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Emerging Therapeutic Targets Volume 4, 2000 - Issue 1
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A return to rational drug discovery: computer-based models of cells, organs and systems in drug target identification

Denis Noble University Laboratory of Physiology, Parks Road, Oxford, OX1 3PT, UK. E-mail: [email protected]
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Thomas J Colatsky Physiome Sciences, Inc., 307 College Road East, PrincetonNJ 08540, USA. [email protected]
Pages 39-49 | Published online: 25 Feb 2005

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Richard Li-Xiang Ho. (2000) Biosystems modelling for in silico target validation: challenges to implementation. Emerging Therapeutic Targets 4:6, pages 699-714.
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Articles from other publishers (24)

John Paul Gosling. (2019) The importance of mathematical modelling in chemical risk assessment and the associated quantification of uncertainty. Computational Toxicology 10, pages 44-50.
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Syed Hussain Basha & R Nalini Prasad. (2012) In-Silico screening of Pleconaril and its novel substituted derivatives with Neuraminidase of H1N1 Influenza strain. BMC Research Notes 5:1.
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Gary R Mirams, Mark R Davies, Yi Cui, Peter Kohl & Denis Noble. (2012) Application of cardiac electrophysiology simulations to pro‐arrhythmic safety testing. British Journal of Pharmacology 167:5, pages 932-945.
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Sean Ekins, Andrej Bugrim, Yuri Nikolsky & Tatiana Nikolskaya. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 61 .
Alan Garny, Denis Noble, Peter J. Hunter & Peter Kohl. (2009) Cellular Open Resource (COR): current status and future directions . Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 367:1895, pages 1885-1905.
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Denis Noble. (2008) Computational Models of the Heart and Their Use in Assessing the Actions of Drugs. Journal of Pharmacological Sciences 107:2, pages 107-117.
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Denis Noble. 2007. Biosimulation in Drug Development. Biosimulation in Drug Development 259 272 .
S Ekins, J Mestres & B Testa. (2007) In silico pharmacology for drug discovery: applications to targets and beyond . British Journal of Pharmacology 152:1, pages 21-37.
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Denis Noble. (2007) From the Hodgkin-Huxley axon to the virtual heart. The Journal of Physiology 580:1, pages 15-22.
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Denis Noble. (2006) Systems biology and the heart. Biosystems 83:2-3, pages 75-80.
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D. Noble. (2005) The heart is already working. Biochemical Society Transactions 33:3, pages 539-542.
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Michael N Moore & Denis Noble. (2004) Editorial: Computational modelling of cell & tissue processes & function. The Histochemical Journal 35:7, pages 655-658.
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A. Finkelstein, J. Hetherington, Linzhong Li, O. Margoninski, P. Saffrey, R. Seymour & A. Warner. (2004) Computational challenges of systems biology. Computer 37:5, pages 26-33.
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Denis Noble. (2003) Will genomics revolutionise pharmaceutical R&D?. Trends in Biotechnology 21:8, pages 333-337.
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C.J Musante, Annette K Lewis & Kevin Hall. (2002) Small- and large-scale biosimulation applied to drug discovery and development. Drug Discovery Today 7:20, pages s192-s196.
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Denis Noble. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences.
Christoph A. Karle, Dierk Thomas & Johann Kiehn. (2006) The Antiarrhythmic Drug BRL‐32872. Cardiovascular Drug Reviews 20:2, pages 111-120.
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Denis Noble. (2002) The rise of computational biology. Nature Reviews Molecular Cell Biology 3:6, pages 459-463.
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Denis Noble. (2002) Unraveling the genetics and mechanisms of cardiac arrhythmia. Proceedings of the National Academy of Sciences 99:9, pages 5755-5756.
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Denis Noble. (2002) Modeling the Heart--from Genes to Cells to the Whole Organ. Science 295:5560, pages 1678-1682.
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Kevin Hall, Rebecca Baillie & Seth Michelson. 2002. Annual Reports in Medicinal Chemistry Volume 37. Annual Reports in Medicinal Chemistry Volume 37 279 288 .
P. J. Hunter, P. KohlD. Noble. (2001) Integrative models of the heart: achievements and limitations. Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences 359:1783, pages 1049-1054.
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A K Macpherson, S Neti & P A Macpherson. (2001) A rapid procedure for initial drug evaluation. Physics in Medicine and Biology 46:6, pages N139-N147.
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Sean Ekins, Chris L Waller, Peter W Swaan, Gabriele Cruciani, Steven A Wrighton & James H Wikel. (2000) Progress in predicting human ADME parameters in silico. Journal of Pharmacological and Toxicological Methods 44:1, pages 251-272.
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