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Drug Safety Evaluations

Clinical safety of tocilizumab in rheumatoid arthritis

, MD & , MD PhD
Pages 123-131 | Published online: 02 Dec 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Eleftherios Pelechas, Paraskevi V Voulgari & Alexandros A. Drosos. (2021) Preclinical discovery and development of adalimumab for the treatment of rheumatoid arthritis. Expert Opinion on Drug Discovery 16:3, pages 227-234.
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Mahtabalsadat Mirjalili, Mojtaba Shafiekhani & Afsaneh Vazin. (2020) Coronavirus Disease 2019 (COVID-19) and Transplantation: Pharmacotherapeutic Management of Immunosuppression Regimen. Therapeutics and Clinical Risk Management 16, pages 617-629.
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Özgül Muştu Koryürek & Göknur Kalkan. (2016) A new alternative therapy in dermatology: tocilizumab. Cutaneous and Ocular Toxicology 35:2, pages 145-152.
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Christophe Richez, Marie-Elise Truchetet, Thierry Schaeverbeke & Bernard Bannwarth. (2014) Atacicept as an investigated therapy for rheumatoid arthritis. Expert Opinion on Investigational Drugs 23:9, pages 1285-1294.
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Sylvain Mathieu, Marion Couderc, Baptiste Glace, Bruno Pereira, Anne Tournadre, Jean-Jacques Dubost & Martin Soubrier. (2013) Effects of 6 months of abatacept treatment on aortic stiffness in patients with rheumatoid arthritis. Biologics: Targets and Therapy 7, pages 259-264.
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Vijay Subramanian & Thalachallour Mohanakumar. (2012) Chronic rejection: a significant role for Th17-mediated autoimmune responses to self-antigens. Expert Review of Clinical Immunology 8:7, pages 663-672.
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Gerd R Burmester, Vibeke Strand, Alan J Kivitz, Chih-Chi Hu, Sheldon Wang, Hubert van Hoogstraten, Gabriella L Klier & Roy Fleischmann. (2023) Long-term safety and efficacy of sarilumab with or without background csDMARDs in rheumatoid arthritis. Rheumatology.
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Yixuan James Zheng, Wilson Ho, Martina Sanlorenzo, Igor Vujic, Adil Daud, Alain Algazi, Klemens Rappersberger & Susana Ortiz-Urda. (2022) Melanoma risk during immunomodulating treatment. Melanoma Research 32:6, pages 411-418.
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Carlota Siljestr�m Berenguer, Gema Bonilla & Cristina Suárez-Ferrer. (2022) Intestinal disease secondary to tocilizumab. Revista Española de Enfermedades Digestivas.
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So Hye Nam, Doo-Ho Lim, Hyun Mi Heo, Ji Seon Oh, Hyouk-Soo Kwon, Tae-Bum Kim, Soo Min Ahn, Seokchan Hong, Chang-Keun Lee, Bin Yoo & Yong-Gil Kim. (2021) Anaphylaxis to tocilizumab in patients with rheumatic disease. Immunotherapy 13:18, pages 1483-1489.
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F. W. Kornitzky, H.-J. Langen & M. Held. (2021) Die Behandlung eines Patienten mit ausgeprägtem Zytokinsturm bei schwerer COVID-19-Pneumonie unter Einsatz von Hämoadsorption in Kombination mit der Gabe von Tocilizumab. Pneumologie 75:09, pages 644-650.
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Jacques Morel, Anne Tournadre, Jérémie Sellam, Yoram Bouhnik, Divi Cornec, Valérie Devauchelle-Pensec, Philippe Dieudé, Philippe Goupille, Nicolas Kluger, Estibaliz Lazaro, Benoit Le Goff, Victor de Lédinghen, Thierry Lequerré, Gaëtane Nocturne, Raphaèle Seror, Marie-Elise Truchetet, Frank Verhoeven, Thao Pham & Christophe Richez. (2021) Practical management of patients on anti-IL6R therapy: Practical guidelines drawn up by the Club Rhumatismes et Inflammation (CRI). Joint Bone Spine 88:4, pages 105221.
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Milo Gatti, Michele Fusaroli, Paolo Caraceni, Elisabetta Poluzzi, Fabrizio De Ponti & Emanuel Raschi. (2020) Serious adverse events with tocilizumab: Pharmacovigilance as an aid to prioritize monitoring in COVID‐19. British Journal of Clinical Pharmacology 87:3, pages 1533-1540.
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Daniel Aletaha, Clifton O Bingham, George Athanasios Karpouzas, Tsutomu Takeuchi, Carter Thorne, Androniki Bili, Prasheen Agarwal, Benjamin Hsu, Ravi Rao, Kurt Brown & Yoshiya Tanaka. (2021) Long-term safety and efficacy of sirukumab for patients with rheumatoid arthritis who previously received sirukumab in randomised controlled trials (SIRROUND-LTE). RMD Open 7:1, pages e001465.
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Muhammad Hamdan Gul, Zin Mar Htun, Nauman Shaukat, Muhammad Imran & Ahmad Khan. (2020) Potential specific therapies in COVID-19. Therapeutic Advances in Respiratory Disease 14, pages 175346662092685.
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Alexander Pfeil, Peter Oelzner & Peter Hellmann. (2019) The Treatment of Giant Cell Arteritis in Different Clinical Settings. Frontiers in Immunology 9.
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Diana Rosa-Gonçalves, Miguel Bernardes & Lúcia Costa. (2018) Necrotizing fasciitis in a patient receiving tocilizumab for rheumatoid arthritis • Case report. Reumatología Clínica (English Edition) 14:3, pages 168-170.
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Diana Rosa-Gonçalves, Miguel Bernardes & Lúcia Costa. (2018) Necrotizing fasciitis in a patient receiving tocilizumab for rheumatoid arthritis – Case report. Reumatología Clínica 14:3, pages 168-170.
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Marc Scherlinger, Sophie Alain & Christophe Richez. (2018) Monitoring of Epstein–Barr virus (EBV)/cytomegalovirus (CMV)/varicella-zoster virus (VZV) load in patients receiving tocilizumab for rheumatoid arthritis. Joint Bone Spine 85:2, pages 259-260.
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Timo Gaber, Martin Hahne, Cindy Strehl, Paula Hoff, Yvonne Dörffel, Eugen Feist, Gerd-Rüdiger Burmester & Frank Buttgereit. (2015) Disentangling the effects of tocilizumab on neutrophil survival and function. Immunologic Research 64:3, pages 665-676.
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Yves-Marie Pers, Roxane Schaub, Elodie Constant, Joseph Lambert, Marie Godfrin-Valnet, Clémentine Fortunet, Waafa Bourichi, Béatrice Pallot Prades, Daniel Wendling, Philippe Gaudin, Christian Jorgensen, Jean-Francis Maillefert & Hubert Marotte. (2015) Efficacy and safety of tocilizumab in elderly patients with rheumatoid arthritis. Joint Bone Spine 82:1, pages 25-30.
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Rainer H. Böger & Gerhard Schmidt. 2015. Arzneiverordnungs-Report 2015. Arzneiverordnungs-Report 2015 501 517 .
Feiyu Xiong, Marco Janko, Mindi Walker, Dorie Makropoulos, Daniel Weinstock, Moshe Kam & Leonid Hrebien. (2014) Analysis of cytokine release assay data using machine learning approaches. International Immunopharmacology 22:2, pages 465-479.
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J. Pfeil, J. Grulich-Henn, D. Wenning, T. Breil, P. Gunther & T. Lutz. (2014) Multiple upper gastrointestinal perforations in a 15-year-old patient treated with tocilizumab. Rheumatology 53:9, pages 1713-1714.
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Audrey Cayot, Davy Laroche, Anne Disson-Dautriche, Anaïs Arbault, Jean-Francis Maillefert & Paul Ornetti. (2014) Cytochrome P450 interactions and clinical implication in rheumatology. Clinical Rheumatology 33:9, pages 1231-1238.
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Qing Jiang. (2014) Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy. Free Radical Biology and Medicine 72, pages 76-90.
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P. Kieffer, O. Hinschberger, E. Ciobanu, F. Jaeger-Bizet, A. Drabo, T. Mostoufizadeh & L. Martzolff. (2014) Efficacité clinique et biologique du tocilizumab au cours de la maladie de Horton : à propos de trois observations et revue de la littérature. La Revue de Médecine Interne 35:1, pages 56-59.
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Rainer H. Böger & Gerhard Schmidt. 2014. Arzneiverordnungs- Report 2014. Arzneiverordnungs- Report 2014 491 512 .
Yun Wang & Qing Jiang. (2013) γ-Tocotrienol inhibits lipopolysaccharide-induced interlukin-6 and granulocyte colony-stimulating factor by suppressing C/EBPβ and NF-κB in macrophages. The Journal of Nutritional Biochemistry 24:6, pages 1146-1152.
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Deborah Palmer & Yasser El Miedany. (2013) Treat-to-target: a tailored treatment approach to rheumatoid arthritis. British Journal of Nursing 22:6, pages 308-318.
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Bernard Bannwarth, Driss Berdaï & Marie Kostine. (2013) Licensing of antirheumatic drugs: Are the EMA and FDA on the same page?. Joint Bone Spine 80:2, pages 121-123.
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Said Younis, Itzhak Rosner, Doron Rimar, Nina Boulman, Michael Rozenbaum, Majed Odeh & Gleb Slobodin. (2013) Weight change during pharmacological blockade of interleukin-6 or tumor necrosis factor-α in patients with inflammatory rheumatic disorders: A 16-week comparative study. Cytokine 61:2, pages 353-355.
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Said Younis, Itzhak Rosner, Doron Rimar, Nina Boulman, Michael Rozenbaum, Majed Odeh & Gleb Slobodin. (2013) Interleukin 6 Blockade–Associated Weight Gain With Abdominal Enlargement in a Patient With Rheumatoid Arthritis. JCR: Journal of Clinical Rheumatology 19:1, pages 48-49.
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Bernard Bannwarth, Driss Berdaï & Marie Kostine. (2013) Autorisation de mise sur le marché des médicaments rhumatologiques : existe-t-il des désaccords entre EMA et FDA ?. Revue du Rhumatisme 80:1, pages 3-5.
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Rainer H. Böger & Gerhard Schmidt. 2013. Arzneiverordnungs-Report 2013. Arzneiverordnungs-Report 2013 435 455 .
Michiel Bonny, Veronique Buyse & Erwin Suys. (2012) Rapidly progressive malignant melanoma in a patient treated with tocilizumab. Journal of the American Academy of Dermatology 67:2, pages e78-e79.
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Peter J Bugelski & Pauline L Martin. (2012) Concordance of preclinical and clinical pharmacology and toxicology of therapeutic monoclonal antibodies and fusion proteins: cell surface targets. British Journal of Pharmacology 166:3, pages 823-846.
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M. G. H. van de Sande & E. R. van Slobbe-Bijlsma. (2011) Necrotizing fasciitis in a rheumatoid arthritis patient treated with tocilizumab. Rheumatology 51:3, pages 577-578.
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D. Focosi, F. Maggi, M. Pistello, U. Boggi & F. Scatena. (2011) Immunosuppressive monoclonal antibodies: current and next generation. Clinical Microbiology and Infection 17:12, pages 1759-1768.
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Robert S. Woodrick & Eric M. Ruderman. (2011) Safety of biologic therapy in rheumatoid arthritis. Nature Reviews Rheumatology 7:11, pages 639-652.
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SAVINO SCIASCIA, DANIELA ROSSI & DARIO ROCCATELLO. (2011) Interleukin 6 Blockade as Steroid-sparing Treatment for 2 Patients with Giant Cell Arteritis: Figure 1.. The Journal of Rheumatology 38:9, pages 2080-2081.
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