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Drug Safety Evaluations

Drug safety evaluation of defibrotide

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Pages 123-136 | Published online: 10 Dec 2012

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Read on this site (7)

Christine Duncan, Justine Kahn, Stephan A. Grupp & Paul G. Richardson. (2019) Recent developments with defibrotide for the treatment of hepatic veno-occlusive disease/sinusoidal obstruction syndrome. Expert Opinion on Orphan Drugs 7:7-8, pages 337-347.
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Paul G. Richardson, Brandon M. Triplett, Vincent T. Ho, Nelson Chao, Fiona L. Dignan, Michelle Maglio & Mohamad Mohty. (2018) Defibrotide sodium for the treatment of hepatic veno-occlusive disease/sinusoidal obstruction syndrome. Expert Review of Clinical Pharmacology 11:2, pages 113-124.
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Selim Corbacioglu & Paul G. Richardson. (2017) Defibrotide for children and adults with hepatic veno-occlusive disease post hematopoietic cell transplantation. Expert Review of Gastroenterology & Hepatology 11:10, pages 885-898.
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Alessandro Fulgenzi & Maria Elena Ferrero. (2016) Defibrotide in the treatment of hepatic veno-occlusive disease. Hepatic Medicine: Evidence and Research 8, pages 105-113.
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Paola Tocchetti, Elena Tudone, Jean-Francois Marier, Thomas C Marbury, Katie Zomorodi & Mark Eller. (2016) Pharmacokinetic profile of defibrotide in patients with renal impairment. Drug Design, Development and Therapy 10, pages 2631-2641.
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Paul G Richardson, Amrita Krishnan, Sergio Giralt & Robert J Soiffer. (2015) Defibrotide for the treatment of severe hepatic veno-occlusive disease/sinusoidal obstruction syndrome: evidence for clinical benefit. Expert Opinion on Orphan Drugs 3:12, pages 1491-1501.
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Gösta Gahrton & Amrita Krishnan. (2014) Allogeneic transplantation in multiple myeloma. Expert Review of Hematology 7:1, pages 79-90.
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Articles from other publishers (55)

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Orly R. Klein, Yiouli P. Ktena, Elizabeth Pierce, Han-Hsuan Fu, Azeb Haile, Chen Liu & Kenneth R. Cooke. (2023) Defibrotide modulates pulmonary endothelial cell activation and protects against lung inflammation in pre-clinical models of LPS-induced lung injury and idiopathic pneumonia syndrome. Frontiers in Immunology 14.
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Yan Han, Alan Bidgoli, Brittany P. DePriest, Alejandra Méndez, Khadijeh Bijangi-Vishehsaraei, Evelio D. Perez-Albuerne, Robert A. Krance, Jamie Renbarger, Jodi L. Skiles, Sung W. Choi, Hao Liu & Sophie Paczesny. (2023) Prospective assessment of risk biomarkers of sinusoidal obstruction syndrome after hematopoietic cell transplantation. JCI Insight 8:10.
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Stephan A Grupp, Selim Corbacioglu, Hyoung Jin Kang, Takanori Teshima, Seong Lin Khaw, Franco Locatelli, Johan Maertens, Matthias Stelljes, Polina Stepensky, Paty Lopez, Vian Amber, Antonio Pagliuca, Paul G Richardson & Mohamad Mohty. (2023) Defibrotide plus best standard of care compared with best standard of care alone for the prevention of sinusoidal obstruction syndrome (HARMONY): a randomised, multicentre, phase 3 trial. The Lancet Haematology 10:5, pages e333-e345.
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Mohamad Mohty, Didier Blaise, Régis Peffault de Latour, Myriam Labopin, Jean Henri Bourhis, Benedicte Bruno, Patrice Ceballos, Marie Detrait, Virginie Gandemer, Anne Huynh, Faezeh Izadifar-Legrand, Charlotte Jubert, Hélène Labussière-Wallet, Delphine Lebon, Sébastien Maury, Catherine Paillard, Cécile Pochon, Cecile Renard, Fanny Rialland, Pascale Schneider, Anne Sirvent, Kobby Asubonteng, Gwennaëlle Guindeuil, Ibrahim Yakoub-Agha & Jean-Hugues Dalle. (2022) Real-world use of defibrotide for veno-occlusive disease/sinusoidal obstruction syndrome: the DEFIFrance Registry Study. Bone Marrow Transplantation 58:4, pages 367-376.
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Selim Corbacioglu, Ozlem Topaloglu & Saurabh Aggarwal. (2022) A Systematic Review and Meta-Analysis of Studies of Defibrotide Prophylaxis for Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome. Clinical Drug Investigation 42:6, pages 465-476.
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Hui Shi, Alex A. Gandhi, Stephanie A. Smith, Qiuyu Wang, Diane Chiang, Srilakshmi Yalavarthi, Ramadan A. Ali, Chao Liu, Gautam Sule, Pei-Suen Tsou, Yu Zuo, Yogendra Kanthi, Evan A. Farkash, Jiandie D. Lin, James H. Morrissey & Jason S. Knight. (2021) Endothelium-protective, histone-neutralizing properties of the polyanionic agent defibrotide. JCI Insight 6:17.
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Paul G. RichardsonEnric CarrerasMassimo Iacobelli & Bijan Nejadnik. (2018) The use of defibrotide in blood and marrow transplantation. Blood Advances 2:12, pages 1495-1509.
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John Coutsouvelis, Sharon Avery, Michael Dooley, Carl Kirkpatrick & Andrew Spencer. (2017) Defibrotide for the treatment of sinusoidal obstruction syndrome: evaluation of response to therapy and patient outcomes. Supportive Care in Cancer 26:3, pages 947-955.
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Mairéad Ní Chonghaile & Karen Wolownik. (2018) Identification and Management: Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease Eelated to Hematopoietic Stem Cell Transplantation
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Raif Nasre Nasser, Magdalena Correa VegaNorlis Colmenares ÁlvarezMariener Sánchez DugarteMartí Quevedo Pinos. (2017) Enfermedad Veno-oclusiva Hepática/Síndrome de Obstrucción Sinusoidal: actualización de los aspectos fisiopatológicos, criterios diagnósticos y opciones terapéuticas.. Oncología (Ecuador), pages 168-188.
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Paul G Richardson, Stephan A Grupp, Antonio Pagliuca, Amrita Krishnan, Vincent T Ho & Selim Corbacioglu. (2017) Defibrotide for the treatment of hepatic veno-occlusive disease/sinusoidal obstruction syndrome with multiorgan failure. International Journal of Hematologic Oncology 6:3, pages 75-93.
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Paul G. Richardson, Angela R. Smith, Brandon M. Triplett, Nancy A. Kernan, Stephan A. Grupp, Joseph H. Antin, Leslie Lehmann, Maja Miloslavsky, Robin Hume, Alison L. Hannah, Bijan Nejadnik & Robert J. Soiffer. (2017) Earlier defibrotide initiation post-diagnosis of veno-occlusive disease/sinusoidal obstruction syndrome improves Day +100 survival following haematopoietic stem cell transplantation. British Journal of Haematology 178:1, pages 112-118.
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Paul G. Richardson, Angela R. Smith, Brandon M. Triplett, Nancy A. Kernan, Stephan A. Grupp, Joseph H. Antin, Leslie Lehmann, Tsiporah Shore, Massimo Iacobelli, Maja Miloslavsky, Robin Hume, Alison L. Hannah, Bijan Nejadnik & Robert J. Soiffer. (2017) Defibrotide for Patients with Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome: Interim Results from a Treatment IND Study. Biology of Blood and Marrow Transplantation 23:6, pages 997-1004.
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Julie Steelandt, François Bocquet, Anne-Laure Cordonnier, Charlotte De Courtivron, Isabelle Fusier & Pascal Paubel. (2017) Defibrotide in Severe Sinusoidal Obstruction Syndrome: Medicine and Economic Issues. Biology of Blood and Marrow Transplantation 23:2, pages 347-356.
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Selim Corbacioglu, Enric Carreras, Mohamad Mohty, Antonio Pagliuca, Jaap Jan Boelens, Gandhi Damaj, Massimo Iacobelli, Dietger Niederwieser, Eduardo Olavarría, Felipe Suarez, Tapani Ruutu, Leo Verdonck, Robin Hume, Bijan Nejadnik, Chinglin Lai, Giorgia Finetto & Paul Richardson. (2016) Defibrotide for the Treatment of Hepatic Veno-Occlusive Disease: Final Results From the International Compassionate-Use Program. Biology of Blood and Marrow Transplantation 22:10, pages 1874-1882.
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Dominique-Charles Valla & Dominique Cazals-Hatem. (2016) Sinusoidal obstruction syndrome. Clinics and Research in Hepatology and Gastroenterology 40:4, pages 378-385.
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Oliver Tavabie & Abid R. Suddle. (2016) Lymphoma and hematological conditions: I. Lymphoma and liver complications of bone marrow transplant. Clinical Liver Disease 8:1, pages 1-5.
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Marta Palomo, Enrique Mir, Montse Rovira, Ginés Escolar, Enric Carreras & Maribel Diaz-Ricart. (2016) What is going on between defibrotide and endothelial cells? Snapshots reveal the hot spots of their romance. Blood 127:13, pages 1719-1727.
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Brandon M. Triplett, Hani I. Kuttab, Guolian Kang & Wing Leung. (2015) Escalation to High-Dose Defibrotide in Patients with Hepatic Veno-Occlusive Disease. Biology of Blood and Marrow Transplantation 21:12, pages 2148-2153.
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Gösta Gahrton. (2015) Allogeneic transplantation in multiple myeloma – How, when or at all?. Acta Haematologica Polonica 46:3, pages 224-232.
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Gillian M. Keating. (2014) Defibrotide: A Review of Its Use in Severe Hepatic Veno-Occlusive Disease Following Haematopoietic Stem Cell Transplantation. Clinical Drug Investigation 34:12, pages 895-904.
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