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Drug Safety Evaluations

Cardiac safety concerns for ondansetron, an antiemetic commonly used for nausea linked to cancer treatment and following anaesthesia

, PhD DSc & , PhD FSB FBPharmcolS
Pages 421-431 | Published online: 12 Apr 2013

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Chengjie Gao, Bo Li, Lufeng Xu, Fubin Lv, Guimao Cao, Huixia Wang, Fei Wang & Guanghan Wu. (2015) Efficacy and safety of ramosetron versus ondansetron for postoperative nausea and vomiting after general anesthesia: a meta-analysis of randomized clinical trials. Drug Design, Development and Therapy 9, pages 2343-2350.
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Articles from other publishers (20)

Ramakrishna Bandaru, Pramila T, Prathibha T & Surendra BV. (2023) A COMPARATIVE STUDY OF ONDANSETRON WITH RAMOSETRON IN PREVENTION OF POST-OPERATIVE NAUSEA AND VOMITING IN PATIENTS UNDERGOING GENERAL ANESTHESIA. Asian Journal of Pharmaceutical and Clinical Research, pages 182-185.
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Mohammad Bashkar, Najmeh Nowrouzi & Mohammad Reza Mohammadizadeh. (2023) Copper‐catalyzed intramolecular annulation through C–H activation: Synthesis of carbazolones. Applied Organometallic Chemistry 37:7.
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Eden Firew, Helen Huang, Ayush Anand, Yonathan Aliye Asfaw, Charmy Parikh & Hamza Rafique Khan. (2022) Ondansetron‐induced pseudoallergy with non‐ischemic myocardial injury: A rare case report of Kounis syndrome. Clinical Case Reports 10:12.
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Eric D. Watt, Tiffany Lee, Shuyun Lily Feng, Peter Kilfoil, David Ackley, Christopher Keefer, Todd Wisialowski & Stephen Jenkinson. (2022) Use of high throughput ion channel profiling and statistical modeling to predict off-target arrhythmia risk - One pharma's experience and perspective. Journal of Pharmacological and Toxicological Methods 118, pages 107213.
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Dexin Xiong & Chao Xiong. (2022) Early Postoperative Ondansetron Exposure is Associated with Reduced 90-Day Mortality in Patients Undergoing Cardiac Surgery. Frontiers in Surgery 9.
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Shihai Li, Zili Xu, Mingkun Guo, Menglong Li & Zhining Wen. (2022) Drug-induced QT Prolongation Atlas (DIQTA) for enhancing cardiotoxicity management. Drug Discovery Today 27:3, pages 831-837.
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Shahrouz Tabrizi, Shaghayegh Heidari & Hooman Rafiei. (2021) Investigation role of ondansetron on long QT interval among non-cardiac patients. Annals of Medicine and Surgery 71, pages 102971.
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Hani Essa, David J. Wright, Rebecca Dobson & Gregory Y.H. Lip. (2021) Chemotherapy-Induced Arrhythmia – Underrecognized and Undertreated. The American Journal of Medicine 134:10, pages 1224-1231.e1.
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Aleksandra Pluta, Michał Jan Stasiowski, Anita Lyssek-Boroń, Seweryn Król, Lech Krawczyk, Ewa Niewiadomska, Jakub Żak, Magdalena Kawka, Dariusz Dobrowolski, Beniamin Oskar Grabarek, Izabela Szumera, Anna Missir, Robert Rejdak & Przemysław Jałowiecki. (2021) Adverse Events during Vitrectomy under Adequacy of Anesthesia—An Additional Report. Journal of Clinical Medicine 10:18, pages 4172.
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Olivia G Fahey, Jennifer K Piccolo, Jason J Bergsbaken & Elizabeth N Dow-Hillgartner. (2020) Hypertension and QT interval prolongation associated with targeted systemic cancer therapies. Journal of Oncology Pharmacy Practice 26:8, pages 1987-1996.
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Anna Funk, David Schnadower & Stephen B. Freedman. (2020) Update on nonantibiotic therapies for acute gastroenteritis. Current Opinion in Infectious Diseases 33:5, pages 381-387.
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Yevgeniya E. Koshman, Amanda S. Wilsey, Brandan M. Bird, Aimee L. Endemann, Sabine Sadilek, Jessica Treadway, Ruth L. Martin, James S. Polakowski, Gary A. Gintant & Scott W. Mittelstadt. (2020) Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs. Journal of Pharmacological and Toxicological Methods 103, pages 106871.
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Reza Safaeian, Valiollah Hassani, Alimohamad Asghari, Masood Mohseni, Haleh Ashraf & Zahra Sadat Koleini. (2020) The effects of ondansetron versus dexamethasone on electrocardiographic markers of ventricular repolarization in children undergoing cochlear implant. International Journal of Pediatric Otorhinolaryngology 132, pages 109896.
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Michele Reibaldi, Matteo Fallico, Antonio Longo, Teresio Avitabile, Marinella Astuto, Paolo Murabito, Carmelo Minardi, Vincenza Bonfiglio, Francesco Boscia, Claudio Furino, Robert Rejdak, Katarzyna Nowomiejska, Mario Toro, Gilda Cennamo, Salvatore Cillino, Michele Rinaldi, Tito Fiore, Carlo Cagini & Andrea Russo. (2019) Efficacy of Three Different Prophylactic Treatments for Postoperative Nausea and Vomiting after Vitrectomy: A Randomized Clinical Trial. Journal of Clinical Medicine 8:3, pages 391.
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Alessandro Giovanni Fiocchi & Valentina Pecora. 2019. Food Protein Induced Enterocolitis (FPIES). Food Protein Induced Enterocolitis (FPIES) 69 76 .
David Neville Levin, Zachary Dulberg, An-Wen Chan, Gregory M. T. Hare, C. David Mazer & Aaron Hong. (2017) A randomized-controlled trial of nabilone for the prevention of acute postoperative nausea and vomiting in elective surgeryUne étude randomisée contrôlée pour évaluer l’efficacité du nabilone pour la prévention des nausées et vomissements postopératoires aigus lors de chirurgie non urgente. Canadian Journal of Anesthesia/Journal canadien d'anesthésie 64:4, pages 385-395.
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Dae-Jun Kim, Hyun-Mo Ryu, Sang-in Park, Soo-Jin Park, Chang-Hyun Song & Sae-Kwang Ku. (2015) Pharmacokinetic Properties of Ondansetron in Combination with Ijintang-gamibang, Polyherbal Complex in Rats. International Journal of Pharmacology 11:4, pages 351-358.
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Karin Sandoval & Ken Witt. 2015. A worldwide yearly survey of new data in adverse drug reactions. A worldwide yearly survey of new data in adverse drug reactions 433 459 .
Pierre Maison-Blanche, Shaker Dakhil, Ari Baron, Sylvie Rottey, Fred Millard, Gedske Daugaard, Jean-Pascal Machiels, William Conkright, Sunil Sharma, Patricia M. M. B. Soetekouw, Jeffrey Yachnin, Lisa Sengeløv, Peter Van Veldhuizen, Sanjiv S. Agarwala, Dorothée Sémiond, Mustapha Chadjaa, Liji Shen & James L. Wade. (2014) An open-label study to investigate the cardiac safety profile of cabazitaxel in patients with advanced solid tumors. Cancer Chemotherapy and Pharmacology 73:6, pages 1241-1252.
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Dimitrios Farmakis, John Parissis & Gerasimos Filippatos. (2014) Insights Into Onco-Cardiology. Journal of the American College of Cardiology 63:10, pages 945-953.
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