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Is there really a link between benzodiazepine use and the risk of dementia?

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Dusan Kolar. (2018) Addictive potential of novel treatments for refractory depression and anxiety. Neuropsychiatric Disease and Treatment 14, pages 1513-1519.
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Tian-Tian Ma, Zixuan Wang, Xiwen Qin, Chengsheng Ju, Wallis C Y Lau, Kenneth K C Man, David Castle, Wing Chung Chang, Adrienne Y L Chan, Edmund C L Cheung, Celine Sze Ling Chui & Ian C K Wong. (2023) Global trends in the consumption of benzodiazepines and Z-drugs in 67 countries and regions from 2008 to 2018: a sales data analysis. SLEEP.
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Manuel Camino, Encarnacion Satorres, Iraida Delhom, Elena Real, Mireia Abella & Juan C. Meléndez. (2022) Mindfulness-based Cognitive Therapy to Improve Sleep Quality in Older Adults with Insomnia. Psychosocial Intervention 31:3, pages 159-167.
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Eunyoung Lee, Youngrong Bang, In-Young Yoon & Ha-Yun Choi. (2022) Entrapment of Binaural Auditory Beats in Subjects with Symptoms of Insomnia. Brain Sciences 12:3, pages 339.
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Patrícia Ferreira, Ana Rita Ferreira, Beatriz Barreto & Lia Fernandes. (2021) Is there a link between the use of benzodiazepines and related drugs and dementia? A systematic review of reviews. European Geriatric Medicine 13:1, pages 19-32.
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Marie Tournier, Elodie Pambrun, Sandy Maumus‐Robert, Antoine Pariente & Hélène Verdoux. (2021) The risk of dementia in patients using psychotropic drugs: Antidepressants, mood stabilizers or antipsychotics. Acta Psychiatrica Scandinavica 145:1, pages 56-66.
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Geoffrey Joyce, Patricia Ferido, Johanna Thunell, Bryan Tysinger & Julie Zissimopoulos. (2022) Benzodiazepine use and the risk of dementia. Alzheimer's & Dementia: Translational Research & Clinical Interventions 8:1.
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Linzi Liu, Linna Jia, Peiying Jian, Yifang Zhou, Jian Zhou, Feng Wu & Yanqing Tang. (2020) The Effects of Benzodiazepine Use and Abuse on Cognition in the Elders: A Systematic Review and Meta-Analysis of Comparative Studies. Frontiers in Psychiatry 11.
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David S. Baldwin & Nathan T. M. Huneke. 2020. Seminars in Clinical Psychopharmacology. Seminars in Clinical Psychopharmacology 268 289 .
Lone Baandrup. (2020) Polypharmacy in schizophrenia. Basic & Clinical Pharmacology & Toxicology 126:3, pages 183-192.
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Christopher N. Kaufmann, Alison A. Moore, Mark W. Bondi, James D. Murphy, Atul Malhotra & Laura A. Hart. (2020) Association Between the Use of Non-benzodiazepine Hypnotics and Cognitive Outcomes: A Systematic Review. Current Sleep Medicine Reports 6:1, pages 11-20.
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Charles D. Ciccone. 2020. Guccione's Geriatric Physical Therapy. Guccione's Geriatric Physical Therapy 102 136 .
Thomas Desmidt, Julien Delrieu, Thibaud Lebouvier, Gabriel Robert, Renaud David, Anna-Chloé Balageas, Alexandre Surget, Catherine Belzung, Nicolas Arlicot, Maria-Joao Ribeiro, Pierre Payoux, Bruno Vellas, Wissam El-Hage, Elsa Tavernier & Vincent Camus. (2019) Benzodiazepine use and brain amyloid load in nondemented older individuals: a florbetapir PET study in the Multidomain Alzheimer Preventive Trial cohort. Neurobiology of Aging 84, pages 61-69.
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Gerd Kempermann. (2019) Making DEEP Sense of Lifestyle Risk and Resilience. Frontiers in Aging Neuroscience 11.
Crossref
Erkki Kronholm, Pekka Jousilahti, Tiina Laatikainen, Tea Lallukka, Markku Peltonen, Johanna Seppänen & Lauri Virta. (2019) Trajectories in hypnotic use and approaching death: a register linked case–control study. Sleep Medicine 57, pages 153-161.
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Stephen T. Chen, Dax Volle, Jason Jalil, Pauline Wu & Gary W. Small. (2019) Health-Promoting Strategies for the Aging Brain. The American Journal of Geriatric Psychiatry 27:3, pages 213-236.
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Sharon L. Crowell‐Davis, Thomas F. Murray & Leticia Mattos DantasLeticia Mattos Dantas & Sharon L. Crowell‐Davis. 2019. Veterinary Psychopharmacology. Veterinary Psychopharmacology 67 102 .
Egemen Savaskan & Marc Walter. 2019. Suchtmedizin. Suchtmedizin 359 367 .
Elsa Bourcier, Amandine Baptiste, Adrien Borowik, Lucas Zerbib, Dominique Bonnet-Zamponi, Florence Tubach, Christine Fernandez & Patrick Hindlet. (2018) Sedative-hypnotic initiation and renewal at discharge in hospitalized older patients: an observational study. BMC Geriatrics 18:1.
Crossref
Rajesh R Tampi, Deena J Tampi, Juan J Young & Ashmita Banerjee. (2018) Benzodiazepine use and the risk for dementia. Future Neurology 13:4, pages 209-217.
Crossref
Rosa Camila Lucchetta, Barbara Paes Miglioli da Mata & Patricia de Carvalho Mastroianni. (2018) Association between Development of Dementia and Use of Benzodiazepines: A Systematic Review and Meta-Analysis. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 38:10, pages 1010-1020.
Crossref
Fábio José Fabrício de Barros Souza, Giliane Franco de Lima, Franciele Tibola, Giancarlo Lucca & Kristian Madeira. (2018) Avaliação do padrão de sono em insones usuários de benzodiazepínicos e análise da trazodona como medicação substitutiva. Jornal Brasileiro de Psiquiatria 67:2, pages 80-86.
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Brendan J. Ng, David G. Le Couteur & Sarah N. Hilmer. (2018) Deprescribing Benzodiazepines in Older Patients: Impact of Interventions Targeting Physicians, Pharmacists, and Patients. Drugs & Aging 35:6, pages 493-521.
Crossref
Ross Penninkilampi & Guy D. Eslick. (2018) A Systematic Review and Meta-Analysis of the Risk of Dementia Associated with Benzodiazepine Use, After Controlling for Protopathic Bias. CNS Drugs 32:6, pages 485-497.
Crossref
Hervé Javelot, Anne Marquis, Emilie Antoine-Bernard, Jean Grandidier, Luisa Weiner, Thierry Javelot & Bruno Michel. (2018) Benzodiazepines Withdrawal: Initial Outcomes and Long-Term Impact on Falls in a French Nursing Home. Pharmacy 6:2, pages 30.
Crossref
Elsa Bourcier, Virginie Korb-Savoldelli, Gilles Hejblum, Christine Fernandez & Patrick Hindlet. (2018) A systematic review of regulatory and educational interventions to reduce the burden associated with the prescriptions of sedative-hypnotics in adults treated for sleep disorders. PLOS ONE 13:1, pages e0191211.
Crossref
Gloria Ortiz-Guerrero, Diana Amador-Muñoz, Carlos Alberto Calderón-Ospina, Daniel López-Fuentes & Mauricio Orlando Nava Mesa. (2018) Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences. Neural Plasticity 2018, pages 1-9.
Crossref
Rajesh R. Tampi, Deena J. Tampi, Wynnelena C. Canio, Poorvanshi Alag, Dhweeja Dasarathy & Joel P. Dey. 2018. Psychiatric Disorders Late in Life. Psychiatric Disorders Late in Life 139 165 .
Jaden Brandt & Christine Leong. (2017) Benzodiazepines and Z-Drugs: An Updated Review of Major Adverse Outcomes Reported on in Epidemiologic Research. Drugs in R&D 17:4, pages 493-507.
Crossref
Tsz-tai Chan, William Chun-yin Leung, Victor Li, Kin-yiu Wesley Wong, Wing-ming Chu, Ka-chun Leung, Yuey-zhun Ng, Yuen-ming Gary Kai, Yat-fung Shea, Shek-kwan Richard Chang & Leung-wing Chu. (2017) Association between high cumulative dose of benzodiazepine in Chinese patients and risk of dementia: a preliminary retrospective case-control study. Psychogeriatrics 17:5, pages 310-316.
Crossref
Julien Bezin, Pauline Bosco-Levy & Antoine Pariente. (2017) False-positive results in pharmacoepidemiology and pharmacovigilance. Therapies 72:4, pages 415-420.
Crossref
Mariana Macedo Alvim, Danielle Teles da Cruz, Marcel de Toledo Vieira, Ronaldo Rocha Bastos & Isabel Cristina Gonçalves Leite. (2017) Prevalence of and factors associated with benzodiazepine use in community-resident elderly persons. Revista Brasileira de Geriatria e Gerontologia 20:4, pages 463-473.
Crossref
Mariana Martins Gonzaga do Nascimento, Juliana Vaz de Melo Mambrini, Maria Fernanda Lima-Costa, Josélia Oliveira Araújo Firmo, Sérgio William Viana Peixoto & Antônio Ignácio de Loyola Filho. (2017) Potentially inappropriate medications: predictor for mortality in a cohort of community-dwelling older adults. European Journal of Clinical Pharmacology 73:5, pages 615-621.
Crossref
Tilman Wetterling & Klaus Junghanns. (2017) Substance Abuse in Older Psychiatric Inpatients. SUCHT 63:2, pages 115-121.
Crossref
Dirk K. Wolter. (2017) Suchtpotenzial und andere Risiken von Benzodiazepinen und Z-Drugs im Alter. SUCHT 63:2, pages 81-97.
Crossref
Anne Bénard-Laribière, Pernelle Noize, Elodie Pambrun, Fabienne Bazin, Hélène Verdoux, Marie Tournier, Bernard Bégaud & Antoine Pariente. (2017) Trends in incident use of benzodiazepines and Z-drugs in France from 2006 to 2012: a population-based study. Pharmacoepidemiology and Drug Safety 26:2, pages 162-169.
Crossref
I. Anghelescu & O. Benkert. 2017. Kompendium der Psychiatrischen Pharmakotherapie. Kompendium der Psychiatrischen Pharmakotherapie 479 528 .
Michael Liebrenz, Marcel Schneider, Anna Buadze, Marie-Therese Gehring, Anish Dube & Carlo Caflisch. (2016) Attitudes towards a maintenance (-agonist) treatment approach in high-dose benzodiazepine-dependent patients: a qualitative study. Harm Reduction Journal 13:1.
Crossref
Michelle G Craske & Murray B Stein. (2016) Anxiety. The Lancet 388:10063, pages 3048-3059.
Crossref
Willy Gomm, Klaus von Holt, Friederike Thomé, Karl Broich, Wolfgang Maier, Klaus Weckbecker, Anne Fink, Gabriele Doblhammer & Britta Haenisch. (2016) Regular Benzodiazepine and Z-Substance Use and Risk of Dementia: An Analysis of German Claims Data. Journal of Alzheimer's Disease 54:2, pages 801-808.
Crossref
Martin Aigner. (2016) Benzodiazepine im FokusBenzodiazepines in focus. psychopraxis. neuropraxis 19:4, pages 115-117.
Crossref
Fanny Etchepare, Elodie Pambrun, Bernard Bégaud, Hélène Verdoux & Marie Tournier. (2016) Compliance of psychotropic drug prescription with clinical practice guidelines in older inpatients. Fundamental & Clinical Pharmacology 30:1, pages 82-92.
Crossref
Ashakumary Lakshmikuttyamma, Sidhartha D. Ray & Abigail Kay. 2016.
Murray B. Stein & Jitender Sareen. (2015) Generalized Anxiety Disorder. New England Journal of Medicine 373:21, pages 2059-2068.
Crossref
S. Billioti De Gage. (2020) Benzodiazépines et risque de démence chez les sujets âgés. European Psychiatry 30:S2, pages S44-S45.
Crossref
Esa R. Korpi, Bjørnar den Hollander, Usman Farooq, Elena Vashchinkina, Ramamoorthy Rajkumar, David J. Nutt, Petri Hyytiä & Gavin S. Dawe. (2015) Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse. Pharmacological Reviews 67:4, pages 872-1004.
Crossref
Suzanne Nielsen. 2017. Non-medical and illicit use of psychoactive drugs. Non-medical and illicit use of psychoactive drugs 141 159 .

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