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Toxicity of sorafenib: clinical and molecular aspects

, PharmD PhD, , , , , , , & show all
Pages 275-287 | Published online: 17 Jan 2010

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Claudio Cerchione, Andrés Peleteiro Raíndo, Adrián Mosquera Orgueira, Alicia Mosquera Torre, Laura Bao Pérez, Giovanni Marconi, Alessandro Isidori, Manuel Mateo Pérez Encinas & Giovanni Martinelli. (2021) Safety of FLT3 inhibitors in patients with acute myeloid leukemia. Expert Review of Hematology 14:9, pages 851-865.
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William H. Smith, Amy S. Law, Miriam Hulkower, Heather M. McGee, Eric J. Lehrer, Myron Schwartz, Bachir Taouli, Max Sung & Michael Buckstein. (2020) The effect of radiation therapy on the objective response and outcomes with nivolumab for hepatocellular carcinoma. Acta Oncologica 59:8, pages 940-943.
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Zeran Yang, Guang Chen, Ye Cui, Guowen Xiao, Tianhao Su, Jianan Yu, Zhiyuan Zhang, Yanjing Han, Kailan Yang & Long Jin. (2019) The safety and efficacy of TACE combined with apatinib on patients with advanced hepatocellular carcinoma: a retrospective study. Cancer Biology & Therapy 20:3, pages 321-327.
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Chun-Bing Chen, Ming-Ying Wu, Chau Yee Ng, Chun-Wei Lu, Jennifer Wu, Pei-Han Kao, Chan-Keng Yang, Meng-Ting Peng, Chen-Yang Huang, Wen-Cheng Chang, Rosaline Chung-Yee Hui, Chih-Hsun Yang, Shun-Fa Yang, Wen-Hung Chung & Shih-Chi Su. (2018) Severe cutaneous adverse reactions induced by targeted anticancer therapies and immunotherapies. Cancer Management and Research 10, pages 1259-1273.
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Joanna Mangana, Mitchell P Levesque, Maria B Karpova & Reinhard Dummer. (2012) Sorafenib in melanoma. Expert Opinion on Investigational Drugs 21:4, pages 557-568.
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Renuka Iyer, Gerald Fetterly, Amit Lugade & Yasmin Thanavala. (2010) Sorafenib: a clinical and pharmacologic review. Expert Opinion on Pharmacotherapy 11:11, pages 1943-1955.
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Parul D. Agarwal, Michael R. Lucey, Adnan Said & Jeremy Kratz. (2023) Immunotherapy for HCC: limitations in patients with NASH. Annals of Hepatology 28:2, pages 100886.
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Xinhong Fei, Shuqin Zhang, Jiangying Gu & Jingbo Wang. (2022) FLT3 inhibitors as maintenance therapy post allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients with FLT3 mutations: A meta‐analysis . Cancer Medicine 12:6, pages 6877-6888.
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Inés Roger, Paula Montero, Martín Pérez-Leal, Javier Milara & Julio Cortijo. (2023) Evaluation of Delayed-Type Hypersensitivity to Antineoplastic Drugs—An Overview. Cancers 15:4, pages 1208.
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Catherine Wegner Wippel, Hari Deshpande, Huned Patwa & Aldo J Peixoto. (2022) Neurogenic orthostatic hypotension after treatment with sorafenib. BMJ Case Reports 15:12, pages e247140.
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Nasrin Nassiri Koopaei, Mehrasa Shademani, Nasrin Shirzad Yazdi, Raheleh Tahmasvand, Mina Dehbid, Mansur Nassiri Koopaei, Homa Azizian, Zahra Mousavi, Ali Almasirad & Mona Salimi. (2022) Design and synthesis of novel ureido and thioureido conjugated hydrazone derivatives with potent anticancer activity. BMC Chemistry 16:1.
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Yuwei LiuDongyang Wang & Xingshun Qi. (2022) Skin Rash After Camrelizumab and Sorafenib in a Patient With Advanced Hepatocellular Carcinoma. The International Journal of Gastroenterology and Hepatology Diseases 1:2.
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In Young Jo, Hee Chul Park, Eun Seog Kim, Seung-Gu Yeo, Myungsoo Kim, Jinsil Seong, Jun Won Kim, Tae Hyun Kim, Won Sup Yoon, Bae Kwon Jeong, Sung Hwan Kim & Jong Hoon Lee. (2022) Stereotactic ablative radiotherapy for pulmonary oligometastases from primary hepatocellular carcinoma: a multicenter and retrospective analysis (KROG 17-08). Japanese Journal of Clinical Oncology 52:6, pages 616-622.
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Chia-Yu Chu. 2022. Drug Eruptions. Drug Eruptions 303 316 .
M. Nazim Abbas, Wei Son Tan & Ganessan Kichenadasse. (2021) Sorafenib-related generalized eruptive keratoacanthomas (Grzybowski syndrome): a case report. Journal of Medical Case Reports 15:1.
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Graziele Baldan Ferrari, Júlia Coelho França Quintanilha, Marília Berlofa Visacri, Camila Oliveira Vaz, Maria Aparecida Cursino, Laís Sampaio Amaral, Brito Bastos, Taynna Tatiane Pereira, João Paulo de Oliveira Guarnieri, Nadine de Godoy Torso, Carmen Silvia Passos Lima & Patricia Moriel. (2020) Outcomes in hepatocellular carcinoma patients undergoing sorafenib treatment: toxicities, cellular oxidative stress, treatment adherence, and quality of life. Anti-Cancer Drugs 31:5, pages 523-527.
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Jianping Wu, Yao Huang, Qian Xie, Junfeng Zhang & Zhen Zhan. (2020) A novel bis-aryl urea compound inhibits tumor proliferation via cathepsin D-associated apoptosis. Anti-Cancer Drugs 31:5, pages 500-506.
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William H. Smith, Meng Ru, Heather M. McGee, Max Sung, Kenneth E. Rosenzweig & Michael Buckstein. (2020) Safety of nivolumab in combination with prior or concurrent radiation therapy in hepatocellular carcinoma. Journal of Radiation Oncology 9:1-2, pages 45-52.
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Hai le Ba, Litaty Mbatchi, Florence Gattacceca, Alexandre Evrard, Bruno Lacarelle, Benoit Blanchet, Joseph Ciccolini & Sébastien Salas. (2020) Pharmacogenetics and pharmacokinetics modeling of unexpected and extremely severe toxicities after sorafenib intake. Pharmacogenomics 21:3, pages 173-179.
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Elisa Callegari, Lucilla D’Abundo, Paola Guerriero, Carolina Simioni, Bahaeldin K. Elamin, Marta Russo, Alice Cani, Cristian Bassi, Barbara Zagatti, Luciano Giacomelli, Stella Blandamura, Farzaneh Moshiri, Simona Ultimo, Antonio Frassoldati, Giuseppe Altavilla, Laura Gramantieri, Luca Maria Neri, Silvia Sabbioni & Massimo Negrini. (2018) miR-199a-3p Modulates MTOR and PAK4 Pathways and Inhibits Tumor Growth in a Hepatocellular Carcinoma Transgenic Mouse Model. Molecular Therapy - Nucleic Acids 11, pages 485-493.
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Valentina Giglio, Maurizio Viale, Vittorio Bertone, Irena Maric, Rita Vaccarone & Graziella Vecchio. (2017) Cyclodextrin polymers as nanocarriers for sorafenib. Investigational New Drugs 36:3, pages 370-379.
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Chau Yee Ng, Chun-Bing Chen, Ming-Ying Wu, Jennifer Wu, Chih-Hsun Yang, Rosaline Chung-Yee Hui, Ya-Ching Chang & Chun-Wei Lu. (2018) Anticancer Drugs Induced Severe Adverse Cutaneous Drug Reactions: An Updated Review on the Risks Associated with Anticancer Targeted Therapy or Immunotherapies. Journal of Immunology Research 2018, pages 1-9.
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Francesca Garuti, Vittoria Camelli, Luca Spinardi, Laura Bucci & Franco Trevisani. (2016) Osteonecrosis of the Jaw during Sorafenib Therapy for Hepatocellular Carcinoma. Tumori Journal 102:2_suppl, pages S69-S70.
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Xiaoxiao Sun, Qiaoling Song, Li He, Lei Yan, Jingli Liu, Qing Zhang & Qiang Yu. (2016) Receptor Tyrosine Kinase Phosphorylation Pattern–Based Multidrug Combination Is an Effective Approach for Personalized Cancer Treatment. Molecular Cancer Therapeutics 15:10, pages 2508-2520.
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Nikki Tang & Desiree Ratner. (2016) Managing Cutaneous Side Effects From Targeted Molecular Inhibitors for Melanoma and Nonmelanoma Skin Cancer. Dermatologic Surgery 42:Supplement 1, pages S40-S48.
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James B. Macdonald, Brooke Macdonald, Loren E. Golitz, Patricia LoRusso & Aleksandar Sekulic. (2015) Cutaneous adverse effects of targeted therapies. Journal of the American Academy of Dermatology 72:2, pages 203-218.
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Snezana Djordjevic & Paul C. Driscoll. (2013) Targeting VEGF signalling via the neuropilin co-receptor. Drug Discovery Today 18:9-10, pages 447-455.
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Syu-Ichi Kanno. (2012) Exogenous albumin inhibits sorafenib-induced cytotoxicity in human cancer cell lines. Molecular and Clinical Oncology.
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David S. HongMaria E. CabanillasJennifer Wheler, Aung NaingApostolia M. TsimberidouLei YeSteven G. WaguespackMike HernandezAlder K. El NaggarSavita BidyasarJohn Wright, Steven I. ShermanRazelle Kurzrock. (2011) Inhibition of the Ras/Raf/MEK/ERK and RET Kinase Pathways with the Combination of the Multikinase Inhibitor Sorafenib and the Farnesyltransferase Inhibitor Tipifarnib in Medullary and Differentiated Thyroid Malignancies. The Journal of Clinical Endocrinology & Metabolism 96:4, pages 997-1005.
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Oliver Waidmann, Wolf-Peter Hofmann, Stefan Zeuzem & Joerg Trojan. (2011) mTOR inhibitors and sorafenib for recurrent heptocellular carcinoma after orthotopic liver transplantation. Journal of Hepatology 54:2, pages 396-398.
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