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Introduction of higher doses of deferasirox: better efficacy but not effective iron removal from the heart and increased risks of serious toxicities

Pages 633-641 | Published online: 16 Jun 2010

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Mahesh Subramanian, Gajanan J. Chintalwar & Subrata Chattopadhyay. (2021) Iron modulatory property of a polysaccharide from Indian medicinal plant Ocimum sanctum. Free Radical Research 55:8, pages 758-767.
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Mohammed A. Alali, Khalid M.A. Alanazi, Sarah N. Alsayil, Zakaria Omari & Ali Shaaban. (2020) Calcium Channel Blockers in Conjunction with Standard Iron-Chelating Agents for β-Thalassemia Major: Systematic Literature Search. Hemoglobin 44:6, pages 446-450.
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Jaroslav Cermak, Anna Jonasova, Jana Vondrakova, Lenka Walterova, Ivana Hochova, Magda Siskova & Radana Neuwirtova. (2011) Efficacy And Safety Of Administration Of Oral Iron Chelator Deferiprone In Patients With Early Myelodysplastic Syndrome. Hemoglobin 35:3, pages 217-227.
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Articles from other publishers (16)

Lars Gerhardsson. 2022. Handbook on the Toxicology of Metals. Handbook on the Toxicology of Metals 663 684 .
Muhammed Khaled Elfaituri, Sherief Ghozy, Amr Ebied, Mostafa Ebraheem Morra, Osama Gamal Hassan, Ahmed Alhusseiny, Alzhraa Salah Abbas, Nourin Ali Sherif, Juliano Lara Fernandes & Nguyen Tien Huy. (2021) Amlodipine as adjuvant therapy to current chelating agents for reducing iron overload in thalassaemia major: a systematic review, meta‐analysis and simulation of future studies. Vox Sanguinis 116:8, pages 887-897.
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Hossein Karami, Hadiseh Khalilzadeh Arjmandi, Ebrahim Salehifar, Hadi Darvishi‐Khezri, Mojdeh Dabirian, Mehrnoush Kosaryan, Aily Aliasgharian, Rosetta Akbarzadeh, Raheleh Naeimayi Aali & Amirreza Nasirzadeh. (2021) A double‐blind, controlled, crossover trial of amlodipine on iron overload status in transfusion dependent β‐thalassemia patients. International Journal of Clinical Practice 75:8.
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Aziz Eghbali, Pooria Shokri, Roghayeh Rahimi Afzal & Bahador Bagheri. (2019) A 1-year randomized trial of deferasirox alone versus deferasirox and deferoxamine combination for the treatment of iron overload in thalassemia major. Transfusion and Apheresis Science 58:4, pages 429-433.
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Saher KhalafAbdullah Shafique AhmadK.V.D. Ranga ChamaraSylvain Doré. (2019) Unique Properties Associated with the Brain Penetrant Iron Chelator HBED Reveal Remarkable Beneficial Effects after Brain Trauma. Journal of Neurotrauma 36:1, pages 43-53.
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Aziz Eghbali, Hamideh Kazemi, Hassan Taherahmadi, Yazdan Ghandi, Mohammad Rafiei & Bahador Bagheri. (2017) A randomized, controlled study evaluating effects of amlodipine addition to chelators to reduce iron loading in patients with thalassemia major. European Journal of Haematology 99:6, pages 577-581.
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Somayeh Kalanaky, Maryam Hafizi, Sepideh Safari, Kazem Mousavizadeh, Mahboubeh Kabiri, Alireza Farsinejad, Saideh Fakharzadeh & Mohammad Hassan Nazaran. (2016) TLc-A, the leading nanochelating-based nanochelator, reduces iron overload in vitro and in vivo. International Journal of Hematology 103:3, pages 274-282.
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Yoshiro Naito, Aya Fujii, Hisashi Sawada, Makiko Oboshi, Toshihiro Iwasaku, Yoshitaka Okuhara, Daisuke Morisawa, Akiyo Eguchi, Shinichi Hirotani & Tohru Masuyama. (2015) Association between renal iron accumulation and renal interstitial fibrosis in a rat model of chronic kidney disease. Hypertension Research 38:7, pages 463-470.
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M Amélia Santos & Sílvia Chaves. (2015) 3-hydroxypyridinone derivatives as metal-sequestering agents for therapeutic use. Future Medicinal Chemistry 7:3, pages 383-410.
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Lars Gerhardsson & George Kazantzis. 2015. Handbook on the Toxicology of Metals. Handbook on the Toxicology of Metals 487 505 .
Christina N Kontoghiorghe. (2014) World health dilemmas: Orphan and rare diseases, orphan drugs and orphan patients. World Journal of Methodology 4:3, pages 163.
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Juliano Lara Fernandes, Erika Fontana Sampaio, Kleber Fertrin, Otavio Rizzi Coelho, Sandra Loggetto, Antonio Piga, Monica Verissimo & Sara T. Saad. (2013) Amlodipine Reduces Cardiac Iron Overload in Patients with Thalassemia Major: A Pilot Trial. The American Journal of Medicine 126:9, pages 834-837.
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Juliano Lara Fernandes. (2012) Iron chelation therapy in the management of transfusion-related cardiac iron overload. Transfusion 52:10, pages 2256-2268.
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Sunil Bhandari & Renzo Galanello. (2012) Renal aspects of thalassaemia a changing paradigm. European Journal of Haematology 89:3, pages 187-197.
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M. Amélia Santos, Sérgio M. Marques & Sílvia Chaves. (2012) Hydroxypyridinones as “privileged” chelating structures for the design of medicinal drugs. Coordination Chemistry Reviews 256:1-2, pages 240-259.
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Efthimia VlachakiK. Chatzinikolaou, E. Bekiari, F. Klonizakis & A. Tsapas. (2011) Is Deferasirox Implicated in Multiple Organ Failure in a Patient With Homozygous β-Thalassemia?. Angiology 62:4, pages 346-348.
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