1,036
Views
42
CrossRef citations to date
0
Altmetric
Review

Changing paradigm to target microglia in neurodegenerative diseases: from anti-inflammatory strategy to active immunomodulation

, , , , , & show all
Pages 627-640 | Received 13 Sep 2015, Accepted 13 Nov 2015, Published online: 15 Dec 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Zhiheng Sun, Yi Lin, Ying Li, Tong Ren, Guicheng Du, Jia Wang, Xin Jin & Li-Chao Yang. (2018) The effect of dexmedetomidine on inflammatory inhibition and microglial polarization in BV-2 cells. Neurological Research 40:10, pages 838-846.
Read now

Articles from other publishers (41)

Yu Wang, Jiayang Zou, Yue Wang, Jinyang Wang, Xiaoming Ji, Tianyun Zhang, Yun Chu, Rui Cui, Guoliang Zhang, Geming Shi, Yuming Wu & Yunxiao Kang. (2023) Hydralazine inhibits neuroinflammation and oxidative stress in APP/PS1 mice via TLR4/NF-κB and Nrf2 pathways. Neuropharmacology 240, pages 109706.
Crossref
Alejandro Lillo, Joan Serrano-Marín, Jaume Lillo, Iu Raïch, Gemma Navarro & Rafael Franco. (2023) Differential Gene Expression in Activated Microglia Treated with Adenosine A2A Receptor Antagonists Highlights Olfactory Receptor 56 and T-Cell Activation GTPase-Activating Protein 1 as Potential Biomarkers of the Polarization of Activated Microglia. Cells 12:18, pages 2213.
Crossref
Md Reyaz Alam & Shamsher Singh. (2023) Neuromodulation in Parkinson’s disease targeting opioid and cannabinoid receptors, understanding the role of NLRP3 pathway: a novel therapeutic approach. Inflammopharmacology 31:4, pages 1605-1627.
Crossref
Fatima Cheataini, Nissrine Ballout & Tareq Al Sagheer. (2023) The effect of neuroinflammation on the cerebral metabolism at baseline and after neural stimulation in neurodegenerative diseases. Journal of Neuroscience Research 101:8, pages 1360-1379.
Crossref
Vivianne E. Morrison & Gregory J. Bix. (2023) The meal Maketh the Microglia: Why studying microglial phagocytosis is critical to stroke research. Neurochemistry International 164, pages 105488.
Crossref
Siew Lee Cheong, Jian Kai Tiew, Yi Hang Fong, How Wan Leong, Yew Mun Chan, Zhi Ling Chan & Ethan Wei Jie Kong. (2022) Current Pharmacotherapy and Multi-Target Approaches for Alzheimer’s Disease. Pharmaceuticals 15:12, pages 1560.
Crossref
Ekta Shirbhate, Vijay K. Patel, Priya Tiwari, Rakesh Kore, Ravichandran Veerasamy, Achal Mishra & Harish Rajak. (2022) Combination Therapy for the Treatment of Alzheimer’s Disease: Recent Progress and Future Prospects. Current Topics in Medicinal Chemistry 22:22, pages 1849-1867.
Crossref
Hui Liu, Caixia Zang, Junmei Shang, Zihong Zhang, Lu Wang, Hanyu Yang, Chanjuan Sheng, Fangyu Yuan, Cheng Ju, Fangyuan Li, Yang Yu, Xinsheng Yao, Xiuqi Bao & Dan Zhang. (2022) <em>Gardenia jasminoides</em> J. Ellis extract GJ-4 attenuates hyperlipidemic vascular dementia in rats via regulating PPAR-γ-mediated microglial polarization. Food & Nutrition Research.
Crossref
Zhiguo Wang & Baofeng YangZhiguo Wang & Baofeng Yang. 2022. Polypharmacology. Polypharmacology 231 269 .
Neus Rabaneda-Lombarte, Joan Serratosa, Jordi Bové, Miquel Vila, Josep Saura & Carme Solà. (2021) The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson’s disease. Journal of Neuroinflammation 18:1.
Crossref
Jiaxin Li, Xinyu Shui, Ruizheng Sun, Lily Wan, Boxin Zhang, Bo Xiao & Zhaohui Luo. (2021) Microglial Phenotypic Transition: Signaling Pathways and Influencing Modulators Involved in Regulation in Central Nervous System Diseases. Frontiers in Cellular Neuroscience 15.
Crossref
Elisa Uliassi, Andressa Souza de Oliveira, Luciana de Camargo Nascente, Luiz Antonio Soares Romeiro & Maria Laura Bolognesi. (2021) Cashew Nut Shell Liquid (CNSL) as a Source of Drugs for Alzheimer’s Disease. Molecules 26:18, pages 5441.
Crossref
Júlia Canet-Pons, Nesli-Ece Sen, Aleksandar Arsović, Luis-Enrique Almaguer-Mederos, Melanie V. Halbach, Jana Key, Claudia Döring, Anja Kerksiek, Gina Picchiarelli, Raphaelle Cassel, Frédérique René, Stéphane Dieterlé, Nina V. Fuchs, Renate König, Luc Dupuis, Dieter Lütjohann, Suzana Gispert & Georg Auburger. (2021) Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression. Neurobiology of Disease 152, pages 105289.
Crossref
Ricardo Lorenzoni, Samuel Davies, Leticia Malgarim Cordenonsi, José Alcides da Silva Viçosa, Nathana Jamille Mezzomo, Amanda Lima de Oliveira, Guilherme Machado do Carmo, Renata Platcheck Raffin, Oswaldo Luiz Alves, Rodrigo De Almeida Vaucher & Virginia Cielo Rech. (2020) Lipid-core nanocapsules containing simvastatin improve the cognitive impairment induced by obesity and hypercholesterolemia in adult rats. European Journal of Pharmaceutical Sciences 151, pages 105397.
Crossref
Md. Tanvir Kabir, Md. Sahab Uddin, Abdullah Al Mamun, Philippe Jeandet, Lotfi Aleya, Rasha A. Mansouri, Ghulam Md Ashraf, Bijo Mathew, May N. Bin-Jumah & Mohamed M. Abdel-Daim. (2020) Combination Drug Therapy for the Management of Alzheimer’s Disease. International Journal of Molecular Sciences 21:9, pages 3272.
Crossref
Chunsheng Ruan, Linlin Sun, Alexandra Kroshilina, Lien Beckers, Philip De Jager, Elizabeth M. Bradshaw, Samuel A. Hasson, Guang Yang & Wassim Elyaman. (2020) A novel Tmem119-tdTomato reporter mouse model for studying microglia in the central nervous system. Brain, Behavior, and Immunity 83, pages 180-191.
Crossref
Katarzyna Kuter. 2020. Genetics, Neurology, Behavior, and Diet in Parkinson's Disease. Genetics, Neurology, Behavior, and Diet in Parkinson's Disease 83 99 .
S. Yu. Bukhvalova, A. A. Maleev, Yu. A. Gracheva, Yu. V. Voitovich, S. K. Ignatov, E. V. Svirshchevskaya & A. Yu. Fedorov. (2020) Gold-catalyzed cyclization in the synthesis of antimitotic 2,3-dihydrobenzo[b]oxepine derivatives of colchicine. Russian Chemical Bulletin 68:12, pages 2205-2215.
Crossref
Viktoriya Ivasiv, Claudia Albertini, Ana E. Gonçalves, Michele Rossi & Maria L. Bolognesi. (2019) Molecular Hybridization as a Tool for Designing Multitarget Drug Candidates for Complex Diseases. Current Topics in Medicinal Chemistry 19:19, pages 1694-1711.
Crossref
Rebeca Alvariño, Eva Alonso, Mikail E. Abbasov, Christian M. Chaheine, Michael L. Conner, Daniel Romo, Amparo Alfonso & Luis M. Botana. (2019) Gracilin A Derivatives Target Early Events in Alzheimer’s Disease: in Vitro Effects on Neuroinflammation and Oxidative Stress. ACS Chemical Neuroscience 10:9, pages 4102-4111.
Crossref
Serena Montanari, Ali Mokhtar Mahmoud, Letizia Pruccoli, Alessandro Rabbito, Marina Naldi, Sabrina Petralla, Ignacio Moraleda, Manuela Bartolini, Barbara Monti, Isabel Iriepa, Federica Belluti, Silvia Gobbi, Vincenzo Di Marzo, Alessandra Bisi, Andrea Tarozzi, Alessia Ligresti & Angela Rampa. (2019) Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment. European Journal of Medicinal Chemistry 178, pages 243-258.
Crossref
Monika Sharma, Naik Arbabzada & Patrick M. Flood. (2019) Mechanism underlying β2-AR agonist-mediated phenotypic conversion of LPS-activated microglial cells. Journal of Neuroimmunology 332, pages 37-48.
Crossref
Peter Riederer, Daniela Berg, Nicolas Casadei, Fubo Cheng, Joseph Classen, Christian Dresel, Wolfgang Jost, Rejko Krüger, Thomas Müller, Heinz Reichmann, Olaf Rieß, Alexander Storch, Sabrina Strobel, Thilo van Eimeren, Hans-Ullrich Völker, Jürgen Winkler, Konstanze F. Winklhofer, Ullrich Wüllner, Friederike Zunke & Camelia-Maria Monoranu. (2019) α-Synuclein in Parkinson’s disease: causal or bystander?. Journal of Neural Transmission 126:7, pages 815-840.
Crossref
Jihye Choi, Juhwan Kim, Dong Yeong Min, Euitaek Jung, Yoongho Lim, Soon Young Shin & Young Han Lee. (2019) Inhibition of TNFα-induced interleukin-6 gene expression by barley (Hordeum vulgare) ethanol extract in BV-2 microglia. Genes & Genomics 41:5, pages 557-566.
Crossref
Angela De Simone, Valeria La Pietra, Nibal Betari, Nicola Petragnani, Mariarosaria Conte, Simona Daniele, Deborah Pietrobono, Claudia Martini, Sabrina Petralla, Raffaella Casadei, Lara Davani, Flavia Frabetti, Pasquale Russomanno, Ettore Novellino, Serena Montanari, Vincenzo Tumiatti, Patrizia Ballerini, Federica Sarno, Angela Nebbioso, Lucia Altucci, Barbara Monti, Vincenza Andrisano & Andrea Milelli. (2019) Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer’s Disease. ACS Medicinal Chemistry Letters 10:4, pages 469-474.
Crossref
Ana Rita Vaz, Sara Pinto, Catarina Ezequiel, Carolina Cunha, Luís A. Carvalho, Rui Moreira & Dora Brites. (2019) Phenotypic Effects of Wild-Type and Mutant SOD1 Expression in N9 Murine Microglia at Steady State, Inflammatory and Immunomodulatory Conditions. Frontiers in Cellular Neuroscience 13.
Crossref
Blanca I. Aldana. (2019) Microglia-Specific Metabolic Changes in Neurodegeneration. Journal of Molecular Biology 431:9, pages 1830-1842.
Crossref
Rebeca Alvariño, Eva Alonso, Rodney Lacret, Daniel Oves-Costales, Olga Genilloud, Fernando Reyes, Amparo Alfonso & Luis M. Botana. (2018) Streptocyclinones A and B ameliorate Alzheimer's disease pathological processes in vitro. Neuropharmacology 141, pages 283-295.
Crossref
Snezana Agatonovic-Kustrin, Christine Kettle & David W. Morton. (2018) A molecular approach in drug development for Alzheimer’s disease. Biomedicine & Pharmacotherapy 106, pages 553-565.
Crossref
Sisi Qin, Canhong Yang, Weihua Huang, Shuhua Du, Hantao Mai, Jijie Xiao & Tianming Lü. (2018) Sulforaphane attenuates microglia-mediated neuronal necroptosis through down-regulation of MAPK/NF-κB signaling pathways in LPS-activated BV-2 microglia. Pharmacological Research 133, pages 218-235.
Crossref
Antony Cougnoux, Rebecca A Drummond, Amanda L Collar, James R Iben, Alexander Salman, Harrison Westgarth, Christopher A Wassif, Niamh X Cawley, Nicole Y Farhat, Keiko Ozato, Michail S Lionakis & Forbes D Porter. (2018) Microglia activation in Niemann–Pick disease, type C1 is amendable to therapeutic intervention. Human Molecular Genetics 27:12, pages 2076-2089.
Crossref
Palsamy Periyasamy, Ke Liao, Yeon Hee Kook, Fang Niu, Shannon E. Callen, Ming-Lei Guo & Shilpa Buch. (2017) Cocaine-Mediated Downregulation of miR-124 Activates Microglia by Targeting KLF4 and TLR4 Signaling. Molecular Neurobiology 55:4, pages 3196-3210.
Crossref
Yingli He, Hua She, Ting Zhang, Haidong Xu, Lihong Cheng, Manuel Yepes, Yingren Zhao & Zixu Mao. (2018) p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1. Journal of Cell Biology 217:1, pages 315-328.
Crossref
Nils Lannes, Elisabeth Eppler, Samar Etemad, Peter Yotovski & Luis Filgueira. (2017) Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system. Oncotarget 8:69, pages 114393-114413.
Crossref
Ekaterina S. Shchegravina, Alexander A. Maleev, Stanislav K. Ignatov, Iuliia A. Gracheva, Andreas Stein, Hans-Günther Schmalz, Andrey E. Gavryushin, Anastasiya A. Zubareva, Elena V. Svirshchevskaya & Alexey Yu. Fedorov. (2017) Synthesis and biological evaluation of novel non-racemic indole-containing allocolchicinoids. European Journal of Medicinal Chemistry 141, pages 51-60.
Crossref
Shaoxia Wang, Fujiang Wang, Hongyun Yang, Ruilin Li, Hong Guo & Limin Hu. (2017) Diosgenin glucoside provides neuroprotection by regulating microglial M1 polarization. International Immunopharmacology 50, pages 22-29.
Crossref
Chunyang Zhao, Weizhen Hou, Hui Lei, Longjian Huang, Shan Wang, Dandan Cui, Changhong Xing, Xiaoliang Wang & Ying Peng. (2017) Potassium 2-(l-hydroxypentyl)-benzoate attenuates neuroinflammatory responses and upregulates heme oxygenase-1 in systemic lipopolysaccharide-induced inflammation in mice. Acta Pharmaceutica Sinica B 7:4, pages 470-478.
Crossref
Sudhakar R. Subramaniam & Howard J. Federoff. (2017) Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson’s Disease. Frontiers in Aging Neuroscience 9.
Crossref
Ming-Liang Zhang, Xiao-Jian Zhang, Jian Kang, Hui-Jun Zhang, Xiao-Long Chen, Nan Liu, Shu-Qing Liu, Wen-Di Ma, Guang-Xian Zhang & Lin Zhu. (2017) Matrine promotes NT3 expression in CNS cells in experimental autoimmune encephalomyelitis. Neuroscience Letters 649, pages 100-106.
Crossref
Jakub Jeřábek, Elisa Uliassi, Laura Guidotti, Jan Korábečný, Ondřej Soukup, Vendula Sepsova, Martina Hrabinova, Kamil Kuča, Manuela Bartolini, Luis Emiliano Peña-Altamira, Sabrina Petralla, Barbara Monti, Marinella Roberti & Maria Laura Bolognesi. (2017) Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease. European Journal of Medicinal Chemistry 127, pages 250-262.
Crossref
Federica Prati, Andrea Cavalli & Maria Bolognesi. (2016) Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer’s Disease. Molecules 21:4, pages 466.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.