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Miscellaneous

Insights into the structure and function of 5-HT2 familyserotonin receptors reveal novel strategies for therapeutic target development

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Pages 685-695 | Published online: 25 Feb 2005

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Benjamin G. Tehan, Andrea Bortolato, Frank E. Blaney, Malcolm P. Weir & Jonathan S. Mason. (2014) Unifying Family A GPCR Theories of Activation. Pharmacology & Therapeutics 143:1, pages 51-60.
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Jae Wan Jang, Min Sup Kim, Yong Seo Cho, Art E. Cho & Ae Nim Pae. (2012) Identification of structural determinants of ligand selectivity in 5-HT2 receptor subtypes on the basis of protein–ligand interactions. Journal of Molecular Graphics and Modelling 38, pages 342-353.
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John A. Allen & Bryan L. Roth. (2011) Strategies to Discover Unexpected Targets for Drugs Active at G Protein–Coupled Receptors. Annual Review of Pharmacology and Toxicology 51:1, pages 117-144.
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Sung Jin ChoNiels H. JensenToru KuromeSudhakar KadariMichael L. ManzanoJessica E. MalbergBarbara CaldaroneBryan L. RothAlan P. Kozikowski. (2009) Selective 5-Hydroxytryptamine 2C Receptor Agonists Derived from the Lead Compound Tranylcypromine: Identification of Drugs with Antidepressant-Like Action. Journal of Medicinal Chemistry 52:7, pages 1885-1902.
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John A. Allen, Prem N. Yadav & Bryan L. Roth. (2008) Insights into the regulation of 5-HT2A serotonin receptors by scaffolding proteins and kinases. Neuropharmacology 55:6, pages 961-968.
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Zhili Zuo, Gang Chen, Xiaomin Luo, Chummok Puah, Weiliang Zhu, Kaixian Chen & Hualiang Jiang. (2007) Pharmacophore-directed Homology Modeling and Molecular Dynamics Simulation of G Protein-coupled Receptor: Study of Possible Binding Modes of 5-HT<sub>2C</sub> Receptor Agonists. Acta Biochimica et Biophysica Sinica 39:6, pages 413-422.
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Kelly A. Berg, Sylvia Navailles, Teresa A. Sanchez, Yamille M. Silva, Martyn D. Wood, Umberto Spampinato & William P. Clarke. (2006) Differential Effects of 5-Methyl-1-[[2-[(2-methyl-3-pyridyl)oxyl]-5-pyridyl]carbamoyl]-6-trifluoromethylindone (SB 243213) on 5-Hydroxytryptamine 2C Receptor-Mediated Responses . Journal of Pharmacology and Experimental Therapeutics 319:1, pages 260-268.
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Ola M. Ghoneim, Jacqueline A. Legere, Alexander Golbraikh, Alexander Tropsha & Raymond G. Booth. (2006) Novel ligands for the human histamine H1 receptor: Synthesis, pharmacology, and comparative molecular field analysis studies of 2-dimethylamino-5-(6)-phenyl-1,2,3,4-tetrahydronaphthalenes. Bioorganic & Medicinal Chemistry 14:19, pages 6640-6658.
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Bryan Roth. (2006) 5-Hydroxytryptamine receptor 2A. AfCS-Nature Molecule Pages.
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Kerry A. O'Connor & Bryan L. Roth. (2005) Finding New Tricks For Old Drugs: An Efficient Route For Public-Sector Drug Discovery. Nature Reviews Drug Discovery 4:12, pages 1005-1014.
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Kelly A. Berg, John A. Harvey, Umberto Spampinato & William P. Clarke. (2005) Physiological relevance of constitutive activity of 5-HT2A and 5-HT2C receptors. Trends in Pharmacological Sciences 26:12, pages 625-630.
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Howard Sard, Govindaraj Kumaran, Cynthia Morency, Bryan L. Roth, Beth Ann Toth, Ping He & Louis Shuster. (2005) SAR of psilocybin analogs: Discovery of a selective 5-HT2C agonist. Bioorganic & Medicinal Chemistry Letters 15:20, pages 4555-4559.
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Anil Purohit, Carol Smith, Katharine Herrick-Davis & Milt Teitler. (2004) Stable expression of constitutively activated mutant h5HT6 and h5HT7 serotonin receptors: inverse agonist activity of antipsychotic drugs. Psychopharmacology 179:2, pages 461-469.
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Maud Deraet, Philippe Manivet, Agnes Janoshazi, Jacques Callebert, Silke Guenther, Ludovic Drouet, Jean-Marie Launay & Luc Maroteaux. (2005) The Natural Mutation Encoding a C Terminus-Truncated 5-Hydroxytryptamine 2B Receptor Is a Gain of Proliferative Functions . Molecular Pharmacology 67:4, pages 983-991.
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Bryan L Roth, Estela Lopez, Scott Beischel, Richard B Westkaemper & Jon M Evans. (2004) Screening the receptorome to discover the molecular targets for plant-derived psychoactive compounds: a novel approach for CNS drug discovery. Pharmacology & Therapeutics 102:2, pages 99-110.
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L. Costa-Campos, S.C. Dassoler, A.P. Rigo, M. Iwu & E. Elisabetsky. (2004) Anxiolytic properties of the antipsychotic alkaloid alstonine. Pharmacology Biochemistry and Behavior 77:3, pages 481-489.
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Ε. Pretorius. (2004) Corticosteroids, Depression and the Role of Serotonin. Reviews in the Neurosciences 15:2.
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Michael D Ennis, Robert L Hoffman, Nabil B Ghazal, Rebecca M Olson, Christopher S Knauer, Chris L Chio, Deborah K Hyslop, Jeffery E Campbell, Lawrence W Fitzgerald, Nanette F Nichols, Kjell A Svensson, Robert B McCall, Christopher L Haber, Michelle L Kagey & Dac M Dinh. (2003) 2,3,4,5-Tetrahydro- and 2,3,4,5,11,11a-hexahydro-1H-[1,4]diazepino[1,7-a]indoles: new templates for 5-HT2C agonists. Bioorganic & Medicinal Chemistry Letters 13:14, pages 2369-2372.
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Bryan L Roth, Douglas Sheffler & Steven G Potkin. (2003) Atypical antipsychotic drug actions: unitary or multiple mechanisms for ‘atypicality’?. Clinical Neuroscience Research 3:1-2, pages 108-117.
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Kateri A. Ahrendt, Robert G. Bergman & Jonathan A. Ellman. (2003) Synthesis of a Tricyclic Mescaline Analogue by Catalytic C−H Bond Activation. Organic Letters 5:8, pages 1301-1303.
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David A. Shapiro, Kurt Kristiansen, David M. Weiner, Wesley K. Kroeze & Bryan L. Roth. (2002) Evidence for a Model of Agonist-induced Activation of 5-Hydroxytryptamine 2A Serotonin Receptors That Involves the Disruption of a Strong Ionic Interaction between Helices 3 and 6. Journal of Biological Chemistry 277:13, pages 11441-11449.
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