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Expert Opinion on Therapeutic Targets Volume 19, 2015 - Issue 7
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Original Research

Polydatin protects hepatocytes against mitochondrial injury in acute severe hemorrhagic shock via SIRT1-SOD2 pathway

Pengyun LiSouthern Medical University, Guangdong Key Laboratory of Shock and Microcirculation Research, Department of Pathophysiology, Guangzhou, 510515, China+86 20 61648232; +86 20 61648299; [email protected], [email protected];Ministry of Education of China, and Institute of Cardiovascular Research, Luzhou Medical College, Key Laboratory of Medical Electrophysiology, Luzhou, Sichuan, 646000, China
,
Xingmin WangMaternal and Child Health Hospital of Liuzhou, Liuzhou, GuangXi, 545000, China
,
Ming ZhaoSouthern Medical University, Guangdong Key Laboratory of Shock and Microcirculation Research, Department of Pathophysiology, Guangzhou, 510515, China+86 20 61648232; +86 20 61648299; [email protected], [email protected]
, MD,
Rui SongSouthern Medical University, Guangdong Key Laboratory of Shock and Microcirculation Research, Department of Pathophysiology, Guangzhou, 510515, China+86 20 61648232; +86 20 61648299; [email protected], [email protected]
, MD PhD &
Ke-seng ZhaoSouthern Medical University, Guangdong Key Laboratory of Shock and Microcirculation Research, Department of Pathophysiology, Guangzhou, 510515, China+86 20 61648232; +86 20 61648299; [email protected], [email protected]
Pages 997-1010 | Published online: 15 Jun 2015

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Paule Bénit, Manuel Schiff, Hélène Cwerman-Thibault, Marisol Corral-Debrinski & Pierre Rustin. (2016) Drug development for mitochondrial disease: recent progress, current challenges, and future prospects. Expert Opinion on Orphan Drugs 4:1, pages 83-92.
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Articles from other publishers (41)

Jiannan Liu, Jianlin Huang, Bo Gong, Songtao Cheng, Yadong Liu, Yaodong Chen, Qiang Feng, Jun Li, Mingxing Qiu, Gui Yu & Yong Liao. (2023) Polydatin protects against calcium oxalate crystal-induced renal injury through the cytoplasmic/mitochondrial reactive oxygen species-NLRP3 inflammasome pathway. Biomedicine & Pharmacotherapy 167, pages 115621.
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Huiqin Chen, Fajian Luo, Huisheng Song, Huiqiang Long, Na Chen, Liang Sun, Fengmei Cui, Jun Wan & Yu Tu. (2023) Radiation Protection of Polydatin Against Radon Exposure Injury of Epithelial Cells and Mice. Dose-Response 21:2, pages 155932582311722.
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Saadet ÇELİKÖZLÜ, Said ALTIKAT, Filiz ÖZYİĞİT, Sibel KÖKTÜRK & Halit ÇELİKÖZLÜ. (2023) POLYDATIN, A HERBAL BIOFLAVONOID, IS PROTECTIVE AGAINST CEREBRAL ISCHEMIA-REPERFUSION INJURY: MOLECULAR, BIOCHEMICAL AND HISTOLOGICAL DATA. Journal of Scientific Reports-A:052, pages 247-265.
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Qin Li, Peng Zhao, Yu Wen, Zhimin Zou, Xihe Qin, Hongping Tan, Jian Gong, Qihua Wu, Chen Zheng, Kun Zhang, Qiaobing Huang, Marc Maegele, Zhengtao Gu & Li Li. (2023) POLYDATIN AMELIORATES TRAUMATIC BRAIN INJURY–INDUCED SECONDARY BRAIN INJURY BY INHIBITING NLRP3-INDUCED NEUROINFLAMMATION ASSOCIATED WITH SOD2 ACETYLATION. Shock 59:3, pages 460-468.
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Bo Jia, Jingjing Ye, Lebin Gan, Rui Li, Mengwei Zhang, Diya Sun, Lin Weng, Yufei Xiong, Jun Xu, Peng Zhang, Wei Huang, Ming Zheng & Tianbing Wang. (2022) Mitochondrial antioxidant SkQ1 decreases inflammation following hemorrhagic shock by protecting myocardial mitochondria. Frontiers in Physiology 13.
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Alexander Wolf, Tobias Fink, Jochen Hinkelbein, Thilo Mertke, Thomas Volk & Alexander Mathes. (2022) Resveratrol therapy improves liver function via estrogen-receptors after hemorrhagic shock in rats. PLOS ONE 17:10, pages e0275632.
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Ahmad Karami, Sajad Fakhri, Leila Kooshki & Haroon Khan. (2022) Polydatin: Pharmacological Mechanisms, Therapeutic Targets, Biological Activities, and Health Benefits. Molecules 27:19, pages 6474.
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Miao-miao Lin, Na Liu, Zheng-hong Qin & Yan Wang. (2022) Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases. Acta Pharmacologica Sinica 43:10, pages 2439-2447.
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Lin Huang, Jiawei Chen, Xiaojie Li, Mingxin Huang, Jilou Liu, Na Qin, Zhenhua Zeng, Xingmin Wang, Fen Li & Hong Yang. (2022) Polydatin Improves Sepsis-Associated Encephalopathy by Activating Sirt1 and Reducing p38 Phosphorylation. Journal of Surgical Research 276, pages 379-393.
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Lucia E. Schimith, Michele G. dos Santos, Bruno D. Arbo, Corinne André‐Miral, Ana L. Muccillo‐Baisch & Mariana A. Hort. (2022) Polydatin as a therapeutic alternative for central nervous system disorders: A systematic review of animal studies. Phytotherapy Research 36:7, pages 2852-2877.
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Yanan Chen, Yue Li, Peilu Jia, Shuli Ji, Hao Zhang & Tian Wang. (2022) Polydatin Attenuates Intra-Uterine Growth Retardation-Induced Liver Injury and Mitochondrial Dysfunction in Weanling Piglets by Improving Energy Metabolism and Redox Balance. Antioxidants 11:4, pages 666.
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Dandan Tang, Qing Zhang, Huxinyue Duan, Xun Ye, Jia Liu, Wei Peng & Chunjie Wu. (2022) Polydatin: A Critical Promising Natural Agent for Liver Protection via Antioxidative Stress. Oxidative Medicine and Cellular Longevity 2022, pages 1-14.
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Penghui Ye, Hefei Wu, Yinxiao Jiang, Xiaolin Xiao, Dan Song, Nuo Xu, Xiao Ma, Jinhao Zeng & Yaoguang Guo. (2021) Old dog, new tricks: Polydatin as a multitarget agent for current diseases. Phytotherapy Research 36:1, pages 214-230.
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Huihui Zhang, Yadan Li, Yu Xun, Hui Liu, Chenxi Wei, Hao Wang, Xiaoping Yang, Shishan Yuan, Ning Liu & Shuanglin Xiang. (2021) Polydatin protects neuronal cells from hydrogen peroxide damage by activating CREB/Ngb signaling. Molecular Medicine Reports 25:1.
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Zhengtao Gu, Li Li, Qin Li, Hongping Tan, Zhimin Zou, Xueyong Chen, Zichen Zhang, Yijun Zhou, Danian Wei, Chengyong Liu, Qiaobing Huang, Marc Maegele, Daozhang Cai & Mingguang Huang. (2021) Polydatin alleviates severe traumatic brain injury induced acute lung injury by inhibiting S100B mediated NETs formation. International Immunopharmacology 98, pages 107699.
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Liangliang Yao, Muhammad Farrukh Nisar, Tingdong Yan & Chunpeng (Craig) Wan. (2021) Potential Effects of Dietary Isoflavones on Drug-Induced Liver Injury. Journal of Food Quality 2021, pages 1-10.
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Zhicheng Sun, Xiyang Wang & Zhenchao Xu. (2021) SIRT1 provides new pharmacological targets for polydatin through its role as a metabolic sensor. Biomedicine & Pharmacotherapy 139, pages 111549.
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Carrie A. Sims, Hanna E. Labiner, Sohini S. Shah & Joseph A. Baur. (2021) Longevity pathways in stress resistance: targeting NAD and sirtuins to treat the pathophysiology of hemorrhagic shock. GeroScience 43:3, pages 1217-1228.
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Yazhong Zhang, Xu Zhu, Genlin Wang, Liang Chen, Huilin Yang, Fan He & Jun Lin. (2020) Melatonin Rescues the Ti Particle-Impaired Osteogenic Potential of Bone Marrow Mesenchymal Stem Cells via the SIRT1/SOD2 Signaling Pathway. Calcified Tissue International 107:5, pages 474-488.
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Chunyang Lv, Yuan He, Mingli Wei, Guiyun Xu, Chuang Chen, Zhen Xu & Zhilong Ding. (2020) CTRP3 ameliorates cerulein-induced severe acute pancreatitis in mice via SIRT1/NF-κB/p53 axis. Bioscience Reports 40:10.
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Hao Zhang, Yanan Chen, Yue Li & Tian Wang. (2020) Protective Effect of Polydatin on Jejunal Mucosal Integrity, Redox Status, Inflammatory Response, and Mitochondrial Function in Intrauterine Growth-Retarded Weanling Piglets. Oxidative Medicine and Cellular Longevity 2020, pages 1-14.
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Shaozhi Zhang, Sijie Wang, Xingzhu Shi & Xizeng Feng. (2020) Polydatin alleviates parkinsonism in MPTP-model mice by enhancing glycolysis in dopaminergic neurons. Neurochemistry International 139, pages 104815.
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Pandian Nagakannan, Parisa Tabeshmehr & Eftekhar Eftekharpour. (2020) Oxidative damage of lysosomes in regulated cell death systems: Pathophysiology and pharmacologic interventions. Free Radical Biology and Medicine 157, pages 94-127.
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Parvej Ahmad, Sahir Sultan Alvi, Danish Iqbal & M. Salman Khan. (2020) Insights into pharmacological mechanisms of polydatin in targeting risk factors-mediated atherosclerosis. Life Sciences 254, pages 117756.
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Yue Zhang, Di Wang, Di Shen, Yang Luo & Yi-Qun Che. (2020) Identification of exosomal miRNAs associated with the anthracycline-induced liver injury in postoperative breast cancer patients by small RNA sequencing. PeerJ 8, pages e9021.
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Xufei Zhang, Xiuwen Wu, Qiongyuan Hu, Jie Wu, Gefei Wang, Zhiwu Hong & Jianan Ren. (2019) Mitochondrial DNA in liver inflammation and oxidative stress. Life Sciences 236, pages 116464.
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Siqi Xu, Zhenhua Zeng, Ming Zhao, Qiaobing Huang, Youguang Gao, Xingui Dai, Jiayin Lu, Weiqing Huang & Keseng Zhao. (2019) Evidence for SIRT1 Mediated HMGB1 Release From Kidney Cells in the Early Stages of Hemorrhagic Shock. Frontiers in Physiology 10.
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Tingdong Yan, Jinlong Huang, Muhammad Farrukh Nisar, Chunpeng Wan & Weifeng Huang. (2019) The Beneficial Roles of SIRT1 in Drug-Induced Liver Injury. Oxidative Medicine and Cellular Longevity 2019, pages 1-14.
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Hao Zhang, Yongchun Chen, Zhipeng Pei, Huanhuan Gao, Wenwen Shi, Mingxue Sun, Qingqiang Xu, Jie Zhao, Wenqi Meng & Kai Xiao. (2019) Protective effects of polydatin against sulfur mustard-induced hepatic injury. Toxicology and Applied Pharmacology 367, pages 1-11.
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Li Li, Hong-Ping Tan, Cheng-Yong Liu, Lin-Tao Yu, Da-Nian Wei, Zi-Chen Zhang, Kui Lu, Ke-Sen Zhao, Marc Maegele, Dao-Zhang Cai & Zheng-Tao Gu. (2019) Polydatin prevents the induction of secondary brain injury after traumatic brain injury by protecting neuronal mitochondria. Neural Regeneration Research 14:9, pages 1573.
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Boyu Pan, Yuanyuan Ren & Liren Liu. (2018) Uncovering the action mechanism of polydatin via network pharmacological target prediction . RSC Advances 8:34, pages 18851-18858.
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Carrie A. Sims & Joseph A. Baur. (2017) The grapes and wrath: using resveratrol to treat the pathophysiology of hemorrhagic shock. Annals of the New York Academy of Sciences 1403:1, pages 70-81.
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Tobias Müller, Michael Kirsch & Frank Petrat. (2017) Attenuation of Multiple Organ Damage by Continuous Low-Dose Solvent-Free Infusions of Resveratrol after Severe Hemorrhagic Shock in Rats. Nutrients 9:8, pages 889.
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Pengyun Li, Yan Liu, Nana Burns, Ke-Seng Zhao & Rui Song. (2017) SIRT1 is required for mitochondrial biogenesis reprogramming in hypoxic human pulmonary arteriolar smooth muscle cells. International Journal of Molecular Medicine 39:5, pages 1127-1136.
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Weijin Zhang, Qiaobing Huang, Zhenhua Zeng, Jie Wu, Yaoyuan Zhang & Zhongqing Chen. (2017) Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells. Oxidative Medicine and Cellular Longevity 2017, pages 1-8.
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Ningbo Pang, Tangting Chen, Xin Deng, Ni Chen, Rong Li, Meiping Ren, Yongjie Li, Mao Luo, Haiyan Hao, Jianbo Wu & Liqun Wang. (2017) Polydatin Prevents Methylglyoxal-Induced Apoptosis through Reducing Oxidative Stress and Improving Mitochondrial Function in Human Umbilical Vein Endothelial Cells. Oxidative Medicine and Cellular Longevity 2017, pages 1-9.
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Weijin Zhang, Yaoyuan Zhang, Xiaohua Guo, Zhenhua Zeng, Jie Wu, Yanan Liu, Jing He, Ruiting Wang, Qiaobing Huang & Zhongqing Chen. (2017) Sirt1 Protects Endothelial Cells against LPS-Induced Barrier Dysfunction. Oxidative Medicine and Cellular Longevity 2017, pages 1-14.
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Junxiang Ma, Li Chen, Dongmei Song, Yuanyuan Zhang, Tian Chen & Piye Niu. (2017) SIRT1 attenuated oxidative stress induced by methyl tert-butyl ether in HT22 cells. Toxicology Research 6:3, pages 290-296.
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Siqi Xu, Youguang Gao, Qin Zhang, Siwei Wei, Zhongqing Chen, Xingui Dai, Zhenhua Zeng & Ke-seng Zhao. (2016) SIRT1/3 Activation by Resveratrol Attenuates Acute Kidney Injury in a Septic Rat Model. Oxidative Medicine and Cellular Longevity 2016, pages 1-12.
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Zhenhua Zeng, Zhongqing Chen, Siqi Xu, Qin Zhang, Xingmin Wang, Youguang Gao & Ke-seng Zhao. (2016) Polydatin Protecting Kidneys against Hemorrhagic Shock-Induced Mitochondrial Dysfunction via SIRT1 Activation and p53 Deacetylation . Oxidative Medicine and Cellular Longevity 2016, pages 1-15.
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Huiqin Chen, Fajian Luo, Huisheng Song, Huiqiang Long, Na Chen, Jun Wan, Liang Sun, Fengmei Cui & Yu Tu. (2022) Radiation Protection Effect of Polydatin on Radon Exposure Injury of Epithelial Cells and Miceradiation Protection Effect of Polydatin on Radon Exposure Injury of Epithelial Cells and Mice. SSRN Electronic Journal.
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