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Expert Opinion on Therapeutic Targets Volume 19, 2015 - Issue 11: Targets in Women’s Health
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MAP kinases and the inflammatory signaling cascade as targets for the treatment of endometriosis?

Pietro SantulliUniversité Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Assistance Publique – Hôpitaux de Paris (AP- HP), Groupe Hospitalier Universitaire (GHU) Ouest, Centre Hospitalier Universitaire (CHU) Cochin, Department of Gynecology Obstetrics II and Reproductive Medicine, 75679 Paris, France+33 1 58 41 36 72; [email protected];Université Paris Descartes, Sorbonne Paris Cité, Department “Development, Reproduction and Cancer,” Institut Cochin, INSERM U1016, Equipe Pr Batteux, Paris, France
, MD PhD,
Louis MarcellinUniversité Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Assistance Publique – Hôpitaux de Paris (AP- HP), Groupe Hospitalier Universitaire (GHU) Ouest, Centre Hospitalier Universitaire (CHU) Cochin, Department of Gynecology Obstetrics II and Reproductive Medicine, 75679 Paris, France+33 1 58 41 36 72; [email protected];Université Paris Descartes, Sorbonne Paris Cité, Department “Development, Reproduction and Cancer,” Institut Cochin, INSERM U1016, Equipe Pr Batteux, Paris, France
, MD,
Claudia TostiUniversity of Siena, Obstetrics and Gynecology, Department of Molecular and Developmental Medicine, Siena, Italy
, MD,
Sandrine ChouzenouxUniversité Paris Descartes, Sorbonne Paris Cité, Department “Development, Reproduction and Cancer,” Institut Cochin, INSERM U1016, Equipe Pr Batteux, Paris, France
,
Olivier CerlesUniversité Paris Descartes, Sorbonne Paris Cité, Department “Development, Reproduction and Cancer,” Institut Cochin, INSERM U1016, Equipe Pr Batteux, Paris, France
, M. Sci,
Bruno BorgheseUniversité Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Assistance Publique – Hôpitaux de Paris (AP- HP), Groupe Hospitalier Universitaire (GHU) Ouest, Centre Hospitalier Universitaire (CHU) Cochin, Department of Gynecology Obstetrics II and Reproductive Medicine, 75679 Paris, France+33 1 58 41 36 72; [email protected];Université Paris Descartes, Sorbonne Paris Cité, Department “Development, Reproduction and Cancer,” Institut Cochin, INSERM U1016, Equipe Pr Batteux, Paris, France
, MD PhD,
Frédéric BatteuxUniversité Paris Descartes, Sorbonne Paris Cité, Department “Development, Reproduction and Cancer,” Institut Cochin, INSERM U1016, Equipe Pr Batteux, Paris, France;Hôpital Cochin, Department of Immunology, AP-HP, 75679 Paris cedex 14, France
, MD PhD &
Charles ChapronUniversité Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Assistance Publique – Hôpitaux de Paris (AP- HP), Groupe Hospitalier Universitaire (GHU) Ouest, Centre Hospitalier Universitaire (CHU) Cochin, Department of Gynecology Obstetrics II and Reproductive Medicine, 75679 Paris, France+33 1 58 41 36 72; [email protected];Université Paris Descartes, Sorbonne Paris Cité, Department “Development, Reproduction and Cancer,” Institut Cochin, INSERM U1016, Equipe Pr Batteux, Paris, France
, MD show all
Pages 1465-1483 | Published online: 21 Sep 2015

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Dan Li, Feijun Luo, Tianyi Guo, Shuai Han, Hanqing Wang & Qinlu Lin. (2023) Targeting NF-κB pathway by dietary lignans in inflammation: expanding roles of gut microbiota and metabolites. Critical Reviews in Food Science and Nutrition 63:22, pages 5967-5983.
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Yi Wen, Lingxiu Fan, Lili Pang, Tingting Zhao, Ruonan Li, Ying Zhang, Liye Zhang & Wei Yang. (2022) NeiyiKangfu tablets control the progression of endometriosis through inhibiting RAF/MEK/ERK signal pathway by targeting RKIP. Gynecological Endocrinology 38:12, pages 1136-1146.
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Yuan Xu, Feng Gao, Jingyong Zhang, Pingping Cai & Dongsheng Xu. (2022) Fibroblast growth factor receptor 2 promotes the proliferation, migration, and invasion of ectopic stromal cells via activation of extracellular-signal-regulated kinase signaling pathway in endometriosis. Bioengineered 13:4, pages 8360-8371.
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Maria Mercedes Binda, Jacques Donnez & Marie-Madeleine Dolmans. (2017) Targeting mast cells: a new way to treat endometriosis. Expert Opinion on Therapeutic Targets 21:1, pages 67-75.
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Pietro Santulli, Louis Marcellin, Sandrine Chouzenoux, Veronique Boulard, Pierre-Alexandre Just, Carole Nicco, Christiane Chereau, Claudia Tosti, Charles Chapron & Frédéric Batteux. (2016) Role of the protein kinase BRAF in the pathogenesis of endometriosis. Expert Opinion on Therapeutic Targets 20:8, pages 1017-1029.
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Articles from other publishers (36)

Ying-Nan Liu, Jin-Wen Kang, Yu Zhang, Shan-Shan Song, Qi-Xin Xu, Han Zhang, Lei Lu, Shu-Wen Wei, Chen Liang & Ren-Wei Su. (2023) Vanillin prevents the growth of endometriotic lesions through anti-inflammatory and antioxidant pathways in a mouse model. Food & Function 14:14, pages 6730-6744.
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Bao Guo, Jia hua Chen, Jun hui Zhang, Yuan Fang, Xiao jing Liu, Jing Zhang, Hai qing Zhu & Lei Zhan. (2023) Pattern-recognition receptors in endometriosis: A narrative review. Frontiers in Immunology 14.
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Luana Grupioni Lourenço Antonio, Juliana Meola, Ana Carolina Japur de Sá Rosa-e-Silva, Antonio Alberto Nogueira, Francisco José Candido dos Reis, Omero Benedicto Poli-Neto & Julio César Rosa-e-Silva. (2023) Altered Differential Expression of Genes and microRNAs Related to Adhesion and Apoptosis Pathways in Patients with Different Phenotypes of Endometriosis. International Journal of Molecular Sciences 24:5, pages 4434.
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Di Zhang, Guozhong Jin, Wei Liu, Mengmeng Dou, Xiao Wang, Wanyu Shi & Yongzhan Bao. (2022) Salvia miltiorrhiza polysaccharides ameliorates Staphylococcus aureus-induced mastitis in rats by inhibiting activation of the NF-κB and MAPK signaling pathways. BMC Veterinary Research 18:1.
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Hyehyun Hong, Tae-Jin Park, Sungchan Jang, Min-Seon Kim, Jin-Soo Park, Won-Jae Chi & Seung-Young Kim. (2022) Anti-inflammatory activity of 6- O -phospho-7-hydroxycoumarin in LPS-induced RAW 264.7 cells . Journal of Applied Biological Chemistry 65:1, pages 33-41.
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Yingchen Wu, Hao Wang, Shengfu Chen, Yueming Lin, Xiaoqian Xie, Guangzheng Zhong & Qingxue Zhang. (2022) Migraine Is More Prevalent in Advanced-Stage Endometriosis, Especially When Co-Occuring with Adenomoysis. Frontiers in Endocrinology 12.
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Louis Marcellin, Pietro Santulli & Charles Chapron. 2022. Immunology of Endometriosis. Immunology of Endometriosis 215 226 .
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Fahimeh Zamani‐Garmsiri, Solaleh Emamgholipour, Soheil Rahmani Fard, Ghasem Ghasempour, Roya Jahangard Ahvazi & Reza Meshkani. (2021) Polyphenols: Potential anti‐inflammatory agents for treatment of metabolic disorders. Phytotherapy Research 36:1, pages 415-432.
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Harshavardhan Lingegowda, Jessica E. Miller, Ryan M. Marks, Lindsey K. Symons, Taylor Alward, Alan E. Lomax, Madhuri Koti & Chandrakant Tayade. (2021) Synthetic Cannabinoid Agonist WIN 55212-2 Targets Proliferation, Angiogenesis, and Apoptosis via MAPK/AKT Signaling in Human Endometriotic Cell Lines and a Murine Model of Endometriosis. Frontiers in Reproductive Health 3.
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Sze Wan Hung, Ruizhe Zhang, Zhouyurong Tan, Jacqueline Pui Wah Chung, Tao Zhang & Chi Chiu Wang. (2021) Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review. Medicinal Research Reviews 41:4, pages 2489-2564.
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Gizem Bora & Aylin Yaba. (2021) The role of mitogen‐activated protein kinase signaling pathway in endometriosis. Journal of Obstetrics and Gynaecology Research 47:5, pages 1610-1623.
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Hyo Kyozuka, Hidekazu Nishigori, Tsuyoshi Murata, Toma Fukuda, Akiko Yamaguchi, Aya Kanno, Shun Yasuda, Akiko Sato, Yuka Ogata, Masahito Kuse, Mitsuaki Hosoya, Seiji Yasumura, Koichi Hashimoto & Keiya Fujimori. (2021) Prepregnancy antiinflammatory diet in pregnant women with endometriosis: The Japan Environment and Children's Study. Nutrition 85, pages 111129.
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Huda A Mohammed Rasheed & Pousette Hamid. (2020) Inflammation to Infertility: Panoramic View on Endometriosis. Cureus.
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Yang Liu, Junyan Ma, Ding Cui, Xiangwei Fei, Yifei Lv & Jun Lin. (2020) LncRNA MEG3-210 regulates endometrial stromal cells migration, invasion and apoptosis through p38 MAPK and PKA/SERCA2 signalling via interaction with Galectin-1 in endometriosis. Molecular and Cellular Endocrinology 513, pages 110870.
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Kangjun Liu, Tao Ding, Li Fang, Luying Cui, Jun Li, Xia Meng, Guoqiang Zhu, Chen Qian, Heng Wang & Jianji Li. (2020) Organic Selenium Ameliorates Staphylococcus aureus-Induced Mastitis in Rats by Inhibiting the Activation of NF-κB and MAPK Signaling Pathways. Frontiers in Veterinary Science 7.
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Lorraine Maitrot-Mantelet, Justine Hugon-Rodin, Magali Vatel, Louis Marcellin, Pietro Santulli, Charles Chapron & Geneviève Plu-Bureau. (2019) Migraine in relation with endometriosis phenotypes: Results from a French case-control study. Cephalalgia 40:6, pages 606-613.
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Yongpei He, Ting Xiong, Fang Guo, Zhenzhen Du, Yixian Fan, Huanhuan Sun, Zuohua Feng & Guimei Zhang. (2020) Interleukin-37b inhibits the growth of murine endometriosis-like lesions by regulating proliferation, invasion, angiogenesis and inflammation. Molecular Human Reproduction 26:4, pages 240-255.
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Brandon Horn & Wendy Yu. 2020. Integrative and Functional Medical Nutrition Therapy. Integrative and Functional Medical Nutrition Therapy 533 561 .
Songjuan Dai, Maobi Zhu, Rongfeng Wu, Dianchao Lin, Zhixiong Huang, Lulu Ren, Sijing Huang, Lei Cheng & Qionghua Chen. (2021) Lipoxin A4 Suppresses IL-1β-Induced Cyclooxygenase-2 Expression Through Inhibition of p38 MAPk Activation in Endometriosis. Reproductive Sciences 26:12, pages 1640-1649.
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Antonio Simone Laganà, Simone Garzon, Martin Götte, Paola Viganò, Massimo Franchi, Fabio Ghezzi & Dan C. Martin. (2019) The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights. International Journal of Molecular Sciences 20:22, pages 5615.
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Charles Chapron, Louis Marcellin, Bruno Borghese & Pietro Santulli. (2019) Rethinking mechanisms, diagnosis and management of endometriosis. Nature Reviews Endocrinology 15:11, pages 666-682.
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L G C Riccio, M Jeljeli, P Santulli, S Chouzenoux, L Doridot, C Nicco, F M Reis, M S Abrão, C Chapron & F Batteux. (2019) B lymphocytes inactivation by Ibrutinib limits endometriosis progression in mice. Human Reproduction 34:7, pages 1225-1234.
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Chloé Maignien, Pietro Santulli, Sandrine Chouzenoux, Iñaki Gonzalez-Foruria, Louis Marcellin, Ludivine Doridot, Mohammed Jeljeli, Philippe Grange, Fernando M Reis, Charles Chapron & Frédéric Batteux. (2019) Reduced α-2,6 sialylation regulates cell migration in endometriosis. Human Reproduction 34:3, pages 479-490.
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Larissa M. Coutinho, Márcia C. Ferreira, Ana Luiza L. Rocha, Márcia M. Carneiro & Fernando M. Reis. 2019. 59 77 .
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Yi-Heng Lin, Ya-Hsin Chen, Heng-Yu Chang, Heng-Kien Au, Chii-Ruey Tzeng & Yen-Hua Huang. (2018) Chronic Niche Inflammation in Endometriosis-Associated Infertility: Current Understanding and Future Therapeutic Strategies. International Journal of Molecular Sciences 19:8, pages 2385.
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Luiza da Gama Coelho Riccio, Pietro Santulli, Louis Marcellin, Mauricio Simões Abrão, Frederic Batteux & Charles Chapron. (2018) Immunology of endometriosis. Best Practice & Research Clinical Obstetrics & Gynaecology 50, pages 39-49.
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Hakan Cakmak, Yasemin Seval-Celik, Sefa Arlier, Ozlem Guzeloglu-Kayisli, Frederick Schatz, Aydin Arici & Umit A. Kayisli. (2018) p38 Mitogen-Activated Protein Kinase is Involved in the Pathogenesis of Endometriosis by Modulating Inflammation, but not Cell Survival. Reproductive Sciences 25:4, pages 587-597.
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J. Bouaziz, R. Mashiach, S. Cohen, A. Kedem, A. Baron, M. Zajicek, I. Feldman, D. Seidman & D. Soriano. (2018) How Artificial Intelligence Can Improve Our Understanding of the Genes Associated with Endometriosis: Natural Language Processing of the PubMed Database. BioMed Research International 2018, pages 1-7.
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L. Marcellin, P. Santulli, S. Chouzenoux, O. Cerles, C. Nicco, B. Dousset, M. Pallardy, S. Kerdine-Römer, PA. Just, C. Chapron & F. Batteux. (2017) Alteration of Nrf2 and Glutamate Cysteine Ligase expression contribute to lesions growth and fibrogenesis in ectopic endometriosis. Free Radical Biology and Medicine 110, pages 1-10.
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Outi Uimari, Nilufer Rahmioglu, Dale R. Nyholt, Katy Vincent, Stacey A. Missmer, Christian Becker, Andrew P. Morris, Grant W. Montgomery & Krina T. Zondervan. (2017) Genome-wide genetic analyses highlight mitogen-activated protein kinase (MAPK) signaling in the pathogenesis of endometriosis. Human Reproduction 32:4, pages 780-793.
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