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Drug Safety Evaluations

Saxagliptin overview: special focus on safety and adverse effects

, MD & , MD
Pages 103-109 | Published online: 09 Nov 2012

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Shweta Sharma, Shubham Srivastava, Apeksha Shrivastava, Ruchi Malik, Faisal Almalki, Khalid Saifullah, Mohammad Mumtaz Alam, Mohammad Shaqiquzzaman, Shakir Ali & Mymoona Akhter. (2020) Mining of potential dipeptidyl peptidase-IV inhibitors as anti-diabetic agents using integrated in silico approaches. Journal of Biomolecular Structure and Dynamics 38:18, pages 5349-5361.
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Simona Cernea, Avivit Cahn & Itamar Raz. (2016) Saxagliptin for the treatment of diabetes - a focus on safety. Expert Opinion on Drug Safety 15:5, pages 697-707.
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Rose Anderson, Jennifer Hayes & Jeffrey W. Stephens. (2016) Pharmacokinetic, pharmacodynamic and clinical evaluation of saxagliptin in type 2 diabetes. Expert Opinion on Drug Metabolism & Toxicology 12:4, pages 467-473.
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André J Scheen. (2015) Safety of dipeptidyl peptidase-4 inhibitors for treating type 2 diabetes. Expert Opinion on Drug Safety 14:4, pages 505-524.
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André J Scheen. (2015) A review of gliptins for 2014. Expert Opinion on Pharmacotherapy 16:1, pages 43-62.
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André J Scheen. (2014) Pharmacokinetic and toxicological considerations for the treatment of diabetes in patients with liver disease. Expert Opinion on Drug Metabolism & Toxicology 10:6, pages 839-857.
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Articles from other publishers (21)

Nourhan Samy Elmalahany, Muhammed Abdel‐Hamied Abdel‐Tawab, Hanan M. Elwy, Hussein M. Fahmy & Rasha M. El Nashar. (2023) Design and application of molecularly imprinted electrochemical sensor for the new generation antidiabetic drug saxagliptin. Electroanalysis 35:5.
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Nicolas Bourdillon, Philippe J. Eugster, Céline Vocat, Toan Nguyen, Gregoire Wuerzner, Eric Grouzmann & Grégoire P. Millet. (2022) Saxagliptin: A potential doping agent? A randomized, double‐blinded, placebo‐controlled, and crossover pilot study in young active men. Physiological Reports 10:23.
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Chen-Hung Lee, Shu-Chun Huang, Kuo-Chun Hung, Chia-Jung Cho & Shih-Jung Liu. (2022) Enhanced Diabetic Wound Healing Using Electrospun Biocompatible PLGA-Based Saxagliptin Fibrous Membranes. Nanomaterials 12:21, pages 3740.
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Harshit Sajal, Shashank M. Patil, Ranjith Raj, Abdullah M. Shbeer, Mohammed Ageel & Ramith Ramu. (2022) Computer-Aided Screening of Phytoconstituents from Ocimum tenuiflorum against Diabetes Mellitus Targeting DPP4 Inhibition: A Combination of Molecular Docking, Molecular Dynamics, and Pharmacokinetics Approaches. Molecules 27:16, pages 5133.
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Reema A. Khalaf, Dalal Masalha & Dima Sabbah. (2020) DPP-IV Inhibitory Phenanthridines: Ligand, Structure-Based Design and Synthesis. Current Computer-Aided Drug Design 16:3, pages 295-307.
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Avinash MishraMegan CrossAndreas HofmannMark J. CosterAbdul KarimAbdul Sattar. (2019) Identification of a Novel Scaffold for Inhibition of Dipeptidyl Peptidase-4. Journal of Computational Biology 26:12, pages 1470-1486.
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Athanasia Papazafiropoulou & Andreas Melidonis. (2019) Antidiabetic agents in patients with hepatic impairment. World Journal of Meta-Analysis 7:8, pages 380-388.
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Nehad A. Abdallah & Heba F. Ibrahim. (2019) Electrochemical determination of Saxagliptin hydrochloride with MWCNTs/CuO/4′aminobenzo-18-crown-6-ether composite modified carbon paste electrode. Microchemical Journal 147, pages 487-496.
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Joelle de Melo Turnes, Taysa Bervian Bassani, Leonardo C Souza & Maria A B F Vital. (2018) Ineffectiveness of saxagliptin as a neuroprotective drug in 6-OHDA-lesioned rats. Journal of Pharmacy and Pharmacology 70:8, pages 1059-1068.
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Olivier Gaudin, Vannina Seta, Marina Alexandre, Gérôme Bohelay, Françoise Aucouturier, Sabine Mignot-Grootenboer, Saskia Ingen-Housz-Oro, Céline Bernardeschi, Pierre Schneider, Benoît Mellottee, Frédéric Caux & Catherine Prost-Squarcioni. (2018) Gliptin Accountability in Mucous Membrane Pemphigoid Induction in 24 Out of 313 Patients. Frontiers in Immunology 9.
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L. Yu. Morgunov. (2017) DIABETES MELLITUS IN PATIENTS WITH LIVER CIRRHOSIS: NEW TREATMENT OPTIONS. Research'n Practical Medicine Journal 4:3, pages 75-85.
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Shanshan Wu, Sanbao Chai, Jun Yang, Ting Cai, Yang Xu, Zhirong Yang, Yuan Zhang, Linong Ji, Feng Sun & Siyan Zhan. (2017) Gastrointestinal Adverse Events of Dipeptidyl Peptidase 4 Inhibitors in Type 2 Diabetes: A Systematic Review and Network Meta-analysis. Clinical Therapeutics 39:9, pages 1780-1789.e33.
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G. Penno, M. Garofolo & S. Del Prato. (2016) Dipeptidyl peptidase-4 inhibition in chronic kidney disease and potential for protection against diabetes-related renal injury. Nutrition, Metabolism and Cardiovascular Diseases 26:5, pages 361-373.
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Jinguang Ruan. (2015) Serum Alanine Transaminase Total Bilirubin Concentrations Predict CYP3A Activity as Measured by Midazolam and 1’-Hydroxylation. Medical Science Monitor 21, pages 396-402.
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André J. Scheen. (2014) Pharmacokinetics and Clinical Use of Incretin-Based Therapies in Patients with Chronic Kidney Disease and Type 2 Diabetes. Clinical Pharmacokinetics 54:1, pages 1-21.
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Boaz Hirshberg, Artist Parker, Helen Edelberg, Mark Donovan & Nayyar Iqbal. (2014) Safety of saxagliptin: events of special interest in 9156 patients with type 2 diabetes mellitus. Diabetes/Metabolism Research and Reviews 30:7, pages 556-569.
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André J. Scheen. (2014) Pharmacokinetics in Patients with Chronic Liver Disease and Hepatic Safety of Incretin-Based Therapies for the Management of Type 2 Diabetes Mellitus. Clinical Pharmacokinetics 53:9, pages 773-785.
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Omprakash Tanwar, Lalima Tanwar, Md. Shaquiquzzaman, Md. Mumtaz Alam & Mymoona Akhter. (2014) Structure based virtual screening of MDPI database: Discovery of structurally diverse and novel DPP-IV inhibitors. Bioorganic & Medicinal Chemistry Letters 24:15, pages 3447-3451.
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Carlo B. Giorda, Elisa Nada & Barbara Tartaglino. (2014) Pharmacokinetics, safety, and efficacy of DPP-4 inhibitors and GLP-1 receptor agonists in patients with type 2 diabetes mellitus and renal or hepatic impairment. A systematic review of the literature. Endocrine 46:3, pages 406-419.
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María Laura Sbaraglini, María Silvina Molinuevo, Claudia Sedlinsky, León Schurman & Antonio Desmond McCarthy. (2014) Saxagliptin affects long-bone microarchitecture and decreases the osteogenic potential of bone marrow stromal cells. European Journal of Pharmacology 727, pages 8-14.
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Joel M. Neutel, Cathy Zhao & Chetan S. Karyekar. (2013) Adding Saxagliptin to Metformin Extended Release (XR) or Uptitration of Metformin XR: Efficacy on Daily Glucose Measures. Diabetes Therapy 4:2, pages 269-283.
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