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Expert Opinion on Drug Safety Volume 13, 2014 - Issue 1
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Original Research

Anaphylaxis associated with gadolinium-based contrast agents: data from the Food and Drug Administration's adverse event reporting system and review of case reports in the literature

Dennis W RaischUniveristy of New Mexico, College of Pharmacy, University of New Mexico, MSC 09 5360, Albuquerque, NM 87131, [email protected]
, PhD,
Vishvas GargUniveristy of New Mexico, College of Pharmacy, University of New Mexico, MSC 09 5360, Albuquerque, NM 87131, [email protected]
,
Rasha ArabyatUniveristy of New Mexico, College of Pharmacy, University of New Mexico, MSC 09 5360, Albuquerque, NM 87131, [email protected]
,
Xian ShenUniversity of Maryland, College of Pharmacy, Baltimore, MD, USA
,
Beatrice J EdwardsMD Anderson, Department of General Internal Medicine, Houston, TX, USA
,
Frank H MillerNorthwestern University, Fineberg School of Medicine, Chicago, IL, USA
,
June M McKoyNorthwestern University, Fineberg School of Medicine, Chicago, IL, USA
,
Beatrice NardoneNorthwestern University, Fineberg School of Medicine, Chicago, IL, USA
&
Dennis P WestNorthwestern University, Fineberg School of Medicine, Chicago, IL, USA
 show all
Pages 15-23 | Published online: 20 Sep 2013

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Nicholas G. Kounis, Ioanna Koniari, Grigorios Tsigkas, George D. Soufras, Panagiotis Plotas, Periklis Davlouros & George Hahalis. (2020) Gadolinium-induced Kounis syndrome including electrocardiographic considerations. Baylor University Medical Center Proceedings 33:3, pages 474-476.
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Articles from other publishers (33)

Hongxia Yan, Jianxin Zhang, Xinfeng Cai, Zhiying Hao & Zhe Guan. (2023) Severe immediate hypersensitivity to gadolinium contrast agent after targeted treatment in a patient with alveolar soft part sarcoma: A case report and review of literature. Medicine 102:46, pages e36092.
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Yuxuan Sun, Ailin Zhang, Meiling Zuo, Jingtao Chen & Liqin Zhu. (2023) A pharmacovigilance study of association between proton‐pump inhibitors and rhabdomyolysis event based on FAERS database. Journal of Gastroenterology and Hepatology.
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Shohei Fujita, Katsuhiro Sano, Gastao Cruz, Carlos Velasco, Hideo Kawasaki, Yuki Fukumura, Masami Yoneyama, Akiyoshi Suzuki, Kotaro Yamamoto, Yuichi Morita, Takashi Arai, Issei Fukunaga, Wataru Uchida, Koji Kamagata, Osamu Abe, Ryohei Kuwatsuru, Akio Saiura, Kenichi Ikejima, René Botnar, Claudia Prieto & Shigeki Aoki. (2023) MR Fingerprinting for Contrast Agent–free and Quantitative Characterization of Focal Liver Lesions. Radiology: Imaging Cancer 5:6.
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Akira Morishima & Nobuko Sasano. (2023) A case of cardiac arrest and DIC caused by anaphylactic reaction to gadoliniumガドリニウムMRI造影剤によるアナフィラキシーから心肺停止と急激なDICをきたした1症例. Journal of the Japanese Society of Intensive Care Medicine 30:5, pages 405-409.
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Weidong Ren, Weihua Wang & Yanli Guo. (2022) Analysis of Adverse Reactions of Aspirin in Prophylaxis Medication Based on FAERS Database. Computational and Mathematical Methods in Medicine 2022, pages 1-8.
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M. Teresa Gracia Bara, Alicia Gallardo-Higueras, Esther M. Moreno, Elena Laffond, Francisco J. Muñoz Bellido, Cristina Martin, Miriam Sobrino, Eva Macias, Sonia Arriba-Méndez, Rosita Castillo & Ignacio Davila. (2022) Hypersensitivity to Gadolinium-Based Contrast Media. Frontiers in Allergy 3.
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Lin Liang, Kyung Hee Park, Jae-Hyun Lee & Jung-Won Park. (2022) Causes and Diagnostic Usefulness of Tryptase Measurements for Anaphylaxis in a Korean Tertiary Care General Hospital. Yonsei Medical Journal 63:12, pages 1099.
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Roger J. Yu, Matthew S. Krantz, Elizabeth J. Phillips & Cosby A. StoneJr.Jr.. (2021) Emerging Causes of Drug-Induced Anaphylaxis: A Review of Anaphylaxis-Associated Reports in the FDA Adverse Event Reporting System (FAERS). The Journal of Allergy and Clinical Immunology: In Practice 9:2, pages 819-829.e2.
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Silvia Maria Lattanzio. (2021) Toxicity associated with gadolinium-based contrast-enhanced examinations. AIMS Biophysics 8:2, pages 198-220.
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Philippa Kate Tucker & Paul Macfarlane. (2020) Severe bronchoconstriction as part of a suspected anaphylactic reaction in a dog following administration of gadobutrol. Veterinary Record Case Reports 8:2.
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Azadeh Hojreh, Andreas Peyrl, Aleksandra Bundalo & Zsolt Szepfalusi. (2020) Subsequent MRI of pediatric patients after an adverse reaction to Gadolinium-based contrast agents. PLOS ONE 15:4, pages e0230781.
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Emanuela Biagioni, Irene Coloretti, Fabrizio Disalvo, Alberto Andreotti, Francesco Sani, Pietro Torricelli, Roberta Gelmini & Massimo Girardis. (2020) Case report of a patient who survived after cardiac arrest and cardiogenic shock by anaphylactic reaction to gadolinium during magnetic resonance imaging. Radiology Case Reports 15:3, pages 266-268.
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Katja Glutig, Gabriele Hahn, Petra Kuvvetli & Jan Endrikat. (2018) Safety of gadobutrol: results of a non-interventional study of 3710 patients, including 404 children. Acta Radiologica 60:7, pages 873-879.
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Guillermo Rodriguez-Nava, Alex M. Kesler, Ismael Carrillo-Martin & Alexei Gonzalez-Estrada. (2019) Gadolinium-induced anaphylaxis with positive skin test results. Annals of Allergy, Asthma & Immunology 122:6, pages 654-655.
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David J. Murphy & Raymond Y. Kwong. 2019. Cardiovascular Magnetic Resonance Imaging. Cardiovascular Magnetic Resonance Imaging 127 143 .
Joyce E. Yu & Robert Y. Lin. (2015) The Epidemiology of Anaphylaxis. Clinical Reviews in Allergy & Immunology 54:3, pages 366-374.
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Pedro Giavina-Bianchi, Marcelo V. Aun & Jorge Kalil. (2018) Drug-induced anaphylaxis: is it an epidemic?. Current Opinion in Allergy & Clinical Immunology 18:1, pages 59-65.
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Sabine Franckenberg, Florian Berger, Sarah Schaerli, Garyfalia Ampanozi & Michael Thali. (2018) Fatal anaphylactic reaction to intravenous gadobutrol, a gadolinium-based MRI contrast agent. Radiology Case Reports 13:1, pages 299-301.
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Priya Sellaturay, Shuaib Nasser & Pamela Ewan. (2018) Skin testing in gadolinium allergy: 2 case reports. The Journal of Allergy and Clinical Immunology: In Practice 6:1, pages 262-264.e1.
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Miguel Ramalho & Joana Ramalho. (2017) Gadolinium-Based Contrast Agents. Magnetic Resonance Imaging Clinics of North America 25:4, pages 755-764.
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Alicia Prieto-García, Esther Pérez-David, Carolina Devesa, Pilar Tornero, Lawrence B. Schwartz, Cristina Pascual & Mariana C. Castells. (2017) Fatal anaphylaxis caused by gadolinium due to beta-tryptase–induced hemorragic diathesis. The Journal of Allergy and Clinical Immunology: In Practice 5:5, pages 1433-1434.
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Jie Shen Fok & William B. Smith. (2017) Hypersensitivity reactions to gadolinium-based contrast agents. Current Opinion in Allergy & Clinical Immunology 17:4, pages 241-246.
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Tyler J. Fraum, Daniel R. Ludwig, Mustafa R. Bashir & Kathryn J. Fowler. (2017) Gadolinium-based contrast agents: A comprehensive risk assessment. Journal of Magnetic Resonance Imaging 46:2, pages 338-353.
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Camille Kolenda, Rolande Dubost, Florence Hacard, Christine Mullet, Diane Le Quang, Lorna Garnier, Jacques Bienvenu, Vincent Piriou, Fr?d?ric B?rard, Fran?oise Bienvenu & S?bastien Viel. (2017) Evaluation of basophil activation test in the management of immediate hypersensitivity reactions to gadolinium-based contrast agents: a five-year experience. The Journal of Allergy and Clinical Immunology: In Practice 5:3, pages 846-849.
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Tara F. Carr. (2016) Pathophysiology of Immediate Reactions to Injectable Gadolinium-based Contrast Agents. Topics in Magnetic Resonance Imaging 25:6, pages 265-268.
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Hans-Klaus Goischke. (2016) ?Gadolinium-Phobia:? Not a Helpful ?Criterion? for Indication for Gadolinium-based Contrast Agent Administration in Multiple Sclerosis. Radiology 281:1, pages 323-324.
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Joep W.M. van OorschotFredy VisserAnouk L.M. EikendalEvert-jan P.A. VonkenPeter R. LuijtenSteven A.J. ChamuleauTim LeinerJaco J.M. Zwanenburg. (2016) Single Breath-Hold T1ρ-Mapping of the Heart for Endogenous Assessment of Myocardial Fibrosis. Investigative Radiology 51:8, pages 505-512.
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J.P. Finn, K.-L. Nguyen, F. Han, Z. Zhou, I. Salusky, I. Ayad & P. Hu. (2016) Cardiovascular MRI with ferumoxytol. Clinical Radiology 71:8, pages 796-806.
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Kevin J. Choi, Mirabelle B. Sajisevi, Russel R. Kahmke & David M. Kaylie. (2015) Incidence of Retrocochlear Pathology Found on MRI in Patients With Non-Pulsatile Tinnitus. Otology & Neurotology 36:10, pages 1730-1734.
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Joep W.M. van Oorschot, Johannes M.I.H. Gho, Gerardus P.J. van Hout, Martijn Froeling, Sanne J. Jansen of Lorkeers, Imo E. Hoefer, Pieter A. Doevendans, Peter R. Luijten, Steven A.J. Chamuleau & Jaco J.M. Zwanenburg. (2015) Endogenous contrast MRI of cardiac fibrosis: Beyond late gadolinium enhancement. Journal of Magnetic Resonance Imaging 41:5, pages 1181-1189.
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Saeed FakhranLea AlhilaliHrishikesh KaleEmanuel Kanal. (2015) Assessment of Rates of Acute Adverse Reactions to Gadobenate Dimeglumine: Review of More Than 130,000 Administrations in 7.5 Years. American Journal of Roentgenology 204:4, pages 703-706.
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F. Estelle R. Simons, Motohiro Ebisawa, Mario Sanchez-Borges, Bernard Y. Thong, Margitta Worm, Luciana Kase Tanno, Richard F. Lockey, Yehia M. El-Gamal, Simon GA Brown, Hae-Sim Park & Aziz Sheikh. (2015) 2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines. World Allergy Organization Journal 8, pages 32.
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Joep WM van Oorschot, Hamza El Aidi, Sanne J Jansen of Lorkeers, Johannes MIH Gho, Martijn Froeling, Fredy Visser, Steven AJ Chamuleau, Pieter A Doevendans, Peter R Luijten, Tim Leiner & Jaco JM Zwanenburg. (2014) Endogenous assessment of chronic myocardial infarction with T1ρ-mapping in patients. Journal of Cardiovascular Magnetic Resonance 16:1.
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