics model of neuron-astrocyte network accounting for febrile seizures. Cognitive Neurodynamics 16:2, pages 411-423.
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E. S. Nikitin & P. M. Balaban. (2021) Diversity and Functional Features of Calcium-Dependent Potassium Channels as Determinants of Their Role in the Plasticity of Cerebral Neurons. Neuroscience and Behavioral Physiology 51:9, pages 1239-1243.
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Carl E. Stafstrom. (2020) How Many Angels Can Dance on the Head of a Patch Pipette? Understanding Neuronal Hyperexcitability in Angelman Syndrome. Epilepsy Currents 20:5, pages 309-311.
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Ji-Hyun Lee, Pyo-Yoon Kang, Young-Eun Jang, Eun-Hee Kim, Jin-Tae Kim & Hee-Soo Kim. (2018) A pharmacodynamic model of respiratory rate and end-tidal carbon dioxide values during anesthesia in children. Acta Pharmacologica Sinica 40:5, pages 642-647.
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Lihong Wang, Jingfang He, Ao Xia, Mengzhu Cheng, Qing Yang, Chunlei Du, Haiyan Wei, Xiaohua Huang & Qing Zhou. (2017) Toxic effects of environmental rare earth elements on delayed outward potassium channels and their mechanisms from a microscopic perspective. Chemosphere 181, pages 690-698.
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Suya Zhang, Yubin Kou, Chunmei Hu & Yan Han. (2017) MicroRNA profiling in the dentate gyrus in epileptic rats. Medicine 96:22, pages e6744.
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