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Dexmedetomidine: pediatric pharmacology, clinical uses and safety

, MD & , MD
Pages 55-66 | Published online: 18 Aug 2010

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Karel Allegaert & Carlo V Bellieni. (2013) Analgosedation in neonates: what we know and how we act. Research and Reports in Neonatology 3, pages 51-61.
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Dengfeng Liu, Li Pan, Yin Gao, Jiefan Liu, Feng Li, Xiangwei Li, Jiale Quan, Congcong Huang & Chunwei Lian. (2021) Efficaciousness of dexmedetomidine in children undergoing cleft lip and palate repair: a systematic review and meta-analysis. BMJ Open 11:8, pages e046798.
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Shan Deng & Yonghao Yu. (2021) Effects of Dexmedetomidine as an Analgesic Adjuvant for Surgery of Femur Fracture: A Systematic Review and Meta-Analysis. Pharmacology 106:9-10, pages 453-461.
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Jingyao Song, Shuyan Liu, Bin Fan, Guangyu Li & Qianchuang Sun. (2021) Perioperative dexmedetomidine reduces emergence agitation without increasing the oculocardiac reflex in children. Medicine 100:18, pages e25717.
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Michelle M. Lee, Karen Caylor & Nicole Gockenbach. (2020) Evaluating the Transition From Dexmedetomidine to Clonidine for the Prevention of Withdrawal in Critically Ill Pediatric Patients. The Journal of Pediatric Pharmacology and Therapeutics 25:2, pages 104-110.
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Mihaela A. Damian, Gregory B. Hammer, Mohammed H. ElkomyAdam Frymoyer, David R. Drover & Felice Su. (2020) Pharmacokinetics of Dexmedetomidine in Infants and Children After Orthotopic Liver Transplantation. Anesthesia & Analgesia 130:1, pages 209-216.
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Edmund H. Jooste, Gregory B. Hammer, Christian R. Reyes, Vaibhav Katkade & Peter Szmuk. (2017) Phase IV, Open-Label, Safety Study Evaluating the Use of Dexmedetomidine in Pediatric Patients Undergoing Procedure-Type Sedation. Frontiers in Pharmacology 8.
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X Fu, F Huang, Y Chen, Y Deng & Z Wang. (2017) Application of dexmedetomidine-remifentanil in high-intensity ultrasound ablation of uterine fibroids: a randomised study. BJOG: An International Journal of Obstetrics & Gynaecology 124, pages 23-29.
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Abby M. Bailey, Regan A. Baum, Karolyn Horn, Tameka Lewis, Kate Morizio, Amy Schultz, Kyle Weant & Stephanie N. Justice. (2017) Review of Intranasally Administered Medications for Use in the Emergency Department. The Journal of Emergency Medicine 53:1, pages 38-48.
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Junhui Zhao & Chuixian Zhou. (2016) The protective and hemodynamic effects of dexmedetomidine on hypertensive cerebral hemorrhage patients in the perioperative period. Experimental and Therapeutic Medicine 12:5, pages 2903-2908.
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Xiahong Luo, Xia Zheng & Hougang Huang. (2016) Protective effects of dexmedetomidine on brain function of glioma patients undergoing craniotomy resection and its underlying mechanism. Clinical Neurology and Neurosurgery 146, pages 105-108.
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Andrew M. Langdon & Rishi Diwan. (2016) Safe sedation of children for diagnostic and therapeutic procedures. Anaesthesia & Intensive Care Medicine 17:6, pages 299-302.
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Hua-Cheng Liu, Wei Sun, Cheng-Yu Wang, Wei-Yang Ying, Li-Dan Zheng, Rui-Feng Zeng, Zhe Wang & Ren-Shan Ge. (2016) Determination of dexmedetomidine in children’s plasma by ultra-performance liquid chromatography tandem mass spectrometry and application to pharmacokinetic study. Journal of Chromatography B 1023-1024, pages 30-35.
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Wenhua Zhang, Zixin Wang, Xingrong Song, Yanting Fan, Hang Tian & Bilian Li. (2016) Comparison of rescue techniques for failed chloral hydrate sedation for magnetic resonance imaging scans-additional chloral hydrate vs intranasal dexmedetomidine. Pediatric Anesthesia 26:3, pages 273-279.
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Lars P. H. Andersen, Mads U. Werner, Mette M. Rosenkilde, Andreas Q. Fenger, Marian C. Petersen, Jacob Rosenberg & Ismail Gögenur. (2016) Pharmacokinetics of high-dose intravenous melatonin in humans. The Journal of Clinical Pharmacology 56:3, pages 324-329.
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Flora Cipriani, Aldo Mancino, Silvia Maria Pulitanò, Marco Piastra & Giorgio Conti. (2015) A cannabinoid-intoxicated child treated with dexmedetomidine: a case report. Journal of Medical Case Reports 9:1.
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YUHONG LI, RUI HE, SHUNFU CHEN & YULIAN QU. (2015) Effect of dexmedetomidine on early postoperative cognitive dysfunction and peri-operative inflammation in elderly patients undergoing laparoscopic cholecystectomy. Experimental and Therapeutic Medicine 10:5, pages 1635-1642.
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Tomomi Hasegawa, Yoshihiro Oshima, Ayako Maruo, Hironori Matsuhisa, Akiko Tanaka, Rei Noda & Shunsuke Matsushima. (2015) Dexmedetomidine in combination with midazolam after pediatric cardiac surgery. Asian Cardiovascular and Thoracic Annals 23:7, pages 802-808.
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J. Yu, Y. Zhang, Y. Lu & C. Dong. (2014) Preemptive dexmedetomidine to prevent propofol injection pain in children. Irish Journal of Medical Science (1971 -) 184:2, pages 375-378.
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Lauren M. Estkowski, Jennifer L. Morris & Elizabeth A. Sinclair. (2015) Characterization of Dexmedetomidine Dosing and Safety in Neonates and Infants. The Journal of Pediatric Pharmacology and Therapeutics 20:2, pages 112-118.
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Jinfen Liu. (2015) Comparison of Adrenal Suppression between Etomidate and Dexmedetomidine in Children with Congenital Heart Disease. Medical Science Monitor 21, pages 1569-1576.
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Gillian R. Lauder. (2015) Total intravenous anesthesia will supercede inhalational anesthesia in pediatric anesthetic practice. Pediatric Anesthesia 25:1, pages 52-64.
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H. Forst, T. Fuchs-Buder, Axel R. Heller & M. WeigandG. Gerresheim & U. Schwemmer. 2015. Weiterbildung Anästhesiologie. Weiterbildung Anästhesiologie 11 22 .
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L. SUN, R. GUO & L. SUN. (2014) Dexmedetomidine for preventing sevoflurane-related emergence agitation in children: a meta-analysis of randomized controlled trials. Acta Anaesthesiologica Scandinavica 58:6, pages 642-650.
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Chengliang Zhang, Jiajia Hu, Xinyao Liu & Jianqin Yan. (2014) Effects of Intravenous Dexmedetomidine on Emergence Agitation in Children under Sevoflurane Anesthesia: A Meta-Analysis of Randomized Controlled Trials. PLoS ONE 9:6, pages e99718.
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Na Young KimSo Yeon KimHye Jin YoonHae Keum Kil. (2014) Effect of Dexmedetomidine on Sevoflurane Requirements and Emergence Agitation in Children Undergoing Ambulatory Surgery. Yonsei Medical Journal 55:1, pages 209.
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G. Gerresheim & U. Schwemmer. (2013) DexmedetomidinDexmedetomidine. Der Anaesthesist 62:8, pages 661-674.
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Tetsuo Kubota, Tatsuya Fukasawa, Erina Kitamura, Miyuki Magota, Yuichi Kato, Jun Natsume & Akihisa Okumura. (2013) Epileptic seizures induced by dexmedetomidine in a neonate. Brain and Development 35:4, pages 360-362.
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Jia-Yao Chen, Ji-E. Jia, Ting-Jie Liu, Ming-Ju Qin & Wen-Xian Li. (2013) Comparison of the effects of dexmedetomidine, ketamine, and placebo on emergence agitation after strabismus surgery in childrenComparaison des effets de la dexmédétomidine, de la kétamine et d’un placebo sur l’agitation au réveil après une chirurgie du strabisme chez les enfants. Canadian Journal of Anesthesia/Journal canadien d'anesthésie 60:4, pages 385-392.
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R. Phillip Dellinger, Mitchell M. Levy, Andrew Rhodes, Djillali Annane, Herwig Gerlach, Steven M. Opal, Jonathan E. Sevransky, Charles L. Sprung, Ivor S. Douglas, Roman Jaeschke, Tiffany M. Osborn, Mark E. Nunnally, Sean R. Townsend, Konrad Reinhart, Ruth M. Kleinpell, Derek C. Angus, Clifford S. Deutschman, Flavia R. Machado, Gordon D. Rubenfeld, Steven A. Webb, Richard J. Beale, Jean-Louis Vincent & Rui Moreno. (2013) Surviving Sepsis Campaign. Critical Care Medicine 41:2, pages 580-637.
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R. P. Dellinger, Mitchell M. Levy, Andrew Rhodes, Djillali Annane, Herwig Gerlach, Steven M. Opal, Jonathan E. Sevransky, Charles L. Sprung, Ivor S. Douglas, Roman Jaeschke, Tiffany M. Osborn, Mark E. Nunnally, Sean R. Townsend, Konrad Reinhart, Ruth M. Kleinpell, Derek C. Angus, Clifford S. Deutschman, Flavia R. Machado, Gordon D. Rubenfeld, Steven Webb, Richard J. Beale, Jean-Louis Vincent & Rui Moreno. (2013) Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012. Intensive Care Medicine 39:2, pages 165-228.
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Erik S. Shank, Robert L. Sheridan, Colleen M. Ryan, Timothy J. Keaney & J.A. Jeevendra Martyn. (2013) Hemodynamic Responses to Dexmedetomidine in Critically Injured Intubated Pediatric Burned Patients. Journal of Burn Care & Research 34:3, pages 311-317.
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Jackson Wong, Garry M. Steil, Michelle Curtis, Alexandra Papas, David Zurakowski & Keira P. Mason. (2012) Cardiovascular Effects of Dexmedetomidine Sedation in Children. Anesthesia & Analgesia 114:1, pages 193-199.
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