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Dose tailoring of dabigatran etexilate: obvious or excessive?

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Thomas Decker Christensen, Erik Lerkevang Grove, Peter Brønnum Nielsen & Torben Bjerregaard Larsen. (2016) Self-managed oral anticoagulant therapy: a call for implementation. Expert Review of Cardiovascular Therapy 14:3, pages 255-257.
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S. R. Gilyarevsky, N. K. Vereina & M. V. Golshmid. (2023) Current insights into the possible role of laboratory monitoring of effectiveness and safety of direct oral anticoagulants. Rational Pharmacotherapy in Cardiology 19:3, pages 290-297.
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Robert C. Gosselin, Emmanuel J. Favaloro & Jonathan Douxfils. (2022) The myths behind DOAC measurement: Analyses of prescribing information from different regulatory bodies and a call for harmonization. Journal of Thrombosis and Haemostasis 20:11, pages 2494-2506.
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Jia‐Wei Ng, Nor Asyikin Mohd Tahir, Paul Ken Leong Chin, Mohd Makmor‐Bakry & Shamin Mohd Saffian. (2022) A systematic review and meta‐analysis of dabigatran peak and trough concentration in adults. British Journal of Clinical Pharmacology 88:10, pages 4443-4459.
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Jonathan Douxfils, Dorothy M. Adcock, Shannon M. Bates, Emmanuel J. Favaloro, Isabelle Gouin-Thibault, Cecilia Guillermo, Yohko Kawai, Edelgard Lindhoff-Last, Steve Kitchen & Robert C. Gosselin. (2021) 2021 Update of the International Council for Standardization in Haematology Recommendations for Laboratory Measurement of Direct Oral Anticoagulants. Thrombosis and Haemostasis 121:08, pages 1008-1020.
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Adela-Nicoleta Roşian, Mihaela Iancu, Adrian Pavel Trifa, Ştefan Horia Roşian, Cristina Mada, Cornelia Paula Gocan, Teodora Niţă, Sabina Istratoaie, Paul-Mihai Boarescu & Anca Dana Buzoianu. (2020) An Exploratory Association Analysis of ABCB1 rs1045642 and ABCB1 rs4148738 with Non-Major Bleeding Risk in Atrial Fibrillation Patients Treated with Dabigatran or Apixaban. Journal of Personalized Medicine 10:3, pages 133.
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Suman M. Wasan, Natalie Feland, Russell Grant & Christopher E. Aston. (2019) Validation of apixaban anti-factor Xa assay and impact of body weight. Thrombosis Research 182, pages 51-55.
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Juan Pablo Salazar Adum, Iva Golemi, Luis H. Paz, Luis Diaz Quintero, Alfonso J. Tafur & Joseph A. Caprini. (2018) Venous thromboembolism controversies. Disease-a-Month 64:9, pages 408-444.
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J. Douxfils, W. Ageno, C.‐M. Samama, S. Lessire, H. ten Cate, P. Verhamme, J. ‐M. Dogné & F. Mullier. (2018) Laboratory testing in patients treated with direct oral anticoagulants: a practical guide for clinicians. Journal of Thrombosis and Haemostasis 16:2, pages 209-219.
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E. Chaussade, Olivier Hanon, C. Boully, F. Labourée, L. Caillard, G. Gerotziafas, J.-S. Vidal & I. Elalamy. (2018) Real-Life Peak and Trough Dabigatran Plasma Measurements Over Time in Hospitalized Geriatric Patients with Atrial Fibrillation. The journal of nutrition, health & aging 22:1, pages 165-173.
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Virginie Dubois, Anne-Sophie Dincq, Jonathan Douxfils, Brigitte Ickx, Charles-Marc Samama, Jean-Michel Dogné, Maximilien Gourdin, Bernard Chatelain, François Mullier & Sarah Lessire. (2017) Perioperative management of patients on direct oral anticoagulants. Thrombosis Journal 15:1.
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W.C.Y. Lau, X. Li, I.C.K. Wong, K.K.C. Man, G.Y.H. Lip, W.K. Leung, C.W. Siu & E.W. Chan. (2017) Bleeding‐related hospital admissions and 30‐day readmissions in patients with non‐valvular atrial fibrillation treated with dabigatran versus warfarin. Journal of Thrombosis and Haemostasis 15:10, pages 1923-1933.
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Anne-Laure Sennesael, Thomas Exner, Bernard Chatelain, Sarah Lessire, Anne-Sophie Larock, Christelle Vancraeynest, Lionel Pochet, Jean-Michel Dogn?Anne Spinewine, Fran?ois Mullier & Jonathan Douxfils. (2017) An optimized dRVVT-based assay to estimate the intensity of anticoagulation in patients treated with direct oral anticoagulants. Thrombosis Research 157, pages 29-37.
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Lina Sabor, Mélanie Raphaël, Jean-Michel Dogné, François Mullier & Jonathan Douxfils. (2017) Heparin-calibrated chromogenic anti-Xa assays are not suitable to assess the presence of significant direct factor Xa inhibitors levels. Thrombosis Research 156, pages 36-38.
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I. Gouin‐Thibault, X. Delavenne, A. Blanchard, V. Siguret, J.E. Salem, C. Narjoz, P. Gaussem, P. Beaune, C. Funck‐Brentano, M. Azizi, P. Mismetti & M.A. Loriot. (2017) Interindividual variability in dabigatran and rivaroxaban exposure: contribution of ABCB1 genetic polymorphisms and interaction with clarithromycin. Journal of Thrombosis and Haemostasis 15:2, pages 273-283.
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Xuanmiao Zhang, Mei Hu, Guangfei Wei, Mengdi Jia, Tao Gong & Ji Liu. (2017) An injectable in situ lipid phase transition system for sustained delivery of dabigatran etexilate with low burst release . RSC Advances 7:89, pages 56594-56601.
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Luigi Brunetti, Betty Sanchez-Catanese, Leonid Kagan, Xia Wen, Min Liu, Brian Buckley, James P. Luyendyk & Lauren M. Aleksunes. (2016) Evaluation of the chromogenic anti-factor IIa assay to assess dabigatran exposure in geriatric patients with atrial fibrillation in an outpatient setting. Thrombosis Journal 14:1.
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Jonathan Douxfils, Lionel Pochet, Sarah Lessire, Christelle Vancraeynest, Jean-Michel Dogné & François Mullier. (2016) Mass spectrometry in the therapeutic drug monitoring of direct oral anticoagulants. Useful or useless?. TrAC Trends in Analytical Chemistry 84, pages 41-50.
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Ovidiu Vornicu, Anne-Sophie Larock, Jonathan Douxfils, François Mullier, Virginie Dubois, Maximilien Gourdin, Sarah Lessire & Anne-Sophie Dincq. (2016) Minimisation of Bleeding Risks Due to Direct Oral Anticoagulants. EMJ Hematology, pages 78-90.
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J. Douxfils, B. Chatelain, C. Chatelain, J.-M. Dogné & F. Mullier. (2015) Edoxaban: Impact on routine and specific coagulation assays. Thrombosis and Haemostasis 115:2, pages 368-381.
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