641
Views
28
CrossRef citations to date
0
Altmetric
Reviews

Detection and management of nephrotoxicity during drug development

, MD, , MD, , MD, , MD PhD & , MD
Pages 581-596 | Published online: 22 May 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Athanasios Tragiannidis, Anastasia Gkampeta, Maria Vousvouki, Eleni Vasileiou & Andreas H. Groll. (2021) Antifungal agents and the kidney: pharmacokinetics, clinical nephrotoxicity, and interactions. Expert Opinion on Drug Safety 20:9, pages 1061-1074.
Read now
Melanie Blank, Aliza Thompson, Elizabeth Hausner & Rodney Rouse. (2018) Biomarkers of drug-induced acute kidney injury: a regulatory perspective. Expert Opinion on Drug Metabolism & Toxicology 14:9, pages 929-936.
Read now
Johnny X Huang, Mark A Blaskovich & Matthew A Cooper. (2014) Cell- and biomarker-based assays for predicting nephrotoxicity. Expert Opinion on Drug Metabolism & Toxicology 10:12, pages 1621-1635.
Read now

Articles from other publishers (25)

Saiqi Qi, Jie Song, Linjun Chen & Huachun Weng. (2023) The role of N-methyladenosine modification in acute and chronic kidney diseases. Molecular Medicine 29:1.
Crossref
Jing Liu & Ying Wang. (2023) Advances in organ‐on‐a‐chip for the treatment of cardiovascular diseases. MedComm – Biomaterials and Applications 2:4.
Crossref
Narendra K. Singh, Jae Yun Kim, Jinah Jang, Yong Kyun Kim & Dong-Woo Cho. (2023) 3D Cell Printing of Advanced Vascularized Proximal Tubule-on-a-Chip for Drug Induced Nephrotoxicity Advancement. ACS Applied Bio Materials.
Crossref
Chiara Minotti, Elisa Barbieri, Denis Doni, Cristina Impieri, Carlo Giaquinto & Daniele Donà. (2022) Anti-infective Medicines Use in Children and Neonates With Pre-existing Kidney Dysfunction: A Systematic Review. Frontiers in Pediatrics 10.
Crossref
Damiën van Berlo & Rosalinde Masereeuw. (2021) Editorial overview: Disrupting the animal test with in vitro innovations. Current Opinion in Toxicology 28, pages 49-51.
Crossref
Can-Ming Li, Ming Li, Wen-Bo Zhao, Zeng-Chun Ye & Hui Peng. (2021) Alteration of N6-Methyladenosine RNA Profiles in Cisplatin-Induced Acute Kidney Injury in Mice. Frontiers in Molecular Biosciences 8.
Crossref
Marco Trevisan, Edouard L Fu, Yang Xu, Kitty Jager, Carmine Zoccali, Friedo W Dekker & Juan Jesus Carrero. (2021) Pharmacoepidemiology for nephrologists (part 1): concept, applications and considerations for study design. Clinical Kidney Journal 14:5, pages 1307-1316.
Crossref
Vincenzo Savarino, Elisa Marabotto, Manuele Furnari, Fabiana Zingone, Patrizia Zentilin & Edoardo Savarino. (2020) Latest insights into the hot question of proton pump inhibitor safety – a narrative review. Digestive and Liver Disease 52:8, pages 842-852.
Crossref
I‐Jung Tsai, Tai‐Shuan Lai, Chih‐Chung Shiao, Tao‐Min Huang, Chih‐Hsien Wang, Chun-Hao Tsao, Liang-Wen Chen, Yen‐Hung Lin, Likwang Chen, Vin‐Cent Wu & Tzong‐Shinn Chu. (2020) Proton Pump Inhibitors Augment the Risk of Major Adverse Cardiovascular Events and End‐Stage Renal Disease in Patients With Acute Kidney Injury After Temporary Dialysis. Clinical Pharmacology & Therapeutics 107:6, pages 1434-1445.
Crossref
Yuki Kato, Yutaka Tonomura, Hiroyuki Hanafusa, Kyohei Nishimura, Tamio Fukushima & Motonobu Ueno. (2020) Adult Zebrafish Model for Screening Drug-Induced Kidney Injury. Toxicological Sciences 174:2, pages 241-253.
Crossref
Daniela Maria Tanase, Evelina Maria Gosav, Smaranda Radu, Claudia Florida Costea, Manuela Ciocoiu, Alexandru Carauleanu, Cristina Mihaela Lacatusu, Minela Aida Maranduca, Mariana Floria & Ciprian Rezus. (2019) The Predictive Role of the Biomarker Kidney Molecule-1 (KIM-1) in Acute Kidney Injury (AKI) Cisplatin-Induced Nephrotoxicity. International Journal of Molecular Sciences 20:20, pages 5238.
Crossref
Bo Sun, Xiaobing Zhou, Zhe Qu, Li Sun, Guilin Cheng, Yanwei Yang, Yufa Miao, Xiaoguang Chen & Bo Li. (2019) Urinary biomarker evaluation for early detection of gentamycin-induced acute kidney injury. Toxicology Letters 300, pages 73-80.
Crossref
Melanie L. Lawrence, Mona Elhendawi & Jamie A. Davies. 2019. Kidney Organogenesis. Kidney Organogenesis 127 142 .
Tobias Getzin, Marcus May, Martina Schmidbauer, Marcel Gutberlet, Petros Martirosian, Reinhard Oertel, Frank Wacker, Christoph Schindler & Katja Hueper. (2017) Usability of Functional MRI in Clinical Studies for Fast and Reliable Assessment of Renal Perfusion and Quantification of Hemodynamic Effects on the Kidney. The Journal of Clinical Pharmacology 58:4, pages 466-473.
Crossref
Derk C.F. Klatte, Alessandro Gasparini, Hong Xu, Pietro de Deco, Marco Trevisan, Anna L.V. Johansson, Björn Wettermark, Johan Ärnlöv, Cynthia J Janmaat, Bengt Lindholm, Friedo W. Dekker, Josef Coresh, Morgan E. Grams & Juan J. Carrero. (2017) Association Between Proton Pump Inhibitor Use and Risk of Progression of Chronic Kidney Disease. Gastroenterology 153:3, pages 702-710.
Crossref
Shelby M. King, J. William Higgins, Celina R. Nino, Timothy R. Smith, Elizabeth H. Paffenroth, Casey E. Fairbairn, Abigail Docuyanan, Vishal D. Shah, Alice E. Chen, Sharon C. Presnell & Deborah G. Nguyen. (2017) 3D Proximal Tubule Tissues Recapitulate Key Aspects of Renal Physiology to Enable Nephrotoxicity Testing. Frontiers in Physiology 8.
Crossref
Laura Vicente-Vicente, Alfredo G. Casanova, María Teresa Hernández-Sánchez, Moisés Pescador, Francisco J. López-Hernández & Ana Isabel Morales. (2017) A systematic meta-analysis on the efficacy of pre-clinically tested nephroprotectants at preventing aminoglycoside nephrotoxicity. Toxicology 377, pages 14-24.
Crossref
James F. Burris, Michael A. Tortorici, Maja Mandic, Michael Neely & Michael D. Reed. (2016) Dosage Adjustments Related to Young or Old Age and Organ Impairment. The Journal of Clinical Pharmacology 56:12, pages 1461-1473.
Crossref
Natalia Sánchez-Romero, Carolien M.S. Schophuizen, Ignacio Giménez & Rosalinde Masereeuw. (2016) In vitro systems to study nephropharmacology: 2D versus 3D models. European Journal of Pharmacology 790, pages 36-45.
Crossref
Björn Runesson, Alessandro Gasparini, Abdul Rashid Qureshi, Olof Norin, Marie Evans, Peter Barany, Björn Wettermark, Carl Gustaf Elinder & Juan Jesús Carrero. (2016) The Stockholm CREAtinine Measurements (SCREAM) project: protocol overview and regional representativeness. Clinical Kidney Journal 9:1, pages 119-127.
Crossref
Michael A. Tortorici, David L. Cutler, Anasuya Hazra, Thomas D. Nolin, Karen Rowland-Yeo & Karthik Venkatakrishnan. (2015) Emerging areas of research in the assessment of pharmacokinetics in patients with chronic kidney disease. The Journal of Clinical Pharmacology 55:3, pages 241-250.
Crossref
William F. Pendergraft, Leal C. Herlitz, Denyse Thornley-Brown, Mitchell Rosner & John L. Niles. (2014) Nephrotoxic Effects of Common and Emerging Drugs of Abuse. Clinical Journal of the American Society of Nephrology 9:11, pages 1996-2005.
Crossref
Leonie van Meer, Matthijs Moerland, Adam F. Cohen & Jacobus Burggraaf. (2014) Urinary kidney biomarkers for early detection of nephrotoxicity in clinical drug development. British Journal of Clinical Pharmacology 77:6, pages 947-957.
Crossref
Gert A. Verpooten. 2014. Mann's Pharmacovigilance. Mann's Pharmacovigilance 567 575 .
W. B. Mattes, H. G. Kamp, E. Fabian, M. Herold, G. Krennrich, R. Looser, W. Mellert, A. Prokoudine, V. Strauss, B. van Ravenzwaay, T. Walk, H. Naraoka, K. Omura, I. Schuppe-Koistinen, S. Nadanaciva, E. D. Bush, N. Moeller, P. Ruiz-Noppinger & S. P. Piccoli. (2013) Prediction of Clinically Relevant Safety Signals of Nephrotoxicity through Plasma Metabolite Profiling. BioMed Research International 2013, pages 1-12.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.