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Statin use and cancer risk: a comprehensive review

, RPh PhD, , MS &
Pages 603-621 | Published online: 09 Apr 2010

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Victor I. Seledtsov & Alexei von Delwig. (2021) Clinically feasible and prospective immunotherapeutic interventions in multidirectional comprehensive treatment of cancer. Expert Opinion on Biological Therapy 21:3, pages 323-342.
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Tao Zhang, Li Zhao, Taotao Zhang, Wangyu Wu, Jie Liu, Xian Wang, Yang Wan, Hao Geng, Xin Sun, Weiwei Qian & Dexin Yu. (2020) Curcumin Negatively Regulates Cigarette Smoke-Induced Renal Cell Carcinoma Epithelial–Mesenchymal Transition Through the ERK5/AP-1 Pathway. OncoTargets and Therapy 13, pages 9689-9700.
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Mayu Hosio, Elina Urpilainen, Ari Hautakoski, Mikko Marttila, Martti Arffman, Reijo Sund, Anne Ahtikoski, Ulla Puistola, Peeter Karihtala, Arja Jukkola & Esa Läärä. (2020) Survival after breast cancer in women with type 2 diabetes using antidiabetic medication and statins: a retrospective cohort study. Acta Oncologica 59:9, pages 1110-1117.
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Anthony Alioui, Olivier Celhay, Silvère Baron & Jean-Marc A Lobaccaro. (2014) Lipids and prostate cancer adenocarcinoma. Clinical Lipidology 9:6, pages 643-655.
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Jennifer W Wu, Denise M Boudreau, Yikyung Park, Naoko I Simonds & Andrew N Freedman. (2014) Commonly used diabetes and cardiovascular medications and cancer recurrence and cancer-specific mortality: a review of the literature. Expert Opinion on Drug Safety 13:8, pages 1071-1099.
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Te-Fu Chan, Chen-Hsuan Wu, Chih-Lung Lin & Chun-Yuh Yang. (2014) Statin use and the risk of breast cancer: a population-based case–control study. Expert Opinion on Drug Safety 13:3, pages 287-293.
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Ishak Mansi & Eric Mortensen. (2013) The controversy of a wider statin utilization: why?. Expert Opinion on Drug Safety 12:3, pages 327-337.
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Wales WN Chan, Gordon TC Wong & Michael G Irwin. (2013) Perioperative statin therapy. Expert Opinion on Pharmacotherapy 14:7, pages 831-842.
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Henry WC Leung, Agnes LF Chan, Daniel Lo, John Hang Leung & Hsiao-Ling Chen. (2013) Common cancer risk and statins: a population-based case–control study in a Chinese population. Expert Opinion on Drug Safety 12:1, pages 19-27.
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Binh An P Phan, Thomas D Dayspring & Peter P Toth. (2012) Ezetimibe therapy: mechanism of action and clinical update. Vascular Health and Risk Management 8, pages 415-427.
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Anna Fenton & Nick Panay. (2010) Statins in women for primary prevention – is there evidence to back up their use??. Climacteric 13:5, pages 403-404.
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Jahn Andreas, Scherer Bo, Fritz Gerhard & Honnen Sebastian. (2020) Statins Induce a DAF-16/Foxo-dependent Longevity Phenotype via JNK-1 through Mevalonate Depletion in C. elegans. Aging and disease 11:1, pages 60.
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Barbara N. Harding, Joseph A. Delaney, Renata R. Urban & Noel S. Weiss. (2019) Use of Statin Medications Following Diagnosis in Relation to Survival among Women with Ovarian Cancer. Cancer Epidemiology, Biomarkers & Prevention 28:7, pages 1127-1133.
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Ali Fatehi Hassanabad. (2019) Can Statins be Protagonists in Our Approach to Cancer Treatment?. American Journal of Clinical Oncology 42:7, pages 547-548.
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Charleston F. Christie, Diana Fang, Elizabeth G. Hunt, Morgan E. Morris, Amandine Rovini, Kareem A. Heslop, Gyda C. Beeson, Craig C. Beeson & Eduardo N. Maldonado. (2019) Statin‐dependent modulation of mitochondrial metabolism in cancer cells is independent of cholesterol content. The FASEB Journal 33:7, pages 8186-8201.
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Yawen Jiang & Weiyi Ni. (2019) Economic Evaluation of the 2016 Chinese Guideline and Alternative Risk Thresholds of Initiating Statin Therapy for the Management of Atherosclerotic Cardiovascular Disease. PharmacoEconomics 37:7, pages 943-952.
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Mayu Hosio, Elina Urpilainen, Mikko Marttila, Ari Hautakoski, Martti Arffman, Reijo Sund, Ulla Puistola, Esa Läärä, Arja Jukkola & Peeter Karihtala. (2019) Association of antidiabetic medication and statins with breast cancer incidence in women with type 2 diabetes. Breast Cancer Research and Treatment 175:3, pages 741-748.
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Giuseppe Berton, Rocco Cordiano, Fiorella Cavuto, Francesco Bagato, Heba Talat Mahmoud & Mattia Pasquinucci. (2019) Association between plasma lipid levels during acute coronary syndrome and long-term malignancy risk. The ABC-4* study on heart disease. BMC Cardiovascular Disorders 19:1.
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Meysam Gachpazan, Hoda Kashani, Majid Khazaei, Seyed Mahdi Hassanian, Majid Rezayi, Fereshteh Asgharzadeh, Majid Ghayour-Mobarhan, Gordon A. Ferns & Amir Avan. (2019) The Impact of Statin Therapy on the Survival of Patients with Gastrointestinal Cancer. Current Drug Targets 20:7, pages 738-747.
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Andrew D. Spence, John Busby, Carmel M. Hughes, Brian T. Johnston, Helen G. Coleman & Chris R. Cardwell. (2018) Statin use and survival in patients with gastric cancer in two independent population‐based cohorts. Pharmacoepidemiology and Drug Safety 28:4, pages 460-470.
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Babatunde Akinwunmi, Allison F. Vitonis, Linda Titus, Kathryn L. Terry & Daniel W. Cramer. (2018) Statin therapy and association with ovarian cancer risk in the New England Case Control (NEC) study. International Journal of Cancer 144:5, pages 991-1000.
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Magdalena Zdybel, Ewa Chodurek & Barbara Pilawa. (2018) Effect of simvastatin in different concentrations on free radicals in A‐2058 human melanoma malignum cells—EPR studies . Journal of Cellular Biochemistry 120:2, pages 2483-2492.
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Belal A. Al-Husein, Bara’ Dawah, Saleem Bani-Hani, Samir M. Al Bashir, Khaled M. Al-Sawalmeh & Nehad M. Ayoub. (2018) Immunomodulatory effect of statins on Regulatory T Lymphocytes in human colorectal cancer is determined by the stage of disease. Oncotarget 9:87, pages 35752-35761.
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Anish Vani & James A. Underberg. (2018) Lowering LDL-Cholesterol and CV Benefits: Is There a Limit to How Low LDL-C Needs to be for Optimal Health Benefits?. Clinical Pharmacology & Therapeutics 104:2, pages 290-296.
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Haige Li, Chen Chen & Dehang Wang. (2018) Low‑frequency ultrasound and microbubbles combined with simvastatin promote the apoptosis of MCF‑7 cells by affecting the LATS1/YAP/RHAMM pathway. Molecular Medicine Reports.
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Ye Sel Kim, Moo-Seok Park, Jun-Hwa Lee, Jong-Won Chung, Mi Ji Lee, Chi Kyung Kim, Jin-Man Jung, Kyungmi Oh, Oh Young Bang, Geong-Moon Kim, Ji-Mi Choi, Juneyoung Lee, Chin Sang Chung, Kwang Ho Lee & Woo-Keun Seo. (2018) Effect of Statins on Survival Following Stroke in Patients With Cancer. Frontiers in Neurology 9.
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Shreyas S. Joshi, Karen Ruth, Marc C. Smaldone, David Y.T. Chen, Richard E. Greenberg, Rosalia Viterbo, Alexander Kutikov & Robert G. Uzzo. (2018) Perioperative Statin Use and Acute Kidney Injury in Patients Undergoing Partial Nephrectomy. Kidney Cancer 2:1, pages 47-55.
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Pinkal Desai, Robert Wallace, Matthew L. Anderson, Barbara V. Howard, Roberta M. Ray, Chunyuan Wu, Monika Safford, Lisa W. Martin, Thomas Rohan, JoAnn E. Manson & Michael S. Simon. (2018) An analysis of the association between statin use and risk of endometrial and ovarian cancers in the Women's Health Initiative. Gynecologic Oncology 148:3, pages 540-546.
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Alfredo Caro-Maldonado, Laura Camacho, Amaia Zabala-Letona, Verónica Torrano, Sonia Fernández-Ruiz, Kepa Zamacola-Bascaran, Leire Arreal, Lorea Valcárcel-Jiménez, Natalia Martín-Martín, Juana M. Flores, Ana R. Cortazar, Patricia Zúñiga-García, Amaia Arruabarrena-Aristorena, Fabienne Guillaumond, Diana Cabrera, Juan M. Falcón-Perez, Ana M. Aransay, Antonio Gomez-Muñoz, Mireia Olivan, Juan Morote & Arkaitz Carracedo. (2017) Low-dose statin treatment increases prostate cancer aggressiveness. Oncotarget 9:2, pages 1494-1504.
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Geoffrey C. Kabat, Mimi Y. Kim, Rowan T. Chlebowski, Mara Z. Vitolins, Sylvia Wassertheil-Smoller & Thomas E. Rohan. (2017) Serum lipids and risk of obesity-related cancers in postmenopausal women. Cancer Causes & Control 29:1, pages 13-24.
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