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Drug Safety Evaluations

Overview and safety of fingolimod hydrochloride use in patients with multiple sclerosis

, MD, , MD & , MD MSc

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Clara G. Chisari, Simona Toscano, Emanuele D’Amico, Salvatore Lo Fermo, Aurora Zanghì, Sebastiano Arena, Mario Zappia & Francesco Patti. (2019) An update on the safety of treating relapsing-remitting multiple sclerosis. Expert Opinion on Drug Safety 18:10, pages 925-948.
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Nikolaos Grigoriadis, Michael Linnebank, Nektaria Alexandri, Sarah Muehl & Günther F. L. Hofbauer. (2016) Considerations on long-term immuno-intervention in the treatment of multiple sclerosis: an expert opinion. Expert Opinion on Pharmacotherapy 17:15, pages 2085-2095.
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Jong-Mi Lee & May H Han. (2015) Patient experience and practice trends in multiple sclerosis – clinical utility of fingolimod. Patient Preference and Adherence 9, pages 685-693.
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Craig J Smith, Adam Denes, Pippa J Tyrrell & Mario Di Napoli. (2015) Phase II anti-inflammatory and immune-modulating drugs for acute ischaemic stroke. Expert Opinion on Investigational Drugs 24:5, pages 623-643.
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Angel P Sempere & Juana Gimenez-Martinez. (2014) Safety considerations when choosing the appropriate treatment for patients with multiple sclerosis. Expert Opinion on Drug Safety 13:10, pages 1287-1289.
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A. A. Garibyan, E. S. Delyagina, M. L. Antipova, E. G. Odintsova, V. E. Petrenko & I. V. Terekhova. (2023) Experimental and Theoretical Investigation of Inclusion Complexes of β-Cyclodextrin with Fingolimod. Russian Journal of Physical Chemistry A 97:3, pages 469-476.
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Simone Dertschnig, Peter Gergely, Jürgen Finke, Urs Schanz, Ernst Holler, Udo Holtick, Gérard Socié, Michael Medinger, Jakob Passweg, Takanori Teshima, Christos Stylianou, Stephan Oehen, Dominik Heim & Christoph Bucher. (2022) Mocravimod, a Selective Sphingosine-1-Phosphate Receptor Modulator, in Allogeneic Hematopoietic Stem Cell Transplantation for Malignancy. Transplantation and Cellular Therapy.
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Ramya Talanki Manjunatha, Salma Habib, Sai Lahari Sangaraju, Daniela Yepez & Xavier A Grandes. (2022) Multiple Sclerosis: Therapeutic Strategies on the Horizon. Cureus.
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Wladimir Mauhin, Abdellah Tebani, Damien Amelin, Lenaig Abily-Donval, Foudil Lamari, Jonathan London, Claire Douillard, Bertrand Dussol, Vanessa Leguy-Seguin, Esther Noel, Agathe Masseau, Didier Lacombe, Hélène Maillard, Soumeya Bekri, Olivier Lidove & Olivier Benveniste. (2022) Sphingosine-1-Phosphate Levels Are Higher in Male Patients with Non-Classic Fabry Disease. Journal of Clinical Medicine 11:5, pages 1233.
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Georges Jalkh, Rachelle Abi Nahed, Gabrielle Macaron & Mary Rensel. (2020) Safety of Newer Disease Modifying Therapies in Multiple Sclerosis. Vaccines 9:1, pages 12.
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Lucia Moiola, Paulus S. Rommer & Uwe K. Zettl. (2020) Prevention and management of adverse effects of disease modifying treatments in multiple sclerosis. Current Opinion in Neurology 33:3, pages 286-294.
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Nadja Demitrowitz & Tjalf Ziemssen. (2020) Multiple Sklerose: Neuroinflammation und -degeneration Hand in Hand. Kompass Autoimmun 2:4, pages 147-150.
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Xiuxiang Liu, Jinjin Wu, Chenying Zhu, Jie Liu, Xiaoli Chen, Tao Zhuang, Yashu Kuang, Yanfang Wang, Hao Hu, Ping Yu, Huimin Fan, Yuzhen Zhang, Zhongmin Liu & Lin Zhang. (2019) Endothelial S1pr1 regulates pressure overload‐induced cardiac remodelling through AKT‐eNOS pathway. Journal of Cellular and Molecular Medicine 24:2, pages 2013-2026.
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Andrew R. Clark & Michael Ohlmeyer. (2019) Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration. Pharmacology & Therapeutics 201, pages 181-201.
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Jonathan Q. Tran, Jeffrey P. Hartung, Allan D. Olson, Boaz Mendzelevski, Gregg A. Timony, Marcus F. Boehm, Robert J. Peach, Sheila Gujrathi & Paul A. Frohna. (2018) Cardiac Safety of Ozanimod, a Novel Sphingosine-1-Phosphate Receptor Modulator: Results of a Thorough QT/QTc Study. Clinical Pharmacology in Drug Development 7:3, pages 263-276.
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Yara Dadalti Fragoso. (2017) Multiple sclerosis treatment with fingolimod: profile of non-cardiologic adverse events. Acta Neurologica Belgica 117:4, pages 821-827.
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P. Soelberg Sorensen. (2017) Safety concerns and risk management of multiple sclerosis therapies. Acta Neurologica Scandinavica 136:3, pages 168-186.
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Frederic D. Darios, Jernej Jorgacevski, Ajda Flašker, Robert Zorec, Virginia García-Martinez, José Villanueva, Luis M. Gutiérrez, Charlotte Leese, Manjot Bal, Elena Nosyreva, Ege T. Kavalali & Bazbek Davletov. (2017) Sphingomimetic multiple sclerosis drug FTY720 activates vesicular synaptobrevin and augments neuroendocrine secretion. Scientific Reports 7:1.
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Sinead O'Sullivan & Kumlesh K. Dev. (2017) Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases. Neuropharmacology 113, pages 597-607.
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Di Fu, Yingchun Li, Jia Li, Xiaoyan Shi, Ronghui Yang, Yuan Zhong, Huihan Wang & Aijun Liao. (2016) The effect of S1P receptor signaling pathway on the survival and drug resistance in multiple myeloma cells. Molecular and Cellular Biochemistry 424:1-2, pages 185-193.
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Aldo Bonaventura, Luca Liberale, Alessandra Vecchié, Matteo Casula, Federico Carbone, Franco Dallegri & Fabrizio Montecucco. (2016) Update on Inflammatory Biomarkers and Treatments in Ischemic Stroke. International Journal of Molecular Sciences 17:12, pages 1967.
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Wohn-Jenn Leu, Sharada Prasanna Swain, She-Hung Chan, Jui-Ling Hsu, Shih-Ping Liu, Mei-Ling Chan, Chia-Chun Yu, Lih-Ching Hsu, Yen-Lin Chou, Wei-Ling Chang, Duen-Ren Hou & Jih-Hwa Guh. (2016) Non-immunosuppressive triazole-based small molecule induces anticancer activity against human hormone-refractory prostate cancers: the role in inhibition of PI3K/AKT/mTOR and c-Myc signaling pathways. Oncotarget 7:47, pages 76995-77009.
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Lorenzo Gaetani, Paola S. Menduno, Francesco Cometa, Maria Di Gregorio, Paola Sarchielli, Carlo Cagini, Paolo Calabresi & Massimiliano Di Filippo. (2015) Retinopathy during interferon-β treatment for multiple sclerosis: case report and review of the literature. Journal of Neurology 263:3, pages 422-427.
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Vittorio Racca, Marco Di Rienzo, Rosella Cavarretta, Anastasia Toccafondi, Emanuele Vaini, Maurizio Ferratini & Marco Rovaris. (2015) Fingolimod effects on left ventricular function in multiple sclerosis. Multiple Sclerosis Journal 22:2, pages 201-211.
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Naoko Ueda & Kyoko Saida. (2015) Retinal hemorrhages following fingolimod treatment for multiple sclerosis; a case report. BMC Ophthalmology 15:1.
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Adnan M. Subei & Daniel Ontaneda. (2015) Risk Mitigation Strategies for Adverse Reactions Associated with the Disease-Modifying Drugs in Multiple Sclerosis. CNS Drugs 29:9, pages 759-771.
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Kathryn J. Quigley, Catherine J. Reynolds, Amelie Goudet, Eleanor J. Raynsford, Ruhena Sergeant, Andrew Quigley, Stefan Worgall, Diana Bilton, Robert Wilson, Michael R. Loebinger, Bernard Maillere, Daniel M. Altmann & Rosemary J. Boyton. (2015) Chronic Infection by Mucoid Pseudomonas aeruginosa Associated with Dysregulation in T-Cell Immunity to Outer Membrane Porin F . American Journal of Respiratory and Critical Care Medicine 191:11, pages 1250-1264.
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Yara Dadalti Fragoso, Tarso Adoni, Sidney Gomes, Marcus Vinicius Magno Goncalves, Andre Palma da Cunha Matta, Maria Fernanda Mendes & Fabio Siquineli. (2015) Persistent Headache in Patients With Multiple Sclerosis Starting Treatment With Fingolimod. Headache: The Journal of Head and Face Pain 55:4, pages 578-579.
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Laure Michel, Catherine Larochelle & Alexandre Prat. (2015) Update on treatments in multiple sclerosis. La Presse Médicale 44:4, pages e137-e151.
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