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Expert Opinion on Drug Safety Volume 13, 2014 - Issue 1
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Drug Safety Evaluations

Targeting thymidylate synthase in colorectal cancer: critical re-evaluation and emerging therapeutic role of raltitrexed

Antonio AvalloneGastrointestinal Medical Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori ‘Fondazione Giovanni Pascale' – IRCCS, Via M. Semmola – 80131 Napoli, Italy+39 081 5903629; +39 081 5903813; [email protected]
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Elena Di GennaroExperimental Pharmacology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori ‘Fondazione Giovanni Pascale' – IRCCS, Napoli, Italy
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Lucrezia SilvestroGastrointestinal Medical Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori ‘Fondazione Giovanni Pascale' – IRCCS, Via M. Semmola – 80131 Napoli, Italy+39 081 5903629; +39 081 5903813; [email protected]
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Vincenzo Rosario IaffaioliGastrointestinal Medical Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori ‘Fondazione Giovanni Pascale' – IRCCS, Via M. Semmola – 80131 Napoli, Italy+39 081 5903629; +39 081 5903813; [email protected]
&
Alfredo BudillonExperimental Pharmacology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori ‘Fondazione Giovanni Pascale' – IRCCS, Napoli, Italy
Pages 113-129 | Published online: 05 Oct 2013

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Lauren C. Chartier, Gordon S. Howarth & Suzanne Mashtoub. (2020) Chemotherapy-induced mucositis development in a murine model of colitis-associated colorectal cancer. Scandinavian Journal of Gastroenterology 55:1, pages 47-54.
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Articles from other publishers (26)

Kai-Xin Huang, Yi-fei Pan, Rui-shuai Dai, Ling-Sha Xu, Bo-Wang Zhu, Xiao-Dong Zhang & Yi-wang Hu. (2023) A Preliminary Study of Immediate Intraperitoneal Chemotherapy for Stage III Colorectal Cancer. American Journal of Clinical Oncology 46:5, pages 193-198.
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Hironaka Yamanobe, Kenta Yamamoto, Saki Kishimoto, Kei Nakai, Fumishige Oseko, Toshiro Yamamoto, Osam Mazda & Narisato Kanamura. (2023) Anti-Inflammatory Effects of β-Cryptoxanthin on 5-Fluorouracil-Induced Cytokine Expression in Human Oral Mucosal Keratinocytes. Molecules 28:7, pages 2935.
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欣鑫 涂. (2023) Efficacy of Raltitrexed in Digestive System Tumors. Advances in Clinical Medicine 13:04, pages 6544-6549.
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Fu-Cheng Wang, Bin Peng, Ting-Ting Ren, Shao-Peng Liu, Jing-Rui Du, Zi-Hao Chen, Ting-Ting Zhang, Xiaoyang Gu, Mo Li, Sheng-Li Cao & Xingzhi Xu. (2022) A 1,2,3-Triazole Derivative of Quinazoline Exhibits Antitumor Activity by Tethering RNF168 to SQSTM1/P62. Journal of Medicinal Chemistry 65:22, pages 15028-15047.
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Bengt Glimelius, Sebastian Stintzing, John Marshall, Takayuki Yoshino & Aimery de Gramont. (2021) Metastatic colorectal cancer: Advances in the folate-fluoropyrimidine chemotherapy backbone. Cancer Treatment Reviews 98, pages 102218.
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Andrada Larisa Deac, Claudia Cristina Burz, Ioana Corina Bocsan & Anca Dana Buzoianu. (2020) Fluoropyrimidine-induced cardiotoxicity. World Journal of Clinical Oncology 11:12, pages 1008-1017.
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Haochen WangJian WangTianshi LvShoujin CaoXiaoqiang TongLi SongYinghua Zou. (2020) Loadability and Releasing Profiles In Vitro and Pharmacokinetics In Vivo of Vinorelbine and Raltitrexed by CalliSpheres Beads . Cancer Biotherapy and Radiopharmaceuticals.
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Rui Guo, Yi Tian, Xueyuan Jin, Xiaozhong Huang & Jun Yang. (2019) Thymidylate Synthase, a New Myoepithelial Biomarker for Breast Lesions. International Journal of Surgical Pathology 27:8, pages 852-858.
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Justyna Sobich, Małgorzata Prokopowicz, Piotr Maj, Piotr Wilk, Zbigniew Zieliński, Tomasz Frączyk & Wojciech Rode. (2019) Thymidylate synthase-catalyzed, tetrahydrofolate-dependent self-inactivation by 5-FdUMP. Archives of Biochemistry and Biophysics 674, pages 108106.
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N. Wei, B. Zhang, Y. Wang, X. H. He, L. C. Xu, G. D. Li, Y. H. Wang, G. Z. Wang, H. Z. Huang & W. T. Li. (2018) Transarterial chemoembolization with raltitrexed-based or floxuridine-based chemotherapy for unresectable colorectal cancer liver metastasis. Clinical and Translational Oncology 21:4, pages 443-450.
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Xue Han, Bin Peng, Bei-Bei Xiao, Sheng-Li Cao, Chao-Rui Yang, Wen-Zhu Wang, Fu-Cheng Wang, Hong-Yun Li, Xiao-Li Yuan, Ruifeng Shi, Ji Liao, Hailong Wang, Jing Li & Xingzhi Xu. (2019) Synthesis and evaluation of chalcone analogues containing a 4-oxoquinazolin-2-yl group as potential anti-tumor agents. European Journal of Medicinal Chemistry 162, pages 586-601.
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Marco Tampellini, Paolo Bironzo, Massimo Di Maio & Giorgio V Scagliotti. (2018) Thymidine phosphorylase: the unforeseen driver in colorectal cancer treatment?. Future Oncology 14:12, pages 1223-1231.
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Ilaria Depetris, Donatella Marino, Alessandro Bonzano, Celeste Cagnazzo, Roberto Filippi, Massimo Aglietta & Francesco Leone. (2018) Fluoropyrimidine-induced cardiotoxicity. Critical Reviews in Oncology/Hematology 124, pages 1-10.
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Xiuwei Wang, Zhen Guan, Yanting Dong, Zhiqiang Zhu, Jianhua Wang & Bo Niu. (2018) Inhibition of thymidylate synthase affects neural tube development in mice. Reproductive Toxicology 76, pages 17-25.
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Larry H. Matherly, Zhanjun Hou & Aleem Gangjee. (2017) The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer. Cancer Chemotherapy and Pharmacology 81:1, pages 1-15.
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Ruijuan Xing, Hongying Zhang, Jiangsong Yuan, Kai Zhang, Lin Li, Huicai Guo, Lijuan Zhao, Congying Zhang, Shuolei Li, Tianfeng Gao, Yi Liu & Lei Wang. (2017) Novel 6-substituted benzoyl and non-benzoyl straight chain pyrrolo[2,3- d ]pyrimidines as potential antitumor agents with multitargeted inhibition of TS, GARFTase and AICARFTase. European Journal of Medicinal Chemistry 139, pages 531-541.
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Stefano Kim, Amaëlle Bisch, Damien Montange, Marie-Justine Paillard, Thierry Nguyen, Marine Jary, Marion Jacquin, Betsy Winkfield, Christophe Borg & Bernard Royer. (2017) A simple and fast LC–MS/MS method with a very high sensitivity for the measurement of raltitrexed in human plasma. Journal of Chromatography B 1060, pages 240-246.
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Cen Qiu, Yueqi Li, Xin Liang, Yingxue Qi, Yiyang Chen, Xianke Meng, Hongtu Zheng, Ye Xu, Sanjun Cai, Guoxiang Cai & Jianwen Liu. (2017) A study of peritoneal metastatic xenograft model of colorectal cancer in the treatment of hyperthermic intraperitoneal chemotherapy with Raltitrexed. Biomedicine & Pharmacotherapy 92, pages 149-156.
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Sandro Barni & Fausto Petrelli. 2017. Manual of Cardio-oncology. Manual of Cardio-oncology 91 106 .
Ronaldo A. Ribeiro, Carlos W. S. Wanderley, Deysi V. T. Wong, José Maurício S. C. Mota, Caio A. V. G. Leite, Marcellus H. L. P. Souza, Fernando Q. Cunha & Roberto C. P. Lima-Júnior. (2016) Irinotecan- and 5-fluorouracil-induced intestinal mucositis: insights into pathogenesis and therapeutic perspectives. Cancer Chemotherapy and Pharmacology 78:5, pages 881-893.
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Bo Jiang, Fen Liu, ZhiHui Liu, Ting Zhang & Dong Hua. (2016) B7-H3 increases thymidylate synthase expression via the PI3k-Akt pathway. Tumor Biology 37:7, pages 9465-9472.
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Hongwei Zhao, Yubao Zhang, Jianmin Sun, Chao Zhan & Liang Zhao. (2016) Raltitrexed Inhibits HepG2 Cell Proliferation via G 0 /G 1 Cell Cycle Arrest . Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 23:5, pages 237-248.
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Jan Ludwiczak, Piotr Maj, Piotr Wilk, Tomasz Frączyk, Tomasz Ruman, Borys Kierdaszuk, Adam Jarmuła & Wojciech Rode. (2016) Phosphorylation of thymidylate synthase affects slow-binding inhibition by 5-fluoro-dUMP and N 4 -hydroxy-dCMP . Molecular BioSystems 12:4, pages 1333-1341.
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Yanting Dong, Xiuwei Wang, Jianlin Zhang, Zhen Guan, Lin Xu, Jianhua Wang, Ting Zhang & Bo Niu. (2014) Raltitrexed’s effect on the development of neural tube defects in mice is associated with DNA damage, apoptosis, and proliferation. Molecular and Cellular Biochemistry 398:1-2, pages 223-231.
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Sandro Barni, Antonio Ghidini, Andrea Coinu, Karen Borgonovo & Fausto Petrelli. (2014) A systematic review of raltitrexed-based first-line chemotherapy in advanced colorectal cancer. Anti-Cancer Drugs 25:10, pages 1122-1128.
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Yu-Ling Xu, Hong-Yan Lin, Run-Jie Cao, Ze-Zhong Ming, Wen-Chao Yang & Guang-Fu Yang. (2014) Pyrazolone?quinazolone hybrids: A novel class of human 4-hydroxyphenylpyruvate dioxygenase inhibitors. Bioorganic & Medicinal Chemistry 22:19, pages 5194-5211.
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