720
Views
67
CrossRef citations to date
0
Altmetric
Reviews

Anticoagulant failure in coagulopathic patients: PTT confounding and other pitfalls

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Xiaoqing Shen, Hongkai Liang, Guishen Wu, Miaolian Chen & Jianwei Li. (2023) A Case Report of Streptococcus Dysgalactiae Toxic Shock Syndrome Complicated with Symmetric Peripheral Gangrene. Infection and Drug Resistance 16, pages 5977-5983.
Read now
Dilli Ram Poudel, Sushil Ghimire, Rashmi Dhital, Daniel A. Forman & Theodore E. Warkentin. (2017) Spontaneous HIT syndrome post-knee replacement surgery with delayed recovery of thrombocytopenia: a case report and literature review. Platelets 28:6, pages 614-620.
Read now
Tamam Bakchoul. (2016) An update on heparin-induced thrombocytopenia: diagnosis and management. Expert Opinion on Drug Safety 15:6, pages 787-797.
Read now

Articles from other publishers (63)

Theodore E. Warkentin. (2023) Autoimmune Heparin-Induced Thrombocytopenia. Journal of Clinical Medicine 12:21, pages 6921.
Crossref
Theodore E. Warkentin. (2023) Heparin-induced thrombocytopenia (and autoimmune heparin-induced thrombocytopenia): an illustrious review. Research and Practice in Thrombosis and Haemostasis 7:8, pages 102245.
Crossref
Martin MIRUS, Lars HEUBNER, Johannes KALBHENN & Peter M. SPIETH. (2023) Hemostatic disorders associated with extracorporeal membrane oxygenation. Minerva Anestesiologica 89:6.
Crossref
Naoki Makita, Tomoyuki Ohara, Yukiko Tsuji, Tetsuhiro Ueda, Takuma Nakamura, Toshiki Mizuno & Masahiro Makino. (2023) Early high-dose intravenous immunoglobulin for refractory heparin-induced thrombocytopenia with stroke: Two case reports. Journal of Stroke and Cerebrovascular Diseases 32:4, pages 107032.
Crossref
Sara Rodriguez-Lopez, Verna Yiu, Stephanie Carlin & Leonardo R. Brandão. 2023. Pediatric Kidney Disease. Pediatric Kidney Disease 877 901 .
Sandra Emily Stoll, Patrick Werner, Wolfgang A. Wetsch, Fabian Dusse, Alexander C. Bunck, Matthias Kochanek, Felix Popp, Thomas Schmidt, Christiane Bruns & Bernd W. Böttiger. (2022) Transjugular intrahepatic portosystemic shunt, local thrombaspiration, and lysis for management of fulminant portomesenteric thrombosis and atraumatic splenic rupture due to vector-vaccine-induced thrombotic thrombocytopenia: a case report. Journal of Medical Case Reports 16:1.
Crossref
Kyle Davis, Jamie Sebaaly, Leslie Wooten, Courtney Khouli, Alexandra Mihm & Sarah A. Nisly. (2022) A Multicenter Retrospective Evaluation of Direct Oral Anticoagulants for the Treatment of Heparin-Induced Thrombocytopenia. American Journal of Cardiovascular Drugs 22:4, pages 417-424.
Crossref
Theodore E. Warkentin. (2022) How to dose and monitor argatroban for treatment of HIT . British Journal of Haematology 197:6, pages 653-655.
Crossref
Matteo Marchetti, Stefano Barelli, Tobias Gleich, Francisco J. Gomez, Matthew Goodyer, Francesco Grandoni & Lorenzo Alberio. (2022) Managing argatroban in heparin‐induced thrombocytopenia: A retrospective analysis of 729 treatment days in 32 patients with confirmed heparin‐induced thrombocytopenia. British Journal of Haematology 197:6, pages 766-790.
Crossref
Aleksandra Tuleja, Dante SalvadorJrJr, Taulant Muka, Sarah Bernhard, Armando Lenz, Iris BaumgartnerMarc Schindewolf. (2022) Cost-effectiveness analysis of alternative anticoagulation in suspected heparin-induced thrombocytopenia. Blood Advances 6:10, pages 3114-3125.
Crossref
Nadia Gabarin, Donald M. Arnold, Ishac Nazy & Theodore E. Warkentin. (2022) Treatment of vaccine-induced immune thrombotic thrombocytopenia (VITT). Seminars in Hematology 59:2, pages 89-96.
Crossref
Theodore E. Warkentin. (2022) Platelet-activating anti-PF4 disorders: An overview. Seminars in Hematology 59:2, pages 59-71.
Crossref
Vittorio Pavoni, Lara Gianesello, Duccio Conti, Piercarlo Ballo, Pietro Dattolo, Domenico Prisco & Klaus Görlinger. (2022) “In Less than No Time”: Feasibility of Rotational Thromboelastometry to Detect Anticoagulant Drugs Activity and to Guide Reversal Therapy. Journal of Clinical Medicine 11:5, pages 1407.
Crossref
Theodore E. Warkentin & Andreas Greinacher. (2021) Spontaneous HIT syndrome: Knee replacement, infection, and parallels with vaccine-induced immune thrombotic thrombocytopenia. Thrombosis Research 204, pages 40-51.
Crossref
Theodore E. Warkentin & Shuoyan Ning. (2021) Symmetrical peripheral gangrene in critical illness. Transfusion and Apheresis Science 60:2, pages 103094.
Crossref
Yi-Chen Li, Rong Wang, Hang Xu, Lan-Ping Ding & Wei-Hong Ge. (2020) Anticoagulation Resumption in a Patient With Mechanical Heart Valves, Antithrombin Deficiency, and Hemorrhagic Transformation Following Thrombectomy After Ischemic Stroke. Frontiers in Pharmacology 11.
Crossref
Gowthami M. Arepally & Anand Padmanabhan. (2020) Heparin-Induced Thrombocytopenia. Arteriosclerosis, Thrombosis, and Vascular Biology.
Crossref
Theodore E. Warkentin & Scott Kaatz. (2020) COVID-19 versus HIT hypercoagulability. Thrombosis Research 196, pages 38-51.
Crossref
Sung Kwang Lee, Woo Hyun Cho, Do Hyung Kim & Hye Ju Yeo. (2020) Lung transplantation using argatroban in severe heparin-induced thrombocytopenia during extracorporeal membrane oxygenation: a case series. General Thoracic and Cardiovascular Surgery 68:12, pages 1565-1568.
Crossref
Jecko Thachil, Nicole P. Juffermans, Marco Ranucci, Jean M. Connors, Theodore E. Warkentin, Thomas L. Ortel, Marcel Levi, Toshiaki Iba & Jerrold H. Levy. (2020) ISTH DIC subcommittee communication on anticoagulation in COVID‐19. Journal of Thrombosis and Haemostasis 18:9, pages 2138-2144.
Crossref
Bartosz Krzowski, Paweł Balsam, Michał Peller, Piotr Lodziński, Marcin Grabowski, Joanna Drozd-Sokołowska, Grzegorz Basak, Monika Gawałko, Grzegorz Opolski & Jedrzej Kosiuk. (2020) Electrophysiological Procedures in Patients With Coagulation Disorders ― A Systemic Review ―. Circulation Journal 84:6, pages 875-882.
Crossref
Nabiha H. Saifee, Thomas V. Brogan, David M. McMullan, Larissa Yalon, Dana C. Matthews, Christopher R. Burke & Wayne L. Chandler. (2020) Monitoring Hemostasis During Extracorporeal Life Support. ASAIO Journal 66:2, pages 230-237.
Crossref
Jacob T. Beyer, Stuart E. Lind, Sheila Fisher, Toby C. Trujillo, Michael F. Wempe & Tyree H. Kiser. (2019) Evaluation of intravenous direct thrombin inhibitor monitoring tests: Correlation with plasma concentrations and clinical outcomes in hospitalized patients. Journal of Thrombosis and Thrombolysis 49:2, pages 259-267.
Crossref
Cheralyn J. Hendrix, Lisbi Rivas & Babak Sarani. 2020. Evidence-Based Practice of Critical Care. Evidence-Based Practice of Critical Care 598 604.e1 .
Jenna Khan & Wayne L. Chandler. (2019) Interference in the anti‐Xa heparin activity assay due to hemolysis and icterus during pediatric extracorporeal life support. Artificial Organs 43:9, pages 880-887.
Crossref
Ashley Barlow, Brooke Barlow, Travis Reinaker & Justin Harris. (2019) Potential Role of Direct Oral Anticoagulants in the Management of Heparin‐induced Thrombocytopenia. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 39:8, pages 837-853.
Crossref
Liane A. Arcinas, Rizwan A. Manji, Carmen Hrymak, Vi Dao, Jo‐Ann I. Sheppard & Theodore E. Warkentin. (2019) Autoimmune heparin‐induced thrombocytopenia and venous limb gangrene after aortic dissection repair: in vitro and in vivo effects of intravenous immunoglobulin. Transfusion.
Crossref
Jenna Khan & Wayne L Chandler. (2019) Discordant Partial Thromboplastin Time (PTT) vs Anti-Xa Heparin Activity. American Journal of Clinical Pathology 151:4, pages 424-432.
Crossref
Molly W. Mandernach & Craig S. Kitchens. 2019. Consultative Hemostasis and Thrombosis. Consultative Hemostasis and Thrombosis 207 225 .
Marc Schindewolf. (2019) Fondaparinux in heparin‐induced thrombocytopenia: A decade's worth of clinical experience. Research and Practice in Thrombosis and Haemostasis 3:1, pages 9-11.
Crossref
Martin Beiderlinden, Patrick Werner, Astrid Bahlmann, Johann Kemper, Tobias Brezina, Maximilian Schäfer, Klaus Görlinger, Holger Seidel, Peter Kienbaum & Tanja A. Treschan. (2018) Monitoring of argatroban and lepirudin anticoagulation in critically ill patients by conventional laboratory parameters and rotational thromboelastometry – a prospectively controlled randomized double-blind clinical trial. BMC Anesthesiology 18:1.
Crossref
A. Greinacher & K. Selleng. (2018) Heparininduzierte ThrombozytopenieHeparin-induced thrombocytopenia. Gefässchirurgie 23:3, pages 193-207.
Crossref
Phu Ngoc Tran & Minh-Ha Tran. (2017) Emerging Role of Direct Oral Anticoagulants in the Management of Heparin-Induced Thrombocytopenia. Clinical and Applied Thrombosis/Hemostasis 24:2, pages 201-209.
Crossref
Theodore E. Warkentin. 2018. Hematology. Hematology 1973 1983 .
Lawrence Rice. (2017) HITs and misses in 100 years of heparin. Hematology 2017:1, pages 667-673.
Crossref
Mario Menk, Philipp Briem, Björn Weiss, Martina Gassner, David Schwaiberger, Anton Goldmann, Christian Pille & Steffen Weber-Carstens. (2017) Efficacy and safety of argatroban in patients with acute respiratory distress syndrome and extracorporeal lung support. Annals of Intensive Care 7:1.
Crossref
A. Greinacher, K. Selleng & T.E. Warkentin. (2017) Autoimmune heparin‐induced thrombocytopenia. Journal of Thrombosis and Haemostasis 15:11, pages 2099-2114.
Crossref
Marc Schindewolf, Julia Steindl, Jan Beyer-Westendorf, Sebastian Schellong, Pascal Maria Dohmen, Johannes Brachmann, Katharina Madlener, Bernd Pötzsch, Robert Klamroth, Johannes Hankowitz, Norbert Banik, Sonja Eberle, Markus Michael Müller, Stefan Kropff & Edelgard Lindhoff-Last. (2017) Use of Fondaparinux Off-Label or Approved Anticoagulants for Management of Heparin-Induced Thrombocytopenia. Journal of the American College of Cardiology 70:21, pages 2636-2648.
Crossref
Curtis G. Jones, Shannon M. Pechauer, Brian R. Curtis, Daniel W. Bougie, Mehraboon S. Irani, Binod Dhakal, Brenda Pierce, Richard H. Aster & Anand Padmanabhan. (2017) A Platelet Factor 4-Dependent Platelet Activation Assay Facilitates Early Detection of Pathogenic Heparin-Induced Thrombocytopenia Antibodies. Chest 152:4, pages e77-e80.
Crossref
Shuoyan Ning & Theodore E. Warkentin. (2017) IV Immunoglobulin for Autoimmune Heparin-Induced Thrombocytopenia. Chest 152:3, pages 453-455.
Crossref
Theodore E. Warkentin, Menaka Pai & Lori-Ann Linkins. (2017) Direct oral anticoagulants for treatment of HIT: update of Hamilton experience and literature review. Blood 130:9, pages 1104-1113.
Crossref
Ching-Hsuan Wu, Ruo-Han Tseng, Guan-Min Lai & Jen-Tsun Lin. (2017) Venous gangrene in a patient with metastatic cancer of the colon after?chemotherapy. Journal of Cancer Research and Practice 4:1, pages 38-41.
Crossref
Shoko Mizuno, Motoshi Kainuma & Kimitoshi Nishiwaki. (2017) Severe consumptive coagulopathy caused by heparin-induced thrombocytopenia. Nihon Shuchu Chiryo Igakukai zasshi Journal of the Japanese Society of Intensive Care Medicine 24:1, pages 22-25.
Crossref
Andreas Greinacher, Tamam Bakchoul, Adam Cuker & Theodore E. Warkentin. 2017. Platelets in Thrombotic and Non-Thrombotic Disorders. Platelets in Thrombotic and Non-Thrombotic Disorders 789 811 .
Ahmed AljabriYvonne HuckleberryJason H. KarnesMahdi GharaibehHussam I. KutbiYuval Raz, Seongseok Yun, Ivo Abraham & Brian Erstad. (2016) Cost-effectiveness of anticoagulants for suspected heparin-induced thrombocytopenia in the United States. Blood 128:26, pages 3043-3051.
Crossref
C. Keyl, C. Lehane, E. Zimmer & D. Trenk. (2016) Monitoring anticoagulation with argatroban in critically ill patients: activated partial thromboplastin time versus diluted thrombin time. Thrombosis and Haemostasis 116:6, pages 1180-1181.
Crossref
Theodore E. Warkentin. (2017) Clinical picture of heparin-induced thrombocytopenia (HIT) and its differentiation from non-HIT thrombocytopenia. Thrombosis and Haemostasis 116:11, pages 813-822.
Crossref
Lydia D. Chen, A. Josh Roberts & William E. Dager. (2016) Safety and efficacy of starting warfarin after two consecutive platelet count rises in heparin-induced thrombocytopenia. Thrombosis Research 144, pages 229-233.
Crossref
Jessica W. Skelley, Jeffrey A. Kyle & Rachel A. Roberts. (2016) Novel oral anticoagulants for heparin-induced thrombocytopenia. Journal of Thrombosis and Thrombolysis 42:2, pages 172-178.
Crossref
Benjamin S. Salter, Menachem M. Weiner, Muoi A. Trinh, Joshua Heller, Adam S. Evans, David H. Adams & Gregory W. Fischer. (2016) Heparin-Induced Thrombocytopenia. Journal of the American College of Cardiology 67:21, pages 2519-2532.
Crossref
A. Cuker. (2016) Management of the multiple phases of heparin-induced thrombocytopenia. Thrombosis and Haemostasis 116:5, pages 835-842.
Crossref
Job Harenberg. (2016) Laboratory determination of old and new targeted anticoagulant agents for prevention of bleeding and thrombotic events in cancer patients. Thrombosis Research 140, pages S165-S167.
Crossref
T.E. Warkentin & M. Pai. (2016) Shock, acute disseminated intravascular coagulation, and microvascular thrombosis: is ‘shock liver’ the unrecognized provocateur of ischemic limb necrosis?. Journal of Thrombosis and Haemostasis 14:2, pages 231-235.
Crossref
Maureen A. Smythe, Jennifer Priziola, Paul P. Dobesh, Diane Wirth, Adam Cuker & Ann K. Wittkowsky. (2016) Guidance for the practical management of the heparin anticoagulants in the treatment of venous thromboembolism. Journal of Thrombosis and Thrombolysis 41:1, pages 165-186.
Crossref
Brigitte Tardy-Poncet, Philippe Nguyen, Jean-Claude Thiranos, Pierre-Emmanuel Morange, Christine Biron-Andréani, Yves Gruel, Jérome Morel, Alain Wynckel, Lelia Grunebaum, Judith Villacorta-Torres, Sandrine Grosjean & Emmanuel de Maistre. (2015) Argatroban in the management of heparin-induced thrombocytopenia: a multicenter clinical trial. Critical Care 19:1.
Crossref
Theodore E. Warkentin. (2015) Heparin-induced thrombocytopenia. Current Opinion in Critical Care 21:6, pages 576-585.
Crossref
Maureen A. Smythe, Lisa L. Forsyth, Theodore E. Warkentin, Marc D. Smith, Jo-Ann I. Sheppard & Francis Shannon. (2015) Progressive, Fatal Thrombosis Associated With Heparin-Induced Thrombocytopenia After Cardiac Surgery Despite “Therapeutic” Anticoagulation With Argatroban: Potential Role for PTT and ACT Confounding. Journal of Cardiothoracic and Vascular Anesthesia 29:5, pages 1319-1321.
Crossref
Theodore E. Warkentin. (2015) Ischemic Limb Gangrene with Pulses. New England Journal of Medicine 373:7, pages 642-655.
Crossref
. (2015) Anticoagulants. Reactions Weekly 1562:1, pages 28-28.
Crossref
Lori-Ann Linkins & Theodore E. Warkentin. (2015) Rivaroxaban for treatment of HIT: A riveting first experience. Thrombosis Research 135:1, pages 1-2.
Crossref
Lori-Ann Linkins, Theodore E. Warkentin, Menaka Pai, Sudeep Shivakumar, Rizwan A. Manji, Philip S. Wells & Mark A. Crowther. (2014) Design of the rivaroxaban for heparin-induced thrombocytopenia study. Journal of Thrombosis and Thrombolysis 38:4, pages 485-492.
Crossref
Theodore E. Warkentin. (2014) Voting with your fondaparinux. Thrombosis Research 134:1, pages 3-4.
Crossref
Marc Schindewolf, Julia Steindl, Jan Beyer-Westendorf, Sebastian Schellong, Pascal Maria Dohmen, Johannes Brachmann, Katharina Madlener, Bernd Pötzsch, Robert Klamroth, Johannes Hankowitz, Norbert Banik, Sonja Eberle, Stefan Kropff, Markus Michael Müller & Edelgard Lindhoff-Last. (2014) Frequent off-label use of fondaparinux in patients with suspected acute heparin-induced thrombocytopenia (HIT) – findings from the GerHIT multi-centre registry study. Thrombosis Research 134:1, pages 29-35.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.