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Expert Opinion on Drug Safety Volume 9, 2010 - Issue 4
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Drug Safety Evaluations

Atorvastatin: safety and tolerability

Vasilios G Athyros Aristotle University of Thessaloniki, Hippokration Hospital, Medical School, Second Propedeutic Department of Internal Medicine, 15 Marmara St, Thessaloniki 551 32, Greece +30 2310 454 237; +30 2310 445 220; [email protected]
, MD FESC FASA FACS,
Konstantinos Tziomalos Aristotle University of Thessaloniki, AHEPA Hospital, Medical School, First Propedeutic Department of Internal Medicine, Thessaloniki, Greece
,
Asterios Karagiannis Aristotle University of Thessaloniki, Hippokration Hospital, Medical School, Second Propedeutic Department of Internal Medicine, 15 Marmara St, Thessaloniki 551 32, Greece +30 2310 454 237; +30 2310 445 220; [email protected]
&
Dimitri P Mikhailidis University College London (UCL), University College London Medical School, Royal Free Hospital campus, Department of Clinical Biochemistry (Vascular Prevention Clinic), London NW3 2QG, UK
Pages 667-674 | Published online: 16 Jun 2010

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Yoon Tae Goo, Yong-Hoon Won, Sun Ho Hong, Ji Yeh Choi, Gi Hyeong Sin, Chang Hyun Kim, Hyun Min Jung & Young Wook Choi. (2023) Optimization of a solidified micelle formulation for enhanced oral bioavailability of atorvastatin calcium using statistical experimental design. Pharmaceutical Development and Technology 28:5, pages 479-491.
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Haiping Zhang, Jiani Wu, Zhuolin Zhang, Haisheng Qian, Yifan Wang, Miaomiao Yang, Yinchu Cheng & Shaowen Tang. (2019) Association of atorvastatin with the risk of hepatotoxicity: a pilot prescription sequence symmetry analysis. Therapeutics and Clinical Risk Management 15, pages 803-810.
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JoAnne M Foody, Peter P Toth, Andrew M Tershakovec, Thomas Musliner, Joanne E Tomassini, Robert S Lowe, David R Neff & Harry R Davis. (2014) Efficacy and safety of ezetimibe plus atorvastatin therapy. Clinical Lipidology 9:4, pages 441-470.
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Antonia Delgado-Montero & Jose L Zamorano. (2012) Atorvastatin calcium plus amlodipine for the treatment of hypertension. Expert Opinion on Pharmacotherapy 13:18, pages 2673-2685.
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André J Scheen. (2012) Pharmacokinetic evaluation of atorvastatin and sitagliptin in combination for the treatment of type 2 diabetes. Expert Opinion on Drug Metabolism & Toxicology 8:6, pages 745-758.
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Vasilios G Athyros, Konstantinos Tziomalos, Asterios Karagiannis & Dimitri P Mikhailidis. (2010) To switch (statins) or not to switch? That is the question. Expert Opinion on Pharmacotherapy 11:18, pages 2943-2946.
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Giuseppe Famularo, Giovanni Minisola & Laura Gasbarrone. (2010) Comment and reply on: Atorvastatin: safety and tolerability. Expert Opinion on Drug Safety 9:6, pages 1005-1006.
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Articles from other publishers (27)

Jirun Jia, Rui Bao, Jiayue Hou, Mengdi Qin, Wen Li, Li Yang & Qiang Fu. (2023) A rapid and sensitive ultra‐high‐performance liquid chromatography‐tandem mass spectrometry method for the simultaneous determination of atorvastatin calcium and lisinopril in rat plasma and its application in a pharmacokinetic study. SEPARATION SCIENCE PLUS 6:12.
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Dong Yang, Yu Fan, Mingrui Xiong, Yuchen Chen, Yihao Zhou, Xikai Liu, Yangmian Yuan, Qing Wang, Yu Zhang, Robert B Petersen, Hua Su, Junqiu Yue, Chun Zhang, Hong Chen, Kun Huang & Ling Zheng. (2023) Loss of renal tubular G9a benefits acute kidney injury by lowering focal lipid accumulation via CES1. EMBO reports 24:6.
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Javier Reig-López, Matilde Merino-Sanjuan, Alfredo García-Arieta & Victor Mangas-Sanjuán. (2022) A physiologically based pharmacokinetic model for open acid and lactone forms of atorvastatin and metabolites to assess the drug-gene interaction with SLCO1B1 polymorphisms. Biomedicine & Pharmacotherapy 156, pages 113914.
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Qingtao Hou, Yuqin Chen, Yingxiao Zhang & Caishuang Pang. (2022) Comparative Muscle Tolerability of Different Types and Intensities of Statins: A Network Meta-Analysis of Double-Blind Randomized Controlled Trials. Cardiovascular Drugs and Therapy.
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Luisa Duque, Gabriel Guerrero, Jhon H. Colorado, Julián A. Restrepo & Ederley Vélez. (2022) Theoretical insight into mechanism of antioxidant capacity of atorvastatin and its o-hydroxy and p-hydroxy metabolites, using DFT methods. Computational and Theoretical Chemistry 1214, pages 113758.
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Jin-Woo Park, Jong-Min Kim, Hwa-Young Lee, Jihyeon Noh, Kyoung-Ah Kim & Ji-Young Park. (2022) CYP3A5*3 and SLCO1B1 c.521T>C Polymorphisms Influence the Pharmacokinetics of Atorvastatin and 2-Hydroxy Atorvastatin. Pharmaceutics 14:7, pages 1491.
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Tingting Cheng, Changkun Li, Linyan Shen, Shujie Wang, Xuelin Li, Chenyang Fu, Tingting Li, Bei Liu, Yanyun Gu, Weiqing Wang & Bo Feng. (2022) The Intestinal Effect of Atorvastatin: Akkermansia muciniphila and Barrier Function. Frontiers in Microbiology 12.
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Javier Reig-López, Alfredo García-Arieta, Víctor Mangas-Sanjuán & Matilde Merino-Sanjuán. (2021) Current Evidence, Challenges, and Opportunities of Physiologically Based Pharmacokinetic Models of Atorvastatin for Decision Making. Pharmaceutics 13:5, pages 709.
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Abdullah K. Altwairgi, Waleed A. Alghareeb, Fouad H. AlNajjar, Hussain Alhussain, Eyad Alsaeed, Ali Abdullah O. Balbaid, Sadeq Aldanan, Yasser Orz & Abdullah A. Alsharm. (2020) Atorvastatin in combination with radiotherapy and temozolomide for glioblastoma: a prospective phase II study. Investigational New Drugs 39:1, pages 226-231.
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Jaecheol MoonSoyeon YooGwanpyo KohKyung-Wan MinHyun Ho Shin. (2020) Efficacy and Safety of High-Dose Atorvastatin in Moderate-to-High Cardiovascular Risk Postmenopausal Korean Women with Dyslipidemia. Journal of Lipid and Atherosclerosis 9:1, pages 162.
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Hua Jiang & Hong Zheng. (2019) Efficacy and adverse reaction to different doses of atorvastatin in the treatment of type II diabetes mellitus. Bioscience Reports 39:7.
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Chen Peng, Ying Ding, Xin Yi, Yupei Shen, Zhiqiang Dong, Limei Cao, Qiang Li, Haiyan Ren, Lin He, Daizhan Zhou & Xu Chen. (2018) Polymorphisms in CYP450 Genes and the Therapeutic Effect of Atorvastatin on Ischemic Stroke: A Retrospective Cohort Study in Chinese Population. Clinical Therapeutics 40:3, pages 469-477.e2.
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Mo Zhou, Jinkai Zheng, Jinfeng Bi, Xinye Wu, Jian Lyu & Kun Gao. (2017) Synergistic inhibition of colon cancer cell growth by a combination of atorvastatin and phloretin. Oncology Letters.
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Ruiqin XieYingtao YangWei CuiHongning YinHongmei ZhengJidong ZhangLing You. (2017) Atorvastatin can ameliorate left atrial stunning induced by radiofrequency ablation for atrial fibrillation. Canadian Journal of Physiology and Pharmacology 95:9, pages 985-992.
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Ran Li & Ye-Hua Gan. (2017) Inhibiting HDAC1 Enhances the Anti-Cancer Effects of Statins through Downregulation of GGTase-Iβ Expression. International Journal of Molecular Sciences 18:5, pages 1010.
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Mohamed O. Mahmoud, Heba M. Aboud, Amira H. Hassan, Adel A. Ali & Thomas P. Johnston. (2017) Transdermal delivery of atorvastatin calcium from novel nanovesicular systems using polyethylene glycol fatty acid esters: Ameliorated effect without liver toxicity in poloxamer 407-induced hyperlipidemic rats. Journal of Controlled Release 254, pages 10-22.
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Ann J. Melvin, Grace Montepiedra, Lisa Aaron, William A. Meyer, Hans M. Spiegel, William Borkowsky, Mark J. Abzug, Brookie M. Best, Marilyn J. Crain, Peggy R. Borum, Bobbie Graham, Patricia Anthony, Katherine Shin & George K. Siberry. (2017) Safety and Efficacy of Atorvastatin in Human Immunodeficiency Virus-infected Children, Adolescents and Young Adults With Hyperlipidemia. Pediatric Infectious Disease Journal 36:1, pages 53-60.
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Osman Baspınar, Fahri Bayram, Selda Korkmaz, Murat Aksu, Derya Kocer, Oğuzhan Sıtkı Dizdar, Yasin Simsek & Peter P. Toth. (2016) The effects of statin treatment on adrenal and sexual function and nitric oxide levels in hypercholesterolemic male patients treated with a statin. Journal of Clinical Lipidology 10:6, pages 1452-1461.
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Haixia Li, Cailian Wang, Shuo Zhang, Sihao Sun, Ruifei Li, Meijuan Zou & Gang Cheng. (2016) Safety Profile of Atorvastatin 80 mg: A Meta-Analysis of 17 Randomized Controlled Trials in 21,910 Participants. Drug Safety 39:5, pages 409-419.
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Shih-Wei Lai, Cheng-Li Lin & Kuan-Fu Liao. (2016) Atorvastatin Use Associated With Acute Pancreatitis. Medicine 95:7, pages e2545.
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Da-Wei Gu & Xun-Xiang Guo. (2015) Synthesis of N-arylcarboxamides by the efficient transamidation of DMF and derivatives with anilines. Tetrahedron 71:48, pages 9117-9122.
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C.E. Herron, C.C. Brueckner, J.P. Chism, D.C. Kemp, J.S. Prescott, G.A. Smith, D.H. Melich, N. Oleas & J.W. Polli. (2015) Toxicokinetics and toxicity of atorvastatin in dogs. Toxicology and Applied Pharmacology 289:1, pages 117-123.
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Mohamed A. El-Moselhy & Azza A.K. El-Sheikh. (2014) Protective mechanisms of atorvastatin against doxorubicin-induced hepato-renal toxicity. Biomedicine & Pharmacotherapy 68:1, pages 101-110.
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Konstantinos Tziomalos. (2014) Lipid-lowering agents in the management of nonalcoholic fatty liver disease. World Journal of Hepatology 6:10, pages 738.
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Miao Hu, Bernard M.Y. Cheung & Brian Tomlinson. (2012) Safety of statins: an update. Therapeutic Advances in Drug Safety 3:3, pages 133-144.
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Kotani Kazuhiko, Yamada Toshiyuki, Miyamoto Michiaki, Ishibashi Shun, Taniguchi Nobuyuki & Gugliucci Alejandro. (2012) Influence of atorvastatin on serum amyloid A-low density lipoprotein complex in hypercholesterolemic patients. Pharmacological Reports 64:1, pages 212-216.
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Satya Prakash, Catherine Tomaro-Duchesneau, Shyamali Saha & Arielle Cantor. (2011) The Gut Microbiota and Human Health with an Emphasis on the Use of Microencapsulated Bacterial Cells. Journal of Biomedicine and Biotechnology 2011, pages 1-12.
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