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Mechanisms underlying methotrexate-induced pulmonary toxicity

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Pages 451-458 | Published online: 21 Jun 2009

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Jennifer Christine Gutierrez & Kathleen Hwang. (2017) The toxicity of methotrexate in male fertility and paternal teratogenicity. Expert Opinion on Drug Metabolism & Toxicology 13:1, pages 51-58.
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Hamit Emre Kızıl, Cuneyt Caglayan, Ekrem Darendelioğlu, Adnan Ayna, Cihan Gür, Fatih Mehmet Kandemir & Sefa Küçükler. (2023) Morin ameliorates methotrexate-induced hepatotoxicity via targeting Nrf2/HO-1 and Bax/Bcl2/Caspase-3 signaling pathways. Molecular Biology Reports 50:4, pages 3479-3488.
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Qiuyu Wu, Xiangjie Chen, Caixia Qiao, Xinhua Cao, Qian Du, Yukang Yuan, Yibo Zuo, Ying Miao, Zhijin Zheng, Tingting Zhang, Lichao Zang, Xinyu Yang, Weifeng Shi, Zhijun Xie, Yang Xu, Depei Wu, Chengping Wen & Hui Zheng. (2023) Methotrexate and Triptolide regulate Notch signaling pathway by targeting the Nedd4-Numb axis. International Immunopharmacology 114, pages 109595.
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Gheorghe-Eduard Marin, Maria-Adriana Neag, Codrin-Constantin Burlacu & Anca-Dana Buzoianu. (2022) The Protective Effects of Nutraceutical Components in Methotrexate-Induced Toxicity Models—An Overview. Microorganisms 10:10, pages 2053.
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Matt Lewis, Lorinda Chung & David Fiorentino. 2022. Interdisciplinary Approaches to Overlap Disorders in Dermatology & Rheumatology. Interdisciplinary Approaches to Overlap Disorders in Dermatology & Rheumatology 53 91 .
Huanhuan Yan, Rui Su, Hongwei Xue, Chong Gao, Xiaofeng Li & Caihong Wang. (2021) Pharmacomicrobiology of Methotrexate in Rheumatoid Arthritis: Gut Microbiome as Predictor of Therapeutic Response. Frontiers in Immunology 12.
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N.M. Millan, J Morano, L Florez, J Carugno & C.A. Medina. (2021) Management of tubal ectopic pregnancy with methotrexate in the setting of symptomatic Coronavirus disease 2019 (COVID-19): A case report. Facts, Views and Vision in ObGyn 13:3, pages 273-277.
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Jia-Ying Wu, Yuen-Cheung Chan, Hui Guo, Ying-Jie Chen, Yu-Xi Liu, Hua Yi & Zhi-Ling Yu. (2020) Twenty-four-week oral dosing toxicities of Herba Siegesbeckiae in rats. BMC Complementary Medicine and Therapies 20:1.
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Pradnya D. Patil & Tanmay S. Panchabhai. 2020. Handbook of Cancer Treatment-Related Symptons and Toxicities. Handbook of Cancer Treatment-Related Symptons and Toxicities 61 72 .
George E Fragoulis, Richard Conway & Elena Nikiphorou. (2019) Methotrexate and interstitial lung disease: controversies and questions. A narrative review of the literature. Rheumatology 58:11, pages 1900-1906.
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A. Gohar. (2019) Lungs, methotrexate and psoriasis. Clinical and Experimental Dermatology 44:5, pages 594-595.
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Itay Ayalon, Shirley Friedman, Yoav Binenbaum, Noga Oppenheimer, Shelly Shiran, Galia Grisaru-Soen, Shimrit Uliel-Sibony, Miguel Glatstein, Jennifer Melissa Kaplan & Efraim Sadot. (2019) A Case of Methotrexate Neurotoxicity Presented as Status Epilepticus, Encephalopathy, and High Fever. Journal of Investigative Medicine High Impact Case Reports 7, pages 232470961986231.
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Simone Barsotti & Ingrid E. Lundberg. (2018) Current Treatment for Myositis. Current Treatment Options in Rheumatology 4:4, pages 299-315.
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Wanying Wang, Hua Zhou & Liang Liu. (2018) Side effects of methotrexate therapy for rheumatoid arthritis: A systematic review. European Journal of Medicinal Chemistry 158, pages 502-516.
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Yasuo Saijo. 2018. Drug-Induced Lung Injury. Drug-Induced Lung Injury 129 138 .
Hidetoshi Nakamura & Minoru Kanazawa. 2018. Drug-Induced Lung Injury. Drug-Induced Lung Injury 3 12 .
Dimos K. Gidaris, Kostas N. Priftis & Michael B. Anthracopoulos. 2018. Pulmonary Complications of Non-Pulmonary Pediatric Disorders. Pulmonary Complications of Non-Pulmonary Pediatric Disorders 241 262 .
Azza A. K. El-Sheikh, Mohamed A. Morsy & Abdulla Y. Al-Taher. (2016) Protective mechanisms of resveratrol against methotrexate-induced renal damage may involve BCRP/ABCG2. Fundamental & Clinical Pharmacology 30:5, pages 406-418.
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Vidyullatha Peddireddy, Siva Prasad Badabagni, Shehnaz Sulthana, Venkata Karunakar Kolla, Sandhya Devi Gundimeda & Hemaprasad Mundluru. (2016) Association of TNFα−308, IFNγ+874, and IL10−1082 gene polymorphisms and the risk of non-small cell lung cancer in the population of the South Indian state of Telangana. International Journal of Clinical Oncology 21:5, pages 843-852.
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Spyros A. Papiris, Effrosyni D. Manali, Likurgos Kolilekas, Konstantinos Kagouridis, Maria Maniati, Gerasimos Filippatos & Demosthenes Bouros. (2016) Acute Respiratory Events in Connective Tissue Disorders. Respiration 91:3, pages 181-201.
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Paul Kevin Hamilton & Philip Toner. 2015. Gastrointestinal emergencies. Gastrointestinal emergencies 117 131 .
Nancy J Olsen, Charles F SpurlockIIIIII & Thomas M Aune. (2014) Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937. Arthritis Research & Therapy 16:1.
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Paul F. Dellaripa & Kevin R. Flaherty. 2014. Pulmonary Manifestations of Rheumatic Disease. Pulmonary Manifestations of Rheumatic Disease 1 11 .
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Angela M. Miller, Gabriela Lopez‐Mitnik, Gabriel Somarriba, Stuart R. Lipsitz, Andrea S. Hinkle, Louis S. Constine, Steven E. Lipshultz & Tracie L. Miller. (2012) Exercise capacity in long‐term survivors of pediatric cancer: An analysis from the cardiac risk factors in childhood cancer survivors study. Pediatric Blood & Cancer 60:4, pages 663-668.
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Margarethe M Bosma-den Boer, Marie-Louise van Wetten & Leo Pruimboom. (2012) Chronic inflammatory diseases are stimulated by current lifestyle: how diet, stress levels and medication prevent our body from recovering. Nutrition & Metabolism 9:1, pages 32.
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Osamu Matsuno. (2012) Drug-induced interstitial lung disease: mechanisms and best diagnostic approaches. Respiratory Research 13:1, pages 39.
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EDWARD C. KEYSTONE, VALERY S. SHIRINSKY, LEE S. SIMON, SIMON PEDDER & L. ARTHUR HEWITT. (2011) Efficacy and Safety of CH-1504, a Metabolically Stable Antifolate, in Patients with Active Rheumatoid Arthritis: Results of a Phase II Multicenter Randomized Study. The Journal of Rheumatology 38:9, pages 1875-1883.
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Noor Al-Dasooqi, Joanne M. Bowen, Rachel J. Gibson, Richard M. Logan, Andrea M. Stringer & Dorothy M. Keefe. (2011) Selection of Housekeeping Genes for Gene Expression Studies in a Rat Model of Irinotecan-Induced Mucositis. Chemotherapy 57:1, pages 43-53.
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Jacyntha A. Sterling. (2009) Recent Publications on Medications and Pharmacy. Hospital Pharmacy 44:9, pages 822-828.
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